Simultaneous perturbation of the MAPK and the PI3K/mTOR pathways does not lead to increased radiosensitization

Radiation Oncology

Volumn 10, Issue 1, 2015, Pages

  Kuger, Sebastian ^a   Flentje, Michael ^a   Djuzenova, Cholpon S ^a  

^a UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

Author keywords

Apoptosis; Autophagy; AZD6244; Cell cycle arrest; NVP BEZ235; Radiosensitivity

Indexed keywords

DACTOLISIB; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; SELUMETINIB; ANTINEOPLASTIC AGENT; BENZIMIDAZOLE DERIVATIVE; ENZYME INHIBITOR; IMIDAZOLE DERIVATIVE; MTOR PROTEIN, HUMAN; QUINOLINE DERIVATIVE; RADIOSENSITIZING AGENT; TARGET OF RAPAMYCIN KINASE;

A549 CELL LINE; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; ASSAY; ATP ASSAY; AUTOPHAGY; CELL VIABILITY ASSAY; COLONY FORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENTIATION; ENZYME INHIBITION; FEEDBACK SYSTEM; G1 PHASE CELL CYCLE CHECKPOINT; GLIOBLASTOMA; GLIOBLASTOMA CELL LINE; HUMAN; HUMAN CELL; IONIZING RADIATION; LUNG CARCINOMA; MOLECULAR INTERACTION; MUTATION; PHENOTYPIC VARIATION; RADIOSENSITIZATION; SHAM PROCEDURE; SIGNAL TRANSDUCTION; SNB19 CELL LINE; TIME SERIES ANALYSIS; TUMOR GROWTH; WESTERN BLOTTING; ANTAGONISTS AND INHIBITORS; CELL PROLIFERATION; DRUG EFFECTS; PHYSIOLOGY; RADIATION TOLERANCE; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; BENZIMIDAZOLES; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG SYNERGISM; ENZYME INHIBITORS; HUMANS; IMIDAZOLES; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHATIDYLINOSITOL 3-KINASES; QUINOLINES; RADIATION TOLERANCE; RADIATION-SENSITIZING AGENTS; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84945124098     PISSN: None     EISSN: 1748717X     Source Type: Journal    
DOI: 10.1186/s13014-015-0514-5     Document Type: Article

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