Correction: Part 8: Post-cardiac arrest care: 2015 American Heart Association guidelines update for cardiopulmonary resuscitation and emergency cardiovascular care (Circulation (2015) 132 (S465-S482) DOI: 10.1161/CIR.0000000000000262);Part 8: Post-cardiac arrest care: 2015 American Heart Association guidelines update for cardiopulmonary resuscitation and emergency cardiovascular care

Circulation

Volumn 132, Issue 18, 2015, Pages S465-S482

  Callaway, Clifton W ^a   Donnino, Michael W ^a   Fink, Ericka L ^a   Geocadin, Romergryko G ^a   Golan, Eyal ^a   Kern, Karl B ^a   Leary, Marion ^a   Meurer, William J ^a   Peberdy, Mary Ann ^a   Thompson, Trevonne M ^a   Zimmerman, Janice L ^a  

^a NONE

Author keywords

Cardiac arrest; Drug; Imaging; Moderate hypothermia

Indexed keywords

ANTICONVULSIVE AGENT; BIOLOGICAL MARKER; GLUCOSE; NEURON SPECIFIC ENOLASE; CARBON DIOXIDE; GLUCOSE BLOOD LEVEL;

ANGIOCARDIOGRAPHY; ANTICONVULSANT THERAPY; ARTICLE; ARTIFICIAL VENTILATION; CARDIOVASCULAR PROCEDURE; CARDIOVASCULAR SYSTEM EXAMINATION; CLINICAL EXAMINATION; COMATOSE PATIENT; COMPUTER ASSISTED TOMOGRAPHY; DIFFUSION WEIGHTED IMAGING; ELECTROENCEPHALOGRAM; EMERGENCY CARE; EVOKED RESPONSE; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HEART ARREST; HEART HEMODYNAMICS; HUMAN; HYPERTHERMIA; INDUCED HYPOTHERMIA; INTENSIVE CARE; MEDICAL SOCIETY; NUCLEAR MAGNETIC RESONANCE; ORGAN DONOR; OXYGENATION; PRACTICE GUIDELINE; PREDICTION; PRIORITY JOURNAL; PROGNOSIS; RESPIRATORY CARE; RESUSCITATION; RETURN OF SPONTANEOUS CIRCULATION; SEIZURE; TREATMENT OUTCOME; ADULT; ANALYSIS; BLOOD; COMA; COMPLICATION; CONSENSUS DEVELOPMENT; ELECTROCARDIOGRAPHY; EMERGENCY HEALTH SERVICE; FEVER; FLUID THERAPY; PROCEDURES; SEIZURES; STANDARDS; WARMING;

ADULT; ANTICONVULSANTS; BIOMARKERS; BLOOD GLUCOSE; CARBON DIOXIDE; CARDIOPULMONARY RESUSCITATION; COMA; ELECTROCARDIOGRAPHY; EMERGENCY MEDICAL SERVICES; FEVER; FLUID THERAPY; HEART ARREST; HUMANS; RESPIRATION, ARTIFICIAL; REWARMING; SEIZURES;

EID: 84945277695     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIR.0000000000000531     Document Type: Erratum

References (198)

1. Morrison LJ, Deakin CD, Morley PT, Callaway CW, Kerber RE, Kronick SL, Lavonas EJ, Link MS, Neumar RW, Otto CW, Parr M, Shuster M, Sunde K, Peberdy MA, Tang W, Hoek TL, Böttiger BW, Drajer S, Lim SH, Nolan JP; Advanced Life Support Chapter Collaborators. Part 8: advanced life support: 2010 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations. Circulation. 2010;122(suppl 2):S345-S421. doi: 10.1161/CIRCULATIONAHA.110.971051.
2. Deakin CD, Morrison LJ, Morley PT, Callaway CW, Kerber RE, Kronick SL, Lavonas EJ, Link MS, Neumar RW, Otto CW, Parr M, Shuster M, Sunde K, Peberdy MA, Tang W, Hoek TL, Böttiger BW, Drajer S, Lim SH, Nolan JP; Advanced Life Support Chapter Collaborators. Part 8: advanced life support: 2010 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations. Resuscitation. 2010;81 suppl 1:e93-e174. doi: 10.1016/j.resuscitation.2010.08.027.
3. Callaway CW, Soar J, Aibiki M, Böttiger BW, Brooks SC, Deakin CD, Donnino MW, Drajer S, Kloeck W, Morley PT, Morrison LJ, Neumar RW, Nicholson TC, Nolan JP, Okada K, O'Neil BJ, Paiva EF, Parr MJ, Wang TL, Witt J; on behalf of the Advanced Life Support Chapter Collaborators. Part 4: advanced life support: 2015 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations. Circulation. 2015;132(suppl 1):S84-S145. doi: 10.1161/CIR.0000000000000273.
4. Soar J, Callaway CW, Aibiki M, Böttiger BW, Brooks SC, Deakin CD, Donnino MW, Drajer S, Kloeck W, Morley PT, Morrison LJ, Neumar RW, Nicholson TC, Nolan JP, Okada K, O'Neil BJ, Paiva EF, Parr MJ, Wang TL, Witt J; on behalf of the Advanced Life Support Chapter Collaborators. Part 4: advanced life support: 2015 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations. Resuscitation. 2015. In press.
5. O'Connor D, Green S, Higgins JPT, eds. Chapter 5: defning the review questions and developing criteria for including studies. In: The Cochrane Collaboration. Higgins JPT, Green S, eds. Cochrane Handbook for Systematic Reviews of Interventions. Version 5.1.0. 2011. http://handbook. cochrane.org/. Accessed May 6, 2015.
6. Schünemann H, Brozek J, Guyatt G, Oxman A. GRADE Handbook. 2013. http://www.guidelinedevelopment.org/handbook/. Accessed May 6, 2015.
7. Neumar RW, Nolan JP, Adrie C, Aibiki M, Berg RA, Böttiger BW, Callaway C, Clark RS, Geocadin RG, Jauch EC, Kern KB, Laurent I, Longstreth WT Jr, Merchant RM, Morley P, Morrison LJ, Nadkarni V, Peberdy MA, Rivers EP, Rodriguez-Nunez A, Sellke FW, Spaulding C, Sunde K, Vanden Hoek T. Post-cardiac arrest syndrome: epidemiology, pathophysiology, treatment, and prognostication: a consensus statement from the International Liaison Committee on Resuscitation (American Heart Association, Australian and New Zealand Council on Resuscitation, European Resuscitation Council, Heart and Stroke Foundation of Canada, InterAmerican Heart Foundation, Resuscitation Council of Asia, and the Resuscitation Council of Southern Africa); the American Heart Association Emergency Cardiovascular Care Committee; the Council on Cardiovascular Surgery and Anesthesia; the Council on Cardiopulmonary, Perioperative, and Critical Care; the Council on Clinical Cardiology; and the Stroke Council. Circulation. 2008;118:2452-2483. doi: 10.1161/CIRCULATIONAHA.108.190652.
8. Davies MJ. Anatomic features in victims of sudden coronary death. Coronary artery pathology. Circulation. 1992;85(1 suppl):I19-I24.
9. Spaulding CM, Joly LM, Rosenberg A, Monchi M, Weber SN, Dhainaut JF, Carli P. Immediate coronary angiography in survivors of out-of-hos-pital cardiac arrest. N Engl J Med. 1997;336:1629-1633. doi: 10.1056/NEJM199706053362302.
10. Dumas F, Cariou A, Manzo-Silberman S, Grimaldi D, Vivien B, Rosencher J, Empana JP, Carli P, Mira JP, Jouven X, Spaulding C. Immediate percutaneous coronary intervention is associated with better survival after out-of-hospital cardiac arrest: insights from the PROCAT (Parisian Region Out of hospital Cardiac ArresT) registry. Circ Cardiovasc Interv. 2010;3:200-207. doi: 10.1161/CIRCINTERVENTIONS.109.913665.
11. Hollenbeck RD, McPherson JA, Mooney MR, Unger BT, Patel NC, McMullan PW Jr, Hsu CH, Seder DB, Kern KB. Early cardiac catheter-ization is associated with improved survival in comatose survivors of cardiac arrest without STEMI. Resuscitation. 2014;85:88-95. doi: 10.1016/j. resuscitation.2013.07.027.
12. Mooney MR, Unger BT, Boland LL, Burke MN, Kebed KY, Graham KJ, Henry TD, Katsiyiannis WT, Satterlee PA, Sendelbach S, Hodges JS, Parham WM. Therapeutic hypothermia after out-of-hospital cardiac arrest: evaluation of a regional system to increase access to cooling. Circulation. 2011;124:206-214. doi: 10.1161/CIRCULATIONAHA.110.986257.
