메뉴 건너뛰기




Volumn 26, Issue , 2016, Pages 54-60

Critical role of the Mac1/NOX2 pathway in mediating reactive microgliosis-generated chronic neuroinflammation and progressive neurodegeneration

Author keywords

[No Author keywords available]

Indexed keywords

INTEGRIN RECEPTOR; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR; OXIDOREDUCTASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; TOLL LIKE RECEPTOR; CD11B ANTIGEN; CYBB PROTEIN, HUMAN; MEMBRANE PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

EID: 84945143762     PISSN: 14714892     EISSN: 14714973     Source Type: Journal    
DOI: 10.1016/j.coph.2015.10.001     Document Type: Review
Times cited : (59)

References (58)
  • 1
    • 33845768784 scopus 로고    scopus 로고
    • Microglia-mediated neurotoxicity: Uncovering the molecular mechanisms
    • M.L. Block, L. Zecca, and J.S. Hong Microglia-mediated neurotoxicity: uncovering the molecular mechanisms Nat Rev Neurosci 8 2007 57 69
    • (2007) Nat Rev Neurosci , vol.8 , pp. 57-69
    • Block, M.L.1    Zecca, L.2    Hong, J.S.3
  • 2
    • 47749126515 scopus 로고    scopus 로고
    • Why neurodegenerative diseases are progressive: Uncontrolled inflammation drives disease progression
    • H.M. Gao, and J.S. Hong Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression Trends Immunol 29 2008 357 365
    • (2008) Trends Immunol , vol.29 , pp. 357-365
    • Gao, H.M.1    Hong, J.S.2
  • 6
    • 84862649049 scopus 로고    scopus 로고
    • Toll-like receptor (TLR) and inflammasome actions in the central nervous system
    • R. Hanamsagar, M.L. Hanke, and T. Kielian Toll-like receptor (TLR) and inflammasome actions in the central nervous system Trends Immunol 33 2012 333 342
    • (2012) Trends Immunol , vol.33 , pp. 333-342
    • Hanamsagar, R.1    Hanke, M.L.2    Kielian, T.3
  • 7
    • 84897935089 scopus 로고    scopus 로고
    • Microglia receptors and their implications in the response to amyloid beta for Alzheimer's disease pathogenesis
    • D. Doens, and P.L. Fernandez Microglia receptors and their implications in the response to amyloid beta for Alzheimer's disease pathogenesis J Neuroinflammation 11 2014 48
    • (2014) J Neuroinflammation , vol.11 , pp. 48
    • Doens, D.1    Fernandez, P.L.2
  • 8
    • 78651308665 scopus 로고    scopus 로고
    • Microglial MAC1 receptor and PI3K are essential in mediating beta-amyloid peptide-induced microglial activation and subsequent neurotoxicity
    • D. Zhang, X. Hu, L. Qian, S.H. Chen, H. Zhou, B. Wilson, D.S. Miller, and J.S. Hong Microglial MAC1 receptor and PI3K are essential in mediating beta-amyloid peptide-induced microglial activation and subsequent neurotoxicity J Neuroinflammation 8 2011 3
    • (2011) J Neuroinflammation , vol.8 , pp. 3
    • Zhang, D.1    Hu, X.2    Qian, L.3    Chen, S.H.4    Zhou, H.5    Wilson, B.6    Miller, D.S.7    Hong, J.S.8
  • 9
    • 78751502344 scopus 로고    scopus 로고
    • HMGB1 acts on microglia Mac1 to mediate chronic neuroinflammation that drives progressive neurodegeneration
    • H.M. Gao, H. Zhou, F. Zhang, B.C. Wilson, W. Kam, and J.S. Hong HMGB1 acts on microglia Mac1 to mediate chronic neuroinflammation that drives progressive neurodegeneration J Neurosci 31 2011 1081 1092
    • (2011) J Neurosci , vol.31 , pp. 1081-1092
    • Gao, H.M.1    Zhou, H.2    Zhang, F.3    Wilson, B.C.4    Kam, W.5    Hong, J.S.6
  • 10
    • 79952575531 scopus 로고    scopus 로고
    • Evaluating the role of Toll-like receptors in diseases of the central nervous system
    • M. Carty, and A.G. Bowie Evaluating the role of Toll-like receptors in diseases of the central nervous system Biochem Pharmacol 81 2011 825 837
    • (2011) Biochem Pharmacol , vol.81 , pp. 825-837
    • Carty, M.1    Bowie, A.G.2
  • 13
    • 84927709043 scopus 로고    scopus 로고
