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Volumn 15, Issue 11, 2015, Pages 668-679

Rethinking ovarian cancer II: Reducing mortality from high-grade serous ovarian cancer

(41)  Bowtell, David D a,b   Böhm, Steffen c   Ahmed, Ahmed A d   Aspuria, Paul Joseph e   Bast, Robert C f   Beral, Valerie g   Berek, Jonathan S h   Birrer, Michael J i   Blagden, Sarah j   Bookman, Michael A k   Brenton, James D l   Chiappinelli, Katherine B m   Martins, Filipe Correia l   Coukos, George n   Drapkin, Ronny o   Edmondson, Richard p   Fotopoulou, Christina j   Gabra, Hani j   Galon, Jérôme q   Gourley, Charlie r   more..


Author keywords

[No Author keywords available]

Indexed keywords

ANTIANGIOGENIC ACTIVITY; CANCER INCIDENCE; CANCER MORTALITY; CANCER PREVENTION; CANCER RESEARCH; DRUG RESPONSE; EXPERIMENTAL MODEL; HIGH GRