-
1
-
-
84866122688
-
Autophagy modulation as a potential therapeutic target for diverse diseases
-
Rubinsztein, D. C., Codogno, P., Levine, B. Autophagy modulation as a potential therapeutic target for diverse diseases. Nat rev 11, 709-730, doi: 10.1038/nrd3802 (2012).
-
(2012)
Nat Rev
, vol.11
, pp. 709-730
-
-
Rubinsztein, D.C.1
Codogno, P.2
Levine, B.3
-
2
-
-
84883452831
-
Up-to-date membrane biogenesis in the autophagosome formation
-
Hamasaki, M., Shibutani, S. T., Yoshimori, T. Up-to-date membrane biogenesis in the autophagosome formation. Curr Opin Cell Biol 25, 455-460, doi: 10.1016/j.ceb.2013.03.004 (2013).
-
(2013)
Curr Opin Cell Biol
, vol.25
, pp. 455-460
-
-
Hamasaki, M.1
Shibutani, S.T.2
Yoshimori, T.3
-
3
-
-
50249084987
-
Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum
-
Axe, E. L. et al. Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum. JCB 182, 685-701, doi: 10.1083/jcb.200803137 (2008).
-
(2008)
JCB
, vol.182
, pp. 685-701
-
-
Axe, E.L.1
-
4
-
-
77955131007
-
Plasma membrane contributes to the formation of preautophagosomal structures
-
Ravikumar, B., Moreau, K., Jahreiss, L., Puri, C., Rubinsztein, D. C. Plasma membrane contributes to the formation of preautophagosomal structures. Nat cell bio 12, 747-757, doi: 10.1038/ncb2078 (2010).
-
(2010)
Nat Cell Bio
, vol.12
, pp. 747-757
-
-
Ravikumar, B.1
Moreau, K.2
Jahreiss, L.3
Puri, C.4
Rubinsztein, D.C.5
-
5
-
-
77952495224
-
Mitochondria supply membranes for autophagosome biogenesis during starvation
-
Hailey, D. W. et al. Mitochondria supply membranes for autophagosome biogenesis during starvation. Cell 141, 656-667, doi: 10.1016/j.cell.2010.04.009 (2010).
-
(2010)
Cell
, vol.141
, pp. 656-667
-
-
Hailey, D.W.1
-
6
-
-
33750366092
-
Starvation and ULK1-dependent cycling of mammalian Atg9 between the TGN and endosomes
-
Young, A. R. et al. Starvation and ULK1-dependent cycling of mammalian Atg9 between the TGN and endosomes. J Cell Sci 119, 3888-3900, doi: 10.1242/jcs.03172 (2006).
-
(2006)
J Cell Sci
, vol.119
, pp. 3888-3900
-
-
Young, A.R.1
-
7
-
-
84882254367
-
The role of autophagy in neurodegenerative disease
-
Nixon, R. A. The role of autophagy in neurodegenerative disease. Nat med 19, 983-997, doi: 10.1038/nm.3232 (2013).
-
(2013)
Nat Med
, vol.19
, pp. 983-997
-
-
Nixon, R.A.1
-
8
-
-
33646800306
-
Loss of autophagy in the central nervous system causes neurodegeneration in mice
-
Komatsu, M. et al. Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature 441, 880-884, doi: 10.1038/nature04723 (2006).
-
(2006)
Nature
, vol.441
, pp. 880-884
-
-
Komatsu, M.1
-
9
-
-
33745192802
-
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
-
Hara, T. et al. Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature 441, 885-889, doi: 10.1038/nature04724 (2006).
-
(2006)
Nature
, vol.441
, pp. 885-889
-
-
Hara, T.1
-
11
-
-
84904729990
-
Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models
-
Barmada, S. J. et al. Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models. Nat chem bio, doi: 10.1038/nchembio.1563 (2014).
