Neuron specific enolase and S-100B as predictors of outcome after cardiac arrest and induced hypothermia

Resuscitation

Volumn 80, Issue 7, 2009, Pages 784-789

  Rundgren, Malin ^a   Karlsson, Torbjörn ^a   Nielsen, Niklas ^b   Cronberg, Tobias ^a   Johnsson, Per ^a   Friberg, Hans ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b HELSINGBORG HOSPITAL   (Sweden)

Author keywords

Cardiac arrest; Hypothermia; NSE; Outcome; S 100B

Indexed keywords

NEURON SPECIFIC ENOLASE; PROTEIN S100B;

ADOLESCENT; ADULT; AGED; ARTICLE; BLOOD SAMPLING; CHILD; FEMALE; HEART ARREST; HUMAN; INDUCED HYPOTHERMIA; MAJOR CLINICAL STUDY; MALE; MENTAL PERFORMANCE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROGNOSIS; PROTEIN BLOOD LEVEL; RISK ASSESSMENT; SCHOOL CHILD;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; CHILD; COHORT STUDIES; FEMALE; HEART ARREST; HUMANS; HYPOTHERMIA, INDUCED; MALE; MIDDLE AGED; NERVE GROWTH FACTORS; PHOSPHOPYRUVATE HYDRATASE; PREDICTIVE VALUE OF TESTS; RETROSPECTIVE STUDIES; S100 PROTEINS; TIME FACTORS; TREATMENT OUTCOME; YOUNG ADULT;

EID: 67349186978     PISSN: 03009572     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.resuscitation.2009.03.025     Document Type: Article

References (40)

