Changes in neuron-specific enolase are more suitable than its absolute serum levels for the prediction of neurologic outcome in hypothermia-treated patients with out-of-hospital cardiac arrest

Neurocritical Care

Volumn 20, Issue 3, 2014, Pages 358-366

  Huntgeburth, Michael ^a   Adler, Christoph ^a   Rosenkranz, Stephan ^a   Zobel, Carsten ^a   Haupt, Walter F ^b   Dohmen, Christian ^b   Reuter, Hannes ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

^b UNIVERSITY HOSPITAL OF COLOGNE   (Germany)

Author keywords

Cardiac arrest; Mild therapeutic hypothermia; Neurologic outcome; Neuron specific enolase; Resuscitation; Somatosensory evoked potentials

Indexed keywords

NEURON SPECIFIC ENOLASE; BIOLOGICAL MARKER; ENOLASE;

ADULT; AGED; ARTICLE; CATHETER; CLINICAL EXAMINATION; COHORT ANALYSIS; COMA; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; ENDOVASCULAR COOLING DEVICE; ENZYME BLOOD LEVEL; EVOKED RESPONSE; FEMALE; HOSPITAL ADMISSION; HUMAN; INDUCED HYPOTHERMIA; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MALE; MEDICAL DEVICE; MILD THERAPEUTIC HYPOTHERMIA; MOTOR PERFORMANCE; NEUROLOGIC EXAMINATION; NEUROLOGIC OUTCOME; NEURON SPECIFIC ENOLASE BLOOD LEVEL; OUT OF HOSPITAL CARDIAC ARREST; OUTCOME ASSESSMENT; PREDICTION; PREDICTIVE VALUE; PRIORITY JOURNAL; PROGNOSIS; RECEIVER OPERATING CHARACTERISTIC; RELIABILITY; RETROSPECTIVE STUDY; SCORING SYSTEM; SEDATION; SENSITIVITY AND SPECIFICITY; THERAPY EFFECT; BLOOD; CONVALESCENCE; INTENSIVE CARE; MIDDLE AGED; OUT-OF-HOSPITAL CARDIAC ARREST; TREATMENT OUTCOME; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; COMA; EVOKED POTENTIALS; FEMALE; HUMANS; HYPOTHERMIA, INDUCED; INTENSIVE CARE; MALE; MIDDLE AGED; NEUROLOGIC EXAMINATION; OUT-OF-HOSPITAL CARDIAC ARREST; PHOSPHOPYRUVATE HYDRATASE; PREDICTIVE VALUE OF TESTS; RECOVERY OF FUNCTION; RETROSPECTIVE STUDIES; ROC CURVE; SENSITIVITY AND SPECIFICITY; TREATMENT OUTCOME;

EID: 84902368509     PISSN: 15416933     EISSN: 15560961     Source Type: Journal    
DOI: 10.1007/s12028-013-9848-8     Document Type: Article

References (31)

