메뉴 건너뛰기




Volumn 69, Issue 1, 2015, Pages 283-304

Molecular Pathogenesis of Ehrlichia chaffeensis Infection

Author keywords

Adhesin; Chemokines; Cytokines; Invasin; MyD88; Outer membrane proteins; Receptor for entry; Two component system; Type I and IV secretion systems

Indexed keywords

BACTERIAL PROTEIN; BACTERIUM ANTIBODY; GAMMA INTERFERON; INVASIN; OMP 1F PROTEIN; PROTEIN P28; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; TYPE IV SECRETION SYSTEM;

EID: 84945255271     PISSN: 00664227     EISSN: 15453251     Source Type: Book Series    
DOI: 10.1146/annurev-micro-091014-104411     Document Type: Article
Times cited : (58)

References (150)
  • 2
  • 4
    • 80052145296 scopus 로고    scopus 로고
    • Wild rodents and novel human pathogen Candidatus Neoehrlichia mikurensis, Southern Sweden
    • Andersson M, Raberg L. 2011. Wild rodents and novel human pathogen Candidatus Neoehrlichia mikurensis, Southern Sweden. Emerg. Infect. Dis. 17: 1716-18
    • (2011) Emerg. Infect. Dis. , vol.17 , pp. 1716-1718
    • Andersson, M.1    Raberg, L.2
  • 6
    • 58149490639 scopus 로고    scopus 로고
    • Four VirB6 paralogs and VirB9 are expressed and interact in Ehrlichia chaffeensis-containing vacuoles
    • BaoW, Kumagai Y, Niu H, Yamaguchi M, Miura K, Rikihisa Y. 2009. Four VirB6 paralogs and VirB9 are expressed and interact in Ehrlichia chaffeensis-containing vacuoles. J. Bacteriol. 191: 278-86
    • (2009) J. Bacteriol. , vol.191 , pp. 278-286
    • Bao, W.1    Kumagai, Y.2    Niu, H.3    Yamaguchi, M.4    Miura, K.5    Rikihisa, Y.6
  • 7
    • 0032900986 scopus 로고    scopus 로고
    • Ehrlichia chaffeensis and E. Sennetsu, but not the human granulocytic ehrlichiosis agent, colocalize with transferrin receptor and up-regulate transferrin receptor mRNA by activating iron-responsive protein 1
    • Barnewall RE, Ohashi N, Rikihisa Y. 1999. Ehrlichia chaffeensis and E. Sennetsu, but not the human granulocytic ehrlichiosis agent, colocalize with transferrin receptor and up-regulate transferrin receptor mRNA by activating iron-responsive protein 1. Infect. Immun. 67: 2258-65
    • (1999) Infect. Immun. , vol.67 , pp. 2258-2265
    • Barnewall, R.E.1    Ohashi, N.2    Rikihisa, Y.3
  • 8
    • 0027938009 scopus 로고
    • Abrogation of gamma interferon-induced inhibition of Ehrlichia chaffeensis infection in human monocytes with iron-transferrin
    • Barnewall RE, Rikihisa Y. 1994. Abrogation of gamma interferon-induced inhibition of Ehrlichia chaffeensis infection in human monocytes with iron-transferrin. Infect. Immun. 62: 4804-10
    • (1994) Infect. Immun. , vol.62 , pp. 4804-4810
    • Barnewall, R.E.1    Rikihisa, Y.2
  • 9
    • 0030959591 scopus 로고    scopus 로고
    • Ehrlichia chaffeensis inclusions are early endosomes which selectively accumulate transferrin receptor
    • Barnewall RE, Rikihisa Y, Lee EH. 1997. Ehrlichia chaffeensis inclusions are early endosomes which selectively accumulate transferrin receptor. Infect. Immun. 65: 1455-61
    • (1997) Infect. Immun. , vol.65 , pp. 1455-1461
    • Barnewall, R.E.1    Rikihisa, Y.2    Lee, E.H.3
  • 10
    • 2442645190 scopus 로고    scopus 로고
    • Production of IFN-by CD4 T cells is essential for resolving ehrlichia infection
    • Bitsaktsis C, Huntington J, Winslow G. 2004. Production of IFN-by CD4 T cells is essential for resolving ehrlichia infection. J. Immunol. 172: 6894-901
    • (2004) J. Immunol. , vol.172 , pp. 6894-6901
    • Bitsaktsis, C.1    Huntington, J.2    Winslow, G.3
  • 11
    • 34848869067 scopus 로고    scopus 로고
    • T-Cell-independent humoral immunity is sufficient for protection against fatal intracellular ehrlichia infection
    • Bitsaktsis C, Nandi B, Racine R, MacNamara KC, Winslow G. 2007. T-Cell-independent humoral immunity is sufficient for protection against fatal intracellular ehrlichia infection. Infect. Immun. 75: 4933-41
    • (2007) Infect. Immun. , vol.75 , pp. 4933-4941
    • Bitsaktsis, C.1    Nandi, B.2    Racine, R.3    MacNamara, K.C.4    Winslow, G.5
  • 12
    • 33749126557 scopus 로고    scopus 로고
    • Fatal recall responses mediated by CD8 T cells during intracellular bacterial challenge infection
    • Bitsaktsis C, Winslow G. 2006. Fatal recall responses mediated by CD8 T cells during intracellular bacterial challenge infection. J. Immunol. 177: 4644-51
    • (2006) J. Immunol. , vol.177 , pp. 4644-4651
    • Bitsaktsis, C.1    Winslow, G.2
  • 14
    • 84873590778 scopus 로고    scopus 로고
    • Notifiable diseases and mortality tables
    • CDC
    • CDC. 2013. Notifiable Diseases and Mortality Tables. Morb. Mortal. Wkly. Rep. 62: ND-695
    • (2013) Morb. Mortal. Wkly. Rep. , vol.62 , pp. ND-695
  • 15
    • 0030727110 scopus 로고    scopus 로고
    • Western immunoblotting analysis of the antibody responses of patients with humanmonocytotropic ehrlichiosis to different strains of Ehrlichia chaffeensis and Ehrlichia canis
    • Chen SM, Cullman LC, Walker DH. 1997. Western immunoblotting analysis of the antibody responses of patients with humanmonocytotropic ehrlichiosis to different strains of Ehrlichia chaffeensis and Ehrlichia canis. Clin. Diagn. Lab. Immunol. 4: 731-35
    • (1997) Clin. Diagn. Lab. Immunol. , vol.4 , pp. 731-735
    • Chen, S.M.1    Cullman, L.C.2    Walker, D.H.3
  • 16
    • 0028047345 scopus 로고
    • Identification of a granulocytotropic Ehrlichia species as the etiologic agent of human disease
    • Chen SM, Dumler JS, Bakken JS, Walker DH. 1994. Identification of a granulocytotropic Ehrlichia species as the etiologic agent of human disease. J. Clin. Microbiol. 32: 589-95
    • (1994) J. Clin. Microbiol. , vol.32 , pp. 589-595
    • Chen, S.M.1    Dumler, J.S.2    Bakken, J.S.3    Walker, D.H.4
  • 17
    • 84874779069 scopus 로고    scopus 로고
    • Targeted and random mutagenesis of Ehrlichia chaffeensis for the identification of genes required for in vivo infection
    • ChengC, Nair AD, Indukuri VV, Gong S, Felsheim RF, et al. 2013. Targeted and random mutagenesis of Ehrlichia chaffeensis for the identification of genes required for in vivo infection. PLOS Pathog. 9: e1003171
    • (2013) PLOS Pathog. , vol.9 , pp. e1003171
    • Cheng, C.1    Nair, A.D.2    Indukuri, V.V.3    Gong, S.4    Felsheim, R.F.5
  • 18
    • 0037217289 scopus 로고    scopus 로고
    • Molecular heterogeneity of Ehrlichia chaffeensis isolates determined by sequence analysis of the 28-kilodalton outer membrane protein genes and other regions of the genome
    • Cheng C, Paddock CD, Reddy Ganta R. 2003. Molecular heterogeneity of Ehrlichia chaffeensis isolates determined by sequence analysis of the 28-kilodalton outer membrane protein genes and other regions of the genome. Infect. Immun. 71: 187-95
    • (2003) Infect. Immun. , vol.71 , pp. 187-195
    • Cheng, C.1    Paddock, C.D.2    Reddy Ganta, R.3
  • 19
    • 84895886531 scopus 로고    scopus 로고
    • Proteomic analysis of the Ehrlichia chaffeensis phagosome in cultured DH82 cells
    • Cheng Y, Liu Y, Wu B, Zhang JZ, Gu J, et al. 2014. Proteomic analysis of the Ehrlichia chaffeensis phagosome in cultured DH82 cells. PLOS ONE 9: e88461
    • (2014) PLOS ONE , vol.9 , pp. e88461
    • Cheng, Y.1    Liu, Y.2    Wu, B.3    Zhang, J.Z.4    Gu, J.5
  • 20
    • 33745771590 scopus 로고    scopus 로고
    • Intra-leukocyte expression of two-component systems in Ehrlichia chaffeensis and Anaplasma phagocytophilum and effects of the histidine kinase inhibitor closantel
    • Cheng Z, Kumagai Y, LinM, Zhang C, Rikihisa Y. 2006. Intra-leukocyte expression of two-component systems in Ehrlichia chaffeensis and Anaplasma phagocytophilum and effects of the histidine kinase inhibitor closantel. Cell. Microbiol. 8: 1241-52
    • (2006) Cell. Microbiol. , vol.8 , pp. 1241-1252
    • Cheng, Z.1    Kumagai, Y.2    Lin, M.3    Zhang, C.4    Rikihisa, Y.5
  • 21
    • 84920913770 scopus 로고    scopus 로고
    • Ehrlichia chaffeensis proliferation begins with NtrY/NtrX and PutA/GlnA upregulation and CtrA degradation induced by proline and glutamine uptake
    • Cheng Z, Lin M, Rikihisa Y. 2014. Ehrlichia chaffeensis proliferation begins with NtrY/NtrX and PutA/GlnA upregulation and CtrA degradation induced by proline and glutamine uptake. mBio 5: e02141-14