-
(2014)
Nat Chem Bio
-
-
Barmada, S.J.1
-
12
-
-
78049231804
-
A small-molecule scaffold induces autophagy in primary neurons and protects against toxicity in a Huntington disease model
-
Tsvetkov, A. S. et al. A small-molecule scaffold induces autophagy in primary neurons and protects against toxicity in a Huntington disease model. PNAS USA 107, 16982-16987, doi: 10.1073/pnas.1004498107 (2010).
-
(2010)
PNAS USA
, vol.107
, pp. 16982-16987
-
-
Tsvetkov, A.S.1
-
13
-
-
33646831810
-
Regulation of autophagy by sphingosine kinase 1 and its role in cell survival during nutrient starvation
-
Lavieu, G. et al. Regulation of autophagy by sphingosine kinase 1 and its role in cell survival during nutrient starvation. JBC 281, 8518-8527, doi: 10.1074/jbc.M506182200 (2006).
-
(2006)
JBC
, vol.281
, pp. 8518-8527
-
-
Lavieu, G.1
-
14
-
-
0037144434
-
PKC-dependent activation of sphingosine kinase 1 and translocation to the plasma membrane Extracellular release of sphingosine-1-phosphate induced by phorbol 12-myristate 13-acetate (PMA)
-
Johnson, K. R., Becker, K. P., Facchinetti, M. M., Hannun, Y. A., Obeid, L. M. PKC-dependent activation of sphingosine kinase 1 and translocation to the plasma membrane. Extracellular release of sphingosine-1-phosphate induced by phorbol 12-myristate 13-acetate (PMA). JBC 277, 35257-35262, doi: 10.1074/jbc.M203033200 (2002).
-
(2002)
JBC
, vol.277
, pp. 35257-35262
-
-
Johnson, K.R.1
Becker, K.P.2
Facchinetti, M.M.3
Hannun, Y.A.4
Obeid, L.M.5
-
15
-
-
84855303523
-
Sphingosine-1-phosphate signaling and its role in disease
-
Maceyka, M., Harikumar, K. B., Milstien, S., Spiegel, S. Sphingosine-1-phosphate signaling and its role in disease. Trends in cell bio 22, 50-60, doi: 10.1016/j.tcb.2011.09.003 (2012).
-
(2012)
Trends in Cell Bio
, vol.22
, pp. 50-60
-
-
Maceyka, M.1
Harikumar, K.B.2
Milstien, S.3
Spiegel, S.4
-
16
-
-
0028128763
-
Sphingosine 1-phosphate generated in the endoplasmic reticulum membrane activates release of stored calcium
-
Ghosh, T. K., Bian, J., Gill, D. L. Sphingosine 1-phosphate generated in the endoplasmic reticulum membrane activates release of stored calcium. JBC 269, 22628-22635 (1994).
-
(1994)
JBC
, vol.269
, pp. 22628-22635
-
-
Ghosh, T.K.1
Bian, J.2
Gill, D.L.3
-
17
-
-
0027991078
-
Sphingosine-1-phosphate a putative second messenger, mobilizes calcium from internal stores via an inositol trisphosphate-independent pathway
-
Mattie, M., Brooker, G., Spiegel, S. Sphingosine-1-phosphate, a putative second messenger, mobilizes calcium from internal stores via an inositol trisphosphate-independent pathway. JBC 269, 3181-3188 (1994).
-
(1994)
JBC
, vol.269
, pp. 3181-3188
-
-
Mattie, M.1
Brooker, G.2
Spiegel, S.3
-
18
-
-
80052638037
-
A dual role for Ca(2+ ) in autophagy regulation
-
Decuypere, J. P., Bultynck, G., Parys, J. B. A dual role for Ca(2+ ) in autophagy regulation. Cell calcium 50, 242-250, doi: 10.1016/j.ceca.2011.04.001 (2011).