1. Field JM, Hazinski MF, Sayre MR, Chameides L, Schexnayder SM, Hemphill R, Samson RA, Kattwinkel J, Berg RA, Bhanji F, Cave DM, Jauch EC, Kudenchuk PJ, Neumar RW, Peberdy MA, Perlman JM, Sinz E, Travers AH, Berg MD, Billi JE, Eigel B, Hickey RW, Kleinman ME, Link MS, Morrison LJ, O'Connor RE, Shuster M, Callaway CW, Cucchiara B, Ferguson JD, Rea TD, Vanden Hoek TL. Part 1: Executive summary: 2010 american heart association guidelines for cardiopulmonary resuscitation and emergency cardiovascular care. Circulation. 2010;122(18 Suppl 3):S640-56.
2. Nolan JP, Soar J, Zideman DA, Biarent D, Bossaert LL, Deakin C, Koster RW, Wyllie J, Bottiger B. European resuscitation council guidelines for resuscitation 2010 section 1. Executive summary. Resuscitation. 2010;81(10):1219-76.
3. Bradley SM, Gabriel EE, Aufderheide TP, Barnes R, Christenson J, Davis DP, Stiell IG, Nichol G. Survival increases with CPR by emergency medical services before defibrillation of out-of-hospital ventricular fibrillation or ventricular tachycardia: Observations from the resuscitation outcomes consortium. Resuscitation. 2010;81(2):155-62.
4. Wijdicks EF, Hijdra A, Young GB, Bassetti CL, Wiebe S. Practice parameter: Prediction of outcome in comatose survivors after cardiopulmonary resuscitation (an evidence-based review): Report of the quality standards subcommittee of the american academy of neurology. Neurology. 2006;67(2):203-10. (Pubitemid 44305400)
5. Lippert FK, Raffay V, Georgiou M, Steen PA, Bossaert L. European resuscitation council guidelines for resuscitation 2010 section 10. The ethics of resuscitation and end-of-life decisions. Resuscitation. 2010;81(10):1445-51.
6. The Hypothermia after Cardiac Arrest Study Group. Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med. 2002;346:549-56.
7. Bernard SA, Gray TW, Buist MD, Jones BM, Silvester W, Gutteridge G, Smith K. Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N Engl J Med. 2002;346(8):557-63. (Pubitemid 34438816)
8. Daubin C, Quentin C, Allouche S, Etard O, Gaillard C, Seguin A, Valette X, Parienti JJ, Prevost F, Ramakers M, Terzi N, Charbonneau P, du Cheyron D. Serum neuron-specific enolase as predictor of outcome in comatose cardiac-arrest survivors: A prospective cohort study. BMC Cardiovasc Disord. 2011;11:48.
9. Zandbergen EG, Hijdra A, Koelman JH, Hart AA, Vos PE, Verbeek MM, de Haan RJ. Prediction of poor outcome within the first 3 days of postanoxic coma. Neurology. 2006;66(1):62-8. (Pubitemid 43739593)
10. Shinozaki K, Oda S, Sadahiro T, NakamuraM, Abe R, Nakada TA, Nomura F, Nakanishi K, Kitamura N, Hirasawa H. Serum s-100b is superior to neuron-specific enolase as an early prognostic biomarker for neurological outcome following cardiopulmonary resuscitation. Resuscitation. 2009;80(8):870-5.
11. Oksanen T, Tiainen M, Skrifvars MB, Varpula T, Kuitunen A, Castren M, Pettila V. Predictive power of serum nse and ohca score regarding 6 months neurologic outcome after out-of-hospital ventricular fibrillation and therapeutic hypothermia. Resuscitation. 2009;80(2):165-70.
12. Cronberg T, Rundgren M, Westhall E, Englund E, Siemund R, Rosen I, Widner H, Friberg H. Neuron-specific enolase correlates with other prognostic markers after cardiac arrest. Neurology. 2011;77(7):623-30.
13. Tiainen M, Roine RO, Pettila V, Takkunen O. Serum neuron-specific enolase and s-100b protein in cardiac arrest patients treated with hypothermia. Stroke. 2003;34(12):2881-6. (Pubitemid 37517761)
14. Rundgren M, Karlsson T, Nielsen N, Cronberg T, Johnsson P, Friberg H. Neuron specific enolase and s-100b as predictors of outcome after cardiac arrest and induced hypothermia. Resuscitation. 2009;80(7):784-9.