    • The dynamics of monocytes and microglia in Alzheimer's disease
    • P. Theriault, A. ElAli, and S. Rivest The dynamics of monocytes and microglia in Alzheimer's disease Alzheimers Res Ther 7 2015 41
    • (2015) Alzheimers Res Ther , vol.7 , pp. 41
    • Theriault, P.1    Elali, A.2    Rivest, S.3
  • 14
    • 84899418705 scopus 로고    scopus 로고
    • Microglia and brain macrophages in the molecular age: From origin to neuropsychiatric disease
    • M. Prinz, and J. Priller Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease Nat Rev Neurosci 15 2014 300 312
    • (2014) Nat Rev Neurosci , vol.15 , pp. 300-312
    • Prinz, M.1    Priller, J.2
  • 15
    • 84892741034 scopus 로고    scopus 로고
    • Reactive gliosis and the multicellular response to CNS damage and disease
    • J.E. Burda, and M.V. Sofroniew Reactive gliosis and the multicellular response to CNS damage and disease Neuron 81 2014 229 248
    • (2014) Neuron , vol.81 , pp. 229-248
    • Burda, J.E.1    Sofroniew, M.V.2
  • 16
    • 84903269246 scopus 로고    scopus 로고
    • Innate immune activation in neurodegenerative disease
    • M.T. Heneka, M.P. Kummer, and E. Latz Innate immune activation in neurodegenerative disease Nat Rev Immunol 14 2014 463 477
    • (2014) Nat Rev Immunol , vol.14 , pp. 463-477
    • Heneka, M.T.1    Kummer, M.P.2    Latz, E.3
  • 17
    • 75849151435 scopus 로고    scopus 로고
    • Innate immunity and neuroinflammation in the CNS: The role of microglia in Toll-like receptor-mediated neuronal injury
    • S. Lehnardt Innate immunity and neuroinflammation in the CNS: the role of microglia in Toll-like receptor-mediated neuronal injury Glia 58 2010 253 263
    • (2010) Glia , vol.58 , pp. 253-263
    • Lehnardt, S.1
  • 18
    • 79956300649 scopus 로고    scopus 로고
    • Toll-like receptors and their crosstalk with other innate receptors in infection and immunity
    • T. Kawai, and S. Akira Toll-like receptors and their crosstalk with other innate receptors in infection and immunity Immunity 34 2011 637 650
    • (2011) Immunity , vol.34 , pp. 637-650
    • Kawai, T.1    Akira, S.2
  • 19
    • 77955383770 scopus 로고    scopus 로고
    • DAMPening inflammation by modulating TLR signalling
    • A.M. Piccinini, and K.S. Midwood DAMPening inflammation by modulating TLR signalling Mediators Inflamm 2010 2010
    • (2010) Mediators Inflamm , pp. 2010
    • Piccinini, A.M.1    Midwood, K.S.2
  • 20
    • 84875898265 scopus 로고    scopus 로고
    • Neuron-released oligomeric alpha-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia
    • C. Kim, D.H. Ho, J.E. Suk, S. You, S. Michael, J. Kang, S. Joong Lee, E. Masliah, D. Hwang, H.J. Lee, and et al. Neuron-released oligomeric alpha-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia Nat Commun 4 2013 1562
    • (2013) Nat Commun , vol.4 , pp. 1562
    • Kim, C.1    Ho, D.H.2    Suk, J.E.3    You, S.4    Michael, S.5    Kang, J.6    Joong Lee, S.7    Masliah, E.8    Hwang, D.9    Lee, H.J.10
  • 23
    • 73649137143 scopus 로고    scopus 로고
    • Microglia activated with the toll-like receptor 9 ligand CpG attenuate oligomeric amyloid {beta} neurotoxicity in in vitro and in vivo models of Alzheimer's disease
    • Y. Doi, T. Mizuno, Y. Maki, S. Jin, H. Mizoguchi, M. Ikeyama, M. Doi, M. Michikawa, H. Takeuchi, and A. Suzumura Microglia activated with the toll-like receptor 9 ligand CpG attenuate oligomeric amyloid {beta} neurotoxicity in in vitro and in vivo models of Alzheimer's disease Am J Pathol 175 2009 2121 2132
    • (2009) Am J Pathol , vol.175 , pp. 2121-2132
    • Doi, Y.1    Mizuno, T.2    Maki, Y.3    Jin, S.4    Mizoguchi, H.5    Ikeyama, M.6    Doi, M.7    Michikawa, M.8    Takeuchi, H.9    Suzumura, A.10
  • 27
    • 70349807619 scopus 로고    scopus 로고
    • Immune activation in brain aging and neurodegeneration: Too much or too little?
