Serum Neuron-Specific Enolase and S-100B Protein in Cardiac Arrest Patients Treated with Hypothermia

Stroke

Volumn 34, Issue 12, 2003, Pages 2881-2886

  Tiainen, Marjaana ^a,b   Roine, Risto O ^a   Pettilä, Ville ^a   Takkunen, Olli ^a  

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^b Meilahti Hospital   (Finland)

Author keywords

Heart arrest; Hypothermia; Nerve tissue protein S 100; Neuron specific enolase

Indexed keywords

NEURON SPECIFIC ENOLASE; PROTEIN S100B;

ADULT; AGED; ARTICLE; BRAIN INJURY; BRAIN ISCHEMIA; CLINICAL ARTICLE; CLINICAL PROTOCOL; CLINICAL TRIAL; CONSCIOUSNESS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORE TEMPERATURE; FEMALE; HEART ARREST; HEART VENTRICLE FIBRILLATION; HUMAN; INDUCED HYPOTHERMIA; MALE; NERVE CELL DEGENERATION; OUTCOMES RESEARCH; PRIORITY JOURNAL; PROGNOSIS; RANDOMIZED CONTROLLED TRIAL; RESUSCITATION; STATISTICAL ANALYSIS; SURVIVAL;

ADOLESCENT; ADULT; AGED; AREA UNDER CURVE; BIOLOGICAL MARKERS; CARDIOPULMONARY RESUSCITATION; FEMALE; FINLAND; HEART ARREST; HUMANS; HYPOTHERMIA, INDUCED; MALE; MIDDLE AGED; NERVE GROWTH FACTORS; PHOSPHOPYRUVATE HYDRATASE; PREDICTIVE VALUE OF TESTS; PROGNOSIS; ROC CURVE; S100 PROTEINS; TREATMENT OUTCOME;

EID: 0344737005     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.STR.0000103320.90706.35     Document Type: Article

References (28)