    • (2014) MBio , vol.5 , pp. e02141-e02214
    • Cheng, Z.1    Lin, M.2    Rikihisa, Y.3
  • 22
    • 82155168196 scopus 로고    scopus 로고
    • Insights into the CtrA regulon in development of stress resistance in obligatory intracellular pathogen Ehrlichia chaffeensis
    • Cheng Z, Miura K, Popov VL, Kumagai Y, Rikihisa Y. 2011. Insights into the CtrA regulon in development of stress resistance in obligatory intracellular pathogen Ehrlichia chaffeensis. Mol Microbiol. 82: 1217-34
    • (2011) Mol Microbiol. , vol.82 , pp. 1217-1234
    • Cheng, Z.1    Miura, K.2    Popov, V.L.3    Kumagai, Y.4    Rikihisa, Y.5
  • 23
    • 40449139085 scopus 로고    scopus 로고
    • Regulation of type IV secretion apparatus genes during Ehrlichia chaffeensis intracellular development by a previously unidentified protein
    • Cheng Z, Wang X, Rikihisa Y. 2008. Regulation of type IV secretion apparatus genes during Ehrlichia chaffeensis intracellular development by a previously unidentified protein. J. Bacteriol. 190: 2096-105
    • (2008) J. Bacteriol. , vol.190 , pp. 2096-2105
    • Cheng, Z.1    Wang, X.2    Rikihisa, Y.3
  • 24
    • 0028010050 scopus 로고
    • Molecular events in the activation of human neutrophils for microbial killing
    • Cohen MS. 1994. Molecular events in the activation of human neutrophils for microbial killing. Clin. Infect. Dis. 18(Suppl. 2): S170-79
    • (1994) Clin. Infect. Dis. , vol.18 , pp. S170-S179
    • Cohen, M.S.1
  • 25
    • 0025787738 scopus 로고
    • Isolation and characterization of an Ehrlichia sp. from a patient diagnosed with human ehrlichiosis
    • Dawson JE, Anderson BE, Fishbein DB, Sanchez JL, Goldsmith CS, et al. 1991. Isolation and characterization of an Ehrlichia sp. from a patient diagnosed with human ehrlichiosis. J. Clin. Microbiol. 29: 2741-45
    • (1991) J. Clin. Microbiol. , vol.29 , pp. 2741-2745
    • Dawson, J.E.1    Anderson, B.E.2    Fishbein, D.B.3    Sanchez, J.L.4    Goldsmith, C.S.5
  • 26
    • 0026902092 scopus 로고
    • Susceptibility of dogs to infection with Ehrlichia chaffeensis, causative agent of human ehrlichiosis
    • Dawson JE, Ewing SA. 1992. Susceptibility of dogs to infection with Ehrlichia chaffeensis, causative agent of human ehrlichiosis. Am. J. Vet. Res. 53: 1322-27
    • (1992) Am. J. Vet. Res. , vol.53 , pp. 1322-1327
    • Dawson, J.E.1    Ewing, S.A.2
  • 27
    • 3342982328 scopus 로고    scopus 로고
    • Modulation of phagocyte apoptosis by bacterial pathogens
    • DeLeo FR. 2004. Modulation of phagocyte apoptosis by bacterial pathogens. Apoptosis 9: 399-413
    • (2004) Apoptosis , vol.9 , pp. 399-413
    • DeLeo, F.R.1
  • 28
    • 29644434935 scopus 로고    scopus 로고
    • Differentially expressed and secreted major immunoreactive protein orthologs of Ehrlichia canis and E. Chaffeensis elicit early antibody responses to epitopes on glycosylated tandem repeats
    • Doyle CK, Nethery KA, Popov VL, McBride JW. 2006. Differentially expressed and secreted major immunoreactive protein orthologs of Ehrlichia canis and E. Chaffeensis elicit early antibody responses to epitopes on glycosylated tandem repeats. Infect. Immun. 74: 711-20
    • (2006) Infect. Immun. , vol.74 , pp. 711-720
    • Doyle, C.K.1    Nethery, K.A.2    Popov, V.L.3    McBride, J.W.4
  • 30
    • 0035192367 scopus 로고    scopus 로고
    • Reorganization of genera in the families Rickettsiaceae and Anaplasmataceae in the order Rickettsiales: Unification of some species of Ehrlichia with Anaplasma, Cowdria with Ehrlichia and Ehrlichia with Neorickettsia, descriptions of six new species combinations and designation of Ehrlichia equi and 'HGE agent' as subjective synonyms of Ehrlichia phagocytophila
    • Dumler JS, Barbet AF, Bekker CP, Dasch GA, Palmer GH, et al. 2001. Reorganization of genera in the families Rickettsiaceae and Anaplasmataceae in the order Rickettsiales: unification of some species of Ehrlichia with Anaplasma, Cowdria with Ehrlichia and Ehrlichia with Neorickettsia, descriptions of six new species combinations and designation of Ehrlichia equi and 'HGE agent' as subjective synonyms of Ehrlichia phagocytophila. Int. J. Syst. Evol. Microbiol. 51: 2145-65
    • (2001) Int. J. Syst. Evol. Microbiol. , vol.51 , pp. 2145-2165
    • Dumler, J.S.1    Barbet, A.F.2    Bekker, C.P.3    Dasch, G.A.4    Palmer, G.H.5
  • 31
    • 0029030449 scopus 로고
    • Isolation and characterization of a new strain of Ehrlichia chaffeensis from a patient with nearly fatal monocytic ehrlichiosis
    • Dumler JS, Chen SM, Asanovich K, Trigiani E, Popov VL, Walker DH. 1995. Isolation and characterization of a new strain of Ehrlichia chaffeensis from a patient with nearly fatal monocytic ehrlichiosis. J. Clin. Microbiol. 33: 1704-11
    • (1995) J. Clin. Microbiol. , vol.33 , pp. 1704-1711
    • Dumler, J.S.1    Chen, S.M.2    Asanovich, K.3    Trigiani, E.4    Popov, V.L.5    Walker, D.H.6
  • 33
    • 84907097000 scopus 로고    scopus 로고
    • Ehrlichia chaffeensis exploits host SUMOylation pathways to mediate effector-host interactions and promote intracellular survival
    • Dunphy PS, Luo T, McBride JW. 2014. Ehrlichia chaffeensis exploits host SUMOylation pathways to mediate effector-host interactions and promote intracellular survival. Infect. Immun. 82: 4154-68
    • (2014) Infect. Immun. , vol.82 , pp. 4154-4168
    • Dunphy, P.S.1    Luo, T.2    McBride, J.W.3
  • 34
    • 0029294739 scopus 로고
    • Experimental transmission of Ehrlichia chaffeensis (Rickettsiales: Ehrlichieae) among white-tailed deer by Amblyomma americanum (Acari: Ixodidae)
    • Ewing SA, Dawson JE, Kocan AA, Barker RW, Warner CK, et al. 1995. Experimental transmission of Ehrlichia chaffeensis (Rickettsiales: Ehrlichieae) among white-tailed deer by Amblyomma americanum (Acari: Ixodidae). J. Med. Entomol. 32: 368-74
    • (1995) J. Med. Entomol. , vol.32 , pp. 368-374
    • Ewing, S.A.1    Dawson, J.E.2    Kocan, A.A.3    Barker, R.W.4    Warner, C.K.5
  • 35
    • 77954432099 scopus 로고    scopus 로고
    • Septicemia caused by tick-borne bacterial pathogen Candidatus Neoehrlichia mikurensis
    • Fehr JS, Bloemberg GV, RitterC, Hombach M, Luscher TF, et al. 2010. Septicemia caused by tick-borne bacterial pathogen Candidatus Neoehrlichia mikurensis. Emerg. Infect. Dis. 16: 1127-29
    • (2010) Emerg. Infect. Dis. , vol.16 , pp. 1127-1129
    • Fehr, J.S.1    Bloemberg, G.V.2    Ritter, C.3    Hombach, M.4    Luscher, T.F.5
  • 36
    • 0035129383 scopus 로고    scopus 로고
    • Sensitive detection of Ehrlichia chaffeensis in cell culture, blood, and tick specimens by reverse transcription-PCR
    • Felek S, Unver A, Stich RW, Rikihisa Y. 2001. Sensitive detection of Ehrlichia chaffeensis in cell culture, blood, and tick specimens by reverse transcription-PCR. J. Clin. Microbiol. 39: 460-63
    • (2001) J. Clin. Microbiol. , vol.39 , pp. 460-463
    • Felek, S.1    Unver, A.2    Stich, R.W.3    Rikihisa, Y.4
  • 37
    • 0006161042 scopus 로고
    • Ehrlichial organisms isolated from Ixodes ovatus ticks and field rodents in Japan
    • Fujita H, Watanabe Y. 1994. Ehrlichial organisms isolated from Ixodes ovatus ticks and field rodents in Japan. Ann. Rep. Ohara Hosp. 37: 13-17
    • (1994) Ann. Rep. Ohara Hosp. , vol.37 , pp. 13-17
    • Fujita, H.1    Watanabe, Y.2
  • 38
    • 33846003533 scopus 로고    scopus 로고
    • Differential clearance and immune responses to tick cell-derived versus macrophage culture-derived Ehrlichia chaffeensis in mice
    • Ganta RR, Cheng C, Miller EC, McGuire BL, Peddireddi L, et al. 2007. Differential clearance and immune responses to tick cell-derived versus macrophage culture-derived Ehrlichia chaffeensis in mice. Infect. Immun. 75: 135-45
    • (2007) Infect. Immun. , vol.75 , pp. 135-145
    • Ganta, R.R.1    Cheng, C.2    Miller, E.C.3    McGuire, B.L.4    Peddireddi, L.5
  • 39
    • 0346881415 scopus 로고    scopus 로고
    • Delayed clearance of Ehrlichia chaffeensis infection in CD4+ T-cell knockout mice
    • Ganta RR, ChengC, WilkersonMJ, Chapes SK. 2004. Delayed clearance of Ehrlichia chaffeensis infection in CD4+ T-cell knockout mice. Infect. Immun. 72: 159-67
    • (2004) Infect. Immun. , vol.72 , pp. 159-167
    • Ganta, R.R.1    Cheng, C.2    Wilkerson, M.J.3    Chapes, S.K.4
