Ehrlichia chaffeensis TRP32 interacts with host cell targets that influence intracellular survival

Infection and Immunity

Volumn 80, Issue 7, 2012, Pages 2297-2306

  Luo, Tian ^a   McBride, Jere W ^a,b  

^a University of Texas Medical Branch School of Medicine   (United States)

^b UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD14 ANTIGEN; CD63 ANTIGEN; DELETED IN AZOOSPERMIA ASSOCIATED PROTEIN 2; FERRITIN LIGHT POLYPEPTIDE; IRON; PROTEASOME SUBUNIT BETA TYPE 1; PROTEIN; RING FINGER AND CCCH TYPE DOMAIN 1; RNA; TANDEM REPEAT PROTEIN 32; TRANSLATION ELONGATION FACTOR 1 ALPHA 1; TUMOR PROTEIN P53 INDUCIBLE PROTEIN 11; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL MIGRATION; CELL SURVIVAL; CONTROLLED STUDY; CYTOPLASM; EHRLICHIA CHAFFEENSIS; FEMALE; HOST CELL; HUMAN; HUMAN CELL; HYBRID; IMMUNOPRECIPITATION; INTRACELLULAR SIGNALING; IRON METABOLISM; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; RNA INTERFERENCE;

BACTERIAL PROTEINS; CELL LINE; CYTOSOL; EHRLICHIA CHAFFEENSIS; HOST-PATHOGEN INTERACTIONS; HUMANS; IMMUNOPRECIPITATION; MICROBIAL VIABILITY; MICROSCOPY, CONFOCAL; TWO-HYBRID SYSTEM TECHNIQUES; VIRULENCE FACTORS;

EID: 84864813807     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.00154-12     Document Type: Article

References (47)

