A Glaucoma-Associated variant of optineurin, M98K, activates Tbk1 to enhance autophagosome formation and retinal cell death dependent on Ser177 phosphorylation of optineurin

PLoS ONE

Volumn 10, Issue 9, 2015, Pages

  Sirohi, Kapil ^a   Kumari, Asha ^a   Radha, Vegesna ^a   Swarup, Ghanshyam ^a  

^a CENTRE FOR CELLULAR AND MOLECULAR BIOLOGY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; PHOSPHOTRANSFERASE; PROTEIN TBK1; SERINE; TRANSFERRIN RECEPTOR; UBIQUITIN; UNCLASSIFIED DRUG; OPTN PROTEIN, HUMAN; PROTEIN BINDING; PROTEIN SERINE THREONINE KINASE; SMALL INTERFERING RNA; TBK1 PROTEIN, MOUSE; TRANSCRIPTION FACTOR IIIA;

ARTICLE; ATG5 GENE; AUTOPHAGOSOME; AUTOPHAGY; CATALYSIS; CELL DEATH; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; GENE; GENE SILENCING; GLAUCOMA; MISSENSE MUTATION; MOLECULAR PATHOLOGY; OPTN GENE; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; RETINA CELL; WILD TYPE; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CULTURE; CONFOCAL MICROSCOPY; GENETICS; HELA CELL LINE; HUMAN; IMMUNOPRECIPITATION; INDIRECT FLUORESCENT ANTIBODY TECHNIQUE; METABOLISM; MOUSE; PATHOLOGY; PHAGOSOME; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN TRANSPORT; RETINA GANGLION CELL; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALS; AUTOPHAGY; BLOTTING, WESTERN; CELLS, CULTURED; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GLAUCOMA; HELA CELLS; HUMANS; IMMUNOPRECIPITATION; MICE; MICROSCOPY, CONFOCAL; PHAGOSOMES; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN TRANSPORT; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, TRANSFERRIN; RETINAL GANGLION CELLS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR TFIIIA;

EID: 84945940836     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0138289     Document Type: Article

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