PI3K and MEK inhibitor combinations: Examining the evidence in selected tumor types

Cancer Chemotherapy and Pharmacology

Volumn 71, Issue 6, 2013, Pages 1395-1409

  Britten, Carolyn D ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

BRAF mutation; MEK inhibitor; NRAS mutation; PI3K inhibitor; PI3K AKT mTOR pathway; RAS RAF MEK ERK pathway

Indexed keywords

1 (1 CYANO 1 METHYLETHYL) 3 METHYL 8 (3 QUINOLINYL)IMIDAZO[4,5 C]QUINOLIN 2(1H,3H) ONE; 4 DIALLYLAMINOMETHYLENE 1,3,4,7,10,11,12,13,14,15,16,17 DODECAHYDRO 6 HYDROXY 1 METHOXYMETHYL 10,13 DIMETHYL 3,7,17 TRIOXO 2 OXACYCLOPENTA[A]PHENANTHREN 11 YL ACETATE; APITOLISIB; B RAF KINASE; BINDING PROTEIN; BUPARLISIB; COPANLISIB; DABRAFENIB; EVEROLIMUS; FK BINDING PROTEIN 12; G PROTEIN COUPLED RECEPTOR; IDELALISIB; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; N RAS PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PICTILISIB; PIMASERTIB; PROTEIN KINASE B; PROTEIN TYROSINE KINASE; RAF PROTEIN; RAPAMYCIN; RAS PROTEIN; TEMSIROLIMUS; TRAMETINIB; UNCLASSIFIED DRUG; UNINDEXED DRUG; XL 147;

ACNE; AMINOTRANSFERASE BLOOD LEVEL; ANOREXIA; BINDING SITE; BLURRED VISION; BRAF GENE; BREAST CANCER; CANCER CHEMOTHERAPY; CANCER COMBINATION CHEMOTHERAPY; CANCER GRADING; CANCER MODEL; CANCER RESISTANCE; CENTRAL SEROUS RETINOPATHY; CHRONIC LYMPHATIC LEUKEMIA; COLORECTAL CANCER; DERMATITIS; DIARRHEA; DRUG DESIGN; DRUG EFFICACY; DRUG ERUPTION; DRUG PROTEIN BINDING; ENDOMETRIUM CANCER; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME INHIBITION; FATIGUE; GENE; GENE AMPLIFICATION; GENE MUTATION; GENETIC ASSOCIATION; HEART LEFT VENTRICLE FAILURE; HUMAN; HYPERGLYCEMIA; KIDNEY CANCER; LUNG NON SMALL CELL CANCER; MELANOMA; MOLECULAR INTERACTION; MOLECULARLY TARGETED THERAPY; MOOD DISORDER; NAUSEA; NONHODGKIN LYMPHOMA; NONHUMAN; NRAS GENE; OVARY CANCER; OVARY CARCINOMA; PANCREAS CANCER; PERIPHERAL EDEMA; PNEUMONIA; PRIORITY JOURNAL; PROGRESSION FREE SURVIVAL; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN SUBUNIT; PROTEIN TARGETING; RETINA VEIN OCCLUSION; REVIEW; SIDE EFFECT; THYROID CANCER; TRIPLE NEGATIVE BREAST CANCER; TUMOR GROWTH; VOMITING;

ANIMALS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CLINICAL TRIALS AS TOPIC; DRUG RESISTANCE, NEOPLASM; ENZYME INHIBITORS; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASES; NEOPLASMS; PHOSPHATIDYLINOSITOL 3-KINASES; TREATMENT OUTCOME;

EID: 84878652051     PISSN: 03445704     EISSN: 14320843     Source Type: Journal    
DOI: 10.1007/s00280-013-2121-1     Document Type: Review

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