    • K.M. Lucin, and T. Wyss-Coray Immune activation in brain aging and neurodegeneration: too much or too little? Neuron 64 2009 110 122
    • (2009) Neuron , vol.64 , pp. 110-122
    • Lucin, K.M.1    Wyss-Coray, T.2
  • 28
    • 20644450804 scopus 로고    scopus 로고
    • Negative regulation of toll-like receptor-mediated immune responses
    • F.Y. Liew, D. Xu, E.K. Brint, and L.A. O'Neill Negative regulation of toll-like receptor-mediated immune responses Nat Rev Immunol 5 2005 446 458
    • (2005) Nat Rev Immunol , vol.5 , pp. 446-458
    • Liew, F.Y.1    Xu, D.2    Brint, E.K.3    O'Neill, L.A.4
  • 29
    • 84878017267 scopus 로고    scopus 로고
    • The role of MAC1 in diesel exhaust particle-induced microglial activation and loss of dopaminergic neuron function
    • S. Levesque, T. Taetzsch, M.E. Lull, J.A. Johnson, C. McGraw, and M.L. Block The role of MAC1 in diesel exhaust particle-induced microglial activation and loss of dopaminergic neuron function J Neurochem 125 2013 756 765
    • (2013) J Neurochem , vol.125 , pp. 756-765
    • Levesque, S.1    Taetzsch, T.2    Lull, M.E.3    Johnson, J.A.4    McGraw, C.5    Block, M.L.6
  • 30
    • 67849121525 scopus 로고    scopus 로고
    • Fibrinogen signal transduction in the nervous system
    • J.K. Ryu, D. Davalos, and K. Akassoglou Fibrinogen signal transduction in the nervous system J Thromb Haemost 7 Suppl 1 2009 151 154
    • (2009) J Thromb Haemost , vol.7 , pp. 151-154
    • Ryu, J.K.1    Davalos, D.2    Akassoglou, K.3
  • 31
    • 58149181977 scopus 로고    scopus 로고
    • Macrophage antigen complex-1 mediates reactive microgliosis and progressive dopaminergic neurodegeneration in the MPTP model of Parkinson's disease
    • X. Hu, D. Zhang, H. Pang, W.M. Caudle, Y. Li, H. Gao, Y. Liu, L. Qian, B. Wilson, D.A. Di Monte, and et al. Macrophage antigen complex-1 mediates reactive microgliosis and progressive dopaminergic neurodegeneration in the MPTP model of Parkinson's disease J Immunol 181 2008 7194 7204
    • (2008) J Immunol , vol.181 , pp. 7194-7204
    • Hu, X.1    Zhang, D.2    Pang, H.3    Caudle, W.M.4    Li, Y.5    Gao, H.6    Liu, Y.7    Qian, L.8    Wilson, B.9    Di Monte, D.A.10
  • 32
    • 0033845499 scopus 로고    scopus 로고
    • Role of the cytoskeleton in rapid activation of CD11b/CD18 function and its subsequent downregulation in neutrophils
    • S.I. Anderson, N.A. Hotchin, and G.B. Nash Role of the cytoskeleton in rapid activation of CD11b/CD18 function and its subsequent downregulation in neutrophils J Cell Sci 113 Pt 15 2000 2737 2745
    • (2000) J Cell Sci , vol.113 , pp. 2737-2745
    • Anderson, S.I.1    Hotchin, N.A.2    Nash, G.B.3
  • 33
    • 84923205517 scopus 로고    scopus 로고
    • Ligand recognition specificity of leukocyte integrin alphaMbeta2 (Mac-1, CD11b/CD18) and its functional consequences
    • N.P. Podolnikova, A.V. Podolnikov, T.A. Haas, V.K. Lishko, and T.P. Ugarova Ligand recognition specificity of leukocyte integrin alphaMbeta2 (Mac-1, CD11b/CD18) and its functional consequences Biochemistry 54 2015 1408 1420
    • (2015) Biochemistry , vol.54 , pp. 1408-1420
    • Podolnikova, N.P.1    Podolnikov, A.V.2    Haas, T.A.3    Lishko, V.K.4    Ugarova, T.P.5
  • 34
    • 0025162755 scopus 로고
    • Brain microglia constitutively express beta-2 integrins
