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Volumn 6, Issue 2, 2013, Pages 169-179

Radiosensitization of glioblastoma cell lines by the dual PI3K and mTOR inhibitor NVP-BEZ235 depends on drug-irradiation schedule

Author keywords

[No Author keywords available]

Indexed keywords

1 (1 CYANO 1 METHYLETHYL) 3 METHYL 8 (3 QUINOLINYL) IMIDAZO [4, 5 C] QUINOLIN 2 (1H, 3H) ONE; 1 (1 CYANO 1 METHYLETHYL) 3 METHYL 8 (3 QUINOLINYL)IMIDAZO[4,5 C]QUINOLIN 2(1H,3H) ONE; HISTONE H2AX; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; UNCLASSIFIED DRUG;

EID: 84875762286     PISSN: None     EISSN: 19365233     Source Type: Journal    
DOI: 10.1593/tlo.12364     Document Type: Article
Times cited : (50)

References (48)
  • 3
    • 0020517665 scopus 로고
    • Comparison of postoperative radiotherapy and combined postoperative radiotherapy and chemotherapy in the multidisciplinary management of malignant gliomas. A joint Radiation Therapy Oncology Group and Eastern Cooperative Oncology Group study
    • Chang CH, Horton J, Schoenfeld D, Salazer O, Perez-Tamayo R, Kramer S, Weinstein A, Nelson JS, and Tsukada Y (1983). Comparison of postoperative radiotherapy and combined postoperative radiotherapy and chemotherapy in the multidisciplinary management of malignant gliomas. A joint Radiation Therapy Oncology Group and Eastern Cooperative Oncology Group study. Cancer 52, 997-1007.
    • (1983) Cancer , vol.52 , pp. 997-1007
    • Chang, C.H.1    Horton, J.2    Schoenfeld, D.3    Salazer, O.4    Perez-Tamayo, R.5    Kramer, S.6    Weinstein, A.7    Nelson, J.S.8    Tsukada, Y.9
  • 4
    • 0034744314 scopus 로고    scopus 로고
    • Chemotherapy for malignant brain tumors of astrocytic and oligodendroglial lineage
    • Hofer S and Herrmann R (2001). Chemotherapy for malignant brain tumors of astrocytic and oligodendroglial lineage. J Cancer Res Clin Oncol 127, 91-95.
    • (2001) J Cancer Res Clin Oncol , vol.127 , pp. 91-95
    • Hofer, S.1    Herrmann, R.2
  • 5
    • 79952111297 scopus 로고    scopus 로고
    • Targeting the RTK-PI3K-mTOR axis in malignant glioma: Overcoming resistance
    • Fan Q-W and Weiss WA (2010). Targeting the RTK-PI3K-mTOR axis in malignant glioma: overcoming resistance. Curr Top Microbiol Immunol 347, 279-296.
    • (2010) Curr Top Microbiol Immunol , vol.347 , pp. 279-296
    • Fan, Q.-W.1    Weiss, W.A.2
  • 6
    • 0345256634 scopus 로고    scopus 로고
    • The role of p53 in chemosensitivity and radiosensitivity
    • El-Deiry WS (2003). The role of p53 in chemosensitivity and radiosensitivity. Oncogene 22, 7486-7495.
    • (2003) Oncogene , vol.22 , pp. 7486-7495
    • El-Deiry, W.S.1
  • 7
    • 0036185848 scopus 로고    scopus 로고
    • The protein kinase B/Akt signalling pathway in human malignancy
    • Nicholson KM and Anderson NG (2002). The protein kinase B/Akt signalling pathway in human malignancy. Cell Signal 14, 381-395.
    • (2002) Cell Signal , vol.14 , pp. 381-395
    • Nicholson, K.M.1    Anderson, N.G.2
  • 8
    • 0034665134 scopus 로고    scopus 로고
    • Prevention of phosphatidylinositol 3'-kinase-Akt survival signaling pathway during topotecaninduced apoptosis
    • Nakashio A, Fujita N, Rokudai S, Sato S, and Tsuruo T (2000). Prevention of phosphatidylinositol 3'-kinase-Akt survival signaling pathway during topotecaninduced apoptosis. Cancer Res 60, 5303-5309.
