Exit mechanisms of the intracellular bacterium ehrlichia

PLoS ONE

Volumn 5, Issue 12, 2010, Pages

  Thomas, Sunil ^a   Popov, Vsevolod L ^a   Walker, David H ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; CYTOCHALASIN D; CHAPERONIN;

ACTIN POLYMERIZATION; ARTICLE; BACTERIAL CELL; BACTERIAL KINETICS; BACTERIAL TRANSMISSION; CONTROLLED STUDY; EHRLICHIA; EHRLICHIA CHAFFEENSIS; EHRLICHIA MURIS; EHRLICHIOSIS; FILOPODIUM; FLUORESCENCE MICROSCOPY; HOST CELL; HOST PATHOGEN INTERACTION; MACROPHAGE FUNCTION; MOUSE; NONHUMAN; PROTEIN SYNTHESIS INHIBITION; SCANNING ELECTRON MICROSCOPY; TRANSMISSION ELECTRON MICROSCOPY; ANIMAL; C57BL MOUSE; HUMAN; IMMUNOLOGY; MACROPHAGE; METABOLISM; METHODOLOGY; MICROBIOLOGY; PHAGOCYTE; PHYSIOLOGY; PROTEIN PROCESSING; PSEUDOPODIUM;

BACTERIA (MICROORGANISMS); EHRLICHIA; EHRLICHIA CHAFFEENSIS; EHRLICHIA MURIS; IXODES OVATUS;

ACTINS; ANIMALS; CHAPERONIN 60; CYTOCHALASIN D; EHRLICHIA; EHRLICHIOSIS; HUMANS; MACROPHAGES; MICE; MICE, INBRED C57BL; MICROSCOPY, ELECTRON, SCANNING; MICROSCOPY, FLUORESCENCE; PHAGOCYTES; PROTEIN PROCESSING, POST-TRANSLATIONAL; PSEUDOPODIA;

EID: 78650973427     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0015775     Document Type: Article

References (23)

1. Paddock CD, Childs JE (2003) Ehrlichia chaffeensis: a prototypical emerging pathogen. Clin Microbiol Rev 16: 37-64.
2. Popov VL, Han VC, Chen SM, Dumler JS, Feng HM, et al. (1998) Ultrastructural differentiation of the genogroups in the genus Ehrlichia. J Med Microbiol 47: 235-251.
3. Maeda K, Markowitz N, Hawley RC, Ristic M, Cox D, et al. (1987) Human infection with Ehrlichia canis, a leukocytic rickettsia. N Engl J Med 316: 853-856.
4. Hagedorn M, Rohde KH, Russell DG, Soldati T (2009) Infection by tubercular mycobacteria is spread by nonlytic ejection from their amoeba hosts. Science 323: 1729-1733.
5. Li JS, Winslow GM (2003) Survival, replication, and antibody susceptibility of Ehrlichia chaffeensis outside of host cells. Infect Immun 71: 4229-4237.
6. Maender JL, Tyring SK (2004) Treatment and prevention of rickettsial and ehrlichial infections. Dermatol Ther 17: 499-504.
7. Rikihisa Y (2010a) Molecular events involved in cellular invasion by Ehrlichia chaffeensis and Anaplasma phagocytophilum. Vet Parasitol 167: 155-166.
8. Rikihisa Y (2010b) Anaplasma phagocytophilum and Ehrlichia chaffeensis: subversive manipulators of host cells. Nat Rev Microbiol 8: 328-339.
9. Thomas S, Thirumalapura N, Crossley EC, Ismail N, Walker DH (2009) Antigenic protein modifications in Ehrlichia. Parasite lmmunol 31: 296- 303.
10. Hartwig JH, Davies WA, Stossel TP (1977) Evidence for contractile protein translocation in macrophage spreading, phagocytosis, and phagolysosome formation. J Cell Biol 75: 956-967.
11. Rosania GR, Swanson JA (1996) Microtubules can modulate pseudopod activity from a distance inside macrophages. Cell Motil Cytoskeleton 34: 230-245.
12. Srivastava KD, Magazine HI (1998) Thrombin receptor activation inhibits monocyte spreading by induction of ET(B) receptor-coupled nitric oxide release. J Immunol 161: 5039-5044.
13. Hybiske K, Stephens RS (2007) Mechanisms of host cell exit by the intracellular bacterium Chlamydia. Proc Natl Acad Sci USA 104: 11430-11435.
14. Pizarro-Cerda J, Cossart P (2006) Bacterial adhesion and entry into host cells. Cell 124: 715-727.
15. Lasunskaia EB, Campos MN, de Andrade MR, Damatta RA, Kipnis TL, et al. (2006) Mycobacteria directly induce cytoskeletal rearrangements for macro-phage spreading and polarization through TLR2-dependent PI3K signaling. J Leukoc Biol 80: 1480-1490.
16. Wood W, Martin P (2002) Structures in focus-filopodia. Int J Biochem Cell Biol 34: 726-730.
17. Van Nhieu GT, Caron E, Hall A, Sansonetti PJ (1999) IpaC induces actin polymerization and filopodia formation during Shigella entry into epithelial cells. EMBO J 18: 3249-3262.
18. Mikaty G, Soyer M, Mairey E, Henry N, Dyer D, et al. (2009) Extracellular bacterial pathogen induces host cell surface reorganization to resist shear stress. PLoS Pathog 5: e1000314.
19. Tilney LG, Portnoy DA (1989) Actin filaments and the growth, movement, and spread of the intracellular bacterial parasite, Listeria monocytogenes. J Cell Biol 109: 1597-1608.
20. Blouin EF, Kocan KM (1998) Morphology and development of Anaplasma marginale (Rickettsiales: Anaplasmataceae) in cultured Ixodes scapularis (Acari: Ixodidae) cells. J Med Entomol 35: 788-797.
21. Kafsack BF, Pena JD, Coppens I, Ravindran S, Boothroyd JC, et al. (2009) Rapid membrane disruption by a perforin-like protein facilitates parasite exit from host cells. Science 323: 530-533.
22. Finlay BB, Falkow S (1988) Comparison of the invasion strategies used by Salmonella cholerae-suis, Shigella flexneri and Yersinia enterocolitica to enter cultured animal cells: endosome acidification is not required for bacterial invasion or intracellular replication. Biochimie 70: 1089-1099.
23. Stevenson HL, Jordan JM, Peerwani Z, Wang HQ, Walker DH, et al. (2006) An intradermal environment promotes a protective type-1 response against lethal systemic monocytotropic ehrlichial infection. Infect Immun 74: 4856-4864.