메뉴 건너뛰기




Volumn 16, Issue 2, 2015, Pages 154-163

Man is the new mouse: Elective surgery as a key translational model for multi-organ dysfunction and sepsis

Author keywords

Animal model; Human; Research; Sepsis; Surgery

Indexed keywords

ARTICLE; ARTIFICIAL VENTILATION; COMORBIDITY; CRITICALLY ILL PATIENT; DISEASE ASSOCIATION; ELECTIVE SURGERY; HUMAN; IMMUNE RESPONSE; IMMUNOSUPPRESSIVE TREATMENT; INCIDENCE; MULTIPLE ORGAN FAILURE; PHENOTYPE; SEPSIS;

EID: 84945198877     PISSN: 17511437     EISSN: None     Source Type: Journal    
DOI: 10.1177/1751143714564826     Document Type: Article
Times cited : (4)

References (111)
  • 1
    • 84861665800 scopus 로고    scopus 로고
    • Drotrecogin Alfa (Activated) in adults with septic shock
    • Marco Ranieri V, Thompson BT, Philip S Barie, et al. Drotrecogin Alfa (Activated) in adults with septic shock. N Engl J Med 2012; 366: 2055–2064.
    • (2012) N Engl J Med , vol.366 , pp. 2055-2064
    • Marco Ranieri, V.1    Thompson, B.T.2    Philip, S.3
  • 2
    • 38049110809 scopus 로고    scopus 로고
    • Hydrocortisone therapy for patients with septic shock
    • Sprung CL, Annane D, Keh D, et al. Hydrocortisone therapy for patients with septic shock. N Engl J Med 2008; 358: 111–124.
    • (2008) N Engl J Med , vol.358 , pp. 111-124
    • Sprung, C.L.1    Annane, D.2    Keh, D.3
  • 3
    • 84898714406 scopus 로고    scopus 로고
    • Ntravenous immunoglobulin for treating sepsis, severe sepsis and septic shock
    • 3rd, CD001090
    • Alejandria MM, Lansang MA, Dans LF, et al. 3rd. Intravenous immunoglobulin for treating sepsis, severe sepsis and septic shock. Cochrane Database Syst Rev 2013; 9: CD001090.
    • (2013) Cochrane Database Syst Rev , vol.9
    • Alejandria, M.M.1    Lansang, M.A.2    Dans, L.F.3
  • 4
    • 0034607323 scopus 로고    scopus 로고
    • E5 murine monoclonal antiendotoxin antibody in gramnegative sepsis: A randomized controlled trial
    • Angus DC, Birmingham MC, Balk RA, et al. E5 murine monoclonal antiendotoxin antibody in gramnegative sepsis: a randomized controlled trial. JAMA 2000; 283: 1723–1730.
    • (2000) JAMA , vol.283 , pp. 1723-1730
    • Angus, D.C.1    Birmingham, M.C.2    Balk, R.A.3
  • 5
    • 84868206959 scopus 로고    scopus 로고
    • Activated protein C and septic shock: A propensity-matched cohort study
    • Rimmer E, Kumar A, Doucette S, et al. Activated protein C and septic shock: a propensity-matched cohort study. Crit Care Med 2012; 40: 2974–2981.
    • (2012) Crit Care Med , vol.40 , pp. 2974-2981
    • Rimmer, E.1    Kumar, A.2    Doucette, S.3
  • 7
    • 33846191028 scopus 로고    scopus 로고
    • Influence of sex and age on mods and cytokines after multiple injuries
    • Frink M, Pape HC, van Griensven M, et al. Influence of sex and age on mods and cytokines after multiple injuries. Shock 2007; 27: 151–156.
    • (2007) Shock , vol.27 , pp. 151-156
    • Frink, M.1    Pape, H.C.2    Van Griensven, M.3
  • 8
    • 84875064772 scopus 로고    scopus 로고
    • The influence of gender on the epidemiology of and outcome from severe sepsis
    • Sakr Y, Elia C, Mascia L, et al. The influence of gender on the epidemiology of and outcome from severe sepsis. Crit Care 2013; 17: R50.
    • (2013) Crit Care , vol.17 , pp. R50
    • Sakr, Y.1    Elia, C.2    Mascia, L.3
  • 9
    • 77953860883 scopus 로고    scopus 로고
    • Infection rate and acute organ dysfunction risk as explanations for racial differences in severe sepsis
    • Mayr FB, Yende S, Linde-Zwirble WT, et al. Infection rate and acute organ dysfunction risk as explanations for racial differences in severe sepsis. JAMA 2010; 303: 2495–2503.
    • (2010) JAMA , vol.303 , pp. 2495-2503
    • Mayr, F.B.1    Yende, S.2    Linde-Zwirble, W.T.3
  • 10
    • 61949155082 scopus 로고    scopus 로고
    • The immune system and chronic heart failure: Is the heart in control?
    • Fildes JE, Shaw SM, Yonan N, et al. The immune system and chronic heart failure: is the heart in control? J Am Coll Cardiol 2009; 53: 1013–1020.
    • (2009) J am Coll Cardiol , vol.53 , pp. 1013-1020
    • Fildes, J.E.1    Shaw, S.M.2    Yonan, N.3
  • 11
    • 79953151458 scopus 로고    scopus 로고
    • Cancer immunoediting: Integrating immunity’s roles in cancer suppression and promotion
    • Schreiber RD, Old LJ, and Smyth MJ. Cancer immunoediting: integrating immunity’s roles in cancer suppression and promotion. Science 2011; 331: 1565–1570.
    • (2011) Science , vol.331 , pp. 1565-1570
    • Schreiber, R.D.1    Old, L.J.2    Smyth, M.J.3
  • 12
    • 77954595517 scopus 로고    scopus 로고
    • Mechanisms of action and clinical application of macrolides as immunomodulatory medications
    • Kanoh S, and Rubin BK. Mechanisms of action and clinical application of macrolides as immunomodulatory medications. Clin Microbiol Rev 2010; 23: 590–615.
    • (2010) Clin Microbiol Rev , vol.23 , pp. 590-615
    • Kanoh, S.1    Rubin, B.K.2
  • 13
    • 84880543846 scopus 로고    scopus 로고
    • Bactericidal antibiotics induce mitochondrial dysfunction and oxidative damage in mammalian cells
    • 192ra85
    • Kalghatgi S, Spina CS, Costello JC, et al. Bactericidal antibiotics induce mitochondrial dysfunction and oxidative damage in mammalian cells. Sci Transl Med 2013; 5: 192ra85.
