Orphan nuclear receptor Nur77 affects cardiomyocyte calcium homeostasis and adverse cardiac remodelling

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Medzikovic, Lejla ^a   Schumacher, Cees A ^a   Verkerk, Arie O ^a   Van Deel, Elza D ^b   Wolswinkel, Rianne ^a   Van Der Made, Ingeborg ^a   Bleeker, Natascha ^a   Cakici, Daniella ^a   Van Den Hoogenhof, Maarten M G ^a   Meggouh, Farid ^a   Creemers, Esther E ^a   Ann Remme, Carol ^a   Baartscheer, Antonius ^a   De Winter, Robbert J ^a   De Vries, Carlie J M ^a   Arkenbout, E Karin ^a,c   De Waard, Vivian ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c TERGOOI HOSPITAL   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CALCIUM; ISOPRENALINE; NR4A1 PROTEIN, HUMAN; NUCLEAR RECEPTOR NUR77;

ANIMAL; CARDIAC MUSCLE CELL; DRUG EFFECTS; GENETICS; HEART CONTRACTION; HEART FAILURE; HEART VENTRICLE REMODELING; HOMEOSTASIS; HUMAN; KNOCKOUT MOUSE; METABOLISM; MOUSE; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY;

ADRENERGIC BETA-AGONISTS; ANIMALS; CALCIUM; HEART FAILURE; HOMEOSTASIS; HUMANS; ISOPROTERENOL; MICE; MICE, KNOCKOUT; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; NUCLEAR RECEPTOR SUBFAMILY 4, GROUP A, MEMBER 1; VENTRICULAR REMODELING;

EID: 84944936974     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep15404     Document Type: Article

References (47)