  • 40
    • 0038649210 scopus 로고    scopus 로고
    • National surveillance for the human ehrlichioses in the United States, 1997-2001, and proposed methods for evaluation of data quality
    • Gardner SL, Holman RC, Krebs JW, Berkelman R, Childs JE. 2003. National surveillance for the human ehrlichioses in the United States, 1997-2001, and proposed methods for evaluation of data quality. Ann. N. Y. Acad. Sci. 990: 80-89
    • (2003) Ann. N. Y. Acad. Sci. , vol.990 , pp. 80-89
    • Gardner, S.L.1    Holman, R.C.2    Krebs, J.W.3    Berkelman, R.4    Childs, J.E.5
  • 41
    • 33746921665 scopus 로고    scopus 로고
    • Anaplasma phagocytophilum delays spontaneous human neutrophil apoptosis by modulation of multiple apoptotic pathways
    • Ge Y, Rikihisa Y. 2006. Anaplasma phagocytophilum delays spontaneous human neutrophil apoptosis by modulation of multiple apoptotic pathways. Cell. Microbiol. 8: 1406-16
    • (2006) Cell. Microbiol. , vol.8 , pp. 1406-1416
    • Ge, Y.1    Rikihisa, Y.2
  • 42
    • 35648974248 scopus 로고    scopus 로고
    • Identification of novel surface proteins of Anaplasma phagocytophilum by affinity purification and proteomics
    • Ge Y, Rikihisa Y. 2007. Identification of novel surface proteins of Anaplasma phagocytophilum by affinity purification and proteomics. J. Bacteriol. 189: 7819-28
    • (2007) J. Bacteriol. , vol.189 , pp. 7819-7828
    • Ge, Y.1    Rikihisa, Y.2
  • 43
    • 34547640142 scopus 로고    scopus 로고
    • Surface-exposed proteins of Ehrlichia chaffeensis
    • Ge Y, Rikihisa Y. 2007. Surface-exposed proteins of Ehrlichia chaffeensis. Infect. Immun. 75: 3833-41
    • (2007) Infect. Immun. , vol.75 , pp. 3833-3841
    • Ge, Y.1    Rikihisa, Y.2
  • 44
    • 12444278282 scopus 로고    scopus 로고
    • Anaplasma phagocytophilum inhibits human neutrophil apoptosis via upregulation of bfl-1, maintenance of mitochondrial membrane potential and prevention of caspase 3 activation
    • Ge Y, Yoshiie K, Kuribayashi F, Lin M, Rikihisa Y. 2005. Anaplasma phagocytophilum inhibits human neutrophil apoptosis via upregulation of bfl-1, maintenance of mitochondrial membrane potential and prevention of caspase 3 activation. Cell. Microbiol. 7: 29-38
    • (2005) Cell. Microbiol. , vol.7 , pp. 29-38
    • Ge, Y.1    Yoshiie, K.2    Kuribayashi, F.3    Lin, M.4    Rikihisa, Y.5
  • 45
    • 28244436432 scopus 로고    scopus 로고
    • Molecular architecture and function of the Omp85 family of proteins
    • Gentle IE, Burri L, Lithgow T. 2005. Molecular architecture and function of the Omp85 family of proteins. Mol. Microbiol. 58: 1216-25
    • (2005) Mol. Microbiol. , vol.58 , pp. 1216-1225
    • Gentle, I.E.1    Burri, L.2    Lithgow, T.3
  • 46
    • 0030044553 scopus 로고    scopus 로고
    • Direct cultivation of the causative agent of human granulocytic ehrlichiosis
    • Goodman JL, Nelson C, Vitale B, Madigan JE, Dumler JS, et al. 1996. Direct cultivation of the causative agent of human granulocytic ehrlichiosis. N. Engl. J. Med. 334: 209-15
    • (1996) N. Engl. J. Med. , vol.334 , pp. 209-215
    • Goodman, J.L.1    Nelson, C.2    Vitale, B.3    Madigan, J.E.4    Dumler, J.S.5
  • 47
    • 0025870123 scopus 로고
    • Chlamydia trachomatis developmentally regulated protein is homologous to eukaryotic histone H1
    • Hackstadt T, Baehr W, Ying Y. 1991. Chlamydia trachomatis developmentally regulated protein is homologous to eukaryotic histone H1. PNAS 88: 3937-41
    • (1991) PNAS , vol.88 , pp. 3937-3941
    • Hackstadt, T.1    Baehr, W.2    Ying, Y.3
  • 49
    • 0029784238 scopus 로고    scopus 로고
    • A developmental stage-specific histone H1 homolog of Coxiella burnetii
    • Heinzen RA, Hackstadt T. 1996. A developmental stage-specific histone H1 homolog of Coxiella burnetii. J. Bacteriol. 178: 5049-52
    • (1996) J. Bacteriol. , vol.178 , pp. 5049-5052
    • Heinzen, R.A.1    Hackstadt, T.2
  • 50
    • 84858157091 scopus 로고    scopus 로고
    • Manganese superoxide dismutase: Beyond life and death
    • Holley AK, Dhar SK, Xu Y, St Clair DK. 2012. Manganese superoxide dismutase: beyond life and death. Amino Acids 42: 139-58
    • (2012) Amino Acids , vol.42 , pp. 139-158
    • Holley, A.K.1    Dhar, S.K.2    Xu, Y.3    St Clair, D.K.4
  • 51
    • 48849086594 scopus 로고    scopus 로고
    • Proteomic analysis of and immune responses to Ehrlichia chaffeensis lipoproteins
    • Huang H, Lin M, Wang X, Kikuchi T, Mottaz H, et al. 2008. Proteomic analysis of and immune responses to Ehrlichia chaffeensis lipoproteins. Infect. Immun. 76: 3405-14
    • (2008) Infect. Immun. , vol.76 , pp. 3405-3414
    • Huang, H.1    Lin, M.2    Wang, X.3    Kikuchi, T.4    Mottaz, H.5
  • 52
    • 84905372666 scopus 로고    scopus 로고
    • Themachinery at endoplasmic reticulum-plasma membrane contact sites contributes to spatial regulation of multiple Legionella effector proteins
    • Hubber A, Arasaki K, Nakatsu F, Hardiman C, Lambright D, et al. 2014. Themachinery at endoplasmic reticulum-plasma membrane contact sites contributes to spatial regulation of multiple Legionella effector proteins. PLOS Pathog. 10: e1004222
    • (2014) PLOS Pathog. , vol.10 , pp. e1004222
    • Hubber, A.1    Arasaki, K.2    Nakatsu, F.3    Hardiman, C.4    Lambright, D.5
  • 54
    • 1642525700 scopus 로고    scopus 로고
    • Overproduction of TNF-by CD8+ type 1 cells and down-regulation of IFN-production by CD4+ Th1 cells contribute to toxic shock-like syndrome in an animal model of fatal monocytotropic ehrlichiosis
    • Ismail N, Soong L, McBride JW, Valbuena G, Olano JP, et al. 2004. Overproduction of TNF-by CD8+ type 1 cells and down-regulation of IFN-production by CD4+ Th1 cells contribute to toxic shock-like syndrome in an animal model of fatal monocytotropic ehrlichiosis. J. Immunol. 172: 1786-800
    • (2004) J. Immunol. , vol.172 , pp. 1786-1800
    • Ismail, N.1    Soong, L.2    McBride, J.W.3    Valbuena, G.4    Olano, J.P.5
  • 55
    • 33644784688 scopus 로고    scopus 로고
    • Role of tumor necrosis factor alpha (TNF-) and interleukin-10 in the pathogenesis of severe murine monocytotropic ehrlichiosis: Increased resistance of TNF receptor p55-and p75-deficient mice to fatal ehrlichial infection
    • Ismail N, Stevenson HL, Walker DH. 2006. Role of tumor necrosis factor alpha (TNF-) and interleukin-10 in the pathogenesis of severe murine monocytotropic ehrlichiosis: increased resistance of TNF receptor p55-and p75-deficient mice to fatal ehrlichial infection. Infect. Immun. 74: 1846-56
    • (2006) Infect. Immun. , vol.74 , pp. 1846-1856
    • Ismail, N.1    Stevenson, H.L.2    Walker, D.H.3
  • 56
    • 33745685255 scopus 로고    scopus 로고
    • Balancing protective immunity and immunopathology: A unifying model of monocytotropic ehrlichiosis
    • Ismail N, Walker DH. 2005. Balancing protective immunity and immunopathology: A unifying model of monocytotropic ehrlichiosis. Ann. N. Y. Acad. Sci. 1063: 383-94
    • (2005) Ann. N. Y. Acad. Sci. , vol.1063 , pp. 383-394
    • Ismail, N.1    Walker, D.H.2
  • 58
    • 0029787187 scopus 로고    scopus 로고
    • Impaired antigen specific responses and enhanced polyclonal stimulation in mice infected with Ehrlichia muris
    • Kawahara M, Suto C, Shibata S, FutohashiM, Rikihisa Y. 1996. Impaired antigen specific responses and enhanced polyclonal stimulation in mice infected with Ehrlichia muris. Microbiol. Immunol. 40: 575-81
    • (1996) Microbiol. Immunol. , vol.40 , pp. 575-581
    • Kawahara, M.1    Suto, C.2    Shibata, S.3    Futohashi, M.4    Rikihisa, Y.5
  • 59
    • 77955361701 scopus 로고    scopus 로고
    • MyD88-dependent signaling contributes to host defense against ehrlichial infection
    • KohYS, Koo JE, Biswas A, KobayashiKS. 2010. MyD88-dependent signaling contributes to host defense against ehrlichial infection. PLOS ONE 5: e11758
    • (2010) PLOS ONE , vol.5 , pp. e11758
    • Koh, Y.S.1    Koo, J.E.2    Biswas, A.3    Kobayashi, K.S.4
  • 60
    • 33748045474 scopus 로고    scopus 로고
    • Biochemical activities of three pairs of Ehrlichia chaffeensis two-component regulatory system proteins involved in inhibition of lysosomal fusion