    • (2013) Sci Transl Med , vol.5
    • Kalghatgi, S.1    Spina, C.S.2    Costello, J.C.3
  • 14
    • 0031660457 scopus 로고    scopus 로고
    • Propofol inhibits human neutrophil functions
    • Mikawa K, Akamatsu H, Nishina K, et al. Propofol inhibits human neutrophil functions. Anesth Analg 1998; 87: 695–700.
    • (1998) Anesth Analg , vol.87 , pp. 695-700
    • Mikawa, K.1    Akamatsu, H.2    Nishina, K.3
  • 15
    • 0027258466 scopus 로고
    • Thymocyte apoptosis induced by p53-dependent and independent pathways
    • Clarke AR, Purdie CA, Harrison DJ, et al. Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature 1993; 362: 849–852.
    • (1993) Nature , vol.362 , pp. 849-852
    • Clarke, A.R.1    Purdie, C.A.2    Harrison, D.J.3
  • 16
    • 84873714375 scopus 로고    scopus 로고
    • Surviving sepsis campaign: International guidelines for management of severe sepsis and septic shock, 2012
    • Dellinger RP, Levy MM, Rhodes A, et al. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Med 2013; 39: 165–228.
    • (2013) Intensive Care Med , vol.39 , pp. 165-228
    • Dellinger, R.P.1    Levy, M.M.2    Rhodes, A.3
  • 17
    • 84991219331 scopus 로고    scopus 로고
    • Uncontrolled sepsis: A systematic review of translational immunology studies in intensive care medicine
    • Cain D, Gutierrez del Arroyo A, and Ackland G. Uncontrolled sepsis: a systematic review of translational immunology studies in intensive care medicine. Intensive Care Med Experimental 2013; 2: 1–25.
    • (2013) Intensive Care Med Experimental , vol.2 , pp. 1-25
    • Cain, D.1    Gutierrez Del Arroyo, A.2    Ackland, G.3
  • 18
    • 84878434234 scopus 로고    scopus 로고
    • Multiplex PCR system for rapid detection of pathogens in patients with presumed sepsis-a systemic review and meta-analysis
    • Chang SS, Hsieh WH, Liu TS, et al. Multiplex PCR system for rapid detection of pathogens in patients with presumed sepsis-a systemic review and meta-analysis. PLos One 2013; 8: e62323.
    • (2013) Plos One , vol.8
    • Chang, S.S.1    Hsieh, W.H.2    Liu, T.S.3
  • 19
    • 80052626087 scopus 로고    scopus 로고
    • The NLRP3 inflammasome in health and disease: The good, the bad and the ugly
    • Menu P, and Vince JE. The NLRP3 inflammasome in health and disease: the good, the bad and the ugly. Clin Exp Immunol 2011; 166: 1–15.
    • (2011) Clin Exp Immunol , vol.166 , pp. 1-15
    • Menu, P.1    Vince, J.E.2
  • 20
    • 84877757139 scopus 로고    scopus 로고
    • Staphylococcus aureus hemolysins, bi-component leukocidins, and cytolytic peptides: A redundant arsenal of membranedamaging virulence factors?
    • Vandenesch F, Lina G, and Henry T. Staphylococcus aureus hemolysins, bi-component leukocidins, and cytolytic peptides: a redundant arsenal of membranedamaging virulence factors? Front Cell Infect Microbiol 2012; 2: 12.
    • (2012) Front Cell Infect Microbiol , vol.2 , pp. 12
    • Vandenesch, F.1    Lina, G.2    Henry, T.3
  • 21
    • 60849114014 scopus 로고    scopus 로고
    • Compensated anti-inflammatory response syndrome
    • Adib-Conquy M, and Cavaillon J-M. Compensated anti-inflammatory response syndrome. Thromb Haemost 2009; 101: 36–47.
    • (2009) Thromb Haemost , vol.101 , pp. 36-47
    • Adib-Conquy, M.1    Cavaillon, J.-M.2
  • 22
    • 84874457770 scopus 로고    scopus 로고
    • Genomic responses in mouse models poorly mimic human inflammatory diseases
    • Seok J, Warren HS, Cuenca AG, et al. Genomic responses in mouse models poorly mimic human inflammatory diseases. Proc Natl Acad Sci USA 2013; 110: 3507–3512.
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 3507-3512
    • Seok, J.1    Warren, H.S.2    Cuenca, A.G.3
  • 23
    • 84862908403 scopus 로고    scopus 로고
    • A genomic storm in critically injured humans
    • Xiao W, Mindrinos MN, Seok J, et al. A genomic storm in critically injured humans. J Exp Med 2011; 208: 2581–2590.
    • (2011) J Exp Med , vol.208 , pp. 2581-2590
    • Xiao, W.1    Mindrinos, M.N.2    Seok, J.3
  • 24
    • 11844267259 scopus 로고    scopus 로고
    • Genetic determinants influencing the response to injury, inflammation, and sepsis
    • De Maio A, Torres MB, and Reeves RH. Genetic determinants influencing the response to injury, inflammation, and sepsis. Shock 2005; 23: 11–17.
    • (2005) Shock , vol.23 , pp. 11-17
    • De Maio, A.1    Torres, M.B.2    Reeves, R.H.3
  • 25
    • 0036781691 scopus 로고    scopus 로고
    • Genetic contribution to the septic response in a mouse model
    • Stewart D, Fulton WB, Wilson C, et al. Genetic contribution to the septic response in a mouse model. Shock 2002; 18: 342–347.
    • (2002) Shock , vol.18 , pp. 342-347
    • Stewart, D.1    Fulton, W.B.2    Wilson, C.3
  • 26
    • 84903637029 scopus 로고    scopus 로고
    • A mouse is not a rat is not a man: Species-specific metabolic responses to sepsis–a nail in the coffin of murine models for critical care research?
    • Radermacher P, and Haouzi P. A mouse is not a rat is not a man: species-specific metabolic responses to sepsis–a nail in the coffin of murine models for critical care research? Intensive Care Med Experimental 2013; 1: 7.
    • (2013) Intensive Care Med Experimental , vol.1 , pp. 7
    • Radermacher, P.1    Haouzi, P.2
  • 28
    • 0036854372 scopus 로고    scopus 로고
    • Analysis of 16S libraries of mouse gastrointestinal microflora reveals a large new group of mouse intestinal bacteria
    • Salzman NH, de Jong H, Paterson Y, et al. Analysis of 16S libraries of mouse gastrointestinal microflora reveals a large new group of mouse intestinal bacteria. Microbiology 2002; 148: 3651–3660.
