Transcriptional regulation of the fetal cardiac gene program

Journal of Pharmacological Sciences

Volumn 119, Issue 3, 2012, Pages 198-203

  Kuwahara, Koichiro ^a   Nishikimi, Toshio ^a   Nakao, Kazuwa ^a  

^a KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Cardiac remodeling; Fetal cardiac gene; Heart failure; Transcription

Indexed keywords

ALPHA ACTIN; ATRIAL NATRIURETIC FACTOR; BRAIN NATRIURETIC PEPTIDE; CALCIUM CHANNEL T TYPE; CYCLIC NUCLEOTIDE GATED CHANNEL; HYPERPOLARIZATION ACTIVATED CYCLIC NUCLEOTIDE GATED CHANNEL 4; MYOSIN HEAVY CHAIN BETA; UNCLASSIFIED DRUG;

ANP GENE; ARRHYTHMOGENESIS; BETA MHC GENE; BNP GENE; CACNA1H GENE; DNA FLANKING REGION; FETAL CARDIAC GENE PROGRAM; FETUS HEART; GENE; GENE ACTIVATION; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE REARRANGEMENT; HCN 4 GENE; HEART ARRHYTHMIA; HEART FAILURE; HEART VENTRICLE HYPERTROPHY; HUMAN; INTRACELLULAR SIGNALING; MOLECULAR GENETICS; NONHUMAN; REVIEW; SKA GENE; SM22ALPHA GENE; SMA GENE; TRANSCRIPTION REGULATION;

EID: 84864498547     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.12R04CP     Document Type: Review

References (51)

