The K+ channel gene, Kcnb1: Genomic structure and characterization of its 5′-regulatory region as part of an overlapping gene group

Biological Chemistry

Volumn 387, Issue 9, 2006, Pages 1237-1246

  Roder, Karim ^a,b   Koren, Gideon ^a,c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b HERIOT WATT UNIVERSITY   (United Kingdom)

^c BROWN UNIVERSITY   (United States)

Author keywords

Ion channel; Kcnb1; Overlapping gene group; Promoter

Indexed keywords

POTASSIUM CHANNEL; PROTEIN; PROTEIN KCNB1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING SITE; BRAIN; CONTROLLED STUDY; GENE CONTROL; GENE EXPRESSION; GENE MUTATION; GENOMICS; HYPOPHYSIS CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; RAT;

ANIMALS; BASE SEQUENCE; CELL LINE; CERCOPITHECUS AETHIOPS; COS CELLS; GENE EXPRESSION REGULATION; HUMANS; MICE; MOLECULAR SEQUENCE DATA; PC12 CELLS; POTASSIUM CHLORIDE; PROMOTER REGIONS (GENETICS); RATS; RESPONSE ELEMENTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEQUENCE ANALYSIS, DNA; SEQUENCE HOMOLOGY, NUCLEIC ACID; SHAB POTASSIUM CHANNELS; SODIUM CHLORIDE; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTION, GENETIC;

EID: 33748745219     PISSN: 14316730     EISSN: 14374315     Source Type: Journal    
DOI: 10.1515/BC.2006.153     Document Type: Article

References (29)