    • (2000) Cancer Res , vol.60 , pp. 5303-5309
    • Nakashio, A.1    Fujita, N.2    Rokudai, S.3    Sato, S.4    Tsuruo, T.5
  • 9
    • 0037499945 scopus 로고    scopus 로고
    • Response to epidermal growth factor receptor inhibitors in non-small cell lung cancer cells: Limited antiproliferative effects and absence of apoptosis associated with persistent activity of extracellular signal-regulated kinase or Akt kinase pathways
    • Janmaat ML, Kruyt FA, Rodriguez JA, and Giaccone G (2003). Response to epidermal growth factor receptor inhibitors in non-small cell lung cancer cells: limited antiproliferative effects and absence of apoptosis associated with persistent activity of extracellular signal-regulated kinase or Akt kinase pathways. Clin Cancer Res 9, 2316-2326.
    • (2003) Clin Cancer Res , vol.9 , pp. 2316-2326
    • Janmaat, M.L.1    Kruyt, F.A.2    Rodriguez, J.A.3    Giaccone, G.4
  • 10
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase AKT pathway in human cancer
    • Vivanco I and Sawyers CL (2002). The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat Rev Cancer 2, 489-501.
    • (2002) Nat Rev Cancer , vol.2 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 11
    • 2342559981 scopus 로고    scopus 로고
    • The TOR pathway: A target for cancer therapy
    • Bjornsti MA and Houghton PJ (2004). The TOR pathway: a target for cancer therapy. Nat Rev Cancer 4, 335-348.
    • (2004) Nat Rev Cancer , vol.4 , pp. 335-348
    • Bjornsti, M.A.1    Houghton, P.J.2
  • 12
    • 77954931806 scopus 로고    scopus 로고
    • Activated PI3K/Akt/COX-2 pathway induces resistance to radiation in human cervical cancer HeLa cells
    • Xia S, Zhao Y, Yu S, and Zhang M (2010). Activated PI3K/Akt/COX-2 pathway induces resistance to radiation in human cervical cancer HeLa cells. Cancer Biother Radiopharm 25, 317-323.
    • (2010) Cancer Biother Radiopharm , vol.25 , pp. 317-323
    • Xia, S.1    Zhao, Y.2    Yu, S.3    Zhang, M.4
  • 13
    • 78149493021 scopus 로고    scopus 로고
    • The Akt-inhibitor Erufosine induces apoptotic cell death in prostate cancer cells and increases the short term effects of ionizing radiation
    • Rudner J, Ruiner CE, Handrick R, Eibl HJ, Belka C, and Jendrossek V (2010). The Akt-inhibitor Erufosine induces apoptotic cell death in prostate cancer cells and increases the short term effects of ionizing radiation. Radiat Oncol 5, 108.
    • (2010) Radiat Oncol , vol.5 , pp. 108
    • Rudner, J.1    Ruiner, C.E.2    Handrick, R.3    Eibl, H.J.4    Belka, C.5    Jendrossek, V.6
  • 14
    • 78649432051 scopus 로고    scopus 로고
    • Inhibition of PI3 kinases enhances the sensitivity of non-small cell lung cancer cells to ionizing radiation
    • Zhang T, Cui GB, Zhang J, Zhang F, Zhou YA, Jiang T, and Li XF (2010). Inhibition of PI3 kinases enhances the sensitivity of non-small cell lung cancer cells to ionizing radiation. Oncol Rep 24, 1683-1689.
    • (2010) Oncol Rep , vol.24 , pp. 1683-1689
    • Zhang, T.1    Cui, G.B.2    Zhang, J.3    Zhang, F.4    Zhou, Y.A.5    Jiang, T.6    Li, X.F.7
  • 15
    • 34547114987 scopus 로고    scopus 로고
    • Inhibition of phosphatidylinositol-3-OH kinase/Akt signaling impairs DNA repair in glioblastoma cells following ionizing radiation
    • Kao GD, Jiang Z, Fernandes AM, Gupta AK, and Maity A (2007). Inhibition of phosphatidylinositol-3-OH kinase/Akt signaling impairs DNA repair in glioblastoma cells following ionizing radiation. J Biol Chem 282, 21206-21212.
    • (2007) J Biol Chem , vol.282 , pp. 21206-21212
    • Kao, G.D.1    Jiang, Z.2    Fernandes, A.M.3    Gupta, A.K.4    Maity, A.5
  • 16
    • 70449515802 scopus 로고    scopus 로고
    • Radiation-induced Akt activation modulates radioresistance in human glioblastoma cells
    • Li H-F, Kim J-S, and Waldman T (2009). Radiation-induced Akt activation modulates radioresistance in human glioblastoma cells. Radiat Oncol 4, 43.
