Pharmacological inhibition of AKT sensitizes MCF-7 human breast cancer-initiating cells to radiation

Cellular Oncology

Volumn 34, Issue 5, 2011, Pages 451-456

  Zhan, Jun Fang ^a   Wu, Liang Ping ^b   Chen, Long Hua ^c   Yuan, Ya Wei ^c   Xie, Guo Zhu ^c   Sun, Ai Min ^c   Liu, Ying ^c   Chen, Zhi Xian ^c  

^a GUANGZHOU FIRST PEOPLE'S HOSPITAL   (China)

^b GUANGZHOU GENERAL HOSPITAL OF GUANGZHOU MILITARY COMMAND   (China)

^c SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

AKT; Breast cancer; Cancer stem cells; Cancer initiating cells; Radioresistance

Indexed keywords

6 HYDROXYMETHYL CHIRO INOSITOL 2 [2 O METHYL 3 O OCTADECYLCARBONATE]; AKT INHIBITOR 8; CD24 ANTIGEN; HERMES ANTIGEN; MESSENGER RNA; PROTEIN AKT1; PROTEIN KINASE B BETA; PROTEIN KINASE B INHIBITOR; PROTEIN SERINE THREONINE KINASE; UNCLASSIFIED DRUG; PROTEIN KINASE B; PROTEIN KINASE INHIBITOR;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER STEM CELL; CELL POPULATION; CELL STRAIN MCF 7; CLONOGENIC ASSAY; CONTROLLED STUDY; GENETIC SCREENING; HUMAN; HUMAN CELL; IONIZING RADIATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIATION DOSE; RADIOSENSITIVITY; CELL SURVIVAL; DRUG ANTAGONISM; DRUG EFFECT; DRUG SCREENING; ENZYMOLOGY; METABOLISM; MULTICELLULAR SPHEROID; PATHOLOGY; RADIATION EXPOSURE; TUMOR CELL LINE; X RAY;

APOPTOSIS; CELL LINE, TUMOR; CELL SURVIVAL; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; NEOPLASTIC STEM CELLS; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; RADIATION TOLERANCE; SPHEROIDS, CELLULAR; X-RAYS;

EID: 84860572194     PISSN: 22113428     EISSN: 22113436     Source Type: Journal    
DOI: 10.1007/s13402-011-0020-1     Document Type: Article

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