    • (2002) Microbiology , vol.148 , pp. 3651-3660
    • Salzman, N.H.1    De Jong, H.2    Paterson, Y.3
  • 29
    • 0036679732 scopus 로고    scopus 로고
    • Of mice and men: Species variations of Tolllike receptor expression
    • Rehli M. Of mice and men: species variations of Tolllike receptor expression. Trends Immunol 2002; 23: 375–378.
    • (2002) Trends Immunol , vol.23 , pp. 375-378
    • Rehli, M.1
  • 30
    • 0042123694 scopus 로고    scopus 로고
    • Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells
    • Lund J, Sato A, Akira S, et al. Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells. J Exp Med 2003; 198: 513–520.
    • (2003) J Exp Med , vol.198 , pp. 513-520
    • Lund, J.1    Sato, A.2    Akira, S.3
  • 31
    • 0033664277 scopus 로고    scopus 로고
    • Leukocyte antimicrobial peptides: Multifunctional effect or molecules of innate immunity
    • Risso A. Leukocyte antimicrobial peptides: multifunctional effect or molecules of innate immunity. J Leukoc Biol 2000; 68: 785–792.
    • (2000) J Leukoc Biol , vol.68 , pp. 785-792
    • Risso, A.1
  • 32
    • 69449107598 scopus 로고    scopus 로고
    • Editorial: Mouse models to study sepsis syndrome in humans
    • Warren HS. Editorial: mouse models to study sepsis syndrome in humans. J Leukoc Biol 2009; 86: 199–201.
    • (2009) J Leukoc Biol , vol.86 , pp. 199-201
    • Warren, H.S.1
  • 33
    • 1342277259 scopus 로고    scopus 로고
    • Gender dimorphism in differential peripheral blood leukocyte counts in mice using cardiac, tail, foot, and saphenous vein puncture methods
    • Doeing DC, Borowicz JL, and Crockett ET. Gender dimorphism in differential peripheral blood leukocyte counts in mice using cardiac, tail, foot, and saphenous vein puncture methods. BMC Clin Pathol 2003; 3: 3.
    • (2003) BMC Clin Pathol , vol.3 , pp. 3
    • Doeing, D.C.1    Borowicz, J.L.2    Crockett, E.T.3
  • 34
    • 27944505611 scopus 로고    scopus 로고
    • Humanized mice: are we there yet?
    • Macchiarini F, Manz MG, Palucka AK, et al. Humanized mice: are we there yet? J Exp Med 2005; 202: 1307–1311.
    • (2005) J Exp Med , vol.202 , pp. 1307-1311
    • Macchiarini, F.1    Manz, M.G.2    Palucka, A.K.3
  • 35
    • 33846630040 scopus 로고    scopus 로고
    • Humanized mice in translational biomedical research
    • Shultz LD, Ishikawa F, and Greiner DL. Humanized mice in translational biomedical research. Nat Rev Immunol 2007; 7: 118–130.
    • (2007) Nat Rev Immunol , vol.7 , pp. 118-130
    • Shultz, L.D.1    Ishikawa, F.2    Greiner, D.L.3
  • 36
    • 0037451929 scopus 로고    scopus 로고
    • The epidemiology of sepsis in the United States from 1979 through 2000
    • Martin GS, Mannino DM, Eaton S, et al. The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med 2003; 348: 1546–1554.
    • (2003) N Engl J Med , vol.348 , pp. 1546-1554
    • Martin, G.S.1    Mannino, D.M.2    Eaton, S.3
  • 37
    • 4043128084 scopus 로고    scopus 로고
    • Multiorgan failure is an adaptive, endocrine-mediated, metabolic response to overwhelming systemic inflammation
    • Singer M, De Santis V, Vitale D, et al. Multiorgan failure is an adaptive, endocrine-mediated, metabolic response to overwhelming systemic inflammation. Lancet 2004; 364: 545–548.
    • (2004) Lancet , vol.364 , pp. 545-548
    • Singer, M.1    De Santis, V.2    Vitale, D.3
  • 38
    • 22144445679 scopus 로고    scopus 로고
    • Treating critical illness: The importance of first doing no harm
    • Singer M, and Glynne P. Treating critical illness: the importance of first doing no harm. PLoS Med 2005; 2: e167.
    • (2005) Plos Med , vol.2
    • Singer, M.1    Glynne, P.2
  • 39
    • 52449098209 scopus 로고    scopus 로고
    • Human endotoxemia as a model of systemic inflammation
    • Andreasen AS, Krabbe KS, Krogh-Madsen R, et al. Human endotoxemia as a model of systemic inflammation. Curr Med Chem 2008; 15: 1697–1705.
    • (2008) Curr Med Chem , vol.15 , pp. 1697-1705
    • Andreasen, A.S.1    Krabbe, K.S.2    Krogh-Madsen, R.3
  • 40
    • 0035100672 scopus 로고    scopus 로고
    • Ageing is associated with a prolonged fever response in human endotoxemia
    • Krabbe KS, Bruunsgaard H, Hansen CM, et al. Ageing is associated with a prolonged fever response in human endotoxemia. Clin Diagn Lab Immunol 2001; 8: 333–338.
    • (2001) Clin Diagn Lab Immunol , vol.8 , pp. 333-338
    • Krabbe, K.S.1    Bruunsgaard, H.2    Hansen, C.M.3
  • 41
    • 0026575846 scopus 로고
    • Cytokine serum level during severe sepsis in human IL-6 as a marker of severity
    • Damas P, Ledoux D, Nys M, et al. Cytokine serum level during severe sepsis in human IL-6 as a marker of severity. Ann Surg 1992; 215: 356–362.
    • (1992) Ann Surg , vol.215 , pp. 356-362
    • Damas, P.1    Ledoux, D.2    Nys, M.3
  • 42
    • 84880866675 scopus 로고    scopus 로고
    • A trial of intraoperative low-tidal-volume ventilation in abdominal surgery
    • Futier E, Constantin JM, Paugam-Burtz C, et al. A trial of intraoperative low-tidal-volume ventilation in abdominal surgery. N Engl J Med 2013; 369: 428–437.
    • (2013) N Engl J Med , vol.369 , pp. 428-437
    • Futier, E.1    Constantin, J.M.2    Paugam-Burtz, C.3
  • 43
    • 0033801728 scopus 로고    scopus 로고
    • Mechanical ventilation in acute lung injury and acute respiratory distress syndrome
    • viii
    • Brower RG, and Fessler HE. Mechanical ventilation in acute lung injury and acute respiratory distress syndrome. Clin Chest Med 2000; 21: 491–510, viii.