    • (2009) Radiat Oncol , vol.4 , pp. 43
    • Li, H.-F.1    Kim, J.-S.2    Waldman, T.3
  • 18
    • 27144482397 scopus 로고    scopus 로고
    • Inhibition of phosphatidylinositol-3-kinase causes increased sensitivity to radiation through a PKB-dependent mechanism
    • Gottschalk AR, Doan A, Nakamura JL, Stokoe D, and Haas-Kogan DA (2005). Inhibition of phosphatidylinositol-3-kinase causes increased sensitivity to radiation through a PKB-dependent mechanism. Int J Radiat Oncol Biol Phys 63, 1221-1227.
    • (2005) Int J Radiat Oncol Biol Phys , vol.63 , pp. 1221-1227
    • Gottschalk, A.R.1    Doan, A.2    Nakamura, J.L.3    Stokoe, D.4    Haas-Kogan, D.A.5
  • 19
    • 8444224619 scopus 로고    scopus 로고
    • Balancing Akt with S6K: Implications for both metabolic diseases and tumorigenesis
    • Manning BD (2004). Balancing Akt with S6K: implications for both metabolic diseases and tumorigenesis. J Cell Biol 167, 399-403.
    • (2004) J Cell Biol , vol.167 , pp. 399-403
    • Manning, B.D.1
  • 20
    • 79957983577 scopus 로고    scopus 로고
    • Targeting the PI3K/Akt/ mTOR pathway-beyond rapalogs
    • Markman B, Dienstmann R, and Tabernero J (2010). Targeting the PI3K/Akt/ mTOR pathway-beyond rapalogs. Oncotarget 1, 530-543.
    • (2010) Oncotarget , vol.1 , pp. 530-543
    • Markman, B.1    Dienstmann, R.2    Tabernero, J.3
  • 21
    • 33947538050 scopus 로고    scopus 로고
    • Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism
    • Wan X, Harkavy B, Shen N, Grohar P, and Helman LJ (2006). Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism. Oncogene 26, 1932-1940.
    • (2006) Oncogene , vol.26 , pp. 1932-1940
    • Wan, X.1    Harkavy, B.2    Shen, N.3    Grohar, P.4    Helman, L.J.5
  • 22
    • 0034794639 scopus 로고    scopus 로고
    • Prospects for phosphoinositide 3-kinase inhibition as a cancer treatment
    • Stein RC (2001). Prospects for phosphoinositide 3-kinase inhibition as a cancer treatment. Endocr Relat Cancer 8, 237-248.
    • (2001) Endocr Relat Cancer , vol.8 , pp. 237-248
    • Stein, R.C.1
  • 24
    • 51049109033 scopus 로고    scopus 로고
    • Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity
    • Maira SM, Stauffer F, Brueggen J, Furet P, Schnell C, Fritsch C, Brachmann S, Chène P, De Pover A, Schoemaker K, et al. (2008). Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity. Mol Cancer Ther 7, 1851-1863.
    • (2008) Mol Cancer Ther , vol.7 , pp. 1851-1863
    • Maira, S.M.1    Stauffer, F.2    Brueggen, J.3    Furet, P.4    Schnell, C.5    Fritsch, C.6    Brachmann, S.7    Chène, P.8    de Pover, A.9    Schoemaker, K.10
  • 27
    • 50149101312 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase inhibitors: Promising drug candidates for cancer therapy
    • KongD and Yamori T (2008). Phosphatidylinositol 3-kinase inhibitors: promising drug candidates for cancer therapy. Cancer Sci 99, 1734-1740.
    • (2008) Cancer Sci , vol.99 , pp. 1734-1740
    • Kong, D.1    Yamori, T.2
  • 28
    • 79958816470 scopus 로고    scopus 로고
    • The combination of RAD001 and NVP-BEZ235 exerts synergistic anticancer activity against non-small cell lung cancer in vitro and in vivo
    • Xu CX, Li Y, Yue P, Owonikoko TK, Ramalingam SS, Khuri FR, and Sun SY (2011). The combination of RAD001 and NVP-BEZ235 exerts synergistic anticancer activity against non-small cell lung cancer in vitro and in vivo. PLoS One 6, e20899.
