Mild hypothermia alters midazolam pharmacokinetics in normal healthy volunteers

Drug Metabolism and Disposition

Volumn 38, Issue 5, 2010, Pages 781-788

  Hostler, David ^a   Zhou, Jiangquan ^a   Tortorici, Michael A ^a   Bies, Robert R ^a   Rittenberger, Jon C ^a   Empey, Philip E ^a   Kochanek, Patrick M ^b   Callaway, Clifton W ^a   Poloyac, Samuel M ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 HYDROXYMIDAZOLAM; BENZODIAZEPINE; CYTOCHROME P450 3A4; CYTOCHROME P450 3A5; DRUG METABOLITE; MAGNESIUM; MIDAZOLAM; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BODY TEMPERATURE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORE TEMPERATURE; CROSSOVER PROCEDURE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISPOSITION; DRUG EFFECT; DRUG METABOLISM; ENZYME ACTIVITY; HUMAN; HUMAN EXPERIMENT; HYPOTHERMIA; LOW TEMPERATURE; MALE; NORMAL HUMAN; PREDICTOR VARIABLE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL;

ADULT; AREA UNDER CURVE; BODY TEMPERATURE; COMPUTER SIMULATION; CROSS-OVER STUDIES; CYTOCHROME P-450 CYP3A; HEART RATE; HUMANS; HYPOTHERMIA; INFUSIONS, INTRAVENOUS; MAGNESIUM SULFATE; MALE; MIDAZOLAM; MODELS, BIOLOGICAL; PHARMACOKINETICS; SODIUM CHLORIDE; TEMPERATURE; YOUNG ADULT;

EID: 77950932737     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.109.031377     Document Type: Article

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