    • Kumagai Y, Cheng Z, LinM, Rikihisa Y. 2006. Biochemical activities of three pairs of Ehrlichia chaffeensis two-component regulatory system proteins involved in inhibition of lysosomal fusion. Infect. Immun. 74: 5014-22
    • (2006) Infect. Immun. , vol.74 , pp. 5014-5022
    • Kumagai, Y.1    Cheng, Z.2    Lin, M.3    Rikihisa, Y.4
  • 61
    • 47049114343 scopus 로고    scopus 로고
    • Expression and porin activity of P28 and OMP-1F during intracellular Ehrlichia chaffeensis development
    • Kumagai Y, Huang H, Rikihisa Y. 2008. Expression and porin activity of P28 and OMP-1F during intracellular Ehrlichia chaffeensis development. J. Bacteriol. 190: 3597-605
    • (2008) J. Bacteriol. , vol.190 , pp. 3597-3605
    • Kumagai, Y.1    Huang, H.2    Rikihisa, Y.3
  • 62
    • 80855127776 scopus 로고    scopus 로고
    • Cyclic dimeric GMP signaling regulates intracellular aggregation, sessility, and growth of Ehrlichia chaffeensis
    • Kumagai Y, Matsuo J, Cheng Z, Hayakawa Y, Rikihisa Y. 2011. Cyclic dimeric GMP signaling regulates intracellular aggregation, sessility, and growth of Ehrlichia chaffeensis. Infect. Immun. 79: 3905-12
    • (2011) Infect. Immun. , vol.79 , pp. 3905-3912
    • Kumagai, Y.1    Matsuo, J.2    Cheng, Z.3    Hayakawa, Y.4    Rikihisa, Y.5
  • 63
    • 77955953184 scopus 로고    scopus 로고
    • Cyclic di-GMP signaling regulates invasion by Ehrlichia chaffeensis of human monocytes
    • Kumagai Y, Matsuo J, Hayakawa Y, Rikihisa Y. 2010. Cyclic di-GMP signaling regulates invasion by Ehrlichia chaffeensis of human monocytes. J. Bacteriol. 192: 4122-33
    • (2010) J. Bacteriol. , vol.192 , pp. 4122-4133
    • Kumagai, Y.1    Matsuo, J.2    Hayakawa, Y.3    Rikihisa, Y.4
  • 65
    • 80052462695 scopus 로고    scopus 로고
    • Ehrlichia chaffeensis transcriptome in mammalian and arthropod hosts reveals differential gene expression and post transcriptional regulation
    • Kuriakose JA, Miyashiro S, Luo T, Zhu B, McBride JW. 2011. Ehrlichia chaffeensis transcriptome in mammalian and arthropod hosts reveals differential gene expression and post transcriptional regulation. PLOS ONE 6: e24136
    • (2011) PLOS ONE , vol.6 , pp. e24136
    • Kuriakose, J.A.1    Miyashiro, S.2    Luo, T.3    Zhu, B.4    McBride, J.W.5
  • 66
    • 84866334350 scopus 로고    scopus 로고
    • Molecular basis of antibody mediated immunity against Ehrlichia chaffeensis involves species-specific linear epitopes in tandem repeat proteins
    • Kuriakose JA, Zhang X, Luo T, McBride JW. 2012. Molecular basis of antibody mediated immunity against Ehrlichia chaffeensis involves species-specific linear epitopes in tandem repeat proteins. Microbes Infect. 14: 1054-63
    • (2012) Microbes Infect. , vol.14 , pp. 1054-1063
    • Kuriakose, J.A.1    Zhang, X.2    Luo, T.3    McBride, J.W.4
  • 67
    • 0030987745 scopus 로고    scopus 로고
    • Anti-Ehrlichia chaffeensis antibody complexed with E. Chaffeensis induces potent proinflammatory cytokinemRNAexpression in humanmonocytes through sustained reduction of IB-and activation of NF-B
    • Lee EH, Rikihisa Y. 1997. Anti-Ehrlichia chaffeensis antibody complexed with E. Chaffeensis induces potent proinflammatory cytokinemRNAexpression in humanmonocytes through sustained reduction of IB-and activation of NF-B. Infect. Immun. 65: 2890-97
    • (1997) Infect. Immun. , vol.65 , pp. 2890-2897
    • Lee, E.H.1    Rikihisa, Y.2
  • 68
    • 0031867451 scopus 로고    scopus 로고
    • Protein kinase A-mediated inhibition of gamma interferon-induced tyrosine phosphorylation of Janus kinases and latent cytoplasmic transcription factors in human monocytes by Ehrlichia chaffeensis
    • Lee EH, Rikihisa Y. 1998. Protein kinase A-mediated inhibition of gamma interferon-induced tyrosine phosphorylation of Janus kinases and latent cytoplasmic transcription factors in human monocytes by Ehrlichia chaffeensis. Infect. Immun. 66: 2514-20
    • (1998) Infect. Immun. , vol.66 , pp. 2514-2520
    • Lee, E.H.1    Rikihisa, Y.2
  • 69
    • 84866530914 scopus 로고    scopus 로고
    • Human infection with Candidatus Neoehrlichia mikurensis, China
    • Li H, Jiang JF, LiuW, Zheng YC, Huo QB, et al. 2012. Human infection with Candidatus Neoehrlichia mikurensis, China. Emerg. Infect. Dis. 18: 1636-39
    • (2012) Emerg. Infect. Dis. , vol.18 , pp. 1636-1639
    • Li, H.1    Jiang, J.F.2    Liu, W.3    Zheng, Y.C.4    Huo, Q.B.5
  • 70
    • 0036681845 scopus 로고    scopus 로고
    • Antibodies highly effective in SCIDmice during infection by the intracellular bacterium Ehrlichia chaffeensis are of picomolar affinity and exhibit preferential epitope and isotype utilization
    • Li JS, Chu F, Reilly A, WinslowGM. 2002. Antibodies highly effective in SCIDmice during infection by the intracellular bacterium Ehrlichia chaffeensis are of picomolar affinity and exhibit preferential epitope and isotype utilization. J. Immunol. 169: 1419-25
    • (2002) J. Immunol. , vol.169 , pp. 1419-1425
    • Li, J.S.1    Chu, F.2    Reilly, A.3    Winslow, G.M.4
  • 71
    • 0035253570 scopus 로고    scopus 로고
    • Outer membrane protein-specific monoclonal antibodies protect SCID mice from fatal infection by the obligate intracellular bacterial pathogen Ehrlichia chaffeensis
    • Li JS, Yager E, Reilly M, Freeman C, Reddy GR, et al. 2001. Outer membrane protein-specific monoclonal antibodies protect SCID mice from fatal infection by the obligate intracellular bacterial pathogen Ehrlichia chaffeensis. J. Immunol. 166: 1855-62
    • (2001) J. Immunol. , vol.166 , pp. 1855-1862
    • Li, J.S.1    Yager, E.2    Reilly, M.3    Freeman, C.4    Reddy, G.R.5
  • 73
    • 34848862803 scopus 로고    scopus 로고
    • Anaplasma phagocytophilum AnkA secreted by type IV secretion system is tyrosine phosphorylated by Abl-1 to facilitate infection
    • Lin M, den Dulk-Ras A, Hooykaas PJ, Rikihisa Y. 2007. Anaplasma phagocytophilum AnkA secreted by type IV secretion system is tyrosine phosphorylated by Abl-1 to facilitate infection. Cell. Microbiol. 9: 2644-57
    • (2007) Cell. Microbiol. , vol.9 , pp. 2644-2657
    • Lin, M.1    Den Dulk-Ras, A.2    Hooykaas, P.J.3    Rikihisa, Y.4
  • 74
    • 0042825338 scopus 로고    scopus 로고
    • Ehrlichia chaffeensis and Anaplasma phagocytophilum lack genes for lipid A biosynthesis and incorporate cholesterol for their survival
    • LinM, Rikihisa Y. 2003. Ehrlichia chaffeensis and Anaplasma phagocytophilum lack genes for lipid A biosynthesis and incorporate cholesterol for their survival. Infect. Immun. 71: 5324-31
    • (2003) Infect. Immun. , vol.71 , pp. 5324-5331
    • Lin, M.1    Rikihisa, Y.2
  • 75
    • 0142217168 scopus 로고    scopus 로고
    • Obligatory intracellular parasitism by Ehrlichia chaffeensis and Anaplasma phagocytophilum involves caveolae and glycosylphosphatidylinositol-anchored proteins
    • LinM, RikihisaY. 2003. Obligatory intracellular parasitism by Ehrlichia chaffeensis and Anaplasma phagocytophilum involves caveolae and glycosylphosphatidylinositol-anchored proteins. Cell. Microbiol. 5: 809-20
    • (2003) Cell. Microbiol. , vol.5 , pp. 809-820
    • Lin, M.1    Rikihisa, Y.2
  • 76
    • 1642473014 scopus 로고    scopus 로고
    • Ehrlichia chaffeensis downregulates surface Toll-like receptors 2/4, CD14 and transcription factors PU. 1 and inhibits lipopolysaccharide activation ofNF-B, ERK 1/2 and p38MAPK in host monocytes
    • Lin M, Rikihisa Y. 2004. Ehrlichia chaffeensis downregulates surface Toll-like receptors 2/4, CD14 and transcription factors PU. 1 and inhibits lipopolysaccharide activation ofNF-B, ERK 1/2 and p38MAPK in host monocytes. Cell. Microbiol. 6: 175-86
    • (2004) Cell. Microbiol. , vol.6 , pp. 175-186
    • Lin, M.1    Rikihisa, Y.2
  • 77
    • 33947101530 scopus 로고    scopus 로고
    • Degradation of p22phox and inhibition of superoxide generation by Ehrlichia chaffeensis in human monocytes
    • Lin M, Rikihisa Y. 2007. Degradation of p22phox and inhibition of superoxide generation by Ehrlichia chaffeensis in human monocytes. Cell. Microbiol. 9: 861-74
    • (2007) Cell. Microbiol. , vol.9 , pp. 861-874
    • Lin, M.1    Rikihisa, Y.2
  • 78
    • 0036150092 scopus 로고    scopus 로고
    • Rapid activation of protein tyrosine kinase and phospholipase C-2 and increase in cytosolic free calcium are required by Ehrlichia chaffeensis for internalization and growth in THP-1 cells