13. Gräsner JT, Meybohm P, Lefering R, Wnent J, Bahr J, Messelken M, Jantzen T, Franz R, Scholz J, Schleppers A, Böttiger BW, Bein B, Fischer M; German Resuscitation Registry Study Group. ROSC after cardiac arrest-the RACA score to predict outcome after out-of-hospital cardiac arrest. Eur Heart J. 2011;32:1649-1656. doi: 10.1093/eurheartj/ehr107.
14. Cronier P, Vignon P, Bouferrache K, Aegerter P, Charron C, Templier F, Castro S, El Mahmoud R, Lory C, Pichon N, Dubourg O, Vieillard-Baron A. Impact of routine percutaneous coronary intervention after out-of-hos-pital cardiac arrest due to ventricular fbrillation. Crit Care. 2011;15:R122. doi: 10.1186/cc10227.
15. Bulut S, Aengevaeren WR, Luijten HJ, Verheugt FW. Successful out-of-hospital cardiopulmonary resuscitation: what is the optimal in-hospital treatment strategy? Resuscitation. 2000;47:155-161.
16. Bro-Jeppesen J, Kjaergaard J, Wanscher M, Pedersen F, Holmvang L, Lippert FK, Møller JE, Køber L, Hassager C. Emergency coronary angi-ography in comatose cardiac arrest patients: do real-life experiences support the guidelines? Eur Heart J Acute Cardiovasc Care. 2012;1:291-301. doi: 10.1177/2048872612465588.
17. Aurore A, Jabre P, Liot P, Margenet A, Lecarpentier E, Combes X. Predictive factors for positive coronary angiography in out-of-hospital cardiac arrest patients. Eur J Emerg Med. 2011;18:73-76. doi: 10.1097/MEJ.0b013e32833d469a.
18. Nanjayya VB, Nayyar V. Immediate coronary angiogram in comatose survivors of out-of-hospital cardiac arrest-an Australian study. Resuscitation. 2012;83:699-704. doi: 10.1016/j.resuscitation.2011.12.004.
19. Reynolds JC, Callaway CW, El Khoudary SR, Moore CG, Alvarez RJ, Rittenberger JC. Coronary angiography predicts improved outcome following cardiac arrest: propensity-adjusted analysis. J Intensive Care Med. 2009;24:179-186. doi: 10.1177/0885066609332725.
20. Strote JA, Maynard C, Olsufka M, Nichol G, Copass MK, Cobb LA, Kim F. Comparison of role of early (less than six hours) to later (more than six hours) or no cardiac catheterization after resuscitation from out-of-hospital cardiac arrest. Am J Cardiol. 2012;109:451-454. doi: 10.1016/j. amjcard.2011.09.036.
21. Tømte O, Andersen GØ, Jacobsen D, Drægni T, Auestad B, Sunde K. Strong and weak aspects of an established post-resuscitation treatment protocol-A fve-year observational study. Resuscitation. 2011;82:1186-1193. doi: 10.1016/j.resuscitation.2011.05.003.
22. Waldo SW, Armstrong EJ, Kulkarni A, Hoffmayer K, Kinlay S, Hsue P, Ganz P, McCabe JM. Comparison of clinical characteristics and outcomes of cardiac arrest survivors having versus not having coronary angiography. Am J Cardiol. 2013;111:1253-1258. doi: 10.1016/j.amjcard.2013.01.267.
23. Nielsen N, Hovdenes J, Nilsson F, Rubertsson S, Stammet P, Sunde K, Valsson F, Wanscher M, Friberg H; Hypothermia Network. Outcome, timing and adverse events in therapeutic hypothermia after out-of-hos-pital cardiac arrest. Acta Anaesthesiol Scand. 2009;53:926-934. doi: 10.1111/j.1399-6576.2009.02021.x.
24. Werling M, Thorén AB, Axelsson C, Herlitz J. Treatment and outcome in post-resuscitation care after out-of-hospital cardiac arrest when a modern therapeutic approach was introduced. Resuscitation. 2007;73:40-45. doi: 10.1016/j.resuscitation.2006.08.018.
25. Zanuttini D, Armellini I, Nucifora G, Carchietti E, Trillò G, Spedicato L, Bernardi G, Proclemer A. Impact of emergency coronary angiogra-phy on in-hospital outcome of unconscious survivors after out-of-hos-pital cardiac arrest. Am J Cardiol. 2012;110:1723-1728. doi: 10.1016/j. amjcard.2012.08.006.
26. O'Gara PT, Kushner FG, Ascheim DD, Casey DE Jr, Chung MK, de Lemos JA, Ettinger SM, Fang JC, Fesmire FM, Franklin BA, Granger CB, Krumholz HM, Linderbaum JA, Morrow DA, Newby LK, Ornato JP, Ou N, Radford MJ, Tamis-Holland JE, Tommaso CL, Tracy CM, Woo YJ, Zhao DX. 2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction: executive summary: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation. 2013;127:529-555. doi: 10.1161/CIR.0b013e3182742c84.
27. Jneid H, Anderson JL, Wright RS, Adams CD, Bridges CR, Casey DE Jr, Ettinger SM, Fesmire FM, Ganiats TG, Lincoff AM, Peterson ED, Philippides GJ, Theroux P, Wenger NK, Zidar JP. 2012 ACCF/AHA focused update of the guideline for the management of patients with unstable angina/non-ST-elevation myocardial infarction (updating the 2007 guideline and replacing the 2011 focused update): a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation. 2012;126:875-910. DOI: 10.1161/CIR.0b013e318256f1e0.
28. Task Force on the Management of ST-Segment Elevation Acute Myocardial Infarction of the European Society of Cardiology, Steg PG, James SK, Atar D, Badano LP, Blomstrom-Lundqvist C, Borger MA, Di Mario C, Dickstein K, Ducrocq G, Fernandez-Aviles F, Gershlick AH, Giannuzzi P, Halvorsen S, Huber K, Juni P, Kastrati A, Knuuti J, Lenzen MJ, Mahaffey KW, Valgimigli M, van 't Hof A, Widimsky P, Zahger D. ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation. Eur Heart J. 2012; 33:2569-2619.
29. Peberdy MA, Donnino MW, Callaway CW, Dimaio JM, Geocadin RG, Ghaemmaghami CA, Jacobs AK, Kern KB, Levy JH, Link MS, Menon V, Ornato JP, Pinto DS, Sugarman J, Yannopoulos D, Ferguson TB Jr; on behalf of the American Heart Association Emergency Cardiovascular Care Committee; Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation. Impact of percutaneous coronary intervention performance reporting on cardiac resuscitation centers: a scientifc statement from the American Heart Association. Circulation. 2013;128:762-773. doi: 10.1161/CIR.0b013e3182a15cd2.
30. Trzeciak S, Jones AE, Kilgannon JH, Milcarek B, Hunter K, Shapiro NI, Hollenberg SM, Dellinger P, Parrillo JE. Signifcance of arterial hypotension after resuscitation from cardiac arrest. Crit Care Med. 2009;37:2895-903; quiz 2904.
31. Bray JE, Bernard S, Cantwell K, Stephenson M, Smith K; VACAR Steering Committee. The association between systolic blood pressure on arrival at hospital and outcome in adults surviving from out-of-hospital cardiac arrests of presumed cardiac aetiology. Resuscitation. 2014;85:509-515. doi: 10.1016/j.resuscitation.2013.12.005.
32. Kilgannon JH, Roberts BW, Reihl LR, Chansky ME, Jones AE, Dellinger RP, Parrillo JE, Trzeciak S. Early arterial hypotension is common in the post-cardiac arrest syndrome and associated with increased in-hospital mortality. Resuscitation. 2008;79:410-416. doi: 10.1016/j. resuscitation.2008.07.019.
33. Müllner M, Sterz F, Binder M, Hellwagner K, Meron G, Herkner H, Laggner AN. Arterial blood pressure after human cardiac arrest and neurological recovery. Stroke. 1996;27:59-62.
34. Beylin ME, Perman SM, Abella BS, Leary M, Shofer FS, Grossestreuer AV, Gaieski DF. Higher mean arterial pressure with or without vasoac-tive agents is associated with increased survival and better neurological outcomes in comatose survivors of cardiac arrest. Intensive Care Med. 2013;39:1981-1988. doi: 10.1007/s00134-013-3075-9.
