Simultaneous inhibition of EGFR and PI3K enhances radiosensitivity in human breast cancer

International Journal of Radiation Oncology Biology Physics

Volumn 83, Issue 3, 2012, Pages

  Li, Ping ^a   Zhang, Qing ^a   Torossian, Artour ^b   Li, Zhao Bin ^a   Xu, Wen Cai ^a   Lu, Bo ^c   Fu, Shen ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Breast cancer; Co targeting inhibition; Epidermal growth factor receptor (EGFR); Phosphoinositide 3 kinase (PI3K); Protein kinase B (Akt PKB); Radiosensitivity

Indexed keywords

BREAST CANCER; EPIDERMAL GROWTH FACTOR RECEPTORS; PHOSPHOINOSITIDE 3-KINASE; PROTEIN KINASE B; RADIOSENSITIVITY;

BIOLOGICAL MATERIALS; CELL CULTURE; CELL DEATH; DISEASES; ENZYMES; FLOW CYTOMETRY; LIGHT EMISSION; PATIENT TREATMENT; PHOSPHORS; RADIATION;

IRRADIATION;

EPIDERMAL GROWTH FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CANCER INHIBITION; CANCER PATIENT; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL STRAIN MCF 7; COLONY FORMATION; CONTROLLED STUDY; DNA DETERMINATION; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IRRADIATION; MITOSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RADIATION DOSE; RADIOSENSITIVITY; SIGNAL TRANSDUCTION; TUMOR XENOGRAFT; WESTERN BLOTTING; WILD TYPE;

ANIMALS; APOPTOSIS; BREAST NEOPLASMS; CELL LINE, TUMOR; CHROMONES; FEMALE; G0 PHASE; G1 PHASE; HUMANS; MICE; MICE, NUDE; MORPHOLINES; NEOPLASM PROTEINS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; QUINAZOLINES; RADIATION TOLERANCE; RADIATION-SENSITIZING AGENTS; RANDOM ALLOCATION; RECEPTOR, EPIDERMAL GROWTH FACTOR; TYRPHOSTINS;

EID: 84862803141     PISSN: 03603016     EISSN: 1879355X     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2011.12.090     Document Type: Article

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