1. Arroyo-Espliguero R, Avanzas P, Jeffery S, Kaski JC. 2004. CD14 and Toll-like receptor 4: a link between infection and acute coronary events? Heart 90: 983-988.
2. Barnewall RE, Rikihisa Y. 1994. Abrogation of gamma interferoninduced inhibition of Ehrlichia chaffeensis infection in human monocytes with iron-transferrin. Infect. Immun. 62: 4804-4810.
3. Barnewall RE, Rikihisa Y, Lee EH. 1997. Ehrlichia chaffeensis inclusions are early endosomes which selectively accumulate transferrin receptor. Infect. Immun. 65: 1455-1461.
4. Berditchevski F. 2001. Complexes of tetraspanins with integrins: more than meets the eye. J. Cell Sci. 114: 4143-4151.
5. Botos E, et al. 2008. Caveolin-1 is transported to multi-vesicular bodies after albumin-induced endocytosis of caveolae in HepG2 cells. J. Cell Mol. Med. 12: 1632-1639.
6. Carlyon JA, Ryan D, Archer K, Fikrig E. 2005. Effects of Anaplasma phagocytophilum on host cell ferritin mRNA and protein levels. Infect. Immun. 73: 7629-7636.
7. Chen SM, Cullman LC, Walker DH. 1997. Western immunoblotting analysis of the antibody responses of patients with human monocytotropic ehrlichiosis to different strains of Ehrlichia chaffeensis and Ehrlichia canis. Clin. Diagn. Lab. Immunol. 4: 731-735.
8. Clontech. 2008. Yeast protocols handbook. Protocol Pt3024-1, version PR742227. Clontech Laboratories Inc., Palo Alto, CA.
9. Condeelis J. 1995. Elongation factor 1 alpha, translation and the cytoskeleton. Trends Biochem. Sci. 20: 169-170.
10. Doyle CK, et al. 2005. Detection of medically important Ehrlichia by quantitative multicolor TaqMan real-time polymerase chain reaction of the dsb gene. J. Mol. Diagn. 7: 504-510.
11. Doyle CK, Nethery KA, Popov VL, McBride JW. 2006. Differentially expressed and secreted major immunoreactive protein orthologs of Ehrlichia canis and E. chaffeensis elicit early antibody responses to epitopes on glycosylated tandem repeats. Infect. Immun. 74: 711-720.
12. Doyle CK, Zhang X, Popov VL, McBride JW. 2005. An immunoreactive 38-kilodalton protein of Ehrlichia canis shares structural homology and iron-binding capacity with the ferric ion-binding protein family. Infect. Immun. 73: 62-69.
13. Dunning Hotopp JC, et al. 2006. Comparative genomics of emerging human ehrlichiosis agents. PLoS Genet. 2: e21. doi: 10.1371/journal.pgen.0020021.
14. Ejiri S. 2002. Moonlighting functions of polypeptide elongation factor 1: from actin bundling to zinc finger protein R1-associated nuclear localization. Biosci. Biotechnol. Biochem. 66: 1-21.
15. Hamilton MH, Tcherepanova I, Huibregtse JM, McDonnell DP. 2001. Nuclear import/export of hRPF1/Nedd4 regulates the ubiquitindependent degradation of its nuclear substrates. J. Biol. Chem. 276: 26324-26331.
16. Kim JE, et al. 2008. Proline-rich transcript in brain protein induces stress granule formation. Mol. Cell. Biol. 28: 803-813.
17. Kruger E, Kloetzel PM, Enenkel C. 2001. 20S proteasome biogenesis. Biochimie 83: 289-293.
18. Kuriakose JA, Zhang X, Luo T, McBride JW. 29 May 2012. Molecular basis of antibody mediated immunity against Ehrlichia chaffeensis involves species-specific linear epitopes in tandem repeat proteins. Microbes Infect. http://dx.doi.org/10.1016/j.micinf.2012.05.012.
19. Latysheva N, et al. 2006. Syntenin-1 is a new component of tetraspaninenriched microdomains: mechanisms and consequences of the interaction of syntenin-1 with CD63. Mol. Cell. Biol. 26: 7707-7718.
20. Lin AE, Mak TW. 2007. The role of E3 ligases in autoimmunity and the regulation of autoreactive T cells. Curr. Opin. Immunol. 19: 665-673.
21. Lin M, Rikihisa Y. 2004. Ehrlichia chaffeensis downregulates surface Toll-like receptors 2/4, CD14 and transcription factors PU. 1 and inhibits lipopolysaccharide activation of NF-kappa B, ERK 1/2 and p38 MAPK in host monocytes. Cell Microbiol. 6: 175-186.
22. Liu CH, Goldberg AL, Qiu XB. 2007. New insights into the role of the ubiquitin-proteasome pathway in the regulation of apoptosis. Chang Gung Med. J. 30: 469-479.
23. Lukas J, et al. 2009. Dazap2 modulates transcription driven by the Wnt effector TCF-4. Nucleic Acids Res. 37: 3007-3020.
24. Luo T, Kuriakose JA, Zhu B, Wakeel A, McBride JW. 2011. Ehrlichia chaffeensis TRP120 interacts with a diverse array of eukaryotic proteins involved in transcription, signaling, and cytoskeleton organization. Infect. Immun. 79: 4382-4391.