-
(2011)
Cell Calcium
, vol.50
, pp. 242-250
-
-
Decuypere, J.P.1
Bultynck, G.2
Parys, J.B.3
-
19
-
-
84885348627
-
Calcium-permeable ion channels in control of autophagy and cancer
-
Kondratskyi, A. et al. Calcium-permeable ion channels in control of autophagy and cancer. Front in physiol 4, 272, doi: 10.3389/fphys.2013.00272 (2013).
-
(2013)
Front in Physiol
, vol.4
, pp. 272
-
-
Kondratskyi, A.1
-
20
-
-
84857858536
-
Autophagosomes initiate distally and mature during transport toward the cell soma in primary neurons
-
Maday, S., Wallace, K. E., Holzbaur, E. L. Autophagosomes initiate distally and mature during transport toward the cell soma in primary neurons. JCB 196, 407-417, doi: 10.1083/jcb.201106120 (2012).
-
(2012)
JCB
, vol.196
, pp. 407-417
-
-
Maday, S.1
Wallace, K.E.2
Holzbaur, E.L.3
-
21
-
-
64049113909
-
Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex
-
Zhong, Y. et al. Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex. Nat cell bio 11, 468-476, doi: 10.1038/ncb1854 (2009).
-
(2009)
Nat Cell Bio
, vol.11
, pp. 468-476
-
-
Zhong, Y.1
-
22
-
-
84872799206
-
The VMP1-Beclin 1 interaction regulates autophagy induction
-
Molejon, M. I., Ropolo, A., Re, A. L., Boggio, V., Vaccaro, M. I. The VMP1-Beclin 1 interaction regulates autophagy induction. Sci rep 3, 1055, doi: 10.1038/srep01055 (2013).
-
(2013)
Sci Rep
, vol.3
, pp. 1055
-
-
Molejon, M.I.1
Ropolo, A.2
Re, A.L.3
Boggio, V.4
Vaccaro, M.I.5
-
23
-
-
84883182319
-
Longitudinal imaging and analysis of neurons expressing polyglutamine-expanded proteins
-
Tsvetkov, A. S., Ando, D. M., Finkbeiner, S. Longitudinal imaging and analysis of neurons expressing polyglutamine-expanded proteins. Methods in mol biol 1017, 1-20, doi: 10.1007/978-1-62703-438-8-1 (2013).
-
(2013)
Methods in Mol Biol
, vol.1017
, pp. 1-20
-
-
Tsvetkov, A.S.1
Ando, D.M.2
Finkbeiner, S.3
-
24
-
-
32544449944
-
Splice variants of the NR1 subunit differentially induce NMDA receptor-dependent gene expression
-
Bradley, J., Carter, S. R., Rao, V. R., Wang, J., Finkbeiner, S. Splice variants of the NR1 subunit differentially induce NMDA receptor-dependent gene expression. J Neurosci 26, 1065-1076, doi: 10.1523/JNEUROSCI.3347-05.2006 (2006).
-
(2006)
J Neurosci
, vol.26
, pp. 1065-1076
-
-
Bradley, J.1
Carter, S.R.2
Rao, V.R.3
Wang, J.4
Finkbeiner, S.5
-
25
-
-
84883204078
-
Proteostasis of polyglutamine varies among neurons and predicts neurodegeneration
-
Tsvetkov, A. S. et al. Proteostasis of polyglutamine varies among neurons and predicts neurodegeneration. Nat chem bio 9, 586-592, doi: 10.1038/nchembio.1308 (2013).
-
(2013)
Nat Chem Bio
, vol.9
, pp. 586-592
-
-
Tsvetkov, A.S.1
-
26
-
-
78049231804
-
A small-molecule scaffold induces autophagy in primary neurons and protects against toxicity in a Huntington disease model
-
Tsvetkov, A. S. et al. A small-molecule scaffold induces autophagy in primary neurons and protects against toxicity in a Huntington disease model. PNAS USA 107, 16982-16987, doi: 10.1073/pnas.1004498107 (2010).
