Enhancedoptineurin E50k-TBK1 interaction evokes protein insolubility and initiates familial primary open-angle glaucoma

Human Molecular Genetics

Volumn 22, Issue 17, 2013, Pages 3559-3567

  Minegishi, Yuriko ^a   Iejima, Daisuke ^a   Kobayashi, Hiroaki ^a   Chi, Zai Long ^a   Kawase, Kazuhide ^b   Yamamoto, Tetsuya ^b   Seki, Tomohisa ^c   Yuasa, Shinsuke ^c   Fukuda, Keiichi ^c   Iwata, Takeshi ^a  

^a NATIONAL HOSPITAL ORGANIZATION TOKYO MEDICAL CENTER   (Japan)

^b GIFU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BX 795; MUTANT PROTEIN; OPTINEURIN; OPTINEURIN E50K; PROTEIN KINASE; PROTEIN KINASE INHIBITOR; TANK BINDING KINASE 1; UNCLASSIFIED DRUG; BX795; OPTN PROTEIN, HUMAN; PROTEIN SERINE THREONINE KINASE; PYRIMIDINE DERIVATIVE; TBK1 PROTEIN, HUMAN; THIOPHENE DERIVATIVE; TRANSCRIPTION FACTOR IIIA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; CELL DEATH; CELL LOSS; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; GENE MUTATION; GLIOSIS; HUMAN; HUMAN CELL; INTRACELLULAR TRANSPORT; LOW TENSION GLAUCOMA; MALE; MOUSE; NONHUMAN; OLIGOMERIZATION; OPEN ANGLE GLAUCOMA; PHENOTYPE; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INSOLUBILITY; PROTEIN PROTEIN INTERACTION; RETINA; RETINA GANGLION CELL; RETINA OUTER MOLECULAR LAYER; SOLUBILITY; TRANSGENIC MOUSE; ANIMAL; CHEMISTRY; DISEASE MODEL; GENETICS; HEK293 CELL LINE; METABOLISM; CELL STRAIN HEK293;

ANIMALS; DISEASE MODELS, ANIMAL; ENDOPLASMIC RETICULUM; GLAUCOMA, OPEN-ANGLE; GLIOSIS; HEK293 CELLS; HUMANS; INDUCED PLURIPOTENT STEM CELLS; MICE; MICE, TRANSGENIC; PROTEIN-SERINE-THREONINE KINASES; PYRIMIDINES; RETINA; THIOPHENES; TRANSCRIPTION FACTOR TFIIIA;

EID: 84881591878     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddt210     Document Type: Article

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