    • H. Akiyama, and P.L. McGeer Brain microglia constitutively express beta-2 integrins J Neuroimmunol 30 1990 81 93
    • (1990) J Neuroimmunol , vol.30 , pp. 81-93
    • Akiyama, H.1    McGeer, P.L.2
  • 37
    • 0141450468 scopus 로고    scopus 로고
    • Microglia and macrophage activation and the regulation of complement-receptor-3 (CR3/MAC-1)-mediated myelin phagocytosis in injury and disease
    • S. Rotshenker Microglia and macrophage activation and the regulation of complement-receptor-3 (CR3/MAC-1)-mediated myelin phagocytosis in injury and disease J Mol Neurosci 21 2003 65 72
    • (2003) J Mol Neurosci , vol.21 , pp. 65-72
    • Rotshenker, S.1
  • 38
    • 34548213150 scopus 로고    scopus 로고
    • MAC1 mediates LPS-induced production of superoxide by microglia: The role of pattern recognition receptors in dopaminergic neurotoxicity
    • Z. Pei, H. Pang, L. Qian, S. Yang, T. Wang, W. Zhang, X. Wu, S. Dallas, B. Wilson, J.M. Reece, and et al. MAC1 mediates LPS-induced production of superoxide by microglia: the role of pattern recognition receptors in dopaminergic neurotoxicity Glia 55 2007 1362 1373
    • (2007) Glia , vol.55 , pp. 1362-1373
    • Pei, Z.1    Pang, H.2    Qian, L.3    Yang, S.4    Wang, T.5    Zhang, W.6    Wu, X.7    Dallas, S.8    Wilson, B.9    Reece, J.M.10
  • 39
    • 33846794822 scopus 로고    scopus 로고
    • The NOX family of ROS-generating NADPH oxidases: Physiology and pathophysiology
    • K. Bedard, and K.H. Krause The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology Physiol Rev 87 2007 245 313
    • (2007) Physiol Rev , vol.87 , pp. 245-313
    • Bedard, K.1    Krause, K.H.2
  • 40
    • 84901045088 scopus 로고    scopus 로고
    • New insights on NOX enzymes in the central nervous system
    • Z. Nayernia, V. Jaquet, and K.H. Krause New insights on NOX enzymes in the central nervous system Antioxid Redox Signal 20 2014 2815 2837
    • (2014) Antioxid Redox Signal , vol.20 , pp. 2815-2837
    • Nayernia, Z.1    Jaquet, V.2    Krause, K.H.3
  • 41
    • 84876463910 scopus 로고    scopus 로고
    • NADPH oxidase and aging drive microglial activation, oxidative stress and dopaminergic neurodegeneration following systemic LPS administration
    • L. Qin, Y. Liu, and J.S.F.T.C. Hong NADPH oxidase and aging drive microglial activation, oxidative stress and dopaminergic neurodegeneration following systemic LPS administration Glia 61 2013 855 868
    • (2013) Glia , vol.61 , pp. 855-868
    • Qin, L.1    Liu, Y.2    Hong, J.S.F.T.C.3
  • 42
    • 84929657195 scopus 로고    scopus 로고
    • Post-treatment with an ultra-low dose of NADPH oxidase inhibitor diphenyleneiodonium attenuates disease progression in multiple Parkinson's disease models
    • Q. Wang, L. Qian, S.H. Chen, C.H. Chu, B. Wilson, E. Oyarzabal, S. Ali, B. Robinson, D. Rao, and J.S. Hong Post-treatment with an ultra-low dose of NADPH oxidase inhibitor diphenyleneiodonium attenuates disease progression in multiple Parkinson's disease models Brain 138 2015 1247 1262
    • (2015) Brain , vol.138 , pp. 1247-1262
    • Wang, Q.1    Qian, L.2    Chen, S.H.3    Chu, C.H.4    Wilson, B.5    Oyarzabal, E.6    Ali, S.7    Robinson, B.8    Rao, D.9    Hong, J.S.10
  • 43
    • 38949146389 scopus 로고    scopus 로고