    • (2011) PLoS One , vol.6
    • Xu, C.X.1    Li, Y.2    Yue, P.3    Owonikoko, T.K.4    Ramalingam, S.S.5    Khuri, F.R.6    Sun, S.Y.7
  • 29
    • 70350228529 scopus 로고    scopus 로고
    • Dual phosphoinositide 3-kinase/mammalian target of rapamycin blockade is an effective radiosensitizing strategy for the treatment of non-small cell lung cancer harboring K-RAS mutations
    • Konstantinidou G, Bey EA, Rabellino A, Schuster K, Maira MS, Gazdar AF, Amici A, Boothman DA, and Scaglioni PP (2009). Dual phosphoinositide 3-kinase/mammalian target of rapamycin blockade is an effective radiosensitizing strategy for the treatment of non-small cell lung cancer harboring K-RAS mutations. Cancer Res 69, 7644-7652.
    • (2009) Cancer Res , vol.69 , pp. 7644-7652
    • Konstantinidou, G.1    Bey, E.A.2    Rabellino, A.3    Schuster, K.4    Maira, M.S.5    Gazdar, A.F.6    Amici, A.7    Boothman, D.A.8    Scaglioni, P.P.9
  • 31
    • 84858857598 scopus 로고    scopus 로고
    • NVP-BEZ235 and NVP-BGT226, dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitors, enhance tumor and endothelial cell radiosensitivity
    • Fokas E, Yoshimura M, Prevo R, Higgins G, Hackl W, Maira SM, Bernhard EJ, McKenna WG, and Muschel RJ (2012). NVP-BEZ235 and NVP-BGT226, dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitors, enhance tumor and endothelial cell radiosensitivity. Radiat Oncol 7, 48.
    • (2012) Radiat Oncol , vol.7 , pp. 48
    • Fokas, E.1    Yoshimura, M.2    Prevo, R.3    Higgins, G.4    Hackl, W.5    Maira, S.M.6    Bernhard, E.J.7    McKenna, W.G.8    Muschel, R.J.9
  • 32
    • 84856993479 scopus 로고    scopus 로고
    • The dual PI3K/mTOR inhibitor NVP-BEZ235 is a potent inhibitor of ATM-and DNA-PKCs-mediated DNA damage responses
    • Mukherjee B, Tomimatsu N, Amancherla K, Camacho CV, Pichamoorthy N, and Burma S (2012). The dual PI3K/mTOR inhibitor NVP-BEZ235 is a potent inhibitor of ATM-and DNA-PKCs-mediated DNA damage responses. Neoplasia 14, 34-43.
    • (2012) Neoplasia , vol.14 , pp. 34-43
    • Mukherjee, B.1    Tomimatsu, N.2    Amancherla, K.3    Camacho, C.V.4    Pichamoorthy, N.5    Burma, S.6
  • 34
    • 3042699832 scopus 로고    scopus 로고
    • Normal expression of DNA repair proteins, hMre11, Rad50 and Rad51 but protracted formation of Rad50 containing foci in X-irradiated skin fibroblasts from radiosensitive cancer patients
    • Djuzenova C, Mühl B, Schakowski R, Oppitz U, and Flentje M (2004). Normal expression of DNA repair proteins, hMre11, Rad50 and Rad51 but protracted formation of Rad50 containing foci in X-irradiated skin fibroblasts from radiosensitive cancer patients. Br J Cancer 90, 2356-2363.
    • (2004) Br J Cancer , vol.90 , pp. 2356-2363
    • Djuzenova, C.1    Mühl, B.2    Schakowski, R.3    Oppitz, U.4    Flentje, M.5
  • 35
    • 50249095733 scopus 로고    scopus 로고
    • An optimized method for measurement of gamma-H2AX in blood mononuclear and cultured cells
    • Muslimovic A, Ismail IH, Gao Y, and Hammarsten O (2008). An optimized method for measurement of gamma-H2AX in blood mononuclear and cultured cells. Nat Protoc 3, 1187-1193.
    • (2008) Nat Protoc , vol.3 , pp. 1187-1193
    • Muslimovic, A.1    Ismail, I.H.2    Gao, Y.3    Hammarsten, O.4
  • 36
    • 0028039924 scopus 로고
    • Effect of electric field pulses on the viability and on the membranebound immunoglobulins of LPS-activated murine B-lymphocytes: Correlation with the cell cycle
    • Djuzenova CS, Sukhorukov VL, Klöck G, Arnold WM, and Zimmermann U (1994). Effect of electric field pulses on the viability and on the membranebound immunoglobulins of LPS-activated murine B-lymphocytes: correlation with the cell cycle. Cytometry 15, 35-45.