    • (2000) Clin Chest Med , vol.21 , pp. 491-510
    • Brower, R.G.1    Fessler, H.E.2
  • 44
    • 84868282970 scopus 로고    scopus 로고
    • Chronic medical conditions and risk of sepsis
    • Wang HE, Shapiro NI, Griffin R, et al. Chronic medical conditions and risk of sepsis. PLoS One 2012; 7: e48307.
    • (2012) Plos One , vol.7
    • Wang, H.E.1    Shapiro, N.I.2    Griffin, R.3
  • 45
    • 46749131798 scopus 로고    scopus 로고
    • An estimation of the global volume of surgery: A modelling strategy based on available data
    • Weiser TG, Regenbogen SE, Thompson KD, et al. An estimation of the global volume of surgery: a modelling strategy based on available data. Lancet 2008; 372: 139–144.
    • (2008) Lancet , vol.372 , pp. 139-144
    • Weiser, T.G.1    Regenbogen, S.E.2    Thompson, K.D.3
  • 46
    • 34447630814 scopus 로고    scopus 로고
    • Identification and characterisation of the high-risk surgical population in the United Kingdom
    • Pearse RM, Harrison DA, James P, et al. Identification and characterisation of the high-risk surgical population in the United Kingdom. Crit Care 2006; 10: R81.
    • (2006) Crit Care , vol.10 , pp. R81
    • Pearse, R.M.1    Harrison, D.A.2    James, P.3
  • 47
    • 0342905428 scopus 로고    scopus 로고
    • Supplemental perioperative oxygen to reduce the incidence of surgicalwound infection
    • Greif R, Akca O, Horn EP, et al. Supplemental perioperative oxygen to reduce the incidence of surgicalwound infection. N Engl J Med 2000; 342: 161–167.
    • (2000) N Engl J Med , vol.342 , pp. 161-167
    • Greif, R.1    Akca, O.2    Horn, E.P.3
  • 48
    • 27544468231 scopus 로고    scopus 로고
    • Garcia de la Asuncion J, et al. Supplemental perioperative oxygen and the risk of surgical wound infection: A randomized controlled trial
    • Belda FJ, Aguilera L, Garcia de la Asuncion J, et al. Supplemental perioperative oxygen and the risk of surgical wound infection: a randomized controlled trial. JAMA 2005; 294: 2035–2042.
    • (2005) JAMA , vol.294 , pp. 2035-2042
    • Belda, F.J.1    Aguilera, L.2
  • 49
    • 0035883865 scopus 로고    scopus 로고
    • Effects of preoperative warming on the incidence of wound infection after clean surgery: A randomised controlled trial
    • Melling AC, Ali B, Scott EM, et al. Effects of preoperative warming on the incidence of wound infection after clean surgery: a randomised controlled trial. Lancet 2001; 358: 876–880.
    • (2001) Lancet , vol.358 , pp. 876-880
    • Melling, A.C.1    Ali, B.2    Scott, E.M.3
  • 51
    • 0021331815 scopus 로고
    • Clinical significance of preoperative nutritional status in 215 noncancer patients
    • Warnold I, and Lundholm K. Clinical significance of preoperative nutritional status in 215 noncancer patients. Ann Surg 1984; 199: 299–305.
    • (1984) Ann Surg , vol.199 , pp. 299-305
    • Warnold, I.1    Lundholm, K.2
  • 52
    • 0023840810 scopus 로고
    • Weight loss with physiologic impairment. A basic indicator of surgical risk
    • Windsor JA, and Hill GL. Weight loss with physiologic impairment. A basic indicator of surgical risk. Ann Surg 1988; 207: 290–296.
    • (1988) Ann Surg , vol.207 , pp. 290-296
    • Windsor, J.A.1    Hill, G.L.2
  • 53
    • 0026064270 scopus 로고
    • POSSUM: A scoring system for surgical audit
    • Copeland GP, Jones D, and Walters M. POSSUM: a scoring system for surgical audit. Br J Surg 1991; 78: 355–360.
    • (1991) Br J Surg , vol.78 , pp. 355-360
    • Copeland, G.P.1    Jones, D.2    Walters, M.3
  • 54
    • 84872176244 scopus 로고    scopus 로고
    • Key factors associated with postoperative complications in patients undergoing colorectal surgery
    • Manilich E, Vogel JD, Kiran RP, et al. Key factors associated with postoperative complications in patients undergoing colorectal surgery. Dis Colon Rectum 2013; 56: 64–71.
    • (2013) Dis Colon Rectum , vol.56 , pp. 64-71
    • Manilich, E.1    Vogel, J.D.2    Kiran, R.P.3
  • 55
    • 84888869565 scopus 로고    scopus 로고
    • Development and validation of a risk calculator for predicting postoperative pneumonia
    • Gupta H, Gupta PK, Schuller D, et al. Development and validation of a risk calculator for predicting postoperative pneumonia. Mayo Clinic Proc 2013; 88: 1241–1249.
    • (2013) Mayo Clinic Proc , vol.88 , pp. 1241-1249
    • Gupta, H.1    Gupta, P.K.2    Schuller, D.3
  • 56
    • 77950803946 scopus 로고    scopus 로고
    • Temporal trends in the epidemiology of severe postoperative sepsis after elective surgery: A large, nationwide sample
    • Bateman BT, Schmidt U, Berman MF, et al. Temporal trends in the epidemiology of severe postoperative sepsis after elective surgery: a large, nationwide sample. Anesthesiology 2010; 112: 917–925.
    • (2010) Anesthesiology , vol.112 , pp. 917-925
    • Bateman, B.T.1    Schmidt, U.2    Berman, M.F.3
  • 57
    • 0033533455 scopus 로고    scopus 로고
    • Derivation and prospective validation of a simple index for prediction of cardiac risk of major noncardiac surgery
    • Lee TH, Marcantonio ER, Mangione CM, et al. Derivation and prospective validation of a simple index for prediction of cardiac risk of major noncardiac surgery. Circulation 1999; 100: 1043–1049.
    • (1999) Circulation , vol.100 , pp. 1043-1049
    • Lee, T.H.1    Marcantonio, E.R.2    Mangione, C.M.3
  • 58
    • 0034958947 scopus 로고    scopus 로고
    • Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care
    • Angus DC, Linde-Zwirble WT, Lidicker J, et al. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med 2001; 29: 1303–1310.
    • (2001) Crit Care Med , vol.29 , pp. 1303-1310
    • Angus, D.C.1    Linde-Zwirble, W.T.2    Lidicker, J.3
  • 59
    • 0038203458 scopus 로고    scopus 로고
    • Treatment algorithms and protocolized care
    • Morris AH. Treatment algorithms and protocolized care. Curr Opin Crit Care 2003; 9: 236–240.