35. Gaieski DF, Band RA, Abella BS, Neumar RW, Fuchs BD, Kolansky DM, Merchant RM, Carr BG, Becker LB, Maguire C, Klair A, Hylton J, Goyal M. Early goal-directed hemodynamic optimization combined with therapeutic hypothermia in comatose survivors of out-of-hospital cardiac arrest. Resuscitation. 2009;80:418-424. doi: 10.1016/j. resuscitation.2008.12.015.
36. Laurent I, Monchi M, Chiche JD, Joly LM, Spaulding C, Bourgeois B, Cariou A, Rozenberg A, Carli P, Weber S, Dhainaut JF. Reversible myo-cardial dysfunction in survivors of out-of-hospital cardiac arrest. J Am Coll Cardiol. 2002;40:2110-2116.
37. Sunde K, Pytte M, Jacobsen D, Mangschau A, Jensen LP, Smedsrud C, Draegni T, Steen PA. Implementation of a standardised treatment protocol for post resuscitation care after out-of-hospital cardiac arrest. Resuscitation. 2007;73:29-39. doi: 10.1016/j.resuscitation.2006.08.016.
38. Walters EL, Morawski K, Dorotta I, Ramsingh D, Lumen K, Bland D, Clem K, Nguyen HB. Implementation of a post-cardiac arrest care bundle including therapeutic hypothermia and hemodynamic optimization in comatose patients with return of spontaneous circulation after out-of-hospital cardiac arrest: a feasibility study. Shock. 2011;35:360-366. doi: 10.1097/SHK.0b013e318204c106.
39. Donnino M, Andersen LW, Berg KM, et al. Temperature management after cardiac arrest: an advisory statement by the Advanced Life Support (ALS) Task Force of the International Liaison Committee on Resuscitation (ILCOR). Circulation. In press.
40. Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med. 2002;346:549-556.
41. Bernard SA, Gray TW, Buist MD, Jones BM, Silvester W, Gutteridge G, Smith K. Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N Engl J Med. 2002;346:557-563. doi: 10.1056/NEJMoa003289.
42. Dumas F, Grimaldi D, Zuber B, Fichet J, Charpentier J, Pène F, Vivien B, Varenne O, Carli P, Jouven X, Empana JP, Cariou A. Is hypothermia after cardiac arrest effective in both shockable and nonshockable patients?: insights from a large registry. Circulation. 2011;123:877-886. doi: 10.1161/CIRCULATIONAHA.110.987347.
43. Testori C, Sterz F, Behringer W, Haugk M, Uray T, Zeiner A, Janata A, Arrich J, Holzer M, Losert H. Mild therapeutic hypothermia is associated with favourable outcome in patients after cardiac arrest with non-shockable rhythms. Resuscitation. 2011;82:1162-1167. doi: 10.1016/j. resuscitation.2011.05.022.
44. Vaahersalo J, Hiltunen P, Tiainen M, Oksanen T, Kaukonen KM, Kurola J, Ruokonen E, Tenhunen J, Ala-Kokko T, Lund V, Reinikainen M, Kiviniemi O, Silfvast T, Kuisma M, Varpula T, Pettilä V; FINNRESUSCI Study Group. Therapeutic hypothermia after out-of-hospital cardiac arrest in Finnish intensive care units: the FINNRESUSCI study. Intensive Care Med. 2013;39:826-837. doi: 10.1007/s00134-013-2868-1.
45. Mader TJ, Nathanson BH, Soares WE 3rd, Coute RA, McNally BF. Comparative Effectiveness of Therapeutic Hypothermia After Out-of-Hospital Cardiac Arrest: Insight from a Large Data Registry. Ther Hypothermia Temp Manag. 2014;4:21-31. doi: 10.1089/ther.2013.0018.
46. Nichol G, Huszti E, Kim F, Fly D, Parnia S, Donnino M, Sorenson T, Callaway CW; American Heart Association Get With The Guideline-Resuscitation Investigators. Does induction of hypothermia improve outcomes after in-hospital cardiac arrest? Resuscitation. 2013;84:620-625. doi: 10.1016/j.resuscitation.2012.12.009.
47. Nielsen N, Wetterslev J, Cronberg T, Erlinge D, Gasche Y, Hassager C, Horn J, Hovdenes J, Kjaergaard J, Kuiper M, Pellis T, Stammet P, Wanscher M, Wise MP, Åneman A, Al-Subaie N, Boesgaard S, Bro-Jeppesen J, Brunetti I, Bugge JF, Hingston CD, Juffermans NP, Koopmans M, Køber L, Langørgen J, Lilja G, Møller JE, Rundgren M, Rylander C, Smid O, Werer C, Winkel P, Friberg H; TTM Trial Investigators. Targeted temperature management at 33°C versus 36°C after cardiac arrest. N Engl J Med. 2013;369:2197-2206. doi: 10.1056/NEJMoa1310519.
48. Watts DD, Trask A, Soeken K, Perdue P, Dols S, Kaufmann C. Hypothermic coagulopathy in trauma: effect of varying levels of hypothermia on enzyme speed, platelet function, and fbrinolytic activity. J Trauma. 1998;44:846-854.
49. Lavinio A, Scudellari A, Gupta AK. Hemorrhagic shock resulting in cardiac arrest: is therapeutic hypothermia contraindicated? Minerva Anestesiol. 2012;78:969-970.
50. Guilliams K, Rosen M, Buttram S, Zempel J, Pineda J, Miller B, Shoykhet M. Hypothermia for pediatric refractory status epilepticus. Epilepsia. 2013;54:1586-1594. doi: 10.1111/epi.12331.
51. Corry JJ, Dhar R, Murphy T, Diringer MN. Hypothermia for refractory status epilepticus. Neurocrit Care. 2008;9:189-197. doi: 10.1007/s12028-008-9092-9.
52. Guluma KZ, Oh H, Yu SW, Meyer BC, Rapp K, Lyden PD. Effect of endovascular hypothermia on acute ischemic edema: morphometric analysis of the ICTuS trial. Neurocrit Care. 2008;8:42-47. doi: 10.1007/s12028-007-9009-z.
53. Kim F, Olsufka M, Longstreth WT Jr, Maynard C, Carlbom D, Deem S, Kudenchuk P, Copass MK, Cobb LA. Pilot randomized clinical trial of prehospital induction of mild hypothermia in out-of-hospital cardiac arrest patients with a rapid infusion of 4 degrees C normal saline. Circulation. 2007;115:3064-3070. doi: 10.1161/CIRCULATIONAHA.106.655480.
54. Kämäräinen A, Virkkunen I, Tenhunen J, Yli-Hankala A, Silfvast T. Prehospital therapeutic hypothermia for comatose survivors of cardiac arrest: a randomized controlled trial. Acta Anaesthesiol Scand. 2009;53:900-907. doi: 10.1111/j.1399-6576.2009.02015.x.
55. Bernard SA, Smith K, Cameron P, Masci K, Taylor DM, Cooper DJ, Kelly AM, Silvester W; Rapid Infusion of Cold Hartmanns (RICH) Investigators. Induction of therapeutic hypothermia by paramedics after resuscitation from out-of-hospital ventricular fbrillation cardiac arrest: a randomized controlled trial. Circulation. 2010;122:737-742. doi: 10.1161/CIRCULATIONAHA.109.906859.
56. Bernard SA, Smith K, Cameron P, Masci K, Taylor DM, Cooper DJ, Kelly AM, Silvester W; Rapid Infusion of Cold Hartmanns Investigators. Induction of prehospital therapeutic hypothermia after resuscitation from nonventricular fbrillation cardiac arrest. Crit Care Med. 2012;40:747-753. doi: 10.1097/CCM.0b013e3182377038.
57. Kim F, Nichol G, Maynard C, Hallstrom A, Kudenchuk PJ, Rea T, Copass MK, Carlbom D, Deem S, Longstreth WT Jr, Olsufka M, Cobb LA. Effect of prehospital induction of mild hypothermia on survival and neurological status among adults with cardiac arrest: a randomized clinical trial. JAMA. 2014;311:45-52. doi: 10.1001/jama.2013.282173.
58. Debaty G, Maignan M, Savary D, Koch FX, Ruckly S, Durand M, Picard J, Escallier C, Chouquer R, Santre C, Minet C, Guergour D, Hammer L, Bouvaist H, Belle L, Adrie C, Payen JF, Carpentier F, Gueugniaud PY
59. Danel V, Timsit JF. Impact of intra-arrest therapeutic hypothermia in outcomes of prehospital cardiac arrest: a randomized controlled trial. Intensive Care Med. 2014;40:1832-1842. doi: 10.1007/s00134-014-3519-x.