-
(2010)
PNAS USA
, vol.107
, pp. 16982-16987
-
-
Tsvetkov, A.S.1
-
27
-
-
59049094829
-
Nutrient deprivation induces neuronal autophagy and implicates reduced insulin signaling in neuroprotective autophagy activation
-
Young, J. E., Martinez, R. A., La Spada, A. R. Nutrient deprivation induces neuronal autophagy and implicates reduced insulin signaling in neuroprotective autophagy activation. JBC 284, 2363-2373, doi: 10.1074/jbc.M806088200 (2009).
-
(2009)
JBC
, vol.284
, pp. 2363-2373
-
-
Young, J.E.1
Martinez, R.A.2
La Spada, A.R.3
-
28
-
-
0034721844
-
Expression of a catalytically inactive sphingosine kinase mutant blocks agonist-induced sphingosine kinase activation A dominant-negative sphingosine kinase
-
Pitson, S. M. et al. Expression of a catalytically inactive sphingosine kinase mutant blocks agonist-induced sphingosine kinase activation. A dominant-negative sphingosine kinase. JBC 275, 33945-33950, doi: 10.1074/jbc.M006176200 (2000).
-
(2000)
JBC
, vol.275
, pp. 33945-33950
-
-
Pitson, S.M.1
-
29
-
-
84875365804
-
Autophagosomes form at ER-mitochondria contact sites
-
Hamasaki, M. et al. Autophagosomes form at ER-mitochondria contact sites. Nature, doi: 10.1038/nature11910 (2013).
-
(2013)
Nature
-
-
Hamasaki, M.1
-
30
-
-
84875462369
-
Endoplasmic reticulum-endosome contact increases as endosomes traffic and mature
-
Friedman, J. R., Dibenedetto, J. R., West, M., Rowland, A. A., Voeltz, G. K. Endoplasmic reticulum-endosome contact increases as endosomes traffic and mature. Mol Biol of cell 24, 1030-1040, doi: 10.1091/mbc.E12-10-0733 (2013).
-
(2013)
Mol Biol of Cell
, vol.24
, pp. 1030-1040
-
-
Friedman, J.R.1
Dibenedetto, J.R.2
West, M.3
Rowland, A.A.4
Voeltz, G.K.5
-
31
-
-
67649600680
-
Cholesterol sensor ORP1L contacts the ER protein VAP to control Rab7-RILP-p150 Glued and late endosome positioning
-
Rocha, N. et al. Cholesterol sensor ORP1L contacts the ER protein VAP to control Rab7-RILP-p150 Glued and late endosome positioning. JCB 185, 1209-1225, doi: 10.1083/jcb.200811005 (2009).
-
(2009)
JCB
, vol.185
, pp. 1209-1225
-
-
Rocha, N.1
-
32
-
-
77955884684
-
Characterization of autophagosome formation site by a hierarchical analysis of mammalian Atg proteins
-
Itakura, E., Mizushima, N. Characterization of autophagosome formation site by a hierarchical analysis of mammalian Atg proteins. Autophagy 6, 764-776 (2010).
-
(2010)
Autophagy
, vol.6
, pp. 764-776
-
-
Itakura, E.1
Mizushima, N.2
-
33
-
-
84921366480
-
WIPI proteins: Essential PtdIns3P effectors at the nascent autophagosome
-
Proikas-Cezanne, T., Takacs, Z., Donnes, P., Kohlbacher, O. WIPI proteins: essential PtdIns3P effectors at the nascent autophagosome. J Cell Sci 128, 207-217, doi: 10.1242/jcs.146258 (2015).
-
(2015)
J Cell Sci
, vol.128
, pp. 207-217
-
-
Proikas-Cezanne, T.1
Takacs, Z.2
Donnes, P.3
Kohlbacher, O.4
-
34
-
-
57649227693
-
Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies
-
Sarkar, S., Ravikumar, B., Floto, R. A., Rubinsztein, D. C. Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies. Cell death and diff 16, 46-56, doi:10.1038/cdd.2008.110 (2009).
