Determinants of amyloid fibril degradation by the PDZ protease HTRA1

Nature Chemical Biology

Volumn 11, Issue 11, 2015, Pages 862-869

  Poepsel, Simon ^a   Sprengel, Andreas ^a   Sacca, Barbara ^a   Kaschani, Farnusch ^a   Kaiser, Markus ^a   Gatsogiannis, Christos ^b   Raunser, Stefan ^b   Clausen, Tim ^c   Ehrmann, Michael ^a,d  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

^b MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

^c RESEARCH INSTITUTE OF MOLECULAR PATHOLOGY   (Austria)

^d CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; AMYLOID; AMYLOID BETA PROTEIN[1-42]; HIGH TEMPERATURE REQUIREMENT A1; PDZ PROTEIN; SERINE PROTEINASE; TAU PROTEIN; UNCLASSIFIED DRUG; AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN (1-42); HTRA1 PROTEIN, HUMAN; HYBRID PROTEIN; MAPT PROTEIN, HUMAN; PEPTIDE FRAGMENT; PROTEIN AGGREGATE;

ALLOSTERISM; ARTICLE; ATOMIC FORCE MICROSCOPY; CONFOCAL LASER MICROSCOPY; CYTOPLASM; ENZYME ACTIVE SITE; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IMAGE ANALYSIS; IN VITRO STUDY; ISOTHERMAL TITRATION CALORIMETRY; PDZ DOMAIN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTEIN STRUCTURE; CHEMISTRY; GENE EXPRESSION; GENETICS; HEK293 CELL LINE; PROTEIN CONFORMATION; TRANSPORT AT THE CELLULAR LEVEL;

AMYLOID; AMYLOID BETA-PEPTIDES; BIOLOGICAL TRANSPORT; GENE EXPRESSION; HEK293 CELLS; HUMANS; PDZ DOMAINS; PEPTIDE FRAGMENTS; PROTEIN AGGREGATES; PROTEIN CONFORMATION; PROTEOLYSIS; RECOMBINANT FUSION PROTEINS; SERINE ENDOPEPTIDASES; TAU PROTEINS;

EID: 84944906590     PISSN: 15524450     EISSN: 15524469     Source Type: Journal    
DOI: 10.1038/nchembio.1931     Document Type: Article

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