    • (2003) Curr Opin Crit Care , vol.9 , pp. 236-240
    • Morris, A.H.1
  • 60
    • 77951439148 scopus 로고    scopus 로고
    • Cardiopulmonary exercise testing: Current applications
    • Stringer WW. Cardiopulmonary exercise testing: current applications. Expert Rev Resp Med 2010; 4: 179–188.
    • (2010) Expert Rev Resp Med , vol.4 , pp. 179-188
    • Stringer, W.W.1
  • 61
    • 80052079321 scopus 로고    scopus 로고
    • Post-operative infection and sepsis in humans is associated with deficient gene expression of gammac cytokines and their apoptosis mediators
    • White M, Mahon V, Grealy R, et al. Post-operative infection and sepsis in humans is associated with deficient gene expression of gammac cytokines and their apoptosis mediators. Crit Care 2011; 15: R158.
    • (2011) Crit Care , vol.15 , pp. R158
    • White, M.1    Mahon, V.2    Grealy, R.3
  • 62
    • 0037298913 scopus 로고    scopus 로고
    • Effects of preoperative oral carbohydrates and peptides on postoperative endocrine response, mobilization, nutrition and muscle function in abdominal surgery
    • Henriksen MG, Hessov I, Dela F, et al. Effects of preoperative oral carbohydrates and peptides on postoperative endocrine response, mobilization, nutrition and muscle function in abdominal surgery. Acta Anaesthesiol Scand 2003; 47: 191–199.
    • (2003) Acta Anaesthesiol Scand , vol.47 , pp. 191-199
    • Henriksen, M.G.1    Hessov, I.2    Dela, F.3
  • 63
    • 43949090489 scopus 로고    scopus 로고
    • Continuous follow-up of surgical site infections for 30 days after colorectal surgery
    • Kobayashi M, Mohri Y, Inoue Y, et al. Continuous follow-up of surgical site infections for 30 days after colorectal surgery. World J Surg 2008; 32: 1142–1146.
    • (2008) World J Surg , vol.32 , pp. 1142-1146
    • Kobayashi, M.1    Mohri, Y.2    Inoue, Y.3
  • 64
    • 0037142987 scopus 로고    scopus 로고
    • Association between mitochondrial dysfunction and severity and outcome of septic shock
    • Brealey D, Brand M, Hargreaves I, et al. Association between mitochondrial dysfunction and severity and outcome of septic shock. Lancet 2002; 360: 219–223.
    • (2002) Lancet , vol.360 , pp. 219-223
    • Brealey, D.1    Brand, M.2    Hargreaves, I.3
  • 65
    • 0025815020 scopus 로고
    • Gut bacterial translocation via the portal vein: A clinical perspective with major torso trauma
    • Moore FA, Moore EE, Poggetti R, et al. Gut bacterial translocation via the portal vein: a clinical perspective with major torso trauma. J Trauma 1991; 31: 629–636.
    • (1991) J Trauma , vol.31 , pp. 629-636
    • Moore, F.A.1    Moore, E.E.2    Poggetti, R.3
  • 66
    • 84884494611 scopus 로고    scopus 로고
    • Value of early cardiovascular magnetic resonance for the prediction of adverse arrhythmic cardiac events after a first noncomplicated ST-segment-elevation myocardial infarction
    • Izquierdo M, Ruiz-Granell R, Bonanad C, et al. Value of early cardiovascular magnetic resonance for the prediction of adverse arrhythmic cardiac events after a first noncomplicated ST-segment-elevation myocardial infarction. Circ Cardiovasc Imaging 2013; 6: 755–761.
    • (2013) Circ Cardiovasc Imaging , vol.6 , pp. 755-761
    • Izquierdo, M.1    Ruiz-Granell, R.2    Bonanad, C.3
  • 67
    • 63849298512 scopus 로고    scopus 로고
    • Simultaneous electroencephalography and functional magnetic resonance imaging of general anesthesia
    • Purdon PL, Pierce ET, Bonmassar G, et al. Simultaneous electroencephalography and functional magnetic resonance imaging of general anesthesia. Ann New York Acad Sci 2009; 1157: 61–70.
    • (2009) Ann New York Acad Sci , vol.1157 , pp. 61-70
    • Purdon, P.L.1    Pierce, E.T.2    Bonmassar, G.3
  • 68
    • 77950275298 scopus 로고    scopus 로고
    • Circulating mitochondrial DAMPs cause inflammatory responses to injury
    • Zhang Q, Raoof M, Chen Y, et al. Circulating mitochondrial DAMPs cause inflammatory responses to injury. Nature 2010; 464: 104–107.
    • (2010) Nature , vol.464 , pp. 104-107
    • Zhang, Q.1    Raoof, M.2    Chen, Y.3
  • 69
    • 84884502884 scopus 로고    scopus 로고
    • Elevated levels of plasma mitochondrial DNA DAMPs are linked to clinical outcome in severely injured human subjects
    • Simmons JD, Lee YL, Mulekar S, et al. Elevated levels of plasma mitochondrial DNA DAMPs are linked to clinical outcome in severely injured human subjects. Ann Surg 2013; 258: 591–596.
    • (2013) Ann Surg , vol.258 , pp. 591-596
    • Simmons, J.D.1    Lee, Y.L.2    Mulekar, S.3
  • 70
    • 0017371350 scopus 로고
    • Dependence of mitochondrial protein synthesis initiation on formylation of the initiator methionyl-tRNAf
    • Bianchetti R, Lucchini G, Crosti P, et al. Dependence of mitochondrial protein synthesis initiation on formylation of the initiator methionyl-tRNAf. J Biol Chem 1977; 252: 2519–2523.
    • (1977) J Biol Chem , vol.252 , pp. 2519-2523
    • Bianchetti, R.1    Lucchini, G.2    Crosti, P.3
  • 71
    • 0033060854 scopus 로고    scopus 로고
    • The mitochondrial genome: Structure, transcription, translation and replication
    • Taanman JW. The mitochondrial genome: structure, transcription, translation and replication. Biochim Biophys Acta 1999; 1410: 103–123.
    • (1999) Biochim Biophys Acta , vol.1410 , pp. 103-123
    • Taanman, J.W.1
  • 72
    • 0033635734 scopus 로고    scopus 로고
    • Effects of mechanical ventilation on release of cytokines into systemic circulation in patients with normal pulmonary function
    • Wrigge H, Zinserling J, Stuber F, et al. Effects of mechanical ventilation on release of cytokines into systemic circulation in patients with normal pulmonary function. Anesthesiology 2000; 93: 1413–1417.