60. Castrén M, Nordberg P, Svensson L, Taccone F, Vincent JL, Desruelles D, Eichwede F, Mols P, Schwab T, Vergnion M, Storm C, Pesenti A, Pachl J, Guérisse F, Elste T, Roessler M, Fritz H, Durnez P, Busch HJ, Inderbitzen B, Barbut D. Intra-arrest transnasal evaporative cooling: a randomized, prehospital, multicenter study (PRINCE: Pre-ROSC IntraNasal Cooling Effectiveness). Circulation. 2010;122:729-736. doi: 10.1161/CIRCULATIONAHA.109.931691.
61. Zeiner A, Holzer M, Sterz F, Schörkhuber W, Eisenburger P, Havel C, Kliegel A, Laggner AN. Hyperthermia after cardiac arrest is associated with an unfavorable neurologic outcome. Arch Intern Med. 2001;161:2007-2012.
62. Langhelle A, Tyvold SS, Lexow K, Hapnes SA, Sunde K, Steen PA. In-hospital factors associated with improved outcome after out-of-hospital cardiac arrest. A comparison between four regions in Norway. Resuscitation. 2003;56:247-263.
63. Nolan JP, Laver SR, Welch CA, Harrison DA, Gupta V, Rowan K. Outcome following admission to UK intensive care units after cardiac arrest: a secondary analysis of the ICNARC Case Mix Programme Database. Anaesthesia. 2007;62:1207-1216. doi: 10.1111/j.1365-2044.2007.05232.x.
64. Suffoletto B, Peberdy MA, van der Hoek T, Callaway C. Body temperature changes are associated with outcomes following in-hospital cardiac arrest and return of spontaneous circulation. Resuscitation. 2009;80:1365-1370. doi: 10.1016/j.resuscitation.2009.08.020.
65. Gebhardt K, Guyette FX, Doshi AA, Callaway CW, Rittenberger JC; Post Cardiac Arrest Service. Prevalence and effect of fever on outcome following resuscitation from cardiac arrest. Resuscitation. 2013;84:1062-1067. doi: 10.1016/j.resuscitation.2013.03.038.
66. Aldhoon B, Melenovsky V, Kettner J, Kautzner J. Clinical predictors of outcome in survivors of out-of-hospital cardiac arrest treated with hypothermia. Cor et Vasa. 2012;54:e68-e75.
67. Benz-Woerner J, Delodder F, Benz R, Cueni-Villoz N, Feihl F, Rossetti AO, Liaudet L, Oddo M. Body temperature regulation and outcome after cardiac arrest and therapeutic hypothermia. Resuscitation. 2012;83:338-342. doi: 10.1016/j.resuscitation.2011.10.026.
68. Bouwes A, Robillard LB, Binnekade JM, de Pont AC, Wieske L, Hartog AW, Schultz MJ, Horn J. The infuence of rewarming after therapeutic hypothermia on outcome after cardiac arrest. Resuscitation. 2012;83:996-1000. doi: 10.1016/j.resuscitation.2012.04.006.
69. Leary M, Grossestreuer AV, Iannacone S, Gonzalez M, Shofer FS, Povey C, Wendell G, Archer SE, Gaieski DF, Abella BS. Pyrexia and neurologic outcomes after therapeutic hypothermia for cardiac arrest. Resuscitation. 2013;84:1056-1061. doi: 10.1016/j.resuscitation.2012.11.003.
70. Cocchi MN, Boone MD, Giberson B, Giberson T, Farrell E, Salciccioli JD, Talmor D, Williams D, Donnino MW. Fever after rewarming: incidence of pyrexia in postcardiac arrest patients who have undergone mild therapeutic hypothermia. J Intensive Care Med. 2014;29:365-369. doi: 10.1177/0885066613491932.
71. Bro-Jeppesen J, Hassager C, Wanscher M, Søholm H, Thomsen JH, Lippert FK, Møller JE, Køber L, Kjaergaard J. Post-hypothermia fever is associated with increased mortality after out-of-hospital cardiac arrest. Resuscitation. 2013;84:1734-1740. doi: 10.1016/j.resuscitation.2013.07.023.
72. Winters SA, Wolf KH, Kettinger SA, Seif EK, Jones JS, Bacon-Baguley T. Assessment of risk factors for post-rewarming "rebound hyperthermia" in cardiac arrest patients undergoing therapeutic hypothermia. Resuscitation. 2013;84:1245-1249. doi: 10.1016/j.resuscitation.2013.03.027.
73. Bohman LE, Levine JM. Fever and therapeutic normothermia in severe brain injury: an update. Curr Opin Crit Care. 2014;20:182-188. doi: 10.1097/MCC.0000000000000070.
74. Badjatia N. Hyperthermia and fever control in brain injury. Crit Care Med. 2009;37(7 suppl):S250-S257. doi: 10.1097/CCM.0b013e3181aa5e8d.
75. Longstreth WT Jr, Fahrenbruch CE, Olsufka M, Walsh TR, Copass MK, Cobb LA. Randomized clinical trial of magnesium, diazepam, or both after out-of-hospital cardiac arrest. Neurology. 2002;59:506-514.
76. Rittenberger JC, Popescu A, Brenner RP, Guyette FX, Callaway CW. Frequency and timing of nonconvulsive status epilepticus in comatose post-cardiac arrest subjects treated with hypothermia. Neurocrit Care. 2012;16:114-122. doi: 10.1007/s12028-011-9565-0.
77. Tomte O, Draegni T, Mangschau A, Jacobsen D, Auestad B, Sunde K. A comparison of intravascular and surface cooling techniques in comatose cardiac arrest survivors. Crit Care Med. 2011;39:443-449.
78. Hofmeijer J, Tjepkema-Cloostermans MC, Blans MJ, Beishuizen A, van Putten MJ. Unstandardized treatment of electroencephalographic status epilepticus does not improve outcome of comatose patients after cardiac arrest. Front Neurol. 2014;5:39. doi: 10.3389/fneur.2014.00039.
79. Crepeau AZ, Rabinstein AA, Fugate JE, Mandrekar J, Wijdicks EF, White RD, Britton JW. Continuous EEG in therapeutic hypothermia after cardiac arrest: prognostic and clinical value. Neurology. 2013;80:339-344. doi: 10.1212/WNL.0b013e31827f089d.
80. Knight WA, Hart KW, Adeoye OM, Bonomo JB, Keegan SP, Ficker DM, Szafarski J P, Privitera MD, Lindsell CJ. The incidence of seizures in patients undergoing therapeutic hypothermia after resuscitation from cardiac arrest. Epilepsy Res. 2013;106:396-402. doi: 10.1016/j.eplepsyres.2013.06.018.
81. Randomized clinical study of thiopental loading in comatose survivors of cardiac arrest. Brain Resuscitation Clinical Trial I Study Group. N Engl J Med. 1986;314:397-403.
82. Monsalve F, Rucabado L, Ruano M, Cuñat J, Lacueva V, Viñuales A. The neurologic effects of thiopental therapy after cardiac arrest. Intensive Care Med. 1987;13:244-248.
83. Friedman D, Claassen J, Hirsch LJ. Continuous electroencephalogram monitoring in the intensive care unit. Anesth Analg. 2009;109:506-523. doi: 10.1213/ane.0b013e3181a9d8b5.
84. Roberts BW, Kilgannon JH, Chansky ME, Mittal N, Wooden J, Trzeciak S. Association between postresuscitation partial pressure of arterial carbon dioxide and neurological outcome in patients with post-cardiac arrest syndrome. Circulation. 2013;127:2107-2113. doi: 10.1161/CIRCULATIONAHA.112.000168.
85. Lee BK, Jeung KW, Lee HY, Lee SJ, Jung YH, Lee WK, Heo T, Min YI. Association between mean arterial blood gas tension and outcome in cardiac arrest patients treated with therapeutic hypothermia. Am J Emerg Med. 2014;32:55-60. doi: 10.1016/j.ajem.2013.09.044.
86. Schneider AG, Eastwood GM, Bellomo R, Bailey M, Lipcsey M, Pilcher D, Young P, Stow P, Santamaria J, Stachowski E, Suzuki S, Woinarski NC, Pilcher J. Arterial carbon dioxide tension and outcome in patients admitted to the intensive care unit after cardiac arrest. Resuscitation. 2013;84:927-934. doi: 10.1016/j.resuscitation.2013.02.014.
87. Vaahersalo J, Bendel S, Reinikainen M, Kurola J, Tiainen M, Raj R, Pettilä V, Varpula T, Skrifvars MB; FINNRESUSCI Study Group. Arterial blood gas tensions after resuscitation from out-of-hospital cardiac arrest: associations with long-term neurologic outcome. Crit Care Med. 2014;42:1463-1470. doi: 10.1097/CCM.0000000000000228.
