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Volumn 54, Issue 11, 2015, Pages 1494-1502

Oxidative stress, mammospheres and Nrf2-new implication for breast cancer therapy?

Author keywords

Cancer stem cell; Chemoresistance; Nrf2

Indexed keywords

BRUSATOL; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR NRF2; ANTINEOPLASTIC AGENT; NFE2L2 PROTEIN, HUMAN; PACLITAXEL;

EID: 84945195574     PISSN: 08991987     EISSN: 10982744     Source Type: Journal    
DOI: 10.1002/mc.22202     Document Type: Article
Times cited : (89)

References (37)
  • 1
    • 77649270763 scopus 로고    scopus 로고
    • Targeting NRF2 signaling for cancer chemoprevention
    • Kwak MK, Kensler TW. Targeting NRF2 signaling for cancer chemoprevention. Toxicol Appl Pharm 2010; 244:66-76.
    • (2010) Toxicol Appl Pharm , vol.244 , pp. 66-76
    • Kwak, M.K.1    Kensler, T.W.2
  • 2
    • 77953228968 scopus 로고    scopus 로고
    • Nrf2-Keap1 signaling as a potential target for chemoprevention of inflammation-associated carcinogenesis
    • Kundu JK, Surh YJ. Nrf2-Keap1 signaling as a potential target for chemoprevention of inflammation-associated carcinogenesis. Pharmaceut Res 2010; 27:999-1013.
    • (2010) Pharmaceut Res , vol.27 , pp. 999-1013
    • Kundu, J.K.1    Surh, Y.J.2
  • 3
    • 84888858310 scopus 로고    scopus 로고
    • Nrf2 in host defense: over the rainbow
    • Cho HY, Kwak MK, Pi J. Nrf2 in host defense: over the rainbow. Oxid Med Cell Longev 2013; 2013:975839.
    • (2013) Oxid Med Cell Longev , vol.2013 , pp. 975839
    • Cho, H.Y.1    Kwak, M.K.2    Pi, J.3
  • 4
    • 77951279075 scopus 로고    scopus 로고
    • Reactive oxygen species in cancer
    • Liou GY, Storz P. Reactive oxygen species in cancer. Free Radic Res 2010; 44:479-496.
    • (2010) Free Radic Res , vol.44 , pp. 479-496
    • Liou, G.Y.1    Storz, P.2
  • 5
    • 33847050801 scopus 로고    scopus 로고
    • Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway
    • Kensler TW, Wakabayashi N, Biswal S. Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annu Rev Pharmacol Toxicol 2007; 47:89-116.
    • (2007) Annu Rev Pharmacol Toxicol , vol.47 , pp. 89-116
    • Kensler, T.W.1    Wakabayashi, N.2    Biswal, S.3
  • 6
    • 3543008924 scopus 로고    scopus 로고
    • Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2
    • Kobayashi A, Kang MI, Okawa H, et al. Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2. Mol Cell Biol 2004; 24:7130-7139.
    • (2004) Mol Cell Biol , vol.24 , pp. 7130-7139
    • Kobayashi, A.1    Kang, M.I.2    Okawa, H.3
  • 7
    • 33845442925 scopus 로고    scopus 로고
    • Mechanistic studies of the Nrf2-Keap1 signaling pathway
    • Zhang DD. Mechanistic studies of the Nrf2-Keap1 signaling pathway. Drug Metab Rev 2006; 38:769-789.
    • (2006) Drug Metab Rev , vol.38 , pp. 769-789
    • Zhang, D.D.1
  • 8
    • 84885944468 scopus 로고    scopus 로고
    • The emerging role of the Nrf2-Keap1 signaling pathway in cancer
    • Jaramillo MC, Zhang DD. The emerging role of the Nrf2-Keap1 signaling pathway in cancer. Gene & Dev 2013; 27:2179-2191.
    • (2013) Gene & Dev , vol.27 , pp. 2179-2191
    • Jaramillo, M.C.1    Zhang, D.D.2
  • 9
    • 10044228504 scopus 로고    scopus 로고
    • Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex
    • Zhang DD, Lo SC, Cross JV, Templeton DJ, Hannink M. Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex. Mol Cell Biol 2004; 24:10941-10953.
    • (2004) Mol Cell Biol , vol.24 , pp. 10941-10953