-
(2009)
Cell Death and Diff
, vol.16
, pp. 46-56
-
-
Sarkar, S.1
Ravikumar, B.2
Floto, R.A.3
Rubinsztein, D.C.4
-
35
-
-
14844359962
-
Automated microscope system for determining factors that predict neuronal fate
-
Arrasate, M., Finkbeiner, S. Automated microscope system for determining factors that predict neuronal fate. PNAS USA 102, 3840-3845, doi: 10.1073/pnas.0409777102 (2005).
-
(2005)
PNAS USA
, vol.102
, pp. 3840-3845
-
-
Arrasate, M.1
Finkbeiner, S.2
-
36
-
-
7244236320
-
Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death
-
Arrasate, M., Mitra, S., Schweitzer, E. S., Segal, M. R., Finkbeiner, S. Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death. Nature 431, 805-810, doi: 10.1038/nature02998 (2004).
-
(2004)
Nature
, vol.431
, pp. 805-810
-
-
Arrasate, M.1
Mitra, S.2
Schweitzer, E.S.3
Segal, M.R.4
Finkbeiner, S.5
-
37
-
-
63249135140
-
Single neuron ubiquitin-proteasome dynamics accompanying inclusion body formation in huntington disease
-
Mitra, S., Tsvetkov, A. S., Finkbeiner, S. Single neuron ubiquitin-proteasome dynamics accompanying inclusion body formation in huntington disease. JBC 284, 4398-4403, doi: 10.1074/jbc.M806269200 (2009).
-
(2009)
JBC
, vol.284
, pp. 4398-4403
-
-
Mitra, S.1
Tsvetkov, A.S.2
Finkbeiner, S.3
-
38
-
-
70349640049
-
Protein turnover and inclusion body formation
-
Mitra, S., Tsvetkov, A. S., Finkbeiner, S. Protein turnover and inclusion body formation. Autophagy 5, 1037-1038 (2009).
-
(2009)
Autophagy
, vol.5
, pp. 1037-1038
-
-
Mitra, S.1
Tsvetkov, A.S.2
Finkbeiner, S.3
-
39
-
-
84873463075
-
Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease
-
Sathasivam, K. et al. Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease. PNAS USA 110, 2366-2370, doi: 10.1073/pnas.1221891110 (2013).
-
(2013)
PNAS USA
, vol.110
, pp. 2366-2370
-
-
Sathasivam, K.1
-
40
-
-
0033953015
-
Caspases and neurodegeneration: On the cutting edge of new therapeutic approaches
-
Wellington, C. L., Hayden, M. R. Caspases and neurodegeneration: on the cutting edge of new therapeutic approaches. Clin gen 57, 1-10 (2000).
-
(2000)
Clin Gen
, vol.57
, pp. 1-10
-
-
Wellington, C.L.1
Hayden, M.R.2
-
41
-
-
16044373842
-
Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice
-
Mangiarini, L. et al. Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice. Cell 87, 493-506 (1996).
-
(1996)
Cell
, vol.87
, pp. 493-506
-
-
Mangiarini, L.1
-
42
-
-
65549163327
-
Cytoplasmic retention of polyglutamine-expanded androgen receptor ameliorates disease via autophagy in a mouse model of spinal and bulbar muscular atrophy
-
Montie, H. L. et al. Cytoplasmic retention of polyglutamine-expanded androgen receptor ameliorates disease via autophagy in a mouse model of spinal and bulbar muscular atrophy. Hum mol gen 18, 1937-1950, doi: Doi 10.1093/Hmg/Ddp115 (2009).
-
(2009)
Hum Mol Gen
, vol.18
, pp. 1937-1950
-
-
Montie, H.L.1
-
43
-
-
84880425119
-
Pharmacology of the sphingosine-1-phosphate signalling system
-
Zu Heringdorf, D. M., Ihlefeld, K., Pfeilschifter, J. Pharmacology of the sphingosine-1-phosphate signalling system. Handbook of experimental pharmacology 215, 239-253, doi: 10.1007/978-3-7091-1368-4-13 (2013).