1. Barry SP, Davidson SM, Townsend PA. Molecular regulation of cardiac hypertrophy. Int J Biochem Cell Biol. 2008;40: 2023-2039.
2. Thum T, Galuppo P, Wolf C, Fiedler J, Kneitz S, van Laake LW, et al. Micrornas in the human heart: a clue to fetal gene reprogramming in heart failure. Circulation. 2007;116:258-267. (Pubitemid 47196561)
3. Black FM, Packer SE, Parker TG, Michael LH, Roberts R, Schwartz RJ, et al. The vascular smooth muscle alpha-actin gene is reactivated during cardiac hypertrophy provoked by load. J Clin Invest. 1991;88:1581-1588.
4. Li L, Miano JM, Cserjesi P, Olson EN. SM22 alpha, a marker of adult smooth muscle, is expressed in multiple myogenic lineages during embryogenesis. Circ Res. 1996;78:188-195.
5. Olson EN. A decade of discoveries in cardiac biology. Nat Med. 2004;10:467-474. (Pubitemid 38667903)
6. Field LJ. Atrial natriuretic factor-SV40 T antigen transgenes produce tumors and cardiac arrhythmias in mice. Science. 1988;239:1029-1033. (Pubitemid 18094172)
7. Seidman CE, Schmidt EV, Seidman JG. Cis-dominance of rat atrial natriuretic factor gene regulatory sequences in transgenic mice. Can J Physiol Pharmacol. 1991;69:1486-1492.
8. Knowlton KU, Rockman HA, Itani M, Vovan A, Seidman CE, Chien KR. Divergent pathways mediate the induction of ANF transgenes in neonatal and hypertrophic ventricular myocardium. J Clin Invest. 1995;96:1311-1318.
9. Argentin S, Ardati A, Tremblay S, Lihrmann I, Robitaille L, Drouin J, et al. Developmental stage-specific regulation of atrial natriuretic factor gene transcription in cardiac cells. Mol Cell Biol. 1994;14:777-790.
10. LaPointe MC, Wu JP, Greenberg B, Gardner DG. Upstream sequences confer atrial-specific expression on the human atrial natriuretic factor gene. J Biol Chem. 1988;263:9075-9078.
11. Houweling AC, van Borren MM, Moorman AF, Christoffels VM. Expression and regulation of the atrial natriuretic factor encoding gene Nppa during development and disease. Cardiovasc Res. 2005;67:583-593. (Pubitemid 41033354)
12. Debrus S, Rahbani L, Marttila M, Delorme B, Paradis P, Nemer M. The zinc finger-only protein Zfp260 is a novel cardiac regulator and a nuclear effector of alpha1-adrenergic signaling. Mol Cell Biol. 2005;25:8669-8682. (Pubitemid 41369185)
13. Kuwahara K, Nakao K. Regulation and significance of atrial and brain natriuretic peptides as cardiac hormones. Endocr J. 2010; 57:555-565.
14. Kuwahara K, Saito Y, Ogawa E, Takahashi N, Nakagawa Y, Naruse Y, et al. The neuron-restrictive silencer element-neuronrestrictive silencer factor system regulates basal and endothelin 1-inducible atrial natriuretic peptide gene expression in ventricular myocytes. Mol Cell Biol. 2001;21:2085-2097. (Pubitemid 32479630)
15. Kuwahara K, Saito Y, Takano M, Arai Y, Yasuno S, Nakagawa Y, et al. NRSF regulates the fetal cardiac gene program and maintains normal cardiac structure and function. Embo J. 2003; 22:6310-6321. (Pubitemid 37522588)
16. Tamura N, Ogawa Y, Yasoda A, Itoh H, Saito Y, Nakao K. Two cardiac natriuretic peptide genes (atrial natriuretic peptide and brain natriuretic peptide) are organized in tandem in the mouse and human genomes. J Mol Cell Cardiol. 1996;28:1811-1815. (Pubitemid 26300580)
17. Ogawa Y, Itoh H, Nakagawa O, Shirakami G, Tamura N, Yoshimasa T, et al. Characterization of the 5?-flanking region and chromosomal assignment of the human brain natriuretic peptide gene. J Mol Med. 1995;73:457-463.
18. He Q, Wang D, Yang XP, Carretero OA, LaPointe MC. Inducible regulation of human brain natriuretic peptide promoter in transgenic mice. Am J Physiol Heart Circ Physiol. 2001;280: H368-H376.
19. Nakagawa O, Ogawa Y, Itoh H, Suga S, Komatsu Y, Kishimoto I, et al. Rapid transcriptional activation and early mrna turnover of brain natriuretic peptide in cardiocyte hypertrophy. Evidence for brain natriuretic peptide as an "emergency" cardiac hormone against ventricular overload. J Clin Invest. 1995;96:1280-1287.
20. Hanford DS, Glembotski CC. Stabilization of the B-type natriuretic peptide mRNA in cardiac myocytes by alpha-adrenergic receptor activation: potential roles for protein kinase C and mitogen-activated protein kinase. Mol Endocrinol. 1996;10: 1719-1727. (Pubitemid 26408759)
21. LaPointe MC, Wu G, Garami M, Yang XP, Gardner DG. Tissue-specific expression of the human brain natriuretic peptide gene in cardiac myocytes. Hypertension. 1996;27:715-722. (Pubitemid 26084638)
22. Ma KK, Banas K, de Bold AJ. Determinants of inducible brain natriuretic peptide promoter activity. Regul Pept. 2005;128: 169-176. (Pubitemid 40544831)
23. LaPointe MC. Molecular regulation of the brain natriuretic peptide gene. Peptides. 2005;26:944-956. (Pubitemid 40725368)
24. Kuwahara K, Kinoshita H, Kuwabara Y, Nakagawa Y, Usami S, Minami T, et al. Myocardin-related transcription factor a is a common mediator of mechanical stress- and neurohumoral stimulation- induced cardiac hypertrophic signaling leading to activation of brain natriuretic peptide gene expression. Mol Cell Biol. 2010;30:4134-4148.
25. Kuwahara K, Wang Y, McAnally J, Richardson JA, Bassel-Duby R, Hill JA, et al. TRPC6 fulfills a calcineurin signaling circuit during pathologic cardiac remodeling. J Clin Invest. 2006;116: 3114-3126. (Pubitemid 44878626)
26. Molkentin JD, Lu JR, Antos CL, Markham B, Richardson J, Robbins J, et al. A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Cell. 1998;93:215-228. (Pubitemid 28180855)