    • Zhang, D.D.1    Lo, S.C.2    Cross, J.V.3    Templeton, D.J.4    Hannink, M.5
  • 10
    • 4544294365 scopus 로고    scopus 로고
    • The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase
    • Cullinan SB, Gordan JD, Jin J, Harper JW, Diehl JA. The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase. Mol Cell Biol 2004; 24:8477-8486.
    • (2004) Mol Cell Biol , vol.24 , pp. 8477-8486
    • Cullinan, S.B.1    Gordan, J.D.2    Jin, J.3    Harper, J.W.4    Diehl, J.A.5
  • 11
    • 11144264663 scopus 로고    scopus 로고
    • BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase
    • Furukawa M, Xiong Y. BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase. Mol Cell Biol 2005; 25:162-171.
    • (2005) Mol Cell Biol , vol.25 , pp. 162-171
    • Furukawa, M.1    Xiong, Y.2
  • 12
    • 0032953192 scopus 로고    scopus 로고
    • Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
    • Itoh K, Wakabayashi N, Katoh Y, et al. Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. Gene Dev 1999; 13:76-86.
    • (1999) Gene Dev , vol.13 , pp. 76-86
    • Itoh, K.1    Wakabayashi, N.2    Katoh, Y.3
  • 13
    • 14044254798 scopus 로고    scopus 로고
    • Molecular mechanisms activating the Nrf2-Keap1 pathway of antioxidant gene regulation
    • Kobayashi M, Yamamoto M. Molecular mechanisms activating the Nrf2-Keap1 pathway of antioxidant gene regulation. Antioxid Redox Signal 2005; 7:385-394.
    • (2005) Antioxid Redox Signal , vol.7 , pp. 385-394
    • Kobayashi, M.1    Yamamoto, M.2
  • 14
    • 33747728194 scopus 로고    scopus 로고
    • Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a "tethering" mechanism: a two-site interaction model for the Nrf2-Keap1 complex
    • McMahon M, Thomas N, Itoh K, Yamamoto M, Hayes JD. Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a "tethering" mechanism: a two-site interaction model for the Nrf2-Keap1 complex. J Biol Chem 2006; 281:24756-24768.
    • (2006) J Biol Chem , vol.281 , pp. 24756-24768
    • McMahon, M.1    Thomas, N.2    Itoh, K.3    Yamamoto, M.4    Hayes, J.D.5
  • 15
    • 0242580049 scopus 로고    scopus 로고
    • Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress
    • Zhang DD, Hannink M. Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress. Mol Cell Biol 2003; 23:8137-8151.
    • (2003) Mol Cell Biol , vol.23 , pp. 8137-8151
    • Zhang, D.D.1    Hannink, M.2
  • 16
    • 63549121490 scopus 로고    scopus 로고
    • NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer
    • Hayes JD, McMahon M. NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer. Trends Biochem Sci 2009; 34:176-188.
    • (2009) Trends Biochem Sci , vol.34 , pp. 176-188
    • Hayes, J.D.1    McMahon, M.2
  • 17
    • 33344456501 scopus 로고    scopus 로고
    • Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer
    • Padmanabhan B, Tong KI, Ohta T, et al. Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer. Mol Cell 2006; 21:689-700.
    • (2006) Mol Cell , vol.21 , pp. 689-700
    • Padmanabhan, B.1    Tong, K.I.2    Ohta, T.3
  • 18
    • 33750885385 scopus 로고    scopus 로고
    • Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer
    • Singh A, Misra V, Thimmulappa RK, et al. Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer. PLoS Med 2006; 3:e420.
    • (2006) PLoS Med , vol.3 , pp. e420
    • Singh, A.1    Misra, V.2    Thimmulappa, R.K.3
  • 19
    • 33644856080 scopus 로고    scopus 로고