    • Lin M, Zhu MX, Rikihisa Y. 2002. Rapid activation of protein tyrosine kinase and phospholipase C-2 and increase in cytosolic free calcium are required by Ehrlichia chaffeensis for internalization and growth in THP-1 cells. Infect. Immun. 70: 889-98
    • (2002) Infect. Immun. , vol.70 , pp. 889-898
    • Lin, M.1    Zhu, M.X.2    Rikihisa, Y.3
  • 79
    • 84862804099 scopus 로고    scopus 로고
    • Ehrlichia type IV secretion effector ECH0825 is translocated to mitochondria and curbs ROS and apoptosis by upregulating hostMnSOD
    • Liu H, Bao W, Lin M, Niu H, Rikihisa Y. 2012. Ehrlichia type IV secretion effector ECH0825 is translocated to mitochondria and curbs ROS and apoptosis by upregulating hostMnSOD. Cell. Microbiol. 14: 1037-50
    • (2012) Cell. Microbiol. , vol.14 , pp. 1037-1050
    • Liu, H.1    Bao, W.2    Lin, M.3    Niu, H.4    Rikihisa, Y.5
  • 80
    • 78951491174 scopus 로고    scopus 로고
    • Obligate intracellular bacterium Ehrlichia inhibiting mitochondrial activity
    • Liu Y, Zhang Z, Jiang Y, Zhang L, Popov VL, et al. 2011. Obligate intracellular bacterium Ehrlichia inhibiting mitochondrial activity. Microbes Infect. 13: 232-38
    • (2011) Microbes Infect. , vol.13 , pp. 232-238
    • Liu, Y.1    Zhang, Z.2    Jiang, Y.3    Zhang, L.4    Popov, V.L.5
  • 81
    • 0030997908 scopus 로고    scopus 로고
    • Isolation of Ehrlichia chaffeensis from wild white-tailed deer (Odocoileus virginianus) confirms their role as natural reservoir hosts
    • Lockhart JM, Davidson WR, Stallknecht DE, Dawson JE, Howerth EW. 1997. Isolation of Ehrlichia chaffeensis from wild white-tailed deer (Odocoileus virginianus) confirms their role as natural reservoir hosts. J. Clin. Microbiol. 35: 1681-86
    • (1997) J. Clin. Microbiol. , vol.35 , pp. 1681-1686
    • Lockhart, J.M.1    Davidson, W.R.2    Stallknecht, D.E.3    Dawson, J.E.4    Howerth, E.W.5
  • 82
    • 0036130678 scopus 로고    scopus 로고
    • Antigenic variation of Ehrlichia chaffeensis resulting from differential expression of the 28-kilodalton protein gene family
    • Long SW, Zhang XF, Qi H, Standaert S, Walker DH, Yu XJ. 2002. Antigenic variation of Ehrlichia chaffeensis resulting from differential expression of the 28-kilodalton protein gene family. Infect. Immun. 70: 1824-31
    • (2002) Infect. Immun. , vol.70 , pp. 1824-1831
    • Long, S.W.1    Zhang, X.F.2    Qi, H.3    Standaert, S.4    Walker, D.H.5    Yu, X.J.6
  • 83
    • 80052427281 scopus 로고    scopus 로고
    • Ehrlichia chaffeensis TRP120 interacts with a diverse array of eukaryotic proteins involved in transcription, signaling, and cytoskeleton organization
    • Luo T, Kuriakose JA, Zhu B, Wakeel A, McBride JW. 2011. Ehrlichia chaffeensis TRP120 interacts with a diverse array of eukaryotic proteins involved in transcription, signaling, and cytoskeleton organization. Infect. Immun. 79: 4382-91
    • (2011) Infect. Immun. , vol.79 , pp. 4382-4391
    • Luo, T.1    Kuriakose, J.A.2    Zhu, B.3    Wakeel, A.4    McBride, J.W.5
  • 84
    • 84864813807 scopus 로고    scopus 로고
    • Ehrlichia chaffeensis TRP32 interacts with host cell targets that influence intracellular survival
    • Luo T, McBride JW. 2012. Ehrlichia chaffeensis TRP32 interacts with host cell targets that influence intracellular survival. Infect. Immun. 80: 2297-306
    • (2012) Infect. Immun. , vol.80 , pp. 2297-2306
    • Luo, T.1    McBride, J.W.2
  • 85
    • 67650410438 scopus 로고    scopus 로고
    • Major species-specific antibody epitopes of the Ehrlichia chaffeensis p120 and E. Canis p140 orthologs in surface-exposed tandem repeat regions
    • Luo T, Zhang X, McBride JW. 2009. Major species-specific antibody epitopes of the Ehrlichia chaffeensis p120 and E. Canis p140 orthologs in surface-exposed tandem repeat regions. Clin. Vaccine Immunol. 16: 982-90
    • (2009) Clin. Vaccine Immunol. , vol.16 , pp. 982-990
    • Luo, T.1    Zhang, X.2    McBride, J.W.3
  • 86
    • 42149191556 scopus 로고    scopus 로고
    • A variable-length PCR target protein of Ehrlichia chaffeensis containsmajor species-specific antibody epitopes in acidic serine-rich tandem repeats
    • Luo T, Zhang X, Wakeel A, Popov VL, McBride JW. 2008. A variable-length PCR target protein of Ehrlichia chaffeensis containsmajor species-specific antibody epitopes in acidic serine-rich tandem repeats. Infect. Immun. 76: 1572-80
    • (2008) Infect. Immun. , vol.76 , pp. 1572-1580
    • Luo, T.1    Zhang, X.2    Wakeel, A.3    Popov, V.L.4    McBride, J.W.5
  • 88
    • 20144389877 scopus 로고    scopus 로고
    • Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections
    • Mattner J, Debord KL, Ismail N, Goff RD, Cantu C 3rd, et al. 2005. Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections. Nature 434: 525-29
    • (2005) Nature , vol.434 , pp. 525-529
    • Mattner, J.1    Debord, K.L.2    Ismail, N.3    Goff, R.D.4    Cantu, C.5
  • 89
    • 0033985107 scopus 로고    scopus 로고
    • Glycosylation of homologous immunodominant proteins of Ehrlichia chaffeensis and Ehrlichia canis
    • McBride JW, Yu XJ, Walker DH. 2000. Glycosylation of homologous immunodominant proteins of Ehrlichia chaffeensis and Ehrlichia canis. Infect. Immun. 68: 13-18
    • (2000) Infect. Immun. , vol.68 , pp. 13-18
    • McBride, J.W.1    Yu, X.J.2    Walker, D.H.3
  • 90
    • 84862908249 scopus 로고    scopus 로고
    • Ehrlichia chaffeensis induces monocyte inflammatory responses through MyD88, ERK, and NF-B but not through TRIF, interleukin-1 receptor 1 (IL-1R1)/IL-18R1, or Toll-like receptors
    • Miura K, Matsuo J, RahmanMA, Kumagai Y, Li X, Rikihisa Y. 2011. Ehrlichia chaffeensis induces monocyte inflammatory responses through MyD88, ERK, and NF-B but not through TRIF, interleukin-1 receptor 1 (IL-1R1)/IL-18R1, or Toll-like receptors. Infect. Immun. 79: 4947-56
    • (2011) Infect. Immun. , vol.79 , pp. 4947-4956
    • Miura, K.1    Matsuo, J.2    Rahman, M.A.3    Kumagai, Y.4    Li, X.5    Rikihisa, Y.6
  • 91
    • 34447255930 scopus 로고    scopus 로고
    • Virulence potential of Ehrlichia chaffeensis strains of distinct genome sequences
    • MiuraK, RikihisaY. 2007. Virulence potential of Ehrlichia chaffeensis strains of distinct genome sequences. Infect. Immun. 75: 3604-13
    • (2007) Infect. Immun. , vol.75 , pp. 3604-3613
    • Miura, K.1    Rikihisa, Y.2
  • 92
    • 58449097407 scopus 로고    scopus 로고
    • Liver transcriptome profiles associated with strain-specific Ehrlichia chaffeensisinduced hepatitis in SCID mice
    • MiuraK, RikihisaY. 2009. Liver transcriptome profiles associated with strain-specific Ehrlichia chaffeensisinduced hepatitis in SCID mice. Infect. Immun. 77: 245-54
    • (2009) Infect. Immun. , vol.77 , pp. 245-254
    • Miura, K.1    Rikihisa, Y.2
  • 93
    • 84887265439 scopus 로고    scopus 로고
    • Ehrlichia chaffeensis uses its surface protein EtpE to bind GPI-anchored protein DNase X and trigger entry into mammalian cells
    • Mohan Kumar D, Yamaguchi M, Miura K, Lin M, Los M, et al. 2013. Ehrlichia chaffeensis uses its surface protein EtpE to bind GPI-anchored protein DNase X and trigger entry into mammalian cells. PLOS Pathog. 9: e1003666
    • (2013) PLOS Pathog. , vol.9 , pp. e1003666
    • Mohan Kumar, D.1    Yamaguchi, M.2    Miura, K.3    Lin, M.4    Los, M.5
  • 94
    • 0033009747 scopus 로고    scopus 로고
    • Human granulocytic ehrlichiosis agent and Ehrlichia chaffeensis reside in different cytoplasmic compartments in HL-60 cells
    • Mott J, Barnewall RE, Rikihisa Y. 1999. Human granulocytic ehrlichiosis agent and Ehrlichia chaffeensis reside in different cytoplasmic compartments in HL-60 cells. Infect. Immun. 67: 1368-78
    • (1999) Infect. Immun. , vol.67 , pp. 1368-1378
    • Mott, J.1    Barnewall, R.E.2    Rikihisa, Y.3
  • 95
    • 77649251212 scopus 로고    scopus 로고
    • Anaplasma phagocytophilum Ats-1 is imported into host cell mitochondria and interferes with apoptosis induction
    • Niu H, Kozjak-Pavlovic V, Rudel T, Rikihisa Y. 2010. Anaplasma phagocytophilum Ats-1 is imported into host cell mitochondria and interferes with apoptosis induction. PLOS Pathog. 6: e1000774
    • (2010) PLOS Pathog. , vol.6 , pp. e1000774
    • Niu, H.1    Kozjak-Pavlovic, V.2    Rudel, T.3    Rikihisa, Y.4