    • NADPH oxidase inhibitor DPI is neuroprotective at femtomolar concentrations through inhibition of microglia over-activation
    • L. Qian, X. Gao, Z. Pei, X. Wu, M. Block, B. Wilson, J.S. Hong, and P.M. Flood NADPH oxidase inhibitor DPI is neuroprotective at femtomolar concentrations through inhibition of microglia over-activation Parkinsonism Relat Disord 13 Suppl 3 2007 S316 S320
    • (2007) Parkinsonism Relat Disord , vol.13 , pp. S316-S320
    • Qian, L.1    Gao, X.2    Pei, Z.3    Wu, X.4    Block, M.5    Wilson, B.6    Hong, J.S.7    Flood, P.M.8
  • 46
    • 84861854211 scopus 로고    scopus 로고
    • NADPH oxidases: Novel therapeutic targets for neurodegenerative diseases
    • H.M. Gao, H. Zhou, and J.S. Hong NADPH oxidases: novel therapeutic targets for neurodegenerative diseases Trends Pharmacological Sci 33 2012 295 303
    • (2012) Trends Pharmacological Sci , vol.33 , pp. 295-303
    • Gao, H.M.1    Zhou, H.2    Hong, J.S.3
  • 48
    • 0037178579 scopus 로고    scopus 로고
    • Dietary intake of antioxidant nutrients and the risk of incident Alzheimer disease in a biracial community study
    • M.C. Morris, D.A. Evans, J.L. Bienias, C.C. Tangney, D.A. Bennett, N. Aggarwal, R.S. Wilson, and P.A. Scherr Dietary intake of antioxidant nutrients and the risk of incident Alzheimer disease in a biracial community study JAMA 287 2002 3230 3237
    • (2002) JAMA , vol.287 , pp. 3230-3237
    • Morris, M.C.1    Evans, D.A.2    Bienias, J.L.3    Tangney, C.C.4    Bennett, D.A.5    Aggarwal, N.6    Wilson, R.S.7    Scherr, P.A.8
  • 50
    • 12244301218 scopus 로고    scopus 로고
    • Mechanisms in mediating the anti-inflammatory effects of baicalin and baicalein in human leukocytes
    • Y.C. Shen, W.F. Chiou, Y.C. Chou, and C.F. Chen Mechanisms in mediating the anti-inflammatory effects of baicalin and baicalein in human leukocytes Eur J Pharmacol 465 2003 171 181
    • (2003) Eur J Pharmacol , vol.465 , pp. 171-181
    • Shen, Y.C.1    Chiou, W.F.2    Chou, Y.C.3    Chen, C.F.4
  • 51
    • 0026532539 scopus 로고
    • N-[9H-(2,7-dimethylfluorenyl-9-methoxy)carbonyl]-L-leucine, NPC 15669, prevents neutrophil adherence to endothelium and inhibits CD11b/CD18 upregulation
    • J.M. Bator, M. Weitzberg, and R.M. Burch N-[9H-(2,7-dimethylfluorenyl-9-methoxy)carbonyl]-L-leucine, NPC 15669, prevents neutrophil adherence to endothelium and inhibits CD11b/CD18 upregulation Immunopharmacology 23 1992 139 149
    • (1992) Immunopharmacology , vol.23 , pp. 139-149
    • Bator, J.M.1    Weitzberg, M.2    Burch, R.M.3
  • 52
    • 0037381043 scopus 로고    scopus 로고
    • Dextromethorphan protects dopaminergic neurons against inflammation-mediated degeneration through inhibition of microglial activation
    • Y. Liu, L. Qin, G. Li, W. Zhang, L. An, B. Liu, and J.S. Hong Dextromethorphan protects dopaminergic neurons against inflammation-mediated degeneration through inhibition of microglial activation J Pharm Exp Ther 305 2003 212 218
    • (2003) J Pharm Exp Ther , vol.305 , pp. 212-218
    • Liu, Y.1    Qin, L.2    Li, G.3    Zhang, W.4    An, L.5    Liu, B.6    Hong, J.S.7
  • 53
    • 35948938955 scopus 로고    scopus 로고
    • Sinomenine, a natural dextrorotatory morphinan analog, is anti-inflammatory and neuroprotective through inhibition of microglial NADPH oxidase