1. Lymperopoulos, A., Rengo, G., Koch, W. J. Adrenergic nervous system in heart failure: pathophysiology and therapy. Circ. Res. 113, 739-53 (2013).
2. Hill, J. A., Olson, E. N. Cardiac plasticity. N. Engl. J. Med. 358, 1370-80 (2008).
3. Barrese, V., Taglialatela, M. New advances in beta-blocker therapy in heart failure. Front. Physiol. 4, 323 (2013).
4. Roger, V. L. Epidemiology of heart failure. Circ. Res. 113, 646-59 (2013).
5. Bers, D. M. Cardiac excitation-contraction coupling. Nature 415, 198-205 (2002).
6. Zarain-Herzberg, A., Fragoso-Medina, J., Estrada-Avilés, R. Calcium-regulated transcriptional pathways in the normal and pathologic heart. IUBMB Life 63, 847-55 (2011).
7. Luo, M., Anderson, M. E. Mechanisms of altered Ca2+ handling in heart failure. Circ. Res. 113, 690-708 (2013).
8. Arkenbout, E. K. et al. Protective function of transcription factor TR3 orphan receptor in atherogenesis: decreased lesion formation in carotid artery ligation model in TR3 transgenic mice. Circulation 106, 1530-5 (2002).
9. Bonta, P. I. et al. Nuclear receptor Nur77 inhibits vascular outward remodelling and reduces macrophage accumulation and matrix metalloproteinase levels. Cardiovasc. Res. 87, 561-8 (2010).
10. Hamers, A. A. J. et al. Bone marrow-specific deficiency of nuclear receptor Nur77 enhances atherosclerosis. Circ. Res. 110, 428-38 (2012).
11. Hanna, R. N. et al. NR4A1 (Nur77) deletion polarizes macrophages toward an inflammatory phenotype and increases atherosclerosis. Circ. Res. 110, 416-27 (2012).
12. Shao, Q. et al. Nuclear receptor Nur77 suppresses inflammatory response dependent on COX-2 in macrophages induced by oxLDL. J. Mol. Cell. Cardiol. 49, 304-11 (2010).
13. Bonta, P. I. et al. Nuclear receptors Nur77, Nurr1, and NOR-1 expressed in atherosclerotic lesion macrophages reduce lipid loading and inflammatory responses. Arterioscler. Thromb. Vasc. Biol. 26, 2288-94 (2006).
14. Zeng, H. et al. Orphan nuclear receptor TR3/Nur77 regulates VEGF-A-induced angiogenesis through its transcriptional activity. J. Exp. Med. 203, 719-29 (2006).
15. Mitochondrial translocation of Nur77 mediates cardiomyocyte apoptosis. Cheng, Z. et al. Mitochondrial translocation of Nur77 mediates cardiomyocyte apoptosis. Eur. Heart J. 32, 2179-88 (2011).
16. Wang, R.-H. et al. The orphan receptor TR3 participates in angiotensin II-induced cardiac hypertrophy by controlling mTOR signalling. EMBO Mol. Med. 5, 137-48 (2013).
17. Hilgendorf, I. et al. Ly-6Chigh monocytes depend on Nr4a1 to balance both inflammatory and reparative phases in the infarcted myocardium. Circ. Res. 114, 1611-22 (2014).
18. Myers, S., Eriksson, N., Burow, R., Wang, S.-C. M., Muscat, G. E. O. Beta-adrenergic signaling regulates NR4A nuclear receptor and metabolic gene expression in multiple tissues. Mol. Cell. Endocrinol. 309, 101-8 (2009).
19. Yan, G. et al. Orphan Nuclear Receptor Nur77 Inhibits Cardiac Hypertrophic Response to Beta-Adrenergic Stimulation. Mol. Cell. Biol. (2015), doi: 10.1128/MCB.00229-15.
20. Kuwahara, K., Nishikimi, T., Nakao, K. Transcriptional regulation of the fetal cardiac gene program. J. Pharmacol. Sci. 119, 198-203 (2012).
21. Dolmetsch, R. E., Lewis, R. S., Goodnow, C. C., Healy, J. I. Differential activation of transcription factors induced by Ca2+ response amplitude and duration. Nature 386, 855-8 (1997).
22. Molkentin, J. D. et al. A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Cell 93, 215-28 (1998).
23. Van Tiel, C. M., de Vries, C. J. M. NR4All in the vessel wall. J. Steroid Biochem. Mol. Biol. 130, 186-93 (2012).
24. To, S. K. Y., Zeng, J.-Z., Wong, A. S. T. Nur77: a potential therapeutic target in cancer. Expert Opin. Ther. Targets 16, 573-85 (2012).
25. Pearen, M. A., Muscat, G. E. O. Minireview: Nuclear hormone receptor 4A signaling: implications for metabolic disease. Mol. Endocrinol. 24, 1891-903 (2010).
26. Paradis, P., Dali-Youcef, N., Paradis, F. W., Thibault, G., Nemer, M. Overexpression of angiotensin II type I receptor in cardiomyocytes induces cardiac hypertrophy and remodeling. Proc. Natl. Acad. Sci. USA 97, 931-6 (2000).
27. Piacentino, V. et al. Cellular basis of abnormal calcium transients of failing human ventricular myocytes. Circ. Res. 92, 651-8 (2003).
28. Hasenfuss, G. et al. Relation between myocardial function and expression of sarcoplasmic reticulum Ca(2+ )-ATPase in failing and nonfailing human myocardium. Circ. Res. 75, 434-42 (1994).
29. Louch, W. E., Sheehan, K. A., Wolska, B. M. Methods in cardiomyocyte isolation, culture, and gene transfer. J. Mol. Cell. Cardiol. 51, 288-98 (2011).
30. el-Sherif, N., Caref, E. B., Yin, H., Restivo, M. The electrophysiological mechanism of ventricular arrhythmias in the long QT syndrome. Tridimensional mapping of activation and recovery patterns. Circ. Res. 79, 474-92 (1996).
31. Benitah, J.-P., Alvarez, J. L., Gómez, A. M. L-type Ca(2+ ) current in ventricular cardiomyocytes. J. Mol. Cell. Cardiol. 48, 26-36 (2010).
32. Rozanski, G. J. Physiological remodelling of potassium channels in the heart. Cardiovasc. Res. 93, 218-9 (2012).
33. Roder, K., Koren, G. The K+ channel gene, Kcnb1: genomic structure and characterization of its 5?-regulatory region as part of an overlapping gene group. Biol. Chem. 387, 1237-46 (2006).
34. Qin, D. et al. Downregulation of K(+ ) channel genes expression in type I diabetic cardiomyopathy. Biochem. Biophys. Res. Commun. 283, 549-53 (2001).
35. Huang, B., Qin, D., El-Sherif, N. Early down-regulation of K+ channel genes and currents in the postinfarction heart. J. Cardiovasc. Electrophysiol. 11, 1252-61 (2000).
36. Yoon, J. K., Lau, L. F. Transcriptional activation of the inducible nuclear receptor gene nur77 by nerve growth factor and membrane depolarization in PC12 cells. J. Biol. Chem. 268, 9148-55 (1993).
37. Enslen, H., Soderling, T. R. Roles of calmodulin-dependent protein kinases and phosphatase in calcium-dependent transcription of immediate early genes. J. Biol. Chem. 269, 20872-7 (1994).
38. Fass, D. M., Butler, J. E. F., Goodman, R. H. Deacetylase activity is required for cAMP activation of a subset of CREB target genes. J. Biol. Chem. 278, 43014-9 (2003).
39. Tokuoka, H., Hatanaka, T., Metzger, D., Ichinose, H. Nurr1 expression is regulated by voltage-dependent calcium channels and calcineurin in cultured hippocampal neurons. Neurosci. Lett. 559, 50-5 (2014).
40. Hanna, R. N. et al. The transcription factor NR4A1 (Nur77) controls bone marrow differentiation and the survival of Ly6Cmonocytes. Nat. Immunol. 12, 778-85 (2011).
41. Nahrendorf, M. et al. The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions. J. Exp. Med. 204, 3037-47 (2007).
42. Osadchii, O. E. Cardiac hypertrophy induced by sustained beta-adrenoreceptor activation: pathophysiological aspects. Heart Fail. Rev. 12, 66-86 (2007).
43. Den Haan, A. D. et al. Organ explant culture of neonatal rat ventricles: a new model to study gene and cell therapy. PLoS One 8, e59290 (2013).
44. Ter Welle, H. F., Baartscheer, A., Fiolet, J. W., Schumacher, C. A. The cytoplasmic free energy of ATP hydrolysis in isolated rod-shaped rat ventricular myocytes. J. Mol. Cell. Cardiol. 20, 435-41 (1988).
45. Baartscheer, A., Schumacher, C. A., Opthof, T., Fiolet, J. W. The origin of increased cytoplasmic calcium upon reversal of the Na+/Ca(2+ )-exchanger in isolated rat ventricular myocytes. J. Mol. Cell. Cardiol. 28, 1963-73 (1996).
46. Shy, D. et al. PDZ domain-binding motif regulates cardiomyocyte compartment-specific NaV1.5 channel expression and function. Circulation 130, 147-60 (2014).
47. Van Deel, E. D. et al. Exercise training does not improve cardiac function in compensated or decompensated left ventricular hypertrophy induced by aortic stenosis. J. Mol. Cell. Cardiol. 50, 1017-25 (2011).