  • 96
    • 84877317415 scopus 로고    scopus 로고
    • Ats-1: A novel bacterial molecule that links autophagy to bacterial nutrition
    • Niu H, Rikihisa Y. 2013. Ats-1: A novel bacterial molecule that links autophagy to bacterial nutrition. Autophagy 9: 787-88
    • (2013) Autophagy , vol.9 , pp. 787-788
    • Niu, H.1    Rikihisa, Y.2
  • 97
    • 33644821065 scopus 로고    scopus 로고
    • Differential expression of VirB9 and VirB6 during the life cycle of Anaplasma phagocytophilum in human leucocytes is associated with differential binding and avoidance of lysosome pathway
    • Niu H, Rikihisa Y, Yamaguchi M, Ohashi N. 2006. Differential expression of VirB9 and VirB6 during the life cycle of Anaplasma phagocytophilum in human leucocytes is associated with differential binding and avoidance of lysosome pathway. Cell. Microbiol. 8: 523-34
    • (2006) Cell. Microbiol. , vol.8 , pp. 523-534
    • Niu, H.1    Rikihisa, Y.2    Yamaguchi, M.3    Ohashi, N.4
  • 98
    • 0035081047 scopus 로고    scopus 로고
    • Analysis of transcriptionally active gene clusters of major outer membrane protein multigene family in Ehrlichia canis and e
    • Ohashi N, Rikihisa Y, Unver A. 2001. Analysis of transcriptionally active gene clusters of major outer membrane protein multigene family in Ehrlichia canis and E. Chaffeensis. Infect. Immun. 69: 2083-91
    • (2001) Chaffeensis. Infect. Immun. , vol.69 , pp. 2083-2091
    • Ohashi, N.1    Rikihisa, Y.2    Unver, A.3
  • 99
    • 0031874241 scopus 로고    scopus 로고
    • Cloning and characterization of multigenes encoding the immunodominant 30-kilodalton major outer membrane proteins of Ehrlichia canis and application of the recombinant protein for serodiagnosis
    • Ohashi N, Unver A, Zhi N, Rikihisa Y. 1998. Cloning and characterization of multigenes encoding the immunodominant 30-kilodalton major outer membrane proteins of Ehrlichia canis and application of the recombinant protein for serodiagnosis. J. Clin. Microbiol. 36: 2671-80
    • (1998) J. Clin. Microbiol. , vol.36 , pp. 2671-2680
    • Ohashi, N.1    Unver, A.2    Zhi, N.3    Rikihisa, Y.4
  • 100
    • 0036126936 scopus 로고    scopus 로고
    • Characterization and transcriptional analysis of gene clusters for a type IVsecretion machinery in human granulocytic and monocytic ehrlichiosis agents
    • Ohashi N, Zhi N, Lin Q, Rikihisa Y. 2002. Characterization and transcriptional analysis of gene clusters for a type IVsecretion machinery in human granulocytic and monocytic ehrlichiosis agents. Infect. Immun. 70: 2128-38
    • (2002) Infect. Immun. , vol.70 , pp. 2128-2138
    • Ohashi, N.1    Zhi, N.2    Lin, Q.3    Rikihisa, Y.4
  • 101
    • 0031976047 scopus 로고    scopus 로고
    • Immunodominant major outer membrane proteins of Ehrlichia chaffeensis are encoded by a polymorphic multigene family
    • Ohashi N, Zhi N, Zhang Y, Rikihisa Y. 1998. Immunodominant major outer membrane proteins of Ehrlichia chaffeensis are encoded by a polymorphic multigene family. Infect. Immun. 66: 132-39
    • (1998) Infect. Immun. , vol.66 , pp. 132-139
    • Ohashi, N.1    Zhi, N.2    Zhang, Y.3    Rikihisa, Y.4
  • 102
    • 0034941188 scopus 로고    scopus 로고
    • Ehrlichial proliferation and acute hepatocellular necrosis in immunocompetent mice experimentally infected with the HF strain of Ehrlichia, closely related to Ehrlichia chaffeensis
    • Okada H, Tajima T, Kawahara M, Rikihisa Y. 2001. Ehrlichial proliferation and acute hepatocellular necrosis in immunocompetent mice experimentally infected with the HF strain of Ehrlichia, closely related to Ehrlichia chaffeensis. J. Comp. Pathol. 124: 165-71
    • (2001) J. Comp. Pathol. , vol.124 , pp. 165-171
    • Okada, H.1    Tajima, T.2    Kawahara, M.3    Rikihisa, Y.4
  • 104
    • 0037240533 scopus 로고    scopus 로고
    • Ehrlichia chaffeensis: A prototypical emerging pathogen
    • Paddock CD, Childs JE. 2003. Ehrlichia chaffeensis: A prototypical emerging pathogen. Clin. Microbiol. Rev. 16: 37-64
    • (2003) Clin. Microbiol. Rev. , vol.16 , pp. 37-64
    • Paddock, C.D.1    Childs, J.E.2
  • 105
    • 0030848759 scopus 로고    scopus 로고
    • Isolation and characterization of Ehrlichia chaffeensis strains from patients with fatal ehrlichiosis
    • Paddock CD, Sumner JW, Shore GM, Bartley DC, Elie RC, et al. 1997. Isolation and characterization of Ehrlichia chaffeensis strains from patients with fatal ehrlichiosis. J. Clin. Microbiol. 35: 2496-502
    • (1997) J. Clin. Microbiol. , vol.35 , pp. 2496-2502
    • Paddock, C.D.1    Sumner, J.W.2    Shore, G.M.3    Bartley, D.C.4    Elie, R.C.5
  • 106
    • 33845738723 scopus 로고    scopus 로고
    • Human infection with Ehrlichia canis accompanied by clinical signs in Venezuela
    • Perez M, Bodor M, Zhang C, Xiong Q, Rikihisa Y. 2006. Human infection with Ehrlichia canis accompanied by clinical signs in Venezuela. Ann. N. Y. Acad. Sci. 1078: 110-17
    • (2006) Ann. N. Y. Acad. Sci. , vol.1078 , pp. 110-117
    • Perez, M.1    Bodor, M.2    Zhang, C.3    Xiong, Q.4    Rikihisa, Y.5
  • 107
    • 0029740665 scopus 로고    scopus 로고
    • Ehrlichia canis-like agent isolated from a man in Venezuela: Antigenic and genetic characterization
    • PerezM, Rikihisa Y, Wen B. 1996. Ehrlichia canis-like agent isolated from a man in Venezuela: Antigenic and genetic characterization. J. Clin. Microbiol. 34: 2133-39
    • (1996) J. Clin. Microbiol. , vol.34 , pp. 2133-2139
    • Perez, M.1    Rikihisa, Y.2    Wen, B.3
  • 109
    • 0033823329 scopus 로고    scopus 로고
    • The 120 kDa outer membrane protein of Ehrlichia chaffeensis: Preferential expression on dense-core cells and gene expression in Escherichia coli associated with attachment and entry
    • Popov VL, Yu X, Walker DH. 2000. The 120 kDa outer membrane protein of Ehrlichia chaffeensis: Preferential expression on dense-core cells and gene expression in Escherichia coli associated with attachment and entry. Microb. Pathog. 28: 71-80
    • (2000) Microb. Pathog. , vol.28 , pp. 71-80
    • Popov, V.L.1    Yu, X.2    Walker, D.H.3
  • 111
    • 84861569476 scopus 로고    scopus 로고
    • Penicillin-binding protein of Ehrlichia chaffeensis: Cytokine induction through MyD88-dependent pathway
    • Rahman MA, Cheng Z, Matsuo J, Rikihisa Y. 2012. Penicillin-binding protein of Ehrlichia chaffeensis: cytokine induction through MyD88-dependent pathway. J. Infect. Dis. 206: 110-16
    • (2012) J. Infect. Dis. , vol.206 , pp. 110-116
    • Rahman, M.A.1    Cheng, Z.2    Matsuo, J.3    Rikihisa, Y.4
  • 112
    • 0025777206 scopus 로고
    • The tribe Ehrlichieae and ehrlichial diseases
    • Rikihisa Y. 1991. The tribe Ehrlichieae and ehrlichial diseases. Clin. Microbiol. Rev. 4: 286-308
    • (1991) Clin. Microbiol. Rev. , vol.4 , pp. 286-308
    • Rikihisa, Y.1
  • 113
    • 0037972836 scopus 로고    scopus 로고
    • Mechanisms to create a safe haven by members of the family Anaplasmataceae
    • Rikihisa Y. 2003. Mechanisms to create a safe haven by members of the family Anaplasmataceae. Ann. N. Y. Acad. Sci. 990: 548-55
    • (2003) Ann. N. Y. Acad. Sci. , vol.990 , pp. 548-555
    • Rikihisa, Y.1
  • 114
    • 75249092539 scopus 로고    scopus 로고
    • Anaplasma phagocytophilum and Ehrlichia chaffeensis type IV secretion and Ank proteins
    • Rikihisa Y, Lin M. 2010. Anaplasma phagocytophilum and Ehrlichia chaffeensis type IV secretion and Ank proteins. Curr. Opin. Microbiol. 13: 59-66
    • (2010) Curr. Opin. Microbiol. , vol.13 , pp. 59-66
    • Rikihisa, Y.1    Lin, M.2
  • 115
    • 0033998269 scopus 로고    scopus 로고
    • New Ehrlichia species closely related to Ehrlichia chaffeensis isolated from Ixodes ovatus ticks in Japan
    • Shibata S, Kawahara M, Rikihisa Y, Fujita H, Watanabe Y, et al. 2000. New Ehrlichia species closely related to Ehrlichia chaffeensis isolated from Ixodes ovatus ticks in Japan. J. Clin. Microbiol. 38: 1331-38
    • (2000) J. Clin. Microbiol. , vol.38 , pp. 1331-1338
    • Shibata, S.1    Kawahara, M.2    Rikihisa, Y.3    Fujita, H.4    Watanabe, Y.5
  • 116
    • 11044231152 scopus 로고    scopus 로고
    • Ehrlichia chaffeensis expresses macrophage-and tick cellspecific 28-kilodalton outer membrane proteins
