Daily ingestion of grains of paradise (Aframomum melegueta) extract increases whole-body energy expenditure and decreases visceral fat in humans

Journal of Nutritional Science and Vitaminology

Volumn 60, Issue 1, 2014, Pages 22-27

  Sugita, Jun ^a,b   Yoneshiro, Takeshi ^c   Sugishima, Yuuki ^d   Ikemoto, Takeshi ^b   Uchiwa, Hideyo ^b   Suzuki, Isao ^d,e   Saito, Masayuki ^a  

^a Tenshi College   (Japan)

^b KANEBO LTD   (Japan)

^c HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d PREFECTURAL UNIVERSITY OF KUMAMOTO   (Japan)

^e Nagoya University of Economics   (Japan)

Author keywords

6 Paradol; Energy expenditure; Grains of paradise; Visceral fat

Indexed keywords

AFRAMOMUM MELEGUETA EXTRACT; PLACEBO; PLANT EXTRACT; UNCLASSIFIED DRUG;

ADULT; AFRAMOMUM MELEGUETA; ANTHROPOMETRIC PARAMETERS; ARTICLE; BLOOD ANALYSIS; BODY MASS; BODY WEIGHT; CALORIMETRY; CLINICAL ARTICLE; CONTROLLED STUDY; CROSSOVER PROCEDURE; ENERGY EXPENDITURE; FEMALE; HUMAN; INTRAABDOMINAL FAT; NORMAL HUMAN; OXYGEN CONSUMPTION; PHYTOCHEMISTRY; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; SUBCUTANEOUS FAT; YOUNG ADULT; ZINGIBERACEAE; BROWN ADIPOSE TISSUE; CHEMISTRY; DRUG EFFECTS; ENERGY METABOLISM; METABOLISM; OBESITY;

ADIPOSE TISSUE, BROWN; ADULT; BODY MASS INDEX; BODY WEIGHT; CROSS-OVER STUDIES; ENERGY METABOLISM; FEMALE; HUMANS; INTRA-ABDOMINAL FAT; OBESITY; PLANT EXTRACTS; SINGLE-BLIND METHOD; YOUNG ADULT; ZINGIBERACEAE;

EID: 84899410105     PISSN: 03014800     EISSN: 18817742     Source Type: Journal    
DOI: 10.3177/jnsv.60.22     Document Type: Article

References (20)

1. Kawada T, Watanabe T, Takaishi T, Tanaka T, Iwai K. 1986. Capsaicin-induced b-adrenergic action on energy metabolism in rats: infuence of capsaicin on oxygen consumption, the respiratory quotient, and substrate utilization. Proc Soc Exp Biol Med 183: 250-256.
2. Kawada T, Hagihara K, Iwai K. 1986. Effects of capsa-icin on lipid metabolism in rats fed a high fat diet. J Nutr 183: 1272-1278.
3. Yoshioka M, Lim K, Kikuzato S, Kiyonaga A, Tanaka H, Shindo M, Suzuki M. 1995. Effects of red-pepper diet on the energy metabolism in men. J Nutr Sci Vitaminol 41: 647-656.
4. Lejeune M P, Kovacs EM, Westerterp-Plantenga MS. 2003. Effects of capsaicin on substrate oxidation and weight maintenance after modest body-weight loss in human subjects. Br J Nutr 90: 651-659.
5. Ludy MJ, Moore GE, Mattes RD. 2012. The effects of cap-saicin and capsiate on energy balance: critical review and meta-analyses of studies in humans. Chem Senses 37: 103-121.
6. Yoneshiro T, Aita S, Kawai Y, Iwanaga T, Saito M. 2012. Non-pungent capsaicin analogs (capsinoids) increase energy expenditure through the activation of brown adipose tissue in humans. Am J Clin Nutr 95: 845-850.
7. Kawabata F, Inoue N, Yazawa S, Kawada T, Inoue K, Fushiki T. 2008. Effects of CH-19 sweet, a non-pungent cultivar of red pepper, in decreasing the body weight and suppressing body fat accumulation by sympathetic nerve activation in humans. Biosci Biotechnol Biochem 70: 2824-2835.
8. Snitker S, Fujishima Y, Shen H, Ott S, Pi-Sunyer X, Furu-hata Y, Sato H, Takahashi M. 2009. Effects of novel cap-sinoid treatment on fatness and energy metabolism in humans: possible pharmacogenetic implications. Am J Clin Nutr 89: 45-50.
9. Saito M, Yoneshiro T. 2013. Capsinoids and related food ingredients activating brown fat thermogenesis and reducing body fat in humans. Curr Opin Lipidol 24: 71-77.
10. Kawabata F, Inoue N, Masamoto Y, Matsumura S, Kimura W, Kadowaki M, Higashi T, Tominaga M, Inoue K, Fushiki T. 2009. Non-pungent capsaicin analogs (capsinoids) increase metabolic rate and enhance ther-mogenesis via gastrointestinal TRPV1 in mice. Biosci Biotechnol Biochem 73: 2690-2697.
11. Akendengué B, Louis AM. 1994. Medicinal plants used by the Masango people in Gabon. J Ethnopharmacol 41: 193-200.
12. Connell DW. 1970. Natural pungent compounds. III. Paradols and associated compounds. Aust J Chem 23: 369-376.
13. Connell DW, McLachlan R. 1972. Natural pungent compounds. I V. Examination of the gingerols, shogaols, paradols, and related compounds by thin-layer and gas chromatography. J Chromatogr A 61: 29-35.
14. Tackie AN, Dwuma-Badu D, Ayim JSK, Dabra TT, Knapp JE, Slatkin DJ, Schiff PL Jr. 1975. Constituents of West African medicinal plants. VIII. Hydroxyphenylalkanones from Amomum melegueta. Phytochemistry 14: 853-854.
15. Riera CE, Menozzi-Smarrito C, Affolter M, Michlig S, Munari C, Robert F, Vogel H, Simon SA, le Coutre J. 2009. Compounds from Sichuan and Melegueta peppers activate, covalently and non-covalently, TRPA1 and TRPV1 channels. Br J Pharmacol 157: 1398-1409.
16. Morera E, De Petrocellis L, Morera L, Moriello AS, Nalli M, Di Marzo V, Ortar G. 2012. Synthesis and biological evaluation of [6]-gingerol analogues as transient receptor potential channel TRPV1 and TRPA1 modulators. Bioorg Med Chem Lett 22: 1674-1677.
17. Iwami M, Mahmoud FA, Shiina T, Hirayama H, Shima T, Sugita J, Shimizu Y. 2011. Extract of grains of paradise and its active principle 6-paradol trigger thermogenesis of brown adipose tissue in rats. Auton Neurosci 161: 63-67.
18. Sugita J, Yoneshiro T, Hatano T, Aita S, Ikemoto T, Uchiwa H, Iwanaga T, Kameya T, Kawai Y, Saito M. 2013. Grains of paradise (Aframomum melegueta) extract activates brown adipose tissue and increases whole-body energy expenditure in men. Br J Nutr 4: 733-738.
19. Tokunaga K, Matsuzawa Y, Ishikawa K, Tarui S. 1983. A novel technique for the determination of body fat by computed tomography. Int J Obes 7: 437-445.
20. Saito M, Okamatsu-Ogura Y, Matsushita M, Watanabe K, Yoneshiro T, Nio-Kobayashi J, Iwanaga T, Miyagawa M, Kameya T, Nakada K, Kawai Y, Tsujisaki M. 2009. High incidence of metabolically active brown adipose tissue in healthy adult humans. Effects of cold exposure and adiposity. Diabetes 58: 1526-1531.