    • (2000) Anesthesiology , vol.93 , pp. 1413-1417
    • Wrigge, H.1    Zinserling, J.2    Stuber, F.3
  • 73
    • 84896539869 scopus 로고    scopus 로고
    • The beta agonist lung injury trial prevention. A randomized controlled trial
    • Perkins GD, Gates S, Park D, et al. The beta agonist lung injury trial prevention. A randomized controlled trial. Am J Respir Crit Care Med 2014; 189: 674–683.
    • (2014) Am J Respir Crit Care Med , vol.189 , pp. 674-683
    • Perkins, G.D.1    Gates, S.2    Park, D.3
  • 74
    • 84891623672 scopus 로고    scopus 로고
    • Effect of simvastatin on physiological and biological outcomes in patients undergoing esophagectomy: A randomized placebo-controlled trial
    • Shyamsundar M, McAuley DF, Shields MO, et al. Effect of simvastatin on physiological and biological outcomes in patients undergoing esophagectomy: a randomized placebo-controlled trial. Ann Surg 2014; 259: 26–31.
    • (2014) Ann Surg , vol.259 , pp. 26-31
    • Shyamsundar, M.1    McAuley, D.F.2    Shields, M.O.3
  • 75
    • 84908434411 scopus 로고    scopus 로고
    • Simvastatin in the acute respiratory distress syndrome
    • McAuley DF, Laffey JG, O’Kane CM, et al. Simvastatin in the acute respiratory distress syndrome. N Engl J Med 2014; 371: 1695–1703.
    • (2014) N Engl J Med , vol.371 , pp. 1695-1703
    • McAuley, D.F.1    Laffey, J.G.2    O’Kane, C.M.3
  • 76
    • 0026774316 scopus 로고
    • Endotoxin after gut ischemia/reperfusion causes irreversible lung injury
    • Koike K, Moore FA, Moore EE, et al. Endotoxin after gut ischemia/reperfusion causes irreversible lung injury. J Surg Res 1992; 52: 656–662.
    • (1992) J Surg Res , vol.52 , pp. 656-662
    • Koike, K.1    Moore, F.A.2    Moore, E.E.3
  • 77
    • 0031924889 scopus 로고    scopus 로고
    • Neutrophil priming: Pathophysiological consequences and underlying mechanisms
    • Condliffe AM, Kitchen E, and Chilvers ER. Neutrophil priming: pathophysiological consequences and underlying mechanisms. Clin Sci 1998; 94: 461–471.
    • (1998) Clin Sci , vol.94 , pp. 461-471
    • Condliffe, A.M.1    Kitchen, E.2    Chilvers, E.R.3
  • 78
    • 33646756907 scopus 로고    scopus 로고
    • The twoevent construct of postinjury multiple organ failure
    • Moore EE, Moore FA, Harken AH, et al. The twoevent construct of postinjury multiple organ failure. Shock 2005; 24 Suppl 1: 71–74.
    • Shock 2005; 24 Suppl , vol.1 , pp. 71-74
    • Moore, E.E.1    Moore, F.A.2    Harken, A.H.3
  • 80
    • 0036900535 scopus 로고    scopus 로고
    • Shock-induced neutrophil mediated priming for acute lung injury in mice: divergent effects of TLR-4 and TLR-4/FasL deficiency
    • Ayala A, Chung CS, Lomas JL, et al. Shock-induced neutrophil mediated priming for acute lung injury in mice: divergent effects of TLR-4 and TLR-4/FasL deficiency. Am J Pathol 2002; 161: 2283–2294.
    • (2002) Am J Pathol , vol.161 , pp. 2283-2294
    • Ayala, A.1    Chung, C.S.2    Lomas, J.L.3
  • 81
    • 80555126061 scopus 로고    scopus 로고
    • Hemorrhagic shock activation of NLRP3 inflammasome in lung endothelial cells
    • Xiang M, Shi X, Li Y, et al. Hemorrhagic shock activation of NLRP3 inflammasome in lung endothelial cells. J Immunol 2011; 187: 4809–4817.
    • (2011) J Immunol , vol.187 , pp. 4809-4817
    • Xiang, M.1    Shi, X.2    Li, Y.3
  • 82
    • 59449109025 scopus 로고    scopus 로고
    • Effect of major abdominal surgery on endotoxin release and expression of Toll-like receptors 2/4
    • Buttenschoen K, Schneider ME, Utz K, et al. Effect of major abdominal surgery on endotoxin release and expression of Toll-like receptors 2/4. Langenbecks Arch Surg 2009; 394: 293–302.
    • (2009) Langenbecks Arch Surg , vol.394 , pp. 293-302
    • Buttenschoen, K.1    Schneider, M.E.2    Utz, K.3
  • 83
    • 47849130092 scopus 로고    scopus 로고
    • Cytomegalovirus reactivation in critically ill immunocompetent patients
    • Limaye AP, Kirby KA, Rubenfeld GD, et al. Cytomegalovirus reactivation in critically ill immunocompetent patients. JAMA 2008; 300: 413–422.
    • (2008) JAMA , vol.300 , pp. 413-422
    • Limaye, A.P.1    Kirby, K.A.2    Rubenfeld, G.D.3
  • 84
    • 34247607201 scopus 로고    scopus 로고
    • Herpes simplex virus lung infection in patients undergoing prolonged mechanical ventilation
    • Luyt CE, Combes A, Deback C, et al. Herpes simplex virus lung infection in patients undergoing prolonged mechanical ventilation. Am J Respir Crit Care Med 2007; 175: 935–942.
    • (2007) Am J Respir Crit Care Med , vol.175 , pp. 935-942
    • Luyt, C.E.1    Combes, A.2    Deback, C.3
  • 85
    • 84893444279 scopus 로고    scopus 로고
    • Severe sepsis facilitates intestinal colonization by ESBL-producing klebsiella pneumoniae and transfer of the SHV-18 resistance gene to escherichia coli during antimicrobial treatment
    • Guan J, Liu S, Lin Z, et al. Severe sepsis facilitates intestinal colonization by ESBL-producing klebsiella pneumoniae and transfer of the SHV-18 resistance gene to escherichia coli during antimicrobial treatment. Antimicrob Agents Chemother 2014; 58: 1039–1046.
    • (2014) Antimicrob Agents Chemother , vol.58 , pp. 1039-1046
    • Guan, J.1    Liu, S.2    Lin, Z.3
  • 86
    • 0035338993 scopus 로고    scopus 로고
    • Sepsisinduced apoptosis causes progressive profound depletion of B and CD4� T lymphocytes in humans
    • Hotchkiss RS, Tinsley KW, Swanson PE, et al. Sepsisinduced apoptosis causes progressive profound depletion of B and CD4� T lymphocytes in humans. J Immunol 2001; 166: 6952–6963.