88. Janz DR, Hollenbeck RD, Pollock JS, McPherson JA, Rice TW. Hyperoxia is associated with increased mortality in patients treated with mild therapeutic hypothermia after sudden cardiac arrest. Crit Care Med. 2012;40:3135-3139. doi: 10.1097/CCM.0b013e3182656976.
89. Kilgannon JH, Jones AE, Shapiro NI, Angelos MG, Milcarek B, Hunter K, Parrillo JE, Trzeciak S; Emergency Medicine Shock Research Network (EMShockNet) Investigators. Association between arterial hyperoxia following resuscitation from cardiac arrest and in-hospital mortality. JAMA. 2010;303:2165-2171. doi: 10.1001/jama.2010.707.
90. Elmer J, Scutella M, Pullalarevu R, Wang B, Vaghasia N, Trzeciak S, Rosario-Rivera BL, Guyette FX, Rittenberger JC, Dezfulian C; Pittsburgh Post-Cardiac Arrest Service (PCAS). The association between hyperoxia and patient outcomes after cardiac arrest: analysis of a high-resolution database. Intensive Care Med. 2015;41:49-57. doi: 10.1007/s00134-014-3555-6.
91. Rachmale S, Li G, Wilson G, Malinchoc M, Gajic O. Practice of excessive F(IO(2)) and effect on pulmonary outcomes in mechanically ventilated patients with acute lung injury. Respir Care. 2012;57:1887-1893. doi: 10.4187/respcare.01696.
92. Bellomo R, Bailey M, Eastwood GM, Nichol A, Pilcher D, Hart GK, Reade MC, Egi M, Cooper DJ; Study of Oxygen in Critical Care (SOCC) Group. Arterial hyperoxia and in-hospital mortality after resuscitation from cardiac arrest. Crit Care. 2011;15:R90. doi: 10.1186/cc10090.
93. Nelskylä A, Parr MJ, Skrifvars MB. Prevalence and factors correlating with hyperoxia exposure following cardiac arrest-an observational single centre study. Scand J Trauma Resusc Emerg Med. 2013;21:35. doi: 10.1186/1757-7241-21-35.
94. Kuisma M, Boyd J, Voipio V, Alaspää A, Roine RO, Rosenberg P. Comparison of 30 and the 100% inspired oxygen concentrations during early post-resuscitation period: a randomised controlled pilot study. Resuscitation. 2006;69:199-206. doi: 10.1016/j.resuscitation.2005.08.010.
95. Ihle JF, Bernard S, Bailey MJ, Pilcher DV, Smith K, Scheinkestel CD. Hyperoxia in the intensive care unit and outcome after out-of-hospital ventricular fbrillation cardiac arrest. Crit Care Resusc. 2013;15:186-190.
96. Oksanen T, Skrifvars MB, Varpula T, Kuitunen A, Pettilä V, Nurmi J, Castrén M. Strict versus moderate glucose control after resuscitation from ventricular fbrillation. Intensive Care Med. 2007;33:2093-2100. doi: 10.1007/s00134-007-0876-8.
97. Wiener RS, Wiener DC, Larson RJ. Benefts and risks of tight glucose control in critically ill adults: a meta-analysis. JAMA. 2008;300:933-944. doi: 10.1001/jama.300.8.933.
98. Marik PE, Preiser JC. Toward understanding tight glycemic control in the ICU: a systematic review and metaanalysis. Chest. 2010;137:544-551. doi: 10.1378/chest.09-1737.
99. Moghissi ES, Korytkowski MT, DiNardo M, Einhorn D, Hellman R, Hirsch IB, Inzucchi SE, Ismail-Beigi F, Kirkman MS, Umpierrez GE; American Association of Clinical Endocrinologists; American Diabetes Association. American Association of Clinical Endocrinologists and American Diabetes Association consensus statement on inpatient gly-cemic control. Diabetes Care. 2009;32:1119-1131. doi: 10.2337/dc09-9029.
100. Sandroni C, Cariou A, Cavallaro F, Cronberg T, Friberg H, Hoedemaekers C, Horn J, Nolan JP, Rossetti AO, Soar J. Prognostication in comatose survivors of cardiac arrest: an advisory statement from the European Resuscitation Council and the European Society of Intensive Care Medicine. Resuscitation. 2014;85:1779-1789. doi: 10.1016/j. resuscitation.2014.08.011.
101. Empey PE, de Mendizabal NV, Bell MJ, Bies RR, Anderson KB, Kochanek PM, Adelson PD, Poloyac SM; Pediatric TBI Consortium: Hypothermia Investigators. Therapeutic hypothermia decreases phenyt-oin elimination in children with traumatic brain injury. Crit Care Med. 2013;41:2379-2387. doi: 10.1097/CCM.0b013e318292316c.
102. Hostler D, Zhou J, Tortorici MA, Bies RR, Rittenberger JC, Empey PE, Kochanek PM, Callaway CW, Poloyac SM. Mild hypothermia alters midazolam pharmacokinetics in normal healthy volunteers. Drug Metab Dispos. 2010;38:781-788. doi: 10.1124/dmd.109.031377.
103. Sandroni C, Cavallaro F, Callaway CW, Sanna T, D'Arrigo S, Kuiper M, Della Marca G, Nolan JP. Predictors of poor neurological outcome in adult comatose survivors of cardiac arrest: a systematic review and meta-analysis. Part 1: patients not treated with therapeutic hypothermia. Resuscitation. 2013;84:1310-1323. doi: 10.1016/j. resuscitation.2013.05.013.
104. Sandroni C, Cavallaro F, Callaway CW, D'Arrigo S, Sanna T, Kuiper MA, Biancone M, Della Marca G, Farcomeni A, Nolan JP. Predictors of poor neurological outcome in adult comatose survivors of cardiac arrest: a systematic review and meta-analysis. Part 2: Patients treated with therapeutic hypothermia. Resuscitation. 2013;84:1324-1338. doi: 10.1016/j. resuscitation.2013.06.020.
105. Bouwes A, Binnekade JM, Kuiper MA, Bosch FH, Zandstra DF, Toornvliet AC, Biemond HS, Kors BM, Koelman JH, Verbeek MM, Weinstein HC, Hijdra A, Horn J. Prognosis of coma after therapeutic hypothermia: a prospective cohort study. Ann Neurol. 2012;71:206-212. doi: 10.1002/ana.22632.
106. Choi SP, Youn CS, Park KN, Wee JH, Park JH, Oh SH, Kim SH, Kim JY. Therapeutic hypothermia in adult cardiac arrest because of drowning. Acta Anaesthesiol Scand. 2012;56:116-123. doi: 10.1111/j.1399-6576.2011.02562.x.
107. Cronberg T, Rundgren M, Westhall E, Englund E, Siemund R, Rosén I, Widner H, Friberg H. Neuron-specifc enolase correlates with other prognostic markers after cardiac arrest. Neurology. 2011;77:623-630. doi: 10.1212/WNL.0b013e31822a276d.
108. Fugate JE, Wijdicks EF, Mandrekar J, Claassen DO, Manno EM, White RD, Bell MR, Rabinstein AA. Predictors of neurologic outcome in hypothermia after cardiac arrest. Ann Neurol. 2010;68:907-914. doi: 10.1002/ana.22133.
109. Samaniego EA, Mlynash M, Caulfeld AF, Eyngorn I, Wijman CA. Sedation confounds outcome prediction in cardiac arrest survivors treated with hypothermia. Neurocrit Care. 2011;15:113-119. doi: 10.1007/s12028-010-9412-8.
110. Bouwes A, van Poppelen D, Koelman JH, Kuiper MA, Zandstra DF, Weinstein HC, Tromp SC, Zandbergen EG, Tijssen MA, Horn J. Acute posthypoxic myoclonus after cardiopulmonary resuscitation. BMC Neurol. 2012;12:63. doi: 10.1186/1471-2377-12-63.
111. Rossetti AO, Oddo M, Logroscino G, Kaplan PW. Prognostication after cardiac arrest and hypothermia: a prospective study. Ann Neurol. 2010;67:301-307. doi: 10.1002/ana.21984.
112. Rossetti AO, Carrera E, Oddo M. Early EEG correlates of neuronal injury after brain anoxia. Neurology. 2012;78:796-802. doi: 10.1212/WNL.0b013e318249f6bb.
113. Bisschops LL, van Alfen N, Bons S, van der Hoeven JG, Hoedemaekers CW. Predictors of poor neurologic outcome in patients after cardiac arrest treated with hypothermia: a retrospective study. Resuscitation. 2011;82:696-701. doi: 10.1016/j.resuscitation.2011.02.020.
