β1- and β2-adrenoceptor-mediated thermogenesis and lipid utilization in obese and lean men

Journal of Clinical Endocrinology and Metabolism

Volumn 86, Issue 5, 2001, Pages 2191-2199

  Schiffelers, S L H ^a   Saris, W H M ^a   Boomsma, F ^b   Van Baak, M A ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ATENOLOL; BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; DOBUTAMINE; FATTY ACID; GLYCEROL; SALBUTAMOL;

ADRENERGIC STIMULATION; ADULT; ARTICLE; BODY DENSITY; CLINICAL ARTICLE; CONTROLLED STUDY; ENERGY EXPENDITURE; HUMAN; LIPID METABOLISM; LIPID OXIDATION; LIPOLYSIS; MALE; OBESITY; PRIORITY JOURNAL; RECEPTOR INTRINSIC ACTIVITY; THERMOGENESIS;

ADULT; ALBUTEROL; DOBUTAMINE; ENERGY METABOLISM; FATTY ACIDS, NONESTERIFIED; HEMODYNAMIC PROCESSES; HUMANS; LIPID METABOLISM; LIPOLYSIS; MALE; MIDDLE AGED; NOREPINEPHRINE; OBESITY; OXIDATION-REDUCTION; RECEPTORS, ADRENERGIC, BETA-1; RECEPTORS, ADRENERGIC, BETA-2; THERMOGENESIS;

EID: 0035023620     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.86.5.2191     Document Type: Article

References (48)