    • (2001) J Immunol , vol.166 , pp. 6952-6963
    • Hotchkiss, R.S.1    Tinsley, K.W.2    Swanson, P.E.3
  • 87
    • 29644441715 scopus 로고    scopus 로고
    • Enhanced regulatory T cell activity is an element of the host response to injury
    • Ni Choileain N, MacConmara M, Zang Y, et al. Enhanced regulatory T cell activity is an element of the host response to injury. J Immunol 2006; 176: 225–236.
    • (2006) J Immunol , vol.176 , pp. 225-236
    • Ni Choileain, N.1    Macconmara, M.2    Zang, Y.3
  • 88
    • 34250359119 scopus 로고    scopus 로고
    • MyD88-dependent expansion of an immature GR-1(�)CD11b(�) population induces T cell suppression and Th2 polarization in sepsis
    • Delano MJ, Scumpia PO, Weinstein JS, et al. MyD88-dependent expansion of an immature GR-1(�)CD11b(�) population induces T cell suppression and Th2 polarization in sepsis. J Exp Med 2007; 204: 1463–1474.
    • (2007) J Exp Med , vol.204 , pp. 1463-1474
    • Delano, M.J.1    Scumpia, P.O.2    Weinstein, J.S.3
  • 89
    • 77955894120 scopus 로고    scopus 로고
    • Preoperative hematologic markers as independent predictors of prognosis in resected pancreatic ductal adenocarcinoma: Neutrophil-lymphocyte versus platelet-lymphocyte ratio
    • Bhatti I, Peacock O, Lloyd G, et al. Preoperative hematologic markers as independent predictors of prognosis in resected pancreatic ductal adenocarcinoma: neutrophil-lymphocyte versus platelet-lymphocyte ratio. Am J Surg 2010; 200: 197–203.
    • (2010) Am J Surg , vol.200 , pp. 197-203
    • Bhatti, I.1    Peacock, O.2    Lloyd, G.3
  • 90
    • 79952183487 scopus 로고    scopus 로고
    • Preoperative neutrophil-to-lymphocyte ratio (NLR) is associated with reduced disease-free survival following curative resection of pancreatic adenocarcinoma
    • Garcea G, Ladwa N, Neal CP, et al. Preoperative neutrophil-to-lymphocyte ratio (NLR) is associated with reduced disease-free survival following curative resection of pancreatic adenocarcinoma. World J Surgery 2011; 35: 868–872.
    • (2011) World J Surgery , vol.35 , pp. 868-872
    • Garcea, G.1    Ladwa, N.2    Neal, C.P.3
  • 91
    • 79954491314 scopus 로고    scopus 로고
    • Neutrophil-lymphocyte ratio predicts medium-term survival following elective major vascular surgery: A cross-sectional study
    • Bhutta H, Agha R, Wong J, et al. Neutrophil-lymphocyte ratio predicts medium-term survival following elective major vascular surgery: a cross-sectional study. Vasc Endovasc Surg 2011; 45: 227–231.
    • (2011) Vasc Endovasc Surg , vol.45 , pp. 227-231
    • Bhutta, H.1    Agha, R.2    Wong, J.3
  • 92
    • 35448936082 scopus 로고    scopus 로고
    • Preoperative neutrophil-lymphocyte ratio and outcome from coronary artery bypass grafting
    • Gibson PH, Croal BL, Cuthbertson BH, et al. Preoperative neutrophil-lymphocyte ratio and outcome from coronary artery bypass grafting. Am Heart J 2007; 154: 995–1002.
    • (2007) Am Heart J , vol.154 , pp. 995-1002
    • Gibson, P.H.1    Croal, B.L.2    Cuthbertson, B.H.3
  • 93
    • 0016796644 scopus 로고
    • Host resistance in sepsis and trauma
    • MacLean LD, Meakins JL, Taguchi K, et al. Host resistance in sepsis and trauma. Ann Surg 1975; 182: 207–217.
    • (1975) Ann Surg , vol.182 , pp. 207-217
    • Maclean, L.D.1    Meakins, J.L.2    Taguchi, K.3
  • 94
    • 0017341656 scopus 로고
    • Microbial ecology of the gastrointestinal tract
    • Savage DC. Microbial ecology of the gastrointestinal tract. Ann Rev Microbiol 1977; 31: 107–133.
    • (1977) Ann Rev Microbiol , vol.31 , pp. 107-133
    • Savage, D.C.1
  • 95
    • 79957571511 scopus 로고    scopus 로고
    • The human microbiome and surgical disease
    • Morowitz MJ, Babrowski T, Carlisle EM, et al. The human microbiome and surgical disease. Ann Surg 2011; 253: 1094–1101.
    • (2011) Ann Surg , vol.253 , pp. 1094-1101
    • Morowitz, M.J.1    Babrowski, T.2    Carlisle, E.M.3
  • 96
    • 0033802740 scopus 로고    scopus 로고
    • Understanding gastrointestinal perfusion in critical care: So near, and yet so far
    • Ackland G, Grocott MP, and Mythen MG. Understanding gastrointestinal perfusion in critical care: so near, and yet so far. Crit Care 2000; 4: 269–281.
    • (2000) Crit Care , vol.4 , pp. 269-281
    • Ackland, G.1    Grocott, M.P.2    Mythen, M.G.3
  • 97
    • 0033814549 scopus 로고    scopus 로고
    • Gut-derived sepsis occurs when the right pathogen with the right virulence genes meets the right host: Evidence for in vivo virulence expression in Pseudomonas aeruginosa
    • Alverdy J, Holbrook C, Rocha F, et al. Gut-derived sepsis occurs when the right pathogen with the right virulence genes meets the right host: evidence for in vivo virulence expression in Pseudomonas aeruginosa. Ann Surg 2000; 232: 480–489.
    • (2000) Ann Surg , vol.232 , pp. 480-489
    • Alverdy, J.1    Holbrook, C.2    Rocha, F.3
  • 98
    • 3042785468 scopus 로고    scopus 로고
    • Diagnostic and prognostic implications of endotoxemia in critical illness: Results of the MEDIC study
    • Marshall JC, Foster D, Vincent JL, et al. Diagnostic and prognostic implications of endotoxemia in critical illness: results of the MEDIC study. J Infect Dis 2004; 190: 527–534.
    • (2004) J Infect Dis , vol.190 , pp. 527-534
    • Marshall, J.C.1    Foster, D.2    Vincent, J.L.3
  • 99
    • 0027489283 scopus 로고
    • Endotoxemia after major vascular operations
    • Roumen RM, Frieling JT, van Tits HW, et al. Endotoxemia after major vascular operations. J Vasc Surg 1993; 18: 853–857.