114. Bertini G, Margheri M, Giglioli C, Cricelli F, De Simone L, Taddei T, Marchionni N, Zini G, Gensini GF. Prognostic signifcance of early clinical manifestations in postanoxic coma: a retrospective study of 58 patients resuscitated after prehospital cardiac arrest. Crit Care Med. 1989;17:627-633.
115. Zandbergen EG, Hijdra A, Koelman JH, Hart AA, Vos PE, Verbeek MM, de Haan RJ; PROPAC Study Group. Prediction of poor outcome within the frst 3 days of postanoxic coma. Neurology. 2006;66:62-68. doi: 10.1212/01.wnl.0000191308.22233.88.
116. Edgren E, Hedstrand U, Nordin M, Rydin E, Ronquist G. Prediction of outcome after cardiac arrest. Crit Care Med. 1987;15:820-825.
117. Young GB, Doig G, Ragazzoni A. Anoxic-ischemic encephalopathy: clinical and electrophysiological associations with outcome. Neurocrit Care. 2005;2:159-164. doi: 10.1385/NCC:2:2:159.
118. Topcuoglu MA, Oguz KK, Buyukserbetci G, Bulut E. Prognostic value of magnetic resonance imaging in post-resuscitation encephalopathy. Intern Med. 2009;48:1635-1645.
119. Legriel S, Hilly-Ginoux J, Resche-Rigon M, Merceron S, Pinoteau J, Henry-Lagarrigue M, Bruneel F, Nguyen A, Guezennec P, Troché G, Richard O, Pico F, Bédos JP. Prognostic value of electrographic postan-oxic status epilepticus in comatose cardiac-arrest survivors in the therapeutic hypothermia era. Resuscitation. 2013;84:343-350. doi: 10.1016/j. resuscitation.2012.11.001.
120. Oddo M, Rossetti AO. Early multimodal outcome prediction after cardiac arrest in patients treated with hypothermia. Crit Care Med. 2014;42:1340-1347. doi: 10.1097/CCM.0000000000000211.
121. Accardo J, De Lisi D, Lazzerini P, Primavera A. Good functional outcome after prolonged postanoxic comatose myoclonic status epilepticus in a patient who had undergone bone marrow transplantation. Case Rep Neurol Med. 2013;2013:872127. doi: 10.1155/2013/872127.
122. Greer DM. Unexpected good recovery in a comatose post-cardiac arrest patient with poor prognostic features. Resuscitation. 2013;84:e81-e82. doi: 10.1016/j.resuscitation.2013.02.011.
123. Lucas JM, Cocchi MN, Salciccioli J, Stanbridge JA, Geocadin RG, Herman ST, Donnino MW. Neurologic recovery after therapeutic hypothermia in patients with post-cardiac arrest myoclonus. Resuscitation. 2012;83:265-269. doi: 10.1016/j.resuscitation.2011.09.017.
124. Wijdicks EF, Parisi JE, Sharbrough FW. Prognostic value of myoclonus status in comatose survivors of cardiac arrest. Ann Neurol. 1994;35:239-243. doi: 10.1002/ana.410350219.
125. Krumholz A, Stern BJ, Weiss HD. Outcome from coma after cardiopul-monary resuscitation: relation to seizures and myoclonus. Neurology. 1988;38:401-405.
126. Hirsch LJ, LaRoche SM, Gaspard N, Gerard E, Svoronos A, Herman ST, Mani R, Arif H, Jette N, Minazad Y, Kerrigan JF, Vespa P, Hantus S, Claassen J, Young GB, So E, Kaplan PW, Nuwer MR, Fountain NB, Drislane FW. American Clinical Neurophysiology Society's Standardized Critical Care EEG Terminology: 2012 version. J Clin Neurophysiol. 2013;30:1-27. doi: 10.1097/WNP.0b013e3182784729.
127. Kawai M, Thapalia U, Verma A. Outcome from therapeutic hypothermia and EEG. J Clin Neurophysiol. 2011;28:483-488. doi: 10.1097/WNP.0b013e318231bfef.
128. Rundgren M, Westhall E, Cronberg T, Rosén I, Friberg H. Continuous amplitude-integrated electroencephalogram predicts outcome in hypothermia-treated cardiac arrest patients. Crit Care Med. 2010;38:1838-1844. doi: 10.1097/CCM.0b013e3181eaa1e7.
129. Cloostermans MC, van Meulen FB, Eertman CJ, Hom HW, van Putten MJ. Continuous electroencephalography monitoring for early prediction of neurological outcome in postanoxic patients after cardiac arrest: a prospective cohort study. Crit Care Med. 2012;40:2867-2875. doi: 10.1097/CCM.0b013e31825b94f0.
130. Mani R, Schmitt SE, Mazer M, Putt ME, Gaieski DF. The frequency and timing of epileptiform activity on continuous electroencephalogram in comatose post-cardiac arrest syndrome patients treated with therapeutic hypothermia. Resuscitation. 2012;83:840-847. doi: 10.1016/j. resuscitation.2012.02.015.
131. Legriel S, Bruneel F, Sediri H, Hilly J, Abbosh N, Lagarrigue MH, Troche G, Guezennec P, Pico F, Bedos JP. Early EEG monitoring for detecting postanoxic status epilepticus during therapeutic hypothermia: a pilot study. Neurocrit Care. 2009;11:338-344. doi: 10.1007/s12028-009-9246-4.
132. Wennervirta JE, Ermes MJ, Tiainen SM, Salmi TK, Hynninen MS, Särkelä MO, Hynynen MJ, Stenman UH, Viertiö-Oja HE, Saastamoinen KP, Pettilä VY, Vakkuri AP. Hypothermia-treated cardiac arrest patients with good neurological outcome differ early in quantitative variables of EEG suppression and epileptiform activity. Crit Care Med. 2009;37:2427-2435. doi: 10.1097/CCM.0b013e3181a0ff84.
133. Stammet P, Wagner DR, Gilson G, Devaux Y. Modeling serum level of s100β and bispectral index to predict outcome after cardiac arrest. J Am Coll Cardiol. 2013;62:851-858. doi: 10.1016/j.jacc.2013.04.039.
134. Bassetti C, Bomio F, Mathis J, Hess CW. Early prognosis in coma after cardiac arrest: a prospective clinical, electrophysiological, and biochemical study of 60 patients. J Neurol Neurosurg Psychiatry. 1996;61:610-615.
135. Rothstein TL, Thomas EM, Sumi SM. Predicting outcome in hypoxic-ischemic coma. A prospective clinical and electrophysiologic study. Electroencephalogr Clin Neurophysiol. 1991;79:101-107.
136. Scollo-Lavizzari G, Bassetti C. Prognostic value of EEG in post-anoxic coma after cardiac arrest. Eur Neurol. 1987;26:161-170.
137. Bouwes A, Binnekade JM, Zandstra DF, Koelman JH, van Schaik IN, Hijdra A, Horn J. Somatosensory evoked potentials during mild hypothermia after cardiopulmonary resuscitation. Neurology. 2009;73:1457-1461. doi: 10.1212/WNL.0b013e3181bf98f4.
138. Tiainen M, Kovala TT, Takkunen OS, Roine RO. Somatosensory and brainstem auditory evoked potentials in cardiac arrest patients treated with hypothermia. Crit Care Med. 2005;33:1736-1740.
139. Leithner C, Ploner CJ, Hasper D, Storm C. Does hypothermia infu-ence the predictive value of bilateral absent N20 after cardiac arrest? Neurology. 2010;74:965-969. doi: 10.1212/WNL.0b013e3181d5a631.
140. Zanatta P, Messerotti Benvenuti S, Baldanzi F, Bosco E. Pain-related middle-latency somatosensory evoked potentials in the prognosis of post an-oxic coma: a preliminary report. Minerva Anestesiol. 2012;78:749-756.
141. Brunko E, Zegers de Beyl D. Prognostic value of early cortical so-matosensory evoked potentials after resuscitation from cardiac arrest. Electroencephalogr Clin Neurophysiol. 1987;66:15-24.
142. Stelzl T, von Bose MJ, Hogl B, Fuchs HH, Flugel KA. A comparison of the prognostic value of neuron-specifc enolase serum levels and somato-sensory evoked potentials in 13 reanimated patients. Eur J Emerg Med. 1995;2:24-27.
143. Rothstein TL. The role of evoked potentials in anoxic-ischemic coma and severe brain trauma. J Clin Neurophysiol. 2000;17:486-497.