1. Bock, J.H., Shuck, M.E., Benjamin, C.W., Chee, M., Bienkowski, M.J., and Slightom, J.L. (1997). Nucleotide sequence analysis of the human KCNJ1 potassium channel locus. Gene 188, 9-16.
2. + channel expression in brain during experimental cancer cachexia. FEBS Lett. 536, 45-50.
3. + channel mRNAs from different subfamilies. J. Neurosci. 12, 538-548.
4. Ebihara, M., Ohba, H., Kikuchi, M., and Yoshikawa, T. (2004). Structural characterization and promoter analysis of human potassium channel Kv8.1 (KCNV1) gene. Gene 325, 89-96.
5. + channel activity and enhances survival in vascular smooth muscle cells. Am. J. Physiol. Cell. Physiol. 281, C157-C165.
6. Gan, L., Hahn, S.J., and Kaczmarek, L.K. (1999). Cell type-specific expression of the Kv3.1 gene is mediated by a negative element in the 5′ untranslated region of the Kv3.1 promoter. J. Neurochem. 73, 1350-1362.
7. + channel genes and currents in the postinfarction heart. J. Cardiovasc. Electrophysiol. 11, 1252-1261.
8. Ishizaki, F., Harada, T., Yoshinaga, H., Nakayama, T., Yamamura, Y., and Nakamura, S. (1996). Prolonged QTc intervals in Parkinson's disease - relation to sudden death and autonomic dysfunction. No To Shinkei 48, 443-448.
9. Law, S.W., Conneely, O.M., DeMayo, F.J., and O'Malley, B.W. (1992). Identification of a new brain-specific transcription factor, NURR1. Mol. Endocrinol. 6, 2129-2135.
10. Le, W.D., Xu, P., Jankovic, J., Jiang, H., Appel, S.H., Smith, R.G., and Vassilatis, D.K. (2003). Mutations in NR4A2 associated with familial Parkinson disease. Nat. Genet. 33, 85-89.
11. + channels in pancreatic β-cells enhances glucose-dependent insulin secretion. J. Biol. Chem. 277, 44938-44945.
12. Mangelsdorf, D.J., Thummel, C., Beato, M., Herrlich, P., Schutz, G., Umesono, K., Blumberg, B., Kastner, P., Mark, M., Chambon, P., et al. (1995). The nuclear receptor superfamily: the second decade. Cell 83, 835-839.
13. Mattick, J.S. (2001). Non-coding RNAs: the architects of eukaryotic complexity. EMBO Rep. 2, 986-991.
14. Michelhaugh, S.K., Vaitkevicius, H., Wang, J., Bouhamdan, M., Krieg, A.R., Walker, J.L., Mendiratta, V., and Bannon, M.J. (2005). Dopamine neurons express multiple isoforms of the nuclear receptor nurr1 with diminished transcriptional activity. J. Neurochem. 95, 1342-1350.
15. Miyata, A., Hara, S., Yokoyama, C., Inoue, H., Ullrich, V., and Tanabe, T. (1994). Molecular cloning and expression of human prostacyclin synthase. Biochem. Biophys. Res. Commun. 200, 1728-1734.
16. Mori, Y., Folco, E., and Koren, G. (1995). GH3 cell-specific expression of Kv1.5 gene. Regulation by a silencer containing a dinucleotide repetitive element. J. Biol. Chem. 270, 27788-27796.
17. Ohkura, N., Hijikuro, M., Yamamoto, A., and Miki, K. (1994). Molecular cloning of a novel thyroid/steroid receptor superfamily gene from cultured rat neuronal cells. Biochem. Biophys. Res. Commun. 205, 1959-1965.
18. Oka, H., Mochio, S., Sato, H., and Katayama, K. (1997). Prolongation of QTc interval in patients with Parkinson's disease. Eur. Neurol. 37, 186-189.
19. Ottschytsch, N., Raes, A., Van Hoorick, D., and Snyders, D.J. (2002). Obligatory heterotetramerization of three previously uncharacterized Kv channel α-subunits identified in the human genome. Proc. Natl. Acad. Sci. USA 99, 7986-7991.
20. + channel with conserved delayed-rectifier properties. J. Neurosci. 11, 869-880.
21. Pal, S., Hartnett, K.A., Nerbonne, J.M., Levitan, E.S., and Aizenman, E. (2003). Mediation of neuronal apoptosis by Kv2.1-encoded potassium channels. J. Neurosci. 23, 4798-4802.
22. + channel genes expression in type I diabetic cardiomyopathy. Biochem. Biophys. Res. Commun. 283, 549-553.
23. Rajpal, A., Cho, Y.A., Yelent, B., Koza-Taylor, P.H., Li, D., Chen, E., Whang, M., Kang, C., Turi, T.G., and Winoto, A. (2003). Transcriptional activation of known and novel apoptotic pathways by Nur77 orphan steroid receptor. EMBO J. 22, 6526-6536.
24. + channels. J. Biol. Chem. 272, 24371-24379.
25. Saucedo-Cardenas, O., Quintana-Hau, J.D., Le, W.D., Smidt, M.P., Cox, J.J., De Mayo, F., Burbach, J.P., and Conneely, O.M. (1998). Nurr1 is essential for the induction of the dopaminergic phenotype and the survival of ventral mesencephalic late dopaminergic precursor neurons. Proc. Natl. Acad. Sci. USA 95, 4013-4018.
26. Shabalina, S.A., Ogurtsov, A.Y., Kondrashov, V.A., and Kondrashov, A.S. (2001). Selective constraint in intergenic regions of human and mouse genomes. Trends Genet. 17, 373-376.
27. Vullhorst, D., Jockusch, H., and Bartsch, J.W. (2001). The genomic basis of K(V)3.4 potassium channel mRNA diversity in mice. Gene 264, 29-35.
28. Wilson, T.E., Fahrner, T.J., Johnston, M., and Milbrandt, J. (1991). Identification of the DNA binding site for NGFI-B by genetic selection in yeast. Science 252, 1296-1300.
29. Wright, F.A., Lemon, W.J., Zhao, W.D., Sears, R., Zhuo, D., Wang, J.P., Yang, H.Y., Baer, T., Stredney, D., Spitzner, J., et al. (2001). A draft annotation and overview of the human genome. Genome Biol. 2, RESEARCH0025.