    • Singu V, Liu H, Cheng C, Ganta RR. 2005. Ehrlichia chaffeensis expresses macrophage-and tick cellspecific 28-kilodalton outer membrane proteins. Infect. Immun. 73: 79-87
    • (2005) Infect. Immun. , vol.73 , pp. 79-87
    • Singu, V.1    Liu, H.2    Cheng, C.3    Ganta, R.R.4
  • 117
    • 0034030762 scopus 로고    scopus 로고
    • Primary isolation of Ehrlichia chaffeensis from patients with febrile illnesses: Clinical andmolecular characteristics
    • Standaert SM, Yu T, ScottMA, Childs JE, Paddock CD, et al. 2000. Primary isolation of Ehrlichia chaffeensis from patients with febrile illnesses: clinical andmolecular characteristics. J. Infect. Dis. 181: 1082-88
    • (2000) J. Infect. Dis. , vol.181 , pp. 1082-1088
    • Standaert, S.M.1    Yu, T.2    Scott, M.A.3    Childs, J.E.4    Paddock, C.D.5
  • 118
    • 77957264827 scopus 로고    scopus 로고
    • Natural killer cells promote tissue injury and systemic inflammatory responses during fatal Ehrlichia-induced toxic shock-like syndrome
    • Stevenson HL, Estes MD, Thirumalapura NR, Walker DH, Ismail N. 2010. Natural killer cells promote tissue injury and systemic inflammatory responses during fatal Ehrlichia-induced toxic shock-like syndrome. Am. J. Pathol. 177(2): 766-76
    • (2010) Am. J. Pathol. , vol.177 , Issue.2 , pp. 766-776
    • Stevenson, H.L.1    Estes, M.D.2    Thirumalapura, N.R.3    Walker, D.H.4    Ismail, N.5
  • 119
    • 44949106317 scopus 로고    scopus 로고
    • Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species
    • Sumimoto H. 2008. Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species. FEBS J. 275: 3249-77
    • (2008) FEBS J. , vol.275 , pp. 3249-3277
    • Sumimoto, H.1
  • 120
    • 0032895270 scopus 로고    scopus 로고
    • Molecular cloning and characterization of the Ehrlichia chaffeensis variable-length PCR target: An antigen-expressing gene that exhibits interstrain variation
    • Sumner JW, Childs JE, Paddock CD. 1999. Molecular cloning and characterization of the Ehrlichia chaffeensis variable-length PCR target: An antigen-expressing gene that exhibits interstrain variation. J. Clin. Microbiol. 37: 1447-53
    • (1999) J. Clin. Microbiol. , vol.37 , pp. 1447-1453
    • Sumner, J.W.1    Childs, J.E.2    Paddock, C.D.3
  • 121
    • 78650973427 scopus 로고    scopus 로고
    • Exit mechanisms of the intracellular bacterium Ehrlichia
    • Thomas S, Popov VL, Walker DH. 2010. Exit mechanisms of the intracellular bacterium Ehrlichia. PLOS ONE 5: e15775
    • (2010) PLOS ONE , vol.5 , pp. e15775
    • Thomas, S.1    Popov, V.L.2    Walker, D.H.3
  • 123
    • 0034764937 scopus 로고    scopus 로고
    • Western blot analysis of sera reactive to human monocytic ehrlichiosis and human granulocytic ehrlichiosis agents
    • Unver A, Felek S, Paddock CD, Zhi N, Horowitz HW, et al. 2001. Western blot analysis of sera reactive to human monocytic ehrlichiosis and human granulocytic ehrlichiosis agents. J. Clin. Microbiol. 39: 3982-86
    • (2001) J. Clin. Microbiol. , vol.39 , pp. 3982-3986
    • Unver, A.1    Felek, S.2    Paddock, C.D.3    Zhi, N.4    Horowitz, H.W.5
  • 124
    • 33845705115 scopus 로고    scopus 로고
    • Cytokine gene expression by peripheral blood leukocytes in dogs experimentally infected with a new virulent strain of Ehrlichia canis
    • Unver A, Huang H, Rikihisa Y. 2006. Cytokine gene expression by peripheral blood leukocytes in dogs experimentally infected with a new virulent strain of Ehrlichia canis. Ann. N. Y. Acad. Sci. 1078: 482-86
    • (2006) Ann. N. Y. Acad. Sci. , vol.1078 , pp. 482-486
    • Unver, A.1    Huang, H.2    Rikihisa, Y.3
  • 125
    • 0034832883 scopus 로고    scopus 로고
    • Transcriptional analysis of p30 major outer membrane multigene family of Ehrlichia canis in dogs, ticks, and cell culture at different temperatures
    • Unver A, Ohashi N, Tajima T, Stich RW, Grover D, Rikihisa Y. 2001. Transcriptional analysis of p30 major outer membrane multigene family of Ehrlichia canis in dogs, ticks, and cell culture at different temperatures. Infect. Immun. 69: 6172-78
    • (2001) Infect. Immun. , vol.69 , pp. 6172-6178
    • Unver, A.1    Ohashi, N.2    Tajima, T.3    Stich, R.W.4    Grover, D.5    Rikihisa, Y.6
  • 126
    • 0032728572 scopus 로고    scopus 로고
    • Western and dot blotting analyses of Ehrlichia chaffeensis indirect fluorescent-antibody assay-positive and-negative human sera by using native and recombinant E. Chaffeensis and E. Canis antigens
    • Unver A, Rikihisa Y, Ohashi N, Cullman LC, Buller R, Storch GA. 1999. Western and dot blotting analyses of Ehrlichia chaffeensis indirect fluorescent-antibody assay-positive and-negative human sera by using native and recombinant E. Chaffeensis and E. Canis antigens. J. Clin. Microbiol. 37: 3888-95
    • (1999) J. Clin. Microbiol. , vol.37 , pp. 3888-3895
    • Unver, A.1    Rikihisa, Y.2    Ohashi, N.3    Cullman, L.C.4    Buller, R.5    Storch, G.A.6
  • 127
    • 0036070770 scopus 로고    scopus 로고
    • The omp-1 major outer membrane multigene family of Ehrlichia chaffeensis is differentially expressed in canine and tick hosts
    • Unver A, Rikihisa Y, Stich RW, Ohashi N, Felek S. 2002. The omp-1 major outer membrane multigene family of Ehrlichia chaffeensis is differentially expressed in canine and tick hosts. Infect. Immun. 70: 4701-704
    • (2002) Infect. Immun. , vol.70 , pp. 4701-4704
    • Unver, A.1    Rikihisa, Y.2    Stich, R.W.3    Ohashi, N.4    Felek, S.5
  • 128
    • 1942456753 scopus 로고    scopus 로고
    • Characterization of a major outer membrane protein multigene family in Ehrlichia ruminantium
    • van Heerden H, Collins NE, Brayton KA, Rademeyer C, Allsopp BA. 2004. Characterization of a major outer membrane protein multigene family in Ehrlichia ruminantium. Gene 330: 159-68
    • (2004) Gene , vol.330 , pp. 159-168
    • Van Heerden, H.1    Collins, N.E.2    Brayton, K.A.3    Rademeyer, C.4    Allsopp, B.A.5
  • 130
    • 14144255290 scopus 로고    scopus 로고
    • Positive charge is an important feature of the C-terminal transport signal of the VirB/D4-translocated proteins of Agrobacterium
    • Vergunst AC, van Lier MCM, den Dulk-Ras A, Grosse Stuve TA, Ouwehand A, Hooykaas PJJ. 2005. Positive charge is an important feature of the C-terminal transport signal of the VirB/D4-translocated proteins of Agrobacterium. PNAS 102: 832-37
    • (2005) PNAS , vol.102 , pp. 832-837
    • Vergunst, A.C.1    Van Lier, M.C.M.2    Den Dulk-Ras, A.3    Grosse Stuve, T.A.4    Ouwehand, A.5    Hooykaas, P.J.J.6
  • 131
    • 77954438808 scopus 로고    scopus 로고
    • Detection of "Candidatus Neoehrlichia mikurensis" in two patients with severe febrile illnesses: Evidence for a European sequence variant
    • von Loewenich FD, GeissdorferW, Disque C, Matten J, Schett G, et al. 2010. Detection of "Candidatus Neoehrlichia mikurensis" in two patients with severe febrile illnesses: evidence for a European sequence variant. J. Clin. Microbiol. 48: 2630-35
    • (2010) J. Clin. Microbiol. , vol.48 , pp. 2630-2635
    • Von Loewenich, F.D.1    Geissdorfer, W.2    Disque, C.3    Matten, J.4    Schett, G.5
  • 132
    • 0037428132 scopus 로고    scopus 로고
    • Role of a highly conserved bacterial protein in outer membrane protein assembly
    • Voulhoux R, Bos MP, Geurtsen J, Mols M, Tommassen J. 2003. Role of a highly conserved bacterial protein in outer membrane protein assembly. Science 299: 262-65
    • (2003) Science , vol.299 , pp. 262-265
    • Voulhoux, R.1    Bos, M.P.2    Geurtsen, J.3    Mols, M.4    Tommassen, J.5
  • 133
    • 84864798310 scopus 로고    scopus 로고
    • Ehrlichia chaffeensis tandem repeat proteins and Ank200 are type 1 secretion system substrates related to the repeats-in-toxin exoprotein family
    • Wakeel A, denDulk-Ras A, Hooykaas PJ, McBride JW. 2011. Ehrlichia chaffeensis tandem repeat proteins and Ank200 are type 1 secretion system substrates related to the repeats-in-toxin exoprotein family. Front. Cell. Infect. Microbiol. 1: 22
    • (2011) Front. Cell. Infect. Microbiol. , vol.1 , pp. 22
    • Wakeel, A.1    DenDulk-Ras, A.2    Hooykaas, P.J.3    McBride, J.W.4
  • 134
    • 65449163095 scopus 로고    scopus 로고
    • An Ehrlichia chaffeensis tandem repeat protein interacts with multiple host targets involved in cell signaling, transcriptional regulation, and vesicle trafficking