144. Berek K, Lechleitner P, Luef G, Felber S, Saltuari L, Schinnerl A, Traweger C, Dienstl F, Aichner F. Early determination of neurological outcome after prehospital cardiopulmonary resuscitation. Stroke. 1995;26:543-549.
145. Zandbergen EG, Koelman JH, de Haan RJ, Hijdra A; PROPAC-Study Group. SSEPs and prognosis in postanoxic coma: only short or also long latency responses? Neurology. 2006;67:583-586. doi: 10.1212/01. wnl.0000230162.35249.7f.
146. Madl C, Kramer L, Domanovits H, Woolard RH, Gervais H, Gendo A, Eisenhuber E, Grimm G, Sterz F. Improved outcome prediction in unconscious cardiac arrest survivors with sensory evoked potentials compared with clinical assessment. Crit Care Med. 2000;28:721-726.
147. Zingler VC, Krumm B, Bertsch T, Fassbender K, Pohlmann-Eden B. Early prediction of neurological outcome after cardiopulmonary resuscitation: a multimodal approach combining neurobiochemical and elec-trophysiological investigations may provide high prognostic certainty in patients after cardiac arrest. Eur Neurol. 2003;49:79-84. doi: 68503.
148. Gendo A, Kramer L, Häfner M, Funk GC, Zauner C, Sterz F, Holzer M, Bauer E, Madl C. Time-dependency of sensory evoked potentials in comatose cardiac arrest survivors. Intensive Care Med. 2001;27:1305-1311.
149. Zhang Y, Su YY, Haupt WF, Zhao JW, Xiao SY, Li HL, Pang Y, Yang QL. Application of electrophysiologic techniques in poor outcome prediction among patients with severe focal and diffuse ischemic brain injury. J Clin Neurophysiol. 2011;28:497-503. doi: 10.1097/WNP.0b013e318231c852.
150. Kottenberg-Assenmacher E, Armbruster W, Bornfeld N, Peters J. Hypothermia does not alter somatosensory evoked potential amplitude and global cerebral oxygen extraction during marked sodium nitroprus-side-induced arterial hypotension. Anesthesiology. 2003;98:1112-1118.
151. Mlynash M, Campbell DM, Leproust EM, Fischbein NJ, Bammer R, Eyngorn I, Hsia AW, Moseley M, Wijman CA. Temporal and spatial profle of brain diffusion-weighted MRI after cardiac arrest. Stroke. 2010;41:1665-1672. doi: 10.1161/STROKEAHA.110.582452.
152. Wijdicks EF, Campeau NG, Miller GM. MR imaging in comatose survivors of cardiac resuscitation. AJNR Am J Neuroradiol. 2001;22:1561-1565.
153. Inamasu J, Miyatake S, Suzuki M, Nakatsukasa M, Tomioka H, Honda M, Kase K, Kobayashi K. Early CT signs in out-of-hospital cardiac arrest survivors: Temporal profle and prognostic signifcance. Resuscitation. 2010;81:534-538. doi: 10.1016/j.resuscitation.2010.01.012.
154. Kim SH, Choi SP, Park KN, Youn CS, Oh SH, Choi SM. Early brain computed tomography fndings are associated with outcome in patients treated with therapeutic hypothermia after out-of-hospital cardiac arrest. Scand J Trauma Resusc Emerg Med. 2013;21:57. doi: 10.1186/1757-7241-21-57.
155. Lee BK, Jeung KW, Lee HY, Jung YH, Lee DH. Combining brain computed tomography and serum neuron specifc enolase improves the prognostic performance compared to either alone in comatose cardiac arrest survivors treated with therapeutic hypothermia. Resuscitation. 2013;84:1387-1392. doi: 10.1016/j.resuscitation.2013.05.026.
156. Morimoto Y, Kemmotsu O, Kitami K, Matsubara I, Tedo I. Acute brain swelling after out-of-hospital cardiac arrest: pathogenesis and outcome. Crit Care Med. 1993;21:104-110.
157. Choi SP, Park HK, Park KN, Kim YM, Ahn KJ, Choi KH, Lee WJ, Jeong SK. The density ratio of grey to white matter on computed tomography as an early predictor of vegetative state or death after cardiac arrest. Emerg Med J. 2008;25:666-669. doi: 10.1136/emj.2007.053306.
158. Torbey MT, Geocadin R, Bhardwaj A. Brain arrest neurological outcome scale (BrANOS): predicting mortality and severe disability following cardiac arrest. Resuscitation. 2004;63:55-63. doi: 10.1016/j. resuscitation.2004.03.021.
159. Wijman CA, Mlynash M, Caulfeld AF, Hsia AW, Eyngorn I, Bammer R, Fischbein N, Albers GW, Moseley M. Prognostic value of brain diffusion-weighted imaging after cardiac arrest. Ann Neurol. 2009;65:394-402. doi: 10.1002/ana.21632.
160. Kim J, Choi BS, Kim K, Jung C, Lee JH, Jo YH, Rhee JE, Kim T, Kang KW. Prognostic performance of diffusion-weighted MRI combined with NSE in comatose cardiac arrest survivors treated with mild hypothermia. Neurocrit Care. 2012;17:412-420. doi: 10.1007/s12028-012-9773-2.
161. Els T, Kassubek J, Kubalek R, Klisch J. Diffusion-weighted MRI during early global cerebral hypoxia: a predictor for clinical outcome? Acta Neurol Scand. 2004;110:361-367. doi: 10.1111/j.1600-0404.2004.00342.x.
162. Wu O, Sorensen AG, Benner T, Singhal AB, Furie KL, Greer DM. Comatose patients with cardiac arrest: predicting clinical outcome with diffusion-weighted MR imaging. Radiology. 2009;252:173-181. doi: 10.1148/radiol.2521081232.
163. Greer D, Scripko P, Bartscher J, Sims J, Camargo E, Singhal A, Parides M, Furie K. Clinical MRI interpretation for outcome prediction in cardiac arrest. Neurocrit Care. 2012;17:240-244. doi: 10.1007/s12028-012-9716-y.
164. Hachimi-Idrissi S, Van der Auwera M, Schiettecatte J, Ebinger G, Michotte Y, Huyghens L. S-100 protein as early predictor of regaining consciousness after out of hospital cardiac arrest. Resuscitation. 2002;53:251-257.
165. Rosén H, Rosengren L, Herlitz J, Blomstrand C. Increased serum levels of the S-100 protein are associated with hypoxic brain damage after cardiac arrest. Stroke. 1998;29:473-477.
166. Steffen IG, Hasper D, Ploner CJ, Schefold JC, Dietz E, Martens F, Nee J, Krueger A, Jörres A, Storm C. Mild therapeutic hypothermia alters neuron specifc enolase as an outcome predictor after resuscitation: 97 prospective hypothermia patients compared to 133 historical non-hypothermia patients. Crit Care. 2010;14:R69. doi: 10.1186/cc8975.
167. Reisinger J, Höllinger K, Lang W, Steiner C, Winter T, Zeindlhofer E, Mori M, Schiller A, Lindorfer A, Wiesinger K, Siostrzonek P. Prediction of neurological outcome after cardiopulmonary resuscitation by serial determination of serum neuron-specifc enolase. Eur Heart J. 2007;28:52-58. doi: 10.1093/eurheartj/ehl316.
168. Tiainen M, Roine RO, Pettilä V, Takkunen O. Serum neuron-spe-cifc enolase and S-100B protein in cardiac arrest patients treated with hypothermia. Stroke. 2003;34:2881-2886. doi: 10.1161/01. STR.0000103320.90706.35.
169. Rosén H, Sunnerhagen KS, Herlitz J, Blomstrand C, Rosengren L. Serum levels of the brain-derived proteins S-100 and NSE predict long-term outcome after cardiac arrest. Resuscitation. 2001;49:183-191.
170. Mussack T, Biberthaler P, Kanz KG, Wiedemann E, Gippner-Steppert C, Mutschler W, Jochum M. Serum S-100B and interleukin-8 as predictive markers for comparative neurologic outcome analysis of patients after cardiac arrest and severe traumatic brain injury. Crit Care Med. 2002;30:2669-2674. doi: 10.1097/01.CCM.0000037963.51270.44.
171. Mörtberg E, Zetterberg H, Nordmark J, Blennow K, Rosengren L, Rubertsson S. S-100B is superior to NSE, BDNF and GFAP in predicting outcome of resuscitation from cardiac arrest with hypothermia treatment. Resuscitation. 2011;82:26-31. doi: 10.1016/j.resuscitation.2010.10.011.