1. Hypothermia After Cardiac Arrest Study Group. Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med. 2002;346:549-556.
2. Bernard S, Gray T, Buist M, Jones B, Silvester W, Gutteridge G, Smith K. Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N Engl J Med. 2002;346:557-563.
3. Schmechel D, Marangos PJ, Zis AP, Brightman M, Goodwin FK. Brain enolases as specific markers of neuronal and glial cells. Science. 1978;199:313-315.
4. Schmechel D, Marangos PJ, Brightman M. Neuron-specific enolase is a molecular marker for peripheral and central neuroendocrine cells. Nature. 1978;276:834-836.
5. Cunningham RT, Young IS, Winder J, O'Kinley MJ, McKinstry S, Johnston CF, Dolan OM, Hawkins SA, Buchanan KD. Serum neurone specific enolase (NSE) levels as an indicator of neuronal damage in patients with cerebral infarction. Eur J Clin Invest. 1991;21:497-500.
6. Skogseid IM, Nordby HK, Urdal P, Paus E, Lilleaas F. Increased serum creatine kinase BB and neuron specific enolase following head injury indicates brain damage. Acta Neurochir (Wien). 1992;115:106-111.
7. Roine RO, Somer M, Kaste M, Viinikka L, Karonen S. Neurological outcome after out-of-hospital cardiac arrest: prediction by cerebrospinal fluid analysis. Arch Neurol. 1989;46:753-756.
8. Jönsson H, Johnsson P, Höglund P, Alling C, Blomqvist S. Elimination of S100B and renal function after cardiac surgery. J Cardiothorac Vasc Anesth. 2000;14:698-701.
9. Kligman D, Hilt DC. The S100B family. Trends Biochem Sci. 1988;11:437-443.
10. Zimmer DB, Cornwall EH, Landar A, Song W. The S100 protein family: history, function and expression. Brain Res Bull. 1995;37:417-429.
11. Elting J, de Jager A, Teelken A, Schaaf M, Maurits N, van der Vaalt J, Sibinga C, Sulter G, de Keyser J. Comparison of serum S-100 protein levels following stroke and traumatic brain injury. J Neurol Sci. 2000;181:104-110.
12. Missler U, Wiemann M, Friedrich C, Kaps M. S-100 protein and neuronspecific enolase concentrations in blood as indicators of infarction volume and prognosis in acute ischemic stroke. Stroke. 1997;28:1956-1960.
13. Jönsson H, Johnsson P, Birch-Iensen M, Alling C, Westaby S, Blomqvist S. S100B as a predictor of size and outcome of stroke after cardiac surgery. Ann Thorac Surg. 2001;71:1433-1437.
14. Martens P, Raabe A, Johnsson P. Serum S-100 and neuron-specific enolase for predicting of regaining consciousness after global cerebral ischemia. Stroke. 1998;2363-2366.
15. Martens P. Serum neuron-specific enolase as a prognostic marker for irreversible brain damage in comatose cardiac arrest survivors. Acad Emerg Med. 1996;3:126-131.
16. Fogel W, Krieger D, Veith M, Adams HP, Hund E, Storch-Hagenlocher B, Buggle F, Mathias D, Hacke W. Serum neuron-specific enolase as early predictor of outcome after cardiac arrest. Crit Care Med. 1997;25:1133-1138.
17. Schoerkhuber W, Kittler H, Sterz F, Behringer W. Holzer M, Frossard M, Spitzauer S. Laggner AN. Time course of serum neuron-specific enolase: a predictor of neurological outcome in patients resuscitated from cardiac arrest. Stroke. 1999;30:1598-1603.
18. Rosén H, Stibrant Sunnerhagen K, Herlitz J, Blomstrand C, Rosengren L. Serum level of the brain-derived proteins S-100 and NSE predict long-term outcome after cardiac arrest. Resuscitation. 2001;49:183-191.
19. Meynaar I, Oudemans-van Straaten H, van der Wetering J, Verlooy P, Slaats E, Bosman R, van der Spoel J, Zandstra D. Serum neuron-specific enolase predicts outcome in post-anoxic coma: a prospective cohort study. Int Care Med. 2003;29:189-195.
20. Hachimi-Idrissi S, van der Auwera M, Schiettecatte J, Ebinger G. Michotte Y, Huyghens L. S-100 protein as early predictor of regaining consciousness after out of hospital cardiac arrest. Resuscitation. 2002;53:251-257.
21. Böttiger B, Möbes S, Glätzer R, Bauer H, Gries A, Bärtsch P, Motsch J, Martin E. Astroglial protein S-100 is an early and sensitive marker of hypoxic brain damage and outcome after cardiac arrest in humans. Circulation. 2001;103:2694-2698.
22. Rosén H, Rosengren L, Herlitz J, Blomstrand C. Increased serum levels of the S-100 protein are associated with hypoxic brain damage after cardiac arrest. Stroke. 1998;29:473-477.
23. Cummins RO, Chamberlain DA, Abramson NS, Alle M, Baskett PJ, Becker L, Bossaert L. Delooz HH, Dick WF, Eisenberg MS. Recommended guidelines for uniform reporting of data from out-of-hospital cardiac arrest: the Utstein Style: a statement for health professionals from a task force of the American Heart Association, the European Resuscitation Council, the Heart and Stroke Foundation of Canada, and the Australian Resuscitation Council. Circulation. 1991;84:960-975.
24. Jennet B, Bond M. Assessment of outcome after severe brain damage. Lancet. 1975;1:480-484.
25. Brain Resuscitation Clinical Trial II Study Group. A randomized clinical study of a calcium-entry blocker (Iidoflazine) in the treatment of comatose survivors of cardiac arrest. N Engl J Med. 1991;324:1225-1231.
26. Berger RP, Pierce MC, Wisniewski SR, Adelson PD, Clark RS, Ruppel RA, Kochanek PM. Neuron-specific enolase and S100B in cerebrospinal fluid after severe traumatic brain injury in infants and children. Pediatrics. 2002;109:E31.
27. Anderson RE, Hansson L, Nilsson O, Liska J, Settergren G, Vaage J. Increase in serum S100A1-B and S100BB during cardiac surgery arises from extracerebral sources. Ann Thorac Surg. 2001;71:1512-1517.
28. Ginsberg MD, Sternau LL, Globus MY-T, Dietrich WD, Busto R. Therapeutic modulation of brain temperature: relevance to ischemic brain injury. Cerebrovasc Brain Metab Rev. 1992;4:189-225.