    • The double-edged sword of Nrf2: subversion of redox homeostasis during the evolution of cancer
    • Hayes JD, McMahon M. The double-edged sword of Nrf2: subversion of redox homeostasis during the evolution of cancer. Mol Cell 2006; 21:732-734.
    • (2006) Mol Cell , vol.21 , pp. 732-734
    • Hayes, J.D.1    McMahon, M.2
  • 20
    • 74049120454 scopus 로고    scopus 로고
    • Nrf2: friend or foe for chemoprevention
    • Kensler TW, Wakabayashi N. Nrf2: friend or foe for chemoprevention? Carcinogenesis 2010; 31:90-99.
    • (2010) Carcinogenesis , vol.31 , pp. 90-99
    • Kensler, T.W.1    Wakabayashi, N.2
  • 22
    • 46649112474 scopus 로고    scopus 로고
    • Increased expression of Nrf2/ARE-dependent anti-oxidant proteins in tamoxifen-resistant breast cancer cells
    • Kim SK, Yang JW, Kim MR, et al. Increased expression of Nrf2/ARE-dependent anti-oxidant proteins in tamoxifen-resistant breast cancer cells. Free Radic Biol Med 2008; 45:537-546.
    • (2008) Free Radic Biol Med , vol.45 , pp. 537-546
    • Kim, S.K.1    Yang, J.W.2    Kim, M.R.3
  • 23
    • 0037948854 scopus 로고    scopus 로고
    • In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells
    • Dontu G, Abdallah WM, Foley JM, et al. In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells. Gene Dev 2003; 17:1253-1270.
    • (2003) Gene Dev , vol.17 , pp. 1253-1270
    • Dontu, G.1    Abdallah, W.M.2    Foley, J.M.3
  • 24
    • 78650859954 scopus 로고    scopus 로고
    • Markers of tumor-initiating cells predict chemoresistance in breast cancer
    • Gong C, Yao H, Liu Q, et al. Markers of tumor-initiating cells predict chemoresistance in breast cancer. PloS one 2010; 5:e15630.
    • (2010) PloS one , vol.5 , pp. e15630
    • Gong, C.1    Yao, H.2    Liu, Q.3
  • 25
    • 84860572194 scopus 로고    scopus 로고
    • Pharmacological inhibition of AKT sensitizes MCF-7 human breast cancer-initiating cells to radiation
    • Zhan JF, Wu LP, Chen LH, et al. Pharmacological inhibition of AKT sensitizes MCF-7 human breast cancer-initiating cells to radiation. Cell Oncol 2011; 34:451-456.
    • (2011) Cell Oncol , vol.34 , pp. 451-456
    • Zhan, J.F.1    Wu, L.P.2    Chen, L.H.3
  • 26
    • 79955608022 scopus 로고    scopus 로고
    • Kruppel-like factor 4 (KLF4) is required for maintenance of breast cancer stem cells and for cell migration and invasion
    • Yu F, Li J, Chen H, et al. Kruppel-like factor 4 (KLF4) is required for maintenance of breast cancer stem cells and for cell migration and invasion. Oncogene 2011; 30:2161-2172.
    • (2011) Oncogene , vol.30 , pp. 2161-2172
    • Yu, F.1    Li, J.2    Chen, H.3
  • 27
    • 0034730151 scopus 로고    scopus 로고
    • Redox state is a central modulator of the balance between self-renewal and differentiation in a dividing glial precursor cell
    • Smith J, Ladi E, Mayer-Proschel M, Noble M. Redox state is a central modulator of the balance between self-renewal and differentiation in a dividing glial precursor cell. Proc Natl Acad Sci USA 2000; 97:10032-10037.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 10032-10037
    • Smith, J.1    Ladi, E.2    Mayer-Proschel, M.3    Noble, M.4
  • 28
    • 64749093574 scopus 로고    scopus 로고
    • Association of reactive oxygen species levels and radioresistance in cancer stem cells
    • Diehn M, Cho RW, Lobo NA, et al. Association of reactive oxygen species levels and radioresistance in cancer stem cells. Nature 2009; 458:780-783.
    • (2009) Nature , vol.458 , pp. 780-783