    • (1993) J Vasc Surg , vol.18 , pp. 853-857
    • Roumen, R.M.1    Frieling, J.T.2    Van Tits, H.W.3
  • 100
    • 0034974535 scopus 로고    scopus 로고
    • The impact of anti-endotoxin core antibodies on endotoxin and cytokine release and ventilation time after cardiac surgery
    • Rothenburger M, Soeparwata R, Deng MC, et al. The impact of anti-endotoxin core antibodies on endotoxin and cytokine release and ventilation time after cardiac surgery. J Am Coll Cardiol 2001; 38: 124–130.
    • (2001) J am Coll Cardiol , vol.38 , pp. 124-130
    • Rothenburger, M.1    Soeparwata, R.2    Deng, M.C.3
  • 101
    • 0034991739 scopus 로고    scopus 로고
    • Decreased endotoxin immunity is associated with greater mortality and/or prolonged hospitalization after surgery
    • Bennett-Guerrero E, Panah MH, Barclay GR, et al. Decreased endotoxin immunity is associated with greater mortality and/or prolonged hospitalization after surgery. Anesthesiology 2001; 94: 992–998.
    • (2001) Anesthesiology , vol.94 , pp. 992-998
    • Bennett-Guerrero, E.1    Panah, M.H.2    Barclay, G.R.3
  • 102
    • 67649219652 scopus 로고    scopus 로고
    • Early use of polymyxin B hemoperfusion in abdominal septic shock: The EUPHAS randomized controlled trial
    • Cruz DN, Antonelli M, Fumagalli R, et al. Early use of polymyxin B hemoperfusion in abdominal septic shock: the EUPHAS randomized controlled trial. JAMA 2009; 301: 2445–2452.
    • (2009) JAMA , vol.301 , pp. 2445-2452
    • Cruz, D.N.1    Antonelli, M.2    Fumagalli, R.3
  • 103
    • 84902545546 scopus 로고    scopus 로고
    • Association between the choice of IV crystalloid and in-hospital mortality among critically ill adults with sepsis
    • Raghunathan K, Shaw A, Nathanson B, et al. Association between the choice of IV crystalloid and in-hospital mortality among critically ill adults with sepsis. Crit Care Med 2014; 42: 1585–1591.
    • (2014) Crit Care Med , vol.42 , pp. 1585-1591
    • Raghunathan, K.1    Shaw, A.2    Nathanson, B.3
  • 104
    • 84899750488 scopus 로고    scopus 로고
    • A randomized trial of protocol-based care for early septic shock
    • Pro CESS Investigators Yealy DM, Kellum JA, et al. A randomized trial of protocol-based care for early septic shock. N Engl J Med 2014; 370: 1683–1693.
    • (2014) N Engl J Med , vol.370 , pp. 1683-1693
    • Yealy, D.M.1    Kellum, J.A.2
  • 105
    • 0026710191 scopus 로고
    • Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM consensus conference committee. American college of chest physicians/society of critical care medicine
    • Bone RC, Balk RA, Cerra FB, et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM consensus conference committee. American college of chest physicians/society of critical care medicine. Chest 1992; 101: 1644–1655.
    • (1992) Chest , vol.101 , pp. 1644-1655
    • Bone, R.C.1    Balk, R.A.2    Cerra, F.B.3
  • 106
    • 84898487262 scopus 로고    scopus 로고
    • Albumin replacement in patients with severe sepsis or septic shock
    • Caironi P, Tognoni G, Masson S, et al. Albumin replacement in patients with severe sepsis or septic shock. N Engl J Med 2014; 370: 1412–1421.
    • (2014) N Engl J Med , vol.370 , pp. 1412-1421
    • Caironi, P.1    Tognoni, G.2    Masson, S.3
  • 107
    • 84898820371 scopus 로고    scopus 로고
    • High versus low blood-pressure target in patients with septic shock
    • Asfar P, Meziani F, Hamel JF, et al. High versus low blood-pressure target in patients with septic shock. N Engl J Med 2014; 370: 1583–1593.
    • (2014) N Engl J Med , vol.370 , pp. 1583-1593
    • Asfar, P.1    Meziani, F.2    Hamel, J.F.3
  • 108
    • 84901497746 scopus 로고    scopus 로고
    • The interaction of vasopressin and corticosteroids in septic shock: A pilot randomized controlled trial
    • Gordon AC, Mason AJ, Perkins GD, et al. The interaction of vasopressin and corticosteroids in septic shock: a pilot randomized controlled trial. Crit Care Med 2014; 42: 1325–1333.
    • (2014) Crit Care Med , vol.42 , pp. 1325-1333
    • Gordon, A.C.1    Mason, A.J.2    Perkins, G.D.3
  • 109
    • 84894456331 scopus 로고    scopus 로고
    • Evaluating the efficacy and safety of two doses of the polyclonal antitumor necrosis factor-alpha fragment antibody AZD9773 in adult patients with severe sepsis and/or septic shock: Randomized, double-blind, placebo-controlled phase IIb study
    • Bernard GR, Francois B, Mira JP, et al. Evaluating the efficacy and safety of two doses of the polyclonal antitumor necrosis factor-alpha fragment antibody AZD9773 in adult patients with severe sepsis and/or septic shock: randomized, double-blind, placebo-controlled phase IIb study. Crit Care Med 2014; 42: 504–511.
    • (2014) Crit Care Med , vol.42 , pp. 504-511
    • Bernard, G.R.1    Francois, B.2    Mira, J.P.3
  • 110
    • 84886279115 scopus 로고    scopus 로고
    • Effect of heart rate control with esmolol on hemodynamic and clinical outcomes in patients with septic shock: A randomized clinical trial
    • Morelli A, Ertmer C, Westphal M, et al. Effect of heart rate control with esmolol on hemodynamic and clinical outcomes in patients with septic shock: a randomized clinical trial. JAMA 2013; 310: 1683–1691.
    • (2013) JAMA , vol.310 , pp. 1683-1691
    • Morelli, A.1    Ertmer, C.2    Westphal, M.3
  • 111
    • 33750312909 scopus 로고    scopus 로고
    • Emerging paradigm: Toll-like receptor 4-sentinel for the detection of tissue damage
    • Mollen KP, Anand RJ, Tsung A, et al. Emerging paradigm: toll-like receptor 4-sentinel for the detection of tissue damage. Shock 2006; 26: 430–437.
    • (2006) Shock , vol.26 , pp. 430-437
    • Mollen, K.P.1    Anand, R.J.2    Tsung, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.