15. Steffen IG, Hasper D, Ploner CJ, Schefold JC, Dietz E, Martens F, Nee J, Krueger A, Jorres A, Storm C. Mild therapeutic hypothermia alters neuron specific enolase as an outcome predictor after resuscitation: 97 prospective hypothermia patients compared to 133 historical non-hypothermia patients. Crit Care. 2010;14(2):R69.
16. Fugate JE, Wijdicks EF, Mandrekar J, Claassen DO, Manno EM, White RD, Bell MR, Rabinstein AA. Predictors of neurologic outcome in hypothermia after cardiac arrest. Ann Neurol. 2010;68(6):907-14.
17. Zimmerman JE, Kramer AA, McNair DS, Malila FM. Acute physiology and chronic health evaluation (apache) IV: Hospital mortality assessment for today's critically ill patients. Crit Care Med. 2006;34(5):1297-310.
18. Cummins RO, Chamberlain DA, Abramson NS, Allen M, Baskett P, Becker L, Bossaert L, Delooz H, Dick W, Eisenberg M, et al. Recommended guidelines for uniform reporting of data from out-of-hospital cardiac arrest: The utstein style. Task force of the american heart association, the european resuscitation council, the heart and stroke foundation of canada, and the australian resuscitation council. Ann Emerg Med. 1991;20(8):861-74.
19. Zandbergen EG, de Haan RJ, Stoutenbeek CP, Koelman JH, Hijdra A. Systematic review of early prediction of poor outcome in anoxic-ischaemic coma. Lancet. 1998;352(9143):1808-12. (Pubitemid 28550069)
20. Chiappa KH, Ropper AH. Evoked potentials in clinical medicine (second of two parts). N Engl J Med. 1982;306(20):1205-11.
21. Chiappa KH, Ropper AH. Evoked potentials in clinical medicine (first of two parts). N Engl J Med. 1982;306(19):1140-50. (Pubitemid 12161337)
22. Bouwes A, Binnekade JM, Zandstra DF, Koelman JH, van Schaik IN, Hijdra A, Horn J. Somatosensory evoked potentials during mild hypothermia after cardiopulmonary resuscitation. Neurology. 2009;73(18):1457-61.
23. Leithner C, Ploner CJ, Hasper D, Storm C. Does hypothermia influence the predictive value of bilateral absent n20 after cardiac arrest? Neurology. 2010;74(12):965-9.
24. Rossetti AO, Oddo M, Logroscino G, Kaplan PW. Prognostication after cardiac arrest and hypothermia: A prospective study. Ann Neurol. 2010;67(3):301-7.
25. Bouwes A, Binnekade JM, Kuiper MA, Bosch FH, Zandstra DF, Toornvliet AC, Biemond HS, Kors BM, Koelman JH, Verbeek MM, Weinstein HC, Hijdra A, Horn J. Prognosis of coma after therapeutic hypothermia: A prospective cohort study. Ann Neurol. 2012;71(2):206-12.
26. Webb AC, Samuels OB. Reversible brain death after cardiopulmonary arrest and induced hypothermia. Crit Care Med. 2011;39(6):1538-42.
27. Mader TJ, Nathanson BH, Millay S, Coute RA, Clapp M, McNally B. Out-of-hospital cardiac arrest outcomes stratified by rhythm analysis. Resuscitation. 2012;83(11):1358-62.
28. Kim YM, Yim HW, Jeong SH, Klem ML, Callaway CW. Does therapeutic hypothermia benefit adult cardiac arrest patients presenting with non-shockable initial rhythms?: A systematic review and meta-analysis of randomized and non-randomized studies. Resuscitation. 2012;83(2):188-96.
29. Peberdy MA, Callaway CW, Neumar RW, Geocadin RG, Zimmerman JL, Donnino M, Gabrielli A, Silvers SM, Zaritsky AL, Merchant R, Vanden Hoek TL, Kronick SL. Part 9: Post-cardiac arrest care: 2010 american heart association guidelines for cardiopulmonary resuscitation and emergency cardiovascular care. Circulation. 2010;122(18 Suppl 3):S768-86.
30. Arrich J, Holzer M, Herkner H, Mullner M (2009) Hypothermia for neuroprotection in adults after cardiopulmonary resuscitation. Cochrane Database Syst Rev (4):CD004128.
31. Testori C, Sterz F, Behringer W, Haugk M, Uray T, Zeiner A, Janata A, Arrich J, Holzer M, Losert H. Mild therapeutic hypothermia is associated with favourable outcome in patients after cardiac arrest with non-shockable rhythms. Resuscitation. 2011;82(9):1162-7.