172. Huntgeburth M, Adler C, Rosenkranz S, Zobel C, Haupt WF, Dohmen C, Reuter H. Changes in neuron-specifc enolase are more suitable than its absolute serum levels for the prediction of neurologic outcome in hypothermia-treated patients with out-of-hospital cardiac arrest. Neurocrit Care. 2014;20:358-366. doi: 10.1007/s12028-013-9848-8.
173. Oksanen T, Tiainen M, Skrifvars MB, Varpula T, Kuitunen A, Castrén M, Pettilä V. Predictive power of serum NSE and OHCA score regarding 6-month neurologic outcome after out-of-hospital ventricular fbrilla-tion and therapeutic hypothermia. Resuscitation. 2009;80:165-170. doi: 10.1016/j.resuscitation.2008.08.017.
174. Rundgren M, Karlsson T, Nielsen N, Cronberg T, Johnsson P, Friberg H. Neuron specifc enolase and S-100B as predictors of outcome after cardiac arrest and induced hypothermia. Resuscitation. 2009;80:784-789. doi: 10.1016/j.resuscitation.2009.03.025.
175. Storm C, Nee J, Jörres A, Leithner C, Hasper D, Ploner CJ. Serial measurement of neuron specifc enolase improves prognostication in cardiac arrest patients treated with hypothermia: a prospective study. Scand J Trauma Resusc Emerg Med. 2012;20:6. doi: 10.1186/1757-7241-20-6.
176. Zellner T, Gärtner R, Schopohl J, Angstwurm M. NSE and S-100B are not suffciently predictive of neurologic outcome after therapeutic hypothermia for cardiac arrest. Resuscitation. 2013;84:1382-1386. doi: 10.1016/j.resuscitation.2013.03.021.
177. Orioles A, Morrison WE, Rossano JW, Shore PM, Hasz RD, Martiner AC, Berg RA, Nadkarni VM. An under-recognized beneft of car-diopulmonary resuscitation: organ transplantation. Crit Care Med. 2013;41:2794-2799. doi: 10.1097/CCM.0b013e31829a7202.
178. Faucher A, Savary D, Jund J, Dorez D, Debaty G, Gaillard A, Atchabahian A, Tazarourte K. Out-of-hospital traumatic cardiac arrest: an underrecog-nized source of organ donors. Transpl Int. 2014;27:42-48. doi: 10.1111/tri.12196.
179. Adrie C, Haouache H, Saleh M, Memain N, Laurent I, Thuong M, Darques L, Guerrini P, Monchi M. An underrecognized source of organ donors: patients with brain death after successfully resuscitated cardiac arrest. Intensive Care Med. 2008;34:132-137. doi: 10.1007/s00134-007-0885-7.
180. Ali AA, Lim E, Thanikachalam M, Sudarshan C, White P, Parameshwar J, Dhital K, Large SR. Cardiac arrest in the organ donor does not negatively infuence recipient survival after heart transplantation. Eur J Cardiothorac Surg. 2007;31:929-933. doi: 10.1016/j.ejcts.2007.01.074.
181. Hsu RB, Chu SH, Chien CY, Chou NK, Chen YS, Ko WJ, Wang SS. Heart transplantation with marginal recipients and donors. J Formos Med Assoc. 1999;98:663-667.
182. Quader MA, Wolfe LG, Kasirajan V. Heart transplantation outcomes from cardiac arrest-resuscitated donors. J Heart Lung Transplant. 2013;32:1090-1095. doi: 10.1016/j.healun.2013.08.002.
183. Pilarczyk K, Osswald BR, Pizanis N, Tsagakis K, Massoudy P, Heckmann J, Jakob HG, Kamler M. Use of donors who have suffered cardiopulmonary arrest and resuscitation in lung transplantation. Eur J Cardiothorac Surg. 2011;39:342-347. doi: 10.1016/j.ejcts.2010.06.038.
184. Sánchez-Lázaro IJ, Almenar-Bonet L, Martínez-Dolz L, Buendía-Fuentes F, Agüero J, Navarro-Manchón J, Raso-Raso R, Salvador-Sanz A. Can we accept donors who have suffered a resuscitated cardiac arrest? Transplant Proc. 2010;42:3091-3092. doi: 10.1016/j. transproceed.2010.05.054.
185. Southerland KW, Castleberry AW, Williams JB, Daneshmand MA, Ali AA, Milano CA. Impact of donor cardiac arrest on heart transplantation. Surgery. 2013;154:312-319. doi: 10.1016/j.surg.2013.04.028.
186. Conway J, Chin C, Kemna M, Burch M, Barnes A, Tresler M, Scheel JN, Naftel DC, Beddow K, Allain-Rooney T, Dipchand AI; Pediatric Heart Transplant Study Investigators. Donors' characteristics and impact on outcomes in pediatric heart transplant recipients. Pediatr Transplant. 2013;17:774-781. doi: 10.1111/petr.12149.
187. de Begona JA, Gundry SR, Razzouk AJ, Boucek MM, Kawauchi M, Bailey LL. Transplantation of hearts after arrest and resuscitation. Early and long-term results. J Thorac Cardiovasc Surg. 1993;106:1196-1201; discussion 1200.
188. Finfer S, Bohn D, Colpitts D, Cox P, Fleming F, Barker G. Intensive care management of paediatric organ donors and its effect on post-transplant organ function. Intensive Care Med. 1996;22:1424-1432.
189. L'Ecuyer T, Sloan K, Tang L. Impact of donor cardiopulmonary resuscitation on pediatric heart transplant outcome. Pediatr Transplant. 2011;15:742-745. doi: 10.1111/j.1399-3046.2011.01565.x.
190. Castleberry AW, Worni M, Osho AA, Snyder LD, Palmer SM, Pietrobon R, Davis RD, Hartwig MG. Use of lung allografts from brain-dead donors after cardiopulmonary arrest and resuscitation. Am J Respir Crit Care Med. 2013;188:466-473. doi: 10.1164/rccm.201303-0588OC.
191. Mercatello A, Roy P, Ng-Sing K, Choux C, Baude C, Garnier JL, Colpart JJ, Finaz J, Petit P, Moskovtchenko JF. Organ transplants from out-of-hospital cardiac arrest patients. Transplant Proc. 1988;20:749-750.
192. Matsumoto CS, Kaufman SS, Girlanda R, Little CM, Rekhtman Y, Raof V, Laurin JM, Shetty K, Fennelly EM, Johnson LB, Fishbein TM. Utilization of donors who have suffered cardiopulmonary arrest and resuscitation in intestinal transplantation. Transplantation. 2008;86:941-946. doi: 10.1097/TP.0b013e3181852f9a.
193. Fondevila C, Hessheimer AJ, Flores E, Ruiz A, Mestres N, Calatayud D, Paredes D, Rodríguez C, Fuster J, Navasa M, Rimola A, Taurá P, García-Valdecasas JC. Applicability and results of Maastricht type 2 donation after cardiac death liver transplantation. Am J Transplant. 2012;12:162-170. doi: 10.1111/j.1600-6143.2011.03834.x.
194. Mateos-Rodríguez AA, Navalpotro-Pascual JM, Del Rio Gallegos F, Andrés-Belmonte A. Out-hospital donors after cardiac death in Madrid, Spain: a 5-year review. Australas Emerg Nurs J. 2012;15:164-169. doi: 10.1016/j.aenj.2012.05.002.
195. Alonso A, Fernández-Rivera C, Villaverde P, Oliver J, Cillero S, Lorenzo D, Valdés F. Renal transplantation from non-heart-beating donors: a single-center 10-year experience. Transplant Proc. 2005;37:3658-3660. doi: 10.1016/j.transproceed.2005.09.104.
196. Casavilla A, Ramirez C, Shapiro R, Nghiem D, Miracle K, Bronsther O, Randhawa P, Broznick B, Fung JJ, Starzl T. Experience with liver and kidney allografts from non-heart-beating donors. Transplantation. 1995;59:197-203.
197. Nicholson ML, Metcalfe MS, White SA, Waller JR, Doughman TM, Horsburgh T, Feehally J, Carr SJ, Veitch PS. A comparison of the results of renal transplantation from non-heart-beating, conventional cadaveric, and living donors. Kidney Int. 2000;58:2585-2591. doi: 10.1046/j.1523-1755.2000.00445.x.
198. Otero A, Gómez-Gutiérrez M, Suárez F, Arnal F, Fernández-García A, Aguirrezabalaga J, García-Buitrón J, Alvarez J, Máñez R. Liver transplantation from maastricht category 2 non-heart-beating donors: a source to increase the donor pool? Transplant Proc. 2004;36:747-750. doi: 10.1016/j.transproceed.2004.03.027.