27. van Rooij E, Quiat D, Johnson BA, Sutherland LB, Qi X, Richardson JA, et al. A family of micrornas encoded by myosin genes governs myosin expression and muscle performance. Dev Cell. 2009;17:662-673.
28. van Rooij E, Sutherland LB, Qi X, Richardson JA, Hill J, Olson EN. Control of stress-dependent cardiac growth and gene expression by a microrna. Science. 2007;316:575-579. (Pubitemid 46683138)
29. Parker TG, Chow KL, Schwartz RJ, Schneider MD. Differential regulation of skeletal alpha-actin transcription in cardiac muscle by two fibroblast growth factors. Proc Natl Acad Sci U S A. 1990;87:7066-7070.
30. MacLellan WR, Lee TC, Schwartz RJ, Schneider MD. Transforming growth factor-beta response elements of the skeletal alpha-actin gene. Combinatorial action of serum response factor, YY1, and the SV40 enhancer-binding protein, TEF-1. J Biol Chem. 1994;269:16754-16760.
31. Karns LR, Kariya K, Simpson PC. M-CAT, CArG, and Sp1 elements are required for alpha 1-adrenergic induction of the skeletal alpha-actin promoter during cardiac myocyte hypertrophy. Transcriptional enhancer factor-1 and protein kinase C as conserved transducers of the fetal program in cardiac growth. J Biol Chem. 1995;270:410-417.
32. Robinson RB, Siegelbaum SA. Hyperpolarization-activated cation currents: from molecules to physiological function. Annu Rev Physiol. 2003;65:453-480. (Pubitemid 38249163)
33. Wahl-Schott C, Biel M. HCN channels: structure, cellular regulation and physiological function. Cell Mol Life Sci. 2009; 66:470-494.
34. Cerbai E, Mugelli A. I(f) in non-pacemaker cells: role and pharmacological implications. Pharmacol Res. 2006;53:416-423. (Pubitemid 43729046)
35. Stillitano F, Lonardo G, Zicha S, Varro A, Cerbai E, Mugelli A, et al. Molecular basis of funny current (if) in normal and failing human heart. J Mol Cell Cardiol. 2008;45:289-299.
36. Kuratomi S, Kuratomi A, Kuwahara K, Ishii TM, Nakao K, Saito Y, et al. NRSF regulates the developmental and hypertrophic changes of HCN4 transcription in rat cardiac myocytes. Biochem Biophys Res Commun. 2007;353:67-73. (Pubitemid 44958342)
37. Kuratomi S, Ohmori Y, Ito M, Shimazaki K, Muramatsu S, Mizukami H, et al. The cardiac pacemaker-specific channel Hcn4 is a direct transcriptional target of MEF2. Cardiovasc Res. 2009;83:682-687.
38. Yasui K, Niwa N, Takemura H, Opthof T, Muto T, Horiba M, et al. Pathophysiological significance of T-type Ca2+ channels: expression of T-type Ca2+ channels in fetal and diseased heart. J Pharmacol Sci. 2005;99:205-210. (Pubitemid 41686442)
39. Niwa N, Yasui K, Opthof T, Takemura H, Shimizu A, Horiba M, et al. Cav3.2 subunit underlies the functional T-type Ca2+ channel in murine hearts during the embryonic period. Am J Physiol Heart Circ Physiol. 2004;286:H2257-H2263. (Pubitemid 38685241)
40. Clozel JP, Ertel EA, Ertel SI. Voltage-gated T-type Ca2+ channels and heart failure. Proc Assoc Am Physicians. 1999;111: 429-437. (Pubitemid 29446886)
41. Ono K, Iijima T. Cardiac T-type Ca(2+) channels in the heart. J Mol Cell Cardiol. 2010;48:65-70.
42. Ruzicka DL, Schwartz RJ. Sequential activation of alpha-actin genes during avian cardiogenesis: vascular smooth muscle alphaactin gene transcripts mark the onset of cardiomyocyte differentiation. J Cell Biol. 1988;107:2575-2586.
43. Tondeleir D, Vandamme D, Vandekerckhove J, Ampe C, Lambrechts A. Actin isoform expression patterns during mammalian development and in pathology: insights from mouse models. Cell Motil Cytoskeleton. 2009;66:798-815.
44. Parker TG, Packer SE, Schneider MD. Peptide growth factors can provoke "fetal" Contractile protein gene expression in rat cardiac myocytes. J Clin Invest. 1990;85:507-514. (Pubitemid 20070059)
45. Mack CP, Owens GK. Regulation of smooth muscle alpha-actin expression in vivo is dependent on CArG elements within the 5′ and first intron promoter regions. Circ Res. 1999;84:852-861. (Pubitemid 29181493)
46. Owens GK, Kumar MS, Wamhoff BR. Molecular regulation of vascular smooth muscle cell differentiation in development and disease. Physiol Rev. 2004;84:767-801. (Pubitemid 38823766)
47. Zhang A, David JJ, Subramanian SV, Liu X, Fuerst MD, Zhao X, et al. Serum response factor neutralizes Pur alpha- and Pur beta-mediated repression of the fetal vascular smooth muscle alphaactin gene in stressed adult cardiomyocytes. Am J Physiol Cell Physiol. 2008;294:C702-C714. (Pubitemid 351468690)
48. Adam PJ, Regan CP, Hautmann MB, Owens GK. Positive- and negative-acting Kruppel-like transcription factors bind a transforming growth factor beta control element required for expression of the smooth muscle cell differentiation marker SM22alpha in vivo. J Biol Chem. 2000;275:37798-37806. (Pubitemid 32004896)
49. Qiu P, Ritchie RP, Fu Z, Cao D, Cumming J, Miano JM, et al. Myocardin enhances Smad3-mediated transforming growth factor- beta1 signaling in a CArG box-independent manner: Smadbinding element is an important cis element for SM22alpha transcription in vivo. Circ Res. 2005;97:983-991. (Pubitemid 41668911)
50. Branishte TA, Dudnakova TV, Dergilev KV, Severin VV, Naumov VG, Shirinskii VP, et al. [Expression of contractile and cytoskeletal proteins in myocardium of patients with dilated cardiomyopathy]. Kardiologiia. 2004;44:31-36. (text in Russian with English abstract)
51. Gardner DG, Chen S, Glenn DJ, Grigsby CL. Molecular biology of the natriuretic peptide system: implications for physiology and hypertension. Hypertension. 2007;49:419-426.