1. Kurpad AV, Khan K, Calder AG, Elia M. 1994 Muscle and whole body metabolism after norepinephrine. Am J Physiol. 266:E877-E884.
2. Kurpad A, Khan K, Calder AG, et al. 1994 Effect of noradrenaline on glycerol turnover and lipolysis in the whole body and subcutaneous adipose tissue in humans in vivo. Clin Sci. 86:177-184.
3. Astrup A, Simonsen L, Bülow J, Madsen J, Christensen NJ. 1989 Epinephrine mediates facultative carbohydrate-induced thermogenesis in human skeletal muscle. Am J Physiol. 257:E340-E345.
4. Simonsen L, Bülow J, Madsen J, Christensen NJ. 1992 Thermogenic response to epinephrine in the forearm and abdominal subcutaneous adipose tissue. Am J Physiol. 263:E850-E855.
5. Connacher AA, Bennet WM, Jung RT, et al. 1991 Effect of adrenaline infusion on fatty acid and glucose turnover in lean and obese human subjects in the post-absorptive and fed states. Clin Sci. 81:635-644.
6. Blaak EE, van Baak MA, Kempen KP, Saris WHM. 1993 Role of α- and β-adrenoceptors in sympathetically mediated thermogenesis. Am J Physiol. 264:E11-E17.
7. Blaak EE, van Baak MA, Kemerink GJ, Pakbiers MT, Heidendal GA, Saris WH. 1994 β-Adrenergic stimulation of energy expenditure and forearm skeletal muscle metabolism in lean and obese men. Am J Physiol. 267:E306-E315.
8. Green CJ, Frazer RS, Underhill S, Maycock P, Fairhurst JA, Campbell IT. 1992 Metabolic effects of dobutamine in normal man. Clin Sci. 82:77-83.
9. 1-adrenoceptor agonist in in vivo studies on human thermogenesis and lipid utilization. J Appl Physiol. 87:977-981.
10. 2-adrenoceptor activation in healthy human volunteers. Br J Clin Pharmacol. 35:35-39.
11. 3-adrenoceptor agonists in the treatment of obesity and diabetes. Int J Obes. 20:191-199.
12. 3-adrenoceptor agonist. Biochem Pharmacol. 54:121-131.
13. Ruffolo Jr RR, Messick K, Horng JS. 1984 Interactions of three inotropic agents, ASL-7022, dobutamine and dopamine, with α- and β-adrenoceptors in vitro. Naunyn Schmiedebergs Arch Pharmacol. 326:317-326.
14. 3-adrenergic receptors: differential agonist activation of recombinant receptors in Chinese hamster ovary cells. Mol Pharmacol. 42:634-637.
15. Jung RT, Shetty PS, James WFT, Barrand M, Callingham M. 1979 Reduced thermogenesis in obesity. Nature. 279:322-323.
16. Connacher AA, Jung RT, Mitchell PE, Ford RP, Leslie P, Illingworth P. 1988 Heterogeneity of noradrenergic thermic responses in obese and lean humans. Int J Obes. 12:267-276.
17. Katzeff HL, O'Connell M, Horton ES, Danforth Jr E, Young JB, Landsberg L. 1986 Metabolic studies in human obesity during overnutrition and under-nutrition: thermogenic and hormonal responses to norepinephrine. Metabolism. 35:166-175.
18. Kush RD, Young JB, Katzeff HL, et al. 1986 Effect of diet on energy expenditure and plasma norepinephrine in lean and obese Pima Indians. Metabolism. 35:1110-1120.
19. Webber J, Taylor J, Greathead H, Dawson J, Buttery PJ, Macdonald IA. 1994 A comparison of the thermogenic, metabolic and haemodynamic responses to infused adrenaline in lean and obese subjects. Int J Obes. 18:717-724.
20. Blaak EE, van Baak MA, Kester AD, Saris WH. 1995 β-Adrenergically mediated thermogenic and heart rate responses: effect of obesity and weight loss. Metabolism. 44:520-524.
21. Wolfe RR, Peters EJ, Klein S, Holland OB, Rosenblatt J, Gary HJ. 1987 Effect of short-term fasting on lipolytic responsiveness in normal and obese human subjects. Am J Physiol. 252:E189-E196.
22. Siri WE. 1956 The gross composition of the body. Adv Biol Med Physiol. 4:239-280.
23. Schoffelen PF, Westerterp KR, Saris WH, Ten Hoor F. 1997 A dual-respiration chamber system with automated calibration. J Appl Physiol. 83:2064-2072.
24. Weir JB. 1949 New methods for calculating metabolic rate with special reference to protein metabolism. J Physiol. 109:1-9.
25. Ferrannini E. 1988 The theoretical bases of indirect calorimetry: a review. Metabolism. 37:287-301.
26. nd Ed. New York: Academic Press; 1464-1468.
27. Alberts G, Boomsma F, Man in't Veld AJ, Schalekamp MA. 1992 Simultaneous determination of catecholamines and dobutamine in human plasma and urine by high-performance liquid chromatography with fluorimetric detection. J Chromatogr. 583:236-240.
28. Ravussin E, Bogardus C. 1989 Relationship of genetics, age, and physical fitness to daily energy expenditure and fuel utilization. Am J Clin Nutr. 49:968-975.
29. 2-adrenoceptors. Diabetologia. 37:428-435.
30. 2-adrenoceptor expression in fat cells. J Clin Invest. 90:2175-2186.
31. 2-adrenergic receptor gene with obesity, hypertriglyceridaemia, and diabetes mellitus. Diabetologia. 42:98-101.
32. 2-adrenoceptor function. J Clin Invest. 100:3005-3013.
33. 2-adrenergic receptor variant is associated with obesity due to subcutaneous fat accumulation in Japanese men. Biochem Biophys Res Commun. 258:138-140.
34. 2-adrenoceptor gene polymorphism on obesity in males and in females. J Intern Med. 245:253-259.
35. Schiffelers SLH, Saris WHM, Van Baak MA. 2001 The effect of an increased free fatty acid concentration on thermogenesis and substrate oxidation in obese and lean men. Int J Obes. 25:33-38.
36. Simonsen L, Stallknecht B, Bülow J. 1993 Contribution of skeletal muscle and adipose tissue to adrenaline-induced thermogenesis in man. Int J Obes. 17:S47-S51.
37. Simoneau JA, Colberg SR, Thaete FL, Kelley DE. 1995 Skeletal muscle glycolytic and oxidative enzyme capacities are determinants of insulin sensitivity and muscle composition in obese women. FASEB J. 9:273-278.
38. Colberg SR, Simoneau JA, Thaete FL, Kelley DE. 1995 Skeletal muscle utilization of free fatty acids in women with visceral obesity. J Clin Invest. 95:1846-1853.
39. Staten MA, Matthews DE, Cryer PE, Bier DM. 1989 Epinephrine's effect on metabolic rate is independent of changes in plasma insulin or glucagon. Am J Physiol. 257:E185-E192.
40. Müller MJ, Acheson KJ, Piolino V, Jeanpretre N, Burger AG, Jéquier E. 1992 Thermic effect of epinephrine: a role for endogenous insulin. Metabolism. 41:582-587.
41. Kerckhoffs DA, Blaak EE, Van Baak MA, Saris WH. 1998 Effect of aging on β-adrenergically mediated thermogenesis in men. Am J Physiol. 274:E1075-E1079.
42. Vestal RE, Wood AJ, Shand DG. 1979 Reduced β-adrenoceptor sensitivity in the elderly. Clin Pharmacol Ther. 26:181-186.
43. Vaz M, Jennings G, Turner A, Cox H, Lambert G, Esler M. 1997 Regional sympathetic nervous activity and oxygen consumption in obese normotensive human subjects. Circulation. 96:3423-3429.
44. Rumantir MS, Vaz M, Jennings GL, et al. 1999 Neural mechanisms in human obesity-related hypertension. J Hypertens. 17:1125-1133.
45. Poehlman ET, Gardner AW, Goran MI, et al. 1995 Sympathetic nervous system activity, body fatness, and body fat distribution in younger and older males. J Appl Physiol. 78:802-806.
46. Schwartz RS, Jaeger LF, Veith RC. 1987 The importance of body composition to the increase in plasma norepinephrine appearance rate in elderly men. J Gerontol. 42:546-551.
47. Blaak EE, van Baak MA, Kemerink GJ, Pakbiers MT, Heidendal GA, Saris WH. 1994 β-Adrenergic stimulation of skeletal muscle metabolism in relation to weight reduction in obese men. Am J Physiol. 267:E316-E322.
48. Astrup A, Andersen T, Christensen NJ, et al. 1990 Impaired glucose-induced thermogenesis and arterial norepinephrine response persists after weight reduction in obese humans. Am J Clin Nutr. 51:331-337.