1. Booth C.M., Boone R.H., Tomlinson G., and Detsky A.S. Is this patient dead, vegetative, or severely neurologically impaired? Assessing outcome for comatose survivors of cardiac arrest. JAMA 291 (2004) 870-879
2. Edgren E., Hedstrand U., Kelsey S., Sutton-Tyrrell K., and Safar P. Assessment of neurological prognosis in comatose survivors of cardiac arrest BRCT I Study Group. Lancet 343 (1994) 1055-1059
3. Levy D.E., Caronna J.J., Singer B.H., Lapinski R.H., Frydman H., and Plum F. Predicting outcome from hypoxic-ischemic coma. JAMA 253 (1985) 1420-1426
4. Madl C., Kramer L., Domanovits H., et al. Improved outcome prediction in unconscious cardiac arrest survivors with sensory evoked potentials compared with clinical assessment. Crit Care Med 28 (2000) 721-726
5. Zandbergen E.G.J., Koelman J.H., de Haan R.J., Hijdra A., and PROPAC-Study Group. SSEPs and prognosis in postanoxic coma: only short or also long latency responses?. Neurology 67 (2006) 583-586
6. Robinson L.R., Micklesen P.J., Tirschwell D.L., Tirschwell D.L., and Lew H.L. Predictive value of somatosensory evoked potentials for awakening from coma. Crit Care Med 31 (2003) 960-967
7. Tiainen M., Kovala T.T., Takkunen O.S., and Roine R.O. Somatosensory and brainstem auditory evoked potentials in cardiac arrest patients treated with hypothermia. Crit Care Med 33 (2005) 1736-1740
8. Rundgren M., Rosén I., and Friberg. Amplitude-integrated EEG (aEEG) predicts outcome after cardiac arrest and induced hypothermia. Intensive Care Med 32 (2006) 836-842
9. Martens P., Raabe A., and Johnsson P. Serum S-100 and neuron-specific enolase for prediction of regaining consciousness after global cerebral ischemia. Stroke 29 (1998) 2363-2366
10. Meynaar I.A., Oudemans-van Straaten H.M., van der Wetering J., et al. Serum neuron-specific enolase predicts outcome in post-anoxic coma: a prospective cohort study. Intensive Care Med 29 (2003) 189-195
11. Schoerkhuber W., Kittler H., Sterz F., et al. Time course of serum neuron-specific enolase A predictor of neurological outcome in patients resuscitated from cardiac arrest. Stroke 30 (1999) 1598-1603
12. Böttiger B.W., Möbes S., Glätzer R., et al. Astroglial protein S-100 is an early and sensitive marker of hypoxic brain damage and outcome after cardiac arrest in humans. Circulation 103 (2001) 2694-2698
13. Rosén H., Stibrant Sunnerhagen K., Herlitz J., Blomstrand C., and Rosengren L. Serum levels of the brain-derived proteins S-100 and NSE predict long-term outcome after cardiac arrest. Resuscitation 49 (2001) 183-191
14. Hachimi-Idrissi S., Zizi M., Nguyen D.N., et al. The evolution of serum astroglial S-100 beta protein in patients with cardiac arrest treated with mild hypothermia. Resuscitation 64 (2005) 187-192
15. Tiainen M., Roine R.O., Pettilä V., and Takkunen O. Serum neuron-specific enolase and S-[100B] protein in cardiac arrest patients treated with hypothermia. Stroke 34 (2003) 2881-2886
16. Oksanen T., Tiainen M., Skrifvars M.B., et al. Predictive power of serum NSE and OHCA score regarding 6-month neurologic outcome after out-of-hospital ventricular fibrillation and therapeutic hypothermia. Resuscitation 80 (2009) 165-170
17. Johnsson P., Blomquist S., Lührs C., et al. Neuron-specific enolase increases in plasma during and immediately after extracorporeal circulation. Ann Thorac Surg 69 (2000) 750-754
18. Ramont L., Thoannes H., Volondat A., Chastang F., Millet M.C., and Maquart F.X. Effects of hemolysis and storage condition on neuron-specific enolase (NSE) in cerebrospinal fluid and serum: implications in clinical practice. Clin Chem Lab Med 43 (2005) 1215-1217
19. Marangos P.J., Campbell I.C., Schmechel D.E., Murphy D.L., and Goodwin F.K. Blood platelets contain a neuron-specific enolase subunit. J Neurochem 34 (1980) 1254-1258
20. Zimmer D.B., Cormwall E.H., Landar A., and Song W. The S100 protein family: history, function, and expression. Brain Res Bull 37 (1995) 417-429
21. Steiner J, Bernstein HG, Bielau H, et al. Evidence for a wide extra-astrocytic distribution of S100B in human brain. BMC Neurosci 2007;8(2). doi:10.1186/1471-2202-8-2.
22. Anderson R.E., Hansson L.O., Nilsson O., Liska J., Settergren G., and Vaage J. Increase in serum S100A1-B and S100BB during cardiac surgery arises from extracerebral sources. Ann Thorac Surg 71 (2001) 1512-1517
23. Jönsson H., Johnsson P., Höglund P., Alling C., and Blomquist S. Elimination of S100B and renal function after cardiac surgery. J Cardiothorac Vasc Anesth 14 (2000) 698-701
24. Ytrebø L.M., Nedredal G.I., Korvald C., et al. Renal elimination of protein S-100β in pigs with acute encephalopathy. Scand J Clin Lab Invest 61 (2001) 217-225
25. Anand N., and Stead L.G. Neuron-specific enolase as a marker for acute ischemic stroke: a systematic review. Cerebrovasc Dis 20 (2005) 213-219
26. Herrmann M., Vos P., Wunderlich M.T., de Bruijn C.H., and Lamers K.J. Release of glial tissue-specific proteins after acute stroke: A comparative analysis of serum concentrations of protein S-100B and glial fibrillary acidic protein. Stroke 31 (2000) 2670-2677
27. Oertel M., Schumacher U., McArthur D.L., Kästner S., and Böker D.K. S-100B and NSE: markers of initial impact of subarachnoid haemorrhage and their relation to vasospasm and outcome. J Clin Neurosci 13 (2006) 834-840
28. Raabe A., Grolms C., and Seifert V. Serum markers of brain damage and outcome prediction in patients after severe head injury. Br J Neurosurg 13 (1999) 56-59
29. Biberthaler P., Linsenmeier U., Pfeifer K.J., et al. Serum S-100B concentration provides additional information for the indication of computed tomography in patients after minor head injury: a prospective multicenter study. Shock 25 (2006) 446-453
30. Jönsson H., Johnsson P., Alling C., Backstrom M., Bergh C., and Blomquist S. S100β after coronary artery surgery: release pattern, source of contamination, and relation to neuropsychological outcome. Ann thorac Surg 68 (1999) 2202-2208
31. Jennett B., and Boyd M. Assessment of outcome after severe brain damage. Lancet 1 (1975) 480-484
32. The Hypothermia After Cardiac Arrest Study Group. Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med 346 (2002) 549-556
33. Zandbergen E.G.J., Hijdra A., Koelman J.H., et al. Prediction of poor outcome within the first 3 days of postanoxic coma. Neurology 66 (2006) 62-68
34. Rech TH, Rios Vieria SR, Nagel F, Brauner JS, Scalco R. Serum neuron-specific enolase as early predictor of outcome after in-hospital cardiac arrest: a cohort study. Crit Care 2006;10:R133. doi:10.1186/cc5049.
35. Reisinger J., Höllinger K., Lang W., et al. Prediction of neurological outcome after cardiopulmonary resuscitation by serial determination of serum neuronspecific enolase. Eur Heart J 28 (2007) 52-58
36. Prohl J., Röther J., Kluge S., et al. Prediction of short-term and long-term outcomes after cardiac arrest: a prospective multivariate approach combining biochemical, clinical, electrophysiological, and neuropsychological investigations. Crit Care Med 35 (2007) 1230-1237
37. Savola O., Pyhtinen J., Leino T.K., Siitonen S., Niemelä O., and Hillbom M. Effects of head and extracranial injuries on serum protein S100B levels in trauma patients. J Trauma 56 (2004) 1229-1234
38. Undén J., Bellner J., Eneroth M., Alling C., Ingebrigtsen T., and Romner B. Raised serum S100B levels after acute bone fractures without cerebral injury. J Trauma 58 (2005) 59-61
39. Pfeifer R., Börner A., Krack A., Sigusch H.H., Surber R., and Figulla H.R. Outcome after cardiac arrest: predictive values and limitations of the neuroproteins neuron-specific enolase and protein S-100 and the Glasgow Coma Scale. Resuscitation 65 (2005) 49-55
40. Müller K., Elverland A., Romner B., et al. Analysis of protein S-100B in serum: a methodological study. Clin Chem Lab Med 44 (2006) 1111-1114