    • Diehn, M.1    Cho, R.W.2    Lobo, N.A.3
  • 29
    • 0141888537 scopus 로고    scopus 로고
    • The role of ABC transporters in clinical practice
    • Leonard GD, Fojo T, Bates SE. The role of ABC transporters in clinical practice. Oncologist 2003; 8:411-424.
    • (2003) Oncologist , vol.8 , pp. 411-424
    • Leonard, G.D.1    Fojo, T.2    Bates, S.E.3
  • 30
    • 43949138899 scopus 로고    scopus 로고
    • Mechanisms and strategies to overcome chemotherapy resistance in metastatic breast cancer
    • Coley HM. Mechanisms and strategies to overcome chemotherapy resistance in metastatic breast cancer. Cancer Treat Rev 2008; 34:378-390.
    • (2008) Cancer Treat Rev , vol.34 , pp. 378-390
    • Coley, H.M.1
  • 31
    • 79952122321 scopus 로고    scopus 로고
    • Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism
    • Ren D, Villeneuve NF, Jiang T, et al. Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism. Proc Nat Acad Sci U S A 2011; 108:1433-1438.
    • (2011) Proc Nat Acad Sci U S A , vol.108 , pp. 1433-1438
    • Ren, D.1    Villeneuve, N.F.2    Jiang, T.3
  • 32
    • 77953288391 scopus 로고    scopus 로고
    • Resveratrol attenuates the anticancer efficacy of paclitaxel in human breast cancer cells in vitro and in vivo
    • Fukui M, Yamabe N, Zhu BT. Resveratrol attenuates the anticancer efficacy of paclitaxel in human breast cancer cells in vitro and in vivo. Eur J Cancer 2010; 46:1882-1891.
    • (2010) Eur J Cancer , vol.46 , pp. 1882-1891
    • Fukui, M.1    Yamabe, N.2    Zhu, B.T.3
  • 33
    • 21344454219 scopus 로고    scopus 로고
    • Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties
    • Ponti D, Costa A, Zaffaroni N, et al. Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties. Cancer Res 2005; 65:5506-5511.
    • (2005) Cancer Res , vol.65 , pp. 5506-5511
    • Ponti, D.1    Costa, A.2    Zaffaroni, N.3
  • 34
    • 33845904383 scopus 로고    scopus 로고
    • The response of CD24(-/low)/CD44+ breast cancer-initiating cells to radiation
    • Phillips TM, McBride WH, Pajonk F. The response of CD24(-/low)/CD44+ breast cancer-initiating cells to radiation. J Natl Cancer Inst 2006; 98:1777-1785.
    • (2006) J Natl Cancer Inst , vol.98 , pp. 1777-1785
    • Phillips, T.M.1    McBride, W.H.2    Pajonk, F.3
  • 35
    • 44349166602 scopus 로고    scopus 로고
    • PML targeting eradicates quiescent leukaemia-initiating cells
    • Ito K, Bernardi R, Morotti A, et al. PML targeting eradicates quiescent leukaemia-initiating cells. Nature 2008; 453:1072-1078.
    • (2008) Nature , vol.453 , pp. 1072-1078
    • Ito, K.1    Bernardi, R.2    Morotti, A.3
  • 36
    • 79952528125 scopus 로고    scopus 로고
    • CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc(-) and thereby promotes tumor growth
    • Ishimoto T, Nagano O, Yae T, et al. CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc(-) and thereby promotes tumor growth. Cancer Cell 2011; 19:387-400.
    • (2011) Cancer Cell , vol.19 , pp. 387-400
    • Ishimoto, T.1    Nagano, O.2    Yae, T.3
  • 37
    • 78149423083 scopus 로고    scopus 로고
    • 26S proteasome activity is down-regulated in lung cancer stem-like cells propagated in vitro
    • Pan J, Zhang Q, Wang Y, You M. 26S proteasome activity is down-regulated in lung cancer stem-like cells propagated in vitro. PloS one 2010; 5:e13298.
    • (2010) PloS one , vol.5 , pp. e13298
    • Pan, J.1    Zhang, Q.2    Wang, Y.3    You, M.4


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