    • Wakeel A, Kuriakose JA, McBride JW. 2009. An Ehrlichia chaffeensis tandem repeat protein interacts with multiple host targets involved in cell signaling, transcriptional regulation, and vesicle trafficking. Infect. Immun. 77: 1734-45
    • (2009) Infect. Immun. , vol.77 , pp. 1734-1745
    • Wakeel, A.1    Kuriakose, J.A.2    McBride, J.W.3
  • 135
    • 77950860206 scopus 로고    scopus 로고
    • New insights into molecular Ehrlichia chaffeensis-host interactions
    • Wakeel A, Zhu B, Yu XJ, McBride JW. 2010. New insights into molecular Ehrlichia chaffeensis-host interactions. Microbes Infect. 12: 337-45
    • (2010) Microbes Infect. , vol.12 , pp. 337-345
    • Wakeel, A.1    Zhu, B.2    Yu, X.J.3    McBride, J.W.4
  • 136
    • 0029679613 scopus 로고    scopus 로고
    • Emergence of the ehrlichioses as human health problems
    • Walker DH, Dumler JS. 1996. Emergence of the ehrlichioses as human health problems. Emerg. Infect. Dis. 2: 18-29
    • (1996) Emerg. Infect. Dis. , vol.2 , pp. 18-29
    • Walker, D.H.1    Dumler, J.S.2
  • 137
    • 77951778374 scopus 로고    scopus 로고
    • First case of human "Candidatus Neoehrlichia mikurensis" infection in a febrile patient with chronic lymphocytic leukemia
    • Welinder-Olsson C, Kjellin E, Vaht K, Jacobsson S, Wenneras C. 2010. First case of human "Candidatus Neoehrlichia mikurensis" infection in a febrile patient with chronic lymphocytic leukemia. J. Clin. Microbiol. 48: 1956-59
    • (2010) J. Clin. Microbiol. , vol.48 , pp. 1956-1959
    • Welinder-Olsson, C.1    Kjellin, E.2    Vaht, K.3    Jacobsson, S.4    Wenneras, C.5
  • 138
    • 0023798540 scopus 로고
    • Lack of lysosomal fusion with phagosomes containing Ehrlichia risticii in P388D1 cells: Abrogation of inhibition with oxytetracycline
    • Wells MY, Rikihisa Y. 1988. Lack of lysosomal fusion with phagosomes containing Ehrlichia risticii in P388D1 cells: Abrogation of inhibition with oxytetracycline. Infect. Immun. 56: 3209-15
    • (1988) Infect. Immun. , vol.56 , pp. 3209-3215
    • Wells, M.Y.1    Rikihisa, Y.2
  • 139
    • 0028921418 scopus 로고
    • Ehrlichia muris sp. Nov. , identified on the basis of 16S rRNA base sequences and serological, morphological, and biological characteristics
    • Wen B, Rikihisa Y, Mott J, Fuerst PA, Kawahara M, Suto C. 1995. Ehrlichia muris sp. Nov. , identified on the basis of 16S rRNA base sequences and serological, morphological, and biological characteristics. Int. J. Syst. Bacteriol. 45: 250-54
    • (1995) Int. J. Syst. Bacteriol. , vol.45 , pp. 250-254
    • Wen, B.1    Rikihisa, Y.2    Mott, J.3    Fuerst, P.A.4    Kawahara, M.5    Suto, C.6
  • 140
    • 0031850056 scopus 로고    scopus 로고
    • Infection of the laboratory mouse with the intracellular pathogen Ehrlichia chaffeensis
    • Winslow GM, Yager E, Shilo K, Collins DN, Chu FK. 1998. Infection of the laboratory mouse with the intracellular pathogen Ehrlichia chaffeensis. Infect. Immun. 66: 3892-99
    • (1998) Infect. Immun. , vol.66 , pp. 3892-3899
    • Winslow, G.M.1    Yager, E.2    Shilo, K.3    Collins, D.N.4    Chu, F.K.5
  • 141
    • 0034060810 scopus 로고    scopus 로고
    • Antibody-mediated elimination of the obligate intracellular bacterial pathogen Ehrlichia chaffeensis during active infection
    • Winslow GM, Yager E, Shilo K, Volk E, Reilly A, Chu FK. 2000. Antibody-mediated elimination of the obligate intracellular bacterial pathogen Ehrlichia chaffeensis during active infection. Infect. Immun. 68: 2187-95
    • (2000) Infect. Immun. , vol.68 , pp. 2187-2195
    • Winslow, G.M.1    Yager, E.2    Shilo, K.3    Volk, E.4    Reilly, A.5    Chu, F.K.6
  • 142
    • 42549101393 scopus 로고    scopus 로고
    • Ehrlichia ewingii infection delays spontaneous neutrophil apoptosis through stabilization of mitochondria
    • Xiong Q, Bao W, Ge Y, Rikihisa Y. 2008. Ehrlichia ewingii infection delays spontaneous neutrophil apoptosis through stabilization of mitochondria. J. Infect. Dis. 197: 1110-18
    • (2008) J. Infect. Dis. , vol.197 , pp. 1110-1118
    • Xiong, Q.1    Bao, W.2    Ge, Y.3    Rikihisa, Y.4
  • 143
    • 28444494729 scopus 로고    scopus 로고
    • Essential role for humoral immunity during Ehrlichia infection in immunocompetent mice
    • Yager E, Bitsaktsis C, Nandi B, McBride JW, Winslow G. 2005. Essential role for humoral immunity during Ehrlichia infection in immunocompetent mice. Infect. Immun. 73: 8009-16
    • (2005) Infect. Immun. , vol.73 , pp. 8009-8016
    • Yager, E.1    Bitsaktsis, C.2    Nandi, B.3    McBride, J.W.4    Winslow, G.5
  • 144
    • 0029858809 scopus 로고    scopus 로고
    • The recombinant 120-kilodalton protein of Ehrlichia chaffeensis, a potential diagnostic tool
    • Yu XJ, Crocquet-Valdes P, Cullman LC, Walker DH. 1996. The recombinant 120-kilodalton protein of Ehrlichia chaffeensis, a potential diagnostic tool. J. Clin. Microbiol. 34: 2853-55
    • (1996) J. Clin. Microbiol. , vol.34 , pp. 2853-2855
    • Yu, X.J.1    Crocquet-Valdes, P.2    Cullman, L.C.3    Walker, D.H.4
  • 145
    • 0344507504 scopus 로고    scopus 로고
    • Genetic diversity of the 28-kilodalton outer membrane protein gene in human isolates of Ehrlichia chaffeensis
    • Yu XJ, McBride JW, Walker DH. 1999. Genetic diversity of the 28-kilodalton outer membrane protein gene in human isolates of Ehrlichia chaffeensis. J. Clin. Microbiol. 37: 1137-43
    • (1999) J. Clin. Microbiol. , vol.37 , pp. 1137-1143
    • Yu, X.J.1    McBride, J.W.2    Walker, D.H.3
  • 146
    • 42049107798 scopus 로고    scopus 로고
    • Identification of 19 polymorphic major outer membrane protein genes and their immunogenic peptides in Ehrlichia ewingii for use in a serodiagnostic assay
    • ZhangC, Xiong Q, KikuchiT, Rikihisa Y. 2008. Identification of 19 polymorphic major outer membrane protein genes and their immunogenic peptides in Ehrlichia ewingii for use in a serodiagnostic assay. Clin. Vaccine Immunol. 15: 402-11
    • (2008) Clin. Vaccine Immunol. , vol.15 , pp. 402-411
    • Zhang, C.1    Xiong, Q.2    Kikuchi, T.3    Rikihisa, Y.4
  • 147
    • 3342964429 scopus 로고    scopus 로고
    • Expression of members of the 28-kilodalton major outer membrane protein family of Ehrlichia chaffeensis during persistent infection
    • Zhang JZ, Guo H, Winslow GM, Yu XJ. 2004. Expression of members of the 28-kilodalton major outer membrane protein family of Ehrlichia chaffeensis during persistent infection. Infect. Immun. 72: 4336-43
    • (2004) Infect. Immun. , vol.72 , pp. 4336-4343
    • Zhang, J.Z.1    Guo, H.2    Winslow, G.M.3    Yu, X.J.4
  • 148
    • 33846934966 scopus 로고    scopus 로고
    • The developmental cycle of Ehrlichia chaffeensis in vertebrate cells
    • Zhang JZ, Popov VL, Gao S, Walker DH, Yu XJ. 2007. The developmental cycle of Ehrlichia chaffeensis in vertebrate cells. Cell. Microbiol. 9: 610-18
    • (2007) Cell. Microbiol. , vol.9 , pp. 610-618
    • Zhang, J.Z.1    Popov, V.L.2    Gao, S.3    Walker, D.H.4    Yu, X.J.5
  • 149
    • 80052480067 scopus 로고    scopus 로고
    • Ehrlichia chaffeensis TRP120 binds a G+C-rich motif in host cell DNA and exhibits eukaryotic transcriptional activator function
    • Zhu B, Kuriakose JA, Luo T, Ballesteros E, Gupta S, et al. 2011. Ehrlichia chaffeensis TRP120 binds a G+C-rich motif in host cell DNA and exhibits eukaryotic transcriptional activator function. Infect. Immun. 79: 4370-81
    • (2011) Infect. Immun. , vol.79 , pp. 4370-4381
    • Zhu, B.1    Kuriakose, J.A.2    Luo, T.3    Ballesteros, E.4    Gupta, S.5
  • 150
    • 70349417835 scopus 로고    scopus 로고
    • Nuclear translocated Ehrlichia chaffeensis ankyrin protein interacts with a specific adenine-rich motif of host promoter and intronic Alu elements
    • Zhu B, Nethery KA, Kuriakose JA, Wakeel A, Zhang X, McBride JW. 2009. Nuclear translocated Ehrlichia chaffeensis ankyrin protein interacts with a specific adenine-rich motif of host promoter and intronic Alu elements. Infect. Immun. 77: 4243-55
    • (2009) Infect. Immun. , vol.77 , pp. 4243-4255
    • Zhu, B.1    Nethery, K.A.2    Kuriakose, J.A.3    Wakeel, A.4    Zhang, X.5    McBride, J.W.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.