    • (1994) Cytometry , vol.15 , pp. 35-45
    • Djuzenova, C.S.1    Sukhorukov, V.L.2    Klöck, G.3    Arnold, W.M.4    Zimmermann, U.5
  • 38
    • 0345732640 scopus 로고    scopus 로고
    • mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E
    • Fingar DC, Richardson CJ, Tee AR, Cheatham L, Tsou C, and Blenis J (2004). mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E. Mol Cell Biol 24, 200-216.
    • (2004) Mol Cell Biol , vol.24 , pp. 200-216
    • Fingar, D.C.1    Richardson, C.J.2    Tee, A.R.3    Cheatham, L.4    Tsou, C.5    Blenis, J.6
  • 39
    • 79960048104 scopus 로고    scopus 로고
    • Regulation of G1 cell cycle progression: Distinguishing the restriction point from a nutrient-sensing cell growth checkpoint(s)
    • Foster DA, Yellen P, Xu L, and Saqcena M (2010). Regulation of G1 cell cycle progression: distinguishing the restriction point from a nutrient-sensing cell growth checkpoint(s). Genes Cancer 1, 1124-1131.
    • (2010) Genes Cancer , vol.1 , pp. 1124-1131
    • Foster, D.A.1    Yellen, P.2    Xu, L.3    Saqcena, M.4
  • 40
    • 0032489520 scopus 로고    scopus 로고
    • DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
    • Rogakou EP, Pilch DR, Orr AH, Ivanova VS, and Bonner WM (1998). DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J Biol Chem 273, 5858-5868.
    • (1998) J Biol Chem , vol.273 , pp. 5858-5868
    • Rogakou, E.P.1    Pilch, D.R.2    Orr, A.H.3    Ivanova, V.S.4    Bonner, W.M.5
  • 42
    • 31544464043 scopus 로고    scopus 로고
    • Synergistic effects of gemcitabine and gefitinib in the treatment of head and neck carcinoma
    • Chun PY, Feng FY, Scheurer AM, Davis MA, Lawrence TS, and Nyati MK (2006). Synergistic effects of gemcitabine and gefitinib in the treatment of head and neck carcinoma. Cancer Res 66, 981-988.
    • (2006) Cancer Res , vol.66 , pp. 981-988
    • Chun, P.Y.1    Feng, F.Y.2    Scheurer, A.M.3    Davis, M.A.4    Lawrence, T.S.5    Nyati, M.K.6
  • 43
    • 70449457461 scopus 로고    scopus 로고
    • Involvement of mTORC1 and mTORC2 in regulation of glioblastoma multiforme growth and motility
    • Gulati N, Karsy M, Albert L, Murali R, and Jhanwar-Uniyal M (2009). Involvement of mTORC1 and mTORC2 in regulation of glioblastoma multiforme growth and motility. Int J Oncol 35, 731-740.
    • (2009) Int J Oncol , vol.35 , pp. 731-740
    • Gulati, N.1    Karsy, M.2    Albert, L.3    Murali, R.4    Jhanwar-Uniyal, M.5
  • 44
    • 75749105049 scopus 로고    scopus 로고
    • mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling
    • Julien L-A, Carriere A, Moreau J, and Roux PP (2010). mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling. Mol Cell Biol 30, 908-921.
    • (2010) Mol Cell Biol , vol.30 , pp. 908-921
    • Julien, L.-A.1    Carriere, A.2    Moreau, J.3    Roux, P.P.4
  • 47
    • 68849091778 scopus 로고    scopus 로고
    • NVP-BEZ235, a novel dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor, elicits multifaceted antitumor activities in human gliomas
    • Liu TJ, Koul D, LaFortune T, Tiao N, Shen RJ, Maira SM, Garcia-Echevrria C, and Yung WK (2009). NVP-BEZ235, a novel dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor, elicits multifaceted antitumor activities in human gliomas. Mol Cancer Ther 8, 2204-2210.
    • (2009) Mol Cancer Ther , vol.8 , pp. 2204-2210
    • Liu, T.J.1    Koul, D.2    LaFortune, T.3    Tiao, N.4    Shen, R.J.5    Maira, S.M.6    Garcia-Echevrria, C.7    Yung, W.K.8


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