    • L. Qian, Z. Xu, W. Zhang, B. Wilson, J.S. Hong, and P.M. Flood Sinomenine, a natural dextrorotatory morphinan analog, is anti-inflammatory and neuroprotective through inhibition of microglial NADPH oxidase J Neuroinflammation 4 2007 23
    • (2007) J Neuroinflammation , vol.4 , pp. 23
    • Qian, L.1    Xu, Z.2    Zhang, W.3    Wilson, B.4    Hong, J.S.5    Flood, P.M.6
  • 54
    • 0034015558 scopus 로고    scopus 로고
    • Naloxone protects rat dopaminergic neurons against inflammatory damage through inhibition of microglia activation and superoxide generation
    • B. Liu, L. Du, and J.S. Hong Naloxone protects rat dopaminergic neurons against inflammatory damage through inhibition of microglia activation and superoxide generation J Pharm Exp Ther 293 2000 607 617
    • (2000) J Pharm Exp Ther , vol.293 , pp. 607-617
    • Liu, B.1    Du, L.2    Hong, J.S.3
  • 55
    • 0028804902 scopus 로고
    • Ultra-low concentrations of naloxone selectively antagonize excitatory effects of morphine on sensory neurons, thereby increasing its antinociceptive potency and attenuating tolerance/dependence during chronic cotreatment
    • S.M. Crain, and K.F. Shen Ultra-low concentrations of naloxone selectively antagonize excitatory effects of morphine on sensory neurons, thereby increasing its antinociceptive potency and attenuating tolerance/dependence during chronic cotreatment Proc Natl Acad Sci U S A 92 1995 10540 10544
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 10540-10544
    • Crain, S.M.1    Shen, K.F.2
  • 56
    • 84862234112 scopus 로고    scopus 로고
    • Endogenous dynorphin protects against neurotoxin-elicited nigrostriatal dopaminergic neuron damage and motor deficits in mice
    • Q. Wang, E.J. Shin, X.K. Nguyen, Q. Li, J.H. Bach, G. Bing, W.K. Kim, H.C. Kim, and J.S. Hong Endogenous dynorphin protects against neurotoxin-elicited nigrostriatal dopaminergic neuron damage and motor deficits in mice J Neuroinflammation 9 2012 124
    • (2012) J Neuroinflammation , vol.9 , pp. 124
    • Wang, Q.1    Shin, E.J.2    Nguyen, X.K.3    Li, Q.4    Bach, J.H.5    Bing, G.6    Kim, W.K.7    Kim, H.C.8    Hong, J.S.9
  • 57
    • 29744453873 scopus 로고    scopus 로고
    • Microglial NADPH oxidase mediates leucine enkephalin dopaminergic neuroprotection
    • L. Qin, Y. Liu, X. Qian, J.S. Hong, and M.L. Block Microglial NADPH oxidase mediates leucine enkephalin dopaminergic neuroprotection Ann N Y Acad Sci 1053 2005 107 120
    • (2005) Ann N y Acad Sci , vol.1053 , pp. 107-120
    • Qin, L.1    Liu, Y.2    Qian, X.3    Hong, J.S.4    Block, M.L.5
  • 58
    • 79955000817 scopus 로고    scopus 로고
    • Beta2-adrenergic receptor activation prevents rodent dopaminergic neurotoxicity by inhibiting microglia via a novel signaling pathway
    • L. Qian, H.M. Wu, S.H. Chen, D. Zhang, S.F. Ali, L. Peterson, B. Wilson, R.B. Lu, J.S. Hong, and P.M. Flood beta2-adrenergic receptor activation prevents rodent dopaminergic neurotoxicity by inhibiting microglia via a novel signaling pathway J Immunol 186 2011 4443 4454
    • (2011) J Immunol , vol.186 , pp. 4443-4454
    • Qian, L.1    Wu, H.M.2    Chen, S.H.3    Zhang, D.4    Ali, S.F.5    Peterson, L.6    Wilson, B.7    Lu, R.B.8    Hong, J.S.9    Flood, P.M.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.