Preoperative neutrophil-to-lymphocyte ratio (NLR) is associated with reduced disease-free survival following curative resection of pancreatic adenocarcinoma

World Journal of Surgery

Volumn 35, Issue 4, 2011, Pages 868-872

  Garcea, G ^a   Ladwa, N ^a   Neal, C P ^a   Metcalfe, M S ^a   Dennison, A R ^a   Berry, D P ^a  

^a LEICESTER GENERAL HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER;

ADENOCARCINOMA; ADULT; AGED; ARTICLE; BLOOD; DISEASE FREE SURVIVAL; FACTUAL DATABASE; FEMALE; HUMAN; KAPLAN MEIER METHOD; LYMPHOCYTE COUNT; MALE; METABOLISM; METHODOLOGY; MIDDLE AGED; MORTALITY; NEUTROPHIL; PANCREAS TUMOR; PANCREATICODUODENECTOMY; PATHOLOGY; PREDICTIVE VALUE; PREOPERATIVE CARE; PROGNOSIS; PROPORTIONAL HAZARDS MODEL; RETROSPECTIVE STUDY; SURVIVAL; TREATMENT OUTCOME; TUMOR RECURRENCE;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; DATABASES, FACTUAL; DISEASE-FREE SURVIVAL; FEMALE; HUMANS; KAPLAN-MEIER ESTIMATE; LYMPHOCYTE COUNT; MALE; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; NEUTROPHILS; PANCREATIC NEOPLASMS; PANCREATICODUODENECTOMY; PREDICTIVE VALUE OF TESTS; PREOPERATIVE CARE; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; RETROSPECTIVE STUDIES; SURVIVAL ANALYSIS; TREATMENT OUTCOME;

EID: 79952183487     PISSN: 03642313     EISSN: 14322323     Source Type: Journal    
DOI: 10.1007/s00268-011-0984-z     Document Type: Article

References (18)

1. F Balkwill A Mantovani 2001 Inflammation and cancer: back to Virchow Lancet 357 539 545 11229684 10.1016/S0140-6736(00)04046-0 1:CAS:528: DC%2BD3MXhsVKltb0%3D (Pubitemid 32173595)
2. CS Roxburgh DC McMillan 2010 Role of systemic inflammatory response in predicting survival in patients with primary operable cancer Future Oncol 6 149 163 20021215 10.2217/fon.09.136 1:CAS:528:DC%2BD1MXhsFyitL3P
3. DC McMillan 2009 Systemic inflammation, nutritional status and survival in patients with cancer Curr Opin Clin Nutr Metab Care 12 223 2236 19318937 10.1097/MCO.0b013e32832a7902
4. P Glen NB Jamieson DC McMillan, et al. 2006 Evaluation of an inflammation-based prognostic score in patients with inoperable pancreatic cancer Pancreatology 6 450 453 16847382 10.1159/000094562 (Pubitemid 44624278)
5. N Sakka RA Smith P Whelan, et al. 2009 A preoperative prognostic score for resected pancreatic and periampullary neuroendocrine tumours Pancreatology 9 670 676 19684431 10.1159/000181179
6. I Bhatti O Peacock G Lloyd 2010 Preoperative hematologic markers as independent predictors of prognosis in resected pancreatic ductal adenocarcinoma: neutrophil-lymphocyte versus platelet-lymphocyte ratio Am J Surg 200 197 203 20122680 10.1016/j.amjsurg.2009.08.041
7. RA Smith L Bosonnet M Raraty, et al. 2009 Preoperative platelet-lymphocyte ratio is an independent significant prognostic marker in resected pancreatic ductal adenocarcinoma Am J Surg 197 466 472 18639229 10.1016/j.amjsurg.2007.12.057
8. RA Smith P Ghaneh R Sutton, et al. 2008 Prognosis of resected ampullary adenocarcinoma by preoperative serum CA19-9 levels and platelet-lymphocyte ratio J Gastrointest Surg 12 1422 1428 18543046 10.1007/s11605-008-0554-3
9. NB Jamieson P Glen DC McMillan, et al. 2005 Systemic inflammatory response predicts outcome in patients undergoing resection for ductal adenocarcinoma head of pancreas Br J Cancer 92 21 23 15597096 10.1038/sj.bjc.6602305 1:STN:280:DC%2BD2M%2Fnt1SmsQ%3D%3D (Pubitemid 40188430)
10. RA Smith L Bosonnet P Ghaneh, et al. 2008 The platelet-lymphocyte ratio improves the predictive value of serum CA19-9 levels in determining patient selection for staging laparoscopy in suspected periampullary cancer Surgery 143 658 666 18436014 10.1016/j.surg.2007.12.014
11. SL Ong G Garcea SC Thomasset, et al. 2008 Surrogate markers of resectability in patients undergoing exploration of potentially resectable pancreatic adenocarcinoma J Gastrointest Surg 12 1068 1073 18043987 10.1007/s11605-007-0422-6 1:STN:280:DC%2BD1c3psVKrsw%3D%3D
12. JK Pine KG Fusai R Young, et al. 2009 Serum C-reactive protein concentration and the prognosis of ductal adenocarcinoma of the head of pancreas Eur J Surg Oncol 35 605 610 19128923 1:STN:280:DC%2BD1MzhsVCltQ%3D%3D
13. MW Müller H Friess J Köninger, et al. 2008 Factors influencing survival after bypass procedures in patients with advanced pancreatic adenocarcinomas Am J Surg 195 221 228 10.1016/j.amjsurg.2007.02.026
14. B Tingstedt P Johansson B Andersson, et al. 2007 Predictive factors in pancreatic ductal adenocarcinoma: role of the inflammatory response Scan J Gastroenterol 42 754 759 10.1080/00365520601058452 1:CAS:528: DC%2BD2sXlt1CnsLc%3D (Pubitemid 46763583)
15. M Aliustaoglu A Bilici M Seker, et al. 2010 The association of pre-treatment peripheral blood markers with survival in patients with pancreatic cancer Hepatogastroenterology 57 640 645 20698242
16. X An PR Ding YH Li, et al. 2010 Elevated neutrophil to lymphocyte ratio predicts survival in advanced pancreatic cancer Biomarkers 15 516 522 20602543 10.3109/1354750X.2010.491557 1:CAS:528:DC%2BC3cXhtVCmsr3N
17. MD Barber JA Ross KC Fearon 1999 Changes in nutritional, functional and inflammatory markers in advanced pancreatic cancer Nutr Cancer 35 106 110 10693162 10.1207/S15327914NC352-2 1:STN:280:DC%2BD3c7lslGmsw%3D%3D (Pubitemid 30115119)
18. MD Barber JA Ross T Preston, et al. 1999 Fish oil-enriched supplement attenuates disease progression of the acute-phase response in weight-losing patients with advanced pancreatic cancer J Nutr 129 1120 1125 10356075 1:CAS:528:DyaK1MXjsFGgsLg%3D (Pubitemid 29250159)