-
(2013)
Handbook of Experimental Pharmacology
, vol.215
, pp. 239-253
-
-
Zu Heringdorf, D.M.1
Ihlefeld, K.2
Pfeilschifter, J.3
-
44
-
-
0142105397
-
Activation of sphingosine kinase 1 by ERK1/2-mediated phosphorylation
-
Pitson, S. M. et al. Activation of sphingosine kinase 1 by ERK1/2-mediated phosphorylation. EMBO 22, 5491-5500, doi: 10.1093/emboj/cdg540 (2003).
-
(2003)
EMBO
, vol.22
, pp. 5491-5500
-
-
Pitson, S.M.1
-
45
-
-
31144472414
-
Mutant huntingtin alters MAPK signaling pathways in PC12 and striatal cells: ERK1/2 protects against mutant huntingtin-associated toxicity
-
Apostol, B. L. et al. Mutant huntingtin alters MAPK signaling pathways in PC12 and striatal cells: ERK1/2 protects against mutant huntingtin-associated toxicity. Hum mol gen 15, 273-285, doi: 10.1093/hmg/ddi443 (2006).
-
(2006)
Hum Mol Gen
, vol.15
, pp. 273-285
-
-
Apostol, B.L.1
-
46
-
-
78650525484
-
ERK activation by the polyphenols fisetin and resveratrol provides neuroprotection in multiple models of Huntington's disease
-
Maher, P. et al. ERK activation by the polyphenols fisetin and resveratrol provides neuroprotection in multiple models of Huntington's disease. Hum mol gen 20, 261-270, doi: 10.1093/hmg/ddq460 (2011).
-
(2011)
Hum Mol Gen
, vol.20
, pp. 261-270
-
-
Maher, P.1
-
47
-
-
0034329418
-
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
-
Kabeya, Y. et al. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO 19, 5720-5728, doi: 10.1093/emboj/19.21.5720 (2000).
-
(2000)
EMBO
, vol.19
, pp. 5720-5728
-
-
Kabeya, Y.1
-
48
-
-
34547659144
-
Bright monomeric red fluorescent protein with an extended fluorescence lifetime
-
Merzlyak, E. M. et al. Bright monomeric red fluorescent protein with an extended fluorescence lifetime. Nat meth 4, 555-557, doi: 10.1038/nmeth1062 (2007).
-
(2007)
Nat Meth
, vol.4
, pp. 555-557
-
-
Merzlyak, E.M.1
-
49
-
-
66349120877
-
Autophagy protects neuron from Abeta-induced cytotoxicity
-
Hung, S. Y., Huang, W. P., Liou, H. C., Fu, W. M. Autophagy protects neuron from Abeta-induced cytotoxicity. Autophagy 5, 502-510 (2009).
-
(2009)
Autophagy
, vol.5
, pp. 502-510
-
-
Hung, S.Y.1
Huang, W.P.2
Liou, H.C.3
Fu, W.M.4
-
50
-
-
84945214607
-
Isolation, characterization and antifungal docking studies of wortmannin isolated from Penicillium radicum
-
Singh, V. et al. Isolation, characterization and antifungal docking studies of wortmannin isolated from Penicillium radicum. Sci rep 5, 11948, doi: 10.1038/srep11948 (2015).
-
(2015)
Sci Rep
, vol.5
, pp. 11948
-
-
Singh, V.1
-
51
-
-
84904729990
-
Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models
-
Barmada, S. J. et al. Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models. Nat chem bio 10, 677-685, doi: 10.1038/nchembio.1563 (2014).
-
(2014)
Nat Chem Bio
, vol.10
, pp. 677-685
-
-
Barmada, S.J.1
|