25. Luo T, Zhang X, McBride JW. 2009. Major species-specific antibody epitopes of the Ehrlichia chaffeensis p120 and E. canis p140 orthologs in surface-exposed tandem repeat regions. Clin. Vaccine Immunol. 16: 982-990.
26. Luo T, Zhang X, Nicholson WL, Zhu B, McBride JW. 2010. Molecular characterization of antibody epitopes of Ehrlichia chaffeensis ankyrin protein 200 and tandem repeat protein 47 and evaluation of synthetic immunodeterminants for serodiagnosis of human monocytotropic ehrlichiosis. Clin. Vaccine Immunol. 17: 87-97.
27. Luo T, Zhang X, Wakeel A, Popov VL, McBride JW. 2008. A variablelength PCR target protein of Ehrlichia chaffeensis contains major speciesspecific antibody epitopes in acidic serine-rich tandem repeats. Infect. Immun. 76: 1572-1580.
28. McBride JW, et al. 2003. Kinetics of antibody response to Ehrlichia canis immunoreactive proteins. Infect. Immun. 71: 2516-2524.
29. McBride JW, et al. 2007. Identification of a glycosylated Ehrlichia canis 19-kilodalton major immunoreactive protein with a species-specific serine-rich glycopeptide epitope. Infect. Immun. 75: 74-82.
30. McBride JW, Walker DH. 2011. Molecular and cellular pathobiology of Ehrlichia infection: targets for new therapeutics and immunomodulation strategies. Expert. Rev. Mol. Med. 13: e3. doi: 10.1017/ S1462399410001730.
31. McBride JW, Zhang X, Wakeel A, Kuriakose JA. 2011. Tyrosinephosphorylated Ehrlichia chaffeensis and Ehrlichia canis tandem repeat orthologs contain a major continuous cross-reactive antibody epitope in lysine-rich repeats. Infect. Immun. 79: 3178-3187.
32. Paddock CD, Childs JE. 2003. Ehrlichia chaffeensis: a prototypical emerging pathogen. Clin. Microbiol. Rev. 16: 37-64.
33. Pols MS, Klumperman J. 2009. Trafficking and function of the tetraspanin CD63. Exp. Cell Res. 315: 1584-1592.
34. Popov VL, Yu X, Walker DH. 2000. The 120 kDa outer membrane protein of Ehrlichia chaffeensis: preferential expression on dense-core cells and gene expression in Escherichia coli associated with attachment and entry. Microb. Pathog. 28: 71-80.
35. Rikihisa Y. 2010. Molecular events involved in cellular invasion by Ehrlichia chaffeensis and Anaplasma phagocytophilum. Vet. Parasitol. 167: 155-166.
36. Shang F, Taylor A. 2011. Ubiquitin-proteasome pathway and cellular responses to oxidative stress. Free Radic. Biol. Med. 51: 5-16.
37. Tsui S, et al. 2000. Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1. Genomics 65: 266-273.
38. Vidal K, Donnet-Hughes A. 2008. CD14: a soluble pattern recognition receptor in milk. Adv. Exp. Med. Biol. 606: 195-216.
39. Vinuesa CG, et al. 2005. A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity. Nature 435: 452-458.
40. Wakeel A, den Dulk-Ras A, Hooykaas PJJ, McBride JW. 30 December 2011. Ehrlichia chaffeensis tandem repeat proteins and Ank200 are type 1 secretion system substrates related to the repeats-in-toxin exoprotein family. Front. Cell. Infect. Microbiol. 1: 22. doi: 10.3389/ fcimb.2011.00022.
41. Wakeel A, Kuriakose JA, McBride JW. 2009. An Ehrlichia chaffeensis tandem repeat protein interacts with multiple host targets involved in cell signaling, transcriptional regulation, and vesicle trafficking. Infect. Immun. 77: 1734-1745.
42. Whist SK, Storset AK, Johansen GM, Larsen HJ. 2003. Modulation of leukocyte populations and immune responses in sheep experimentally infected with Anaplasma (formerly Ehrlichia) phagocytophilum. Vet. Immunol. Immunopathol. 94: 163-175.
43. Winkel A, et al. 2008. Wnt-ligand-dependent interaction of TAK1 (TGFbeta-activated kinase-1) with the receptor tyrosine kinase Ror2 modulates canonical Wnt-signalling. Cell. Signal. 20: 2134-2144.
44. Yoshiie K, Kim HY, Mott J, Rikihisa Y. 2000. Intracellular infection by the human granulocytic ehrlichiosis agent inhibits human neutrophil apoptosis. Infect. Immun. 68: 1125-1133.
45. Zhang JZ, Sinha M, Luxon BA, Yu XJ. 2004. Survival strategy of obligately intracellular Ehrlichia chaffeensis: novel modulation of immune response and host cell cycles. Infect. Immun. 72: 498-507.
46. Zhu B, et al. 2011. Ehrlichia chaffeensis TRP120 binds a G+C-rich motif in host cell DNA and exhibits eukaryotic transcriptional activator function. Infect. Immun. 79: 4370-4381.
47. Zhu B, et al. 2009. Nuclear translocated Ehrlichia chaffeensis ankyrin protein interacts with a specific adenine-rich motif of host promoter and intronic Alu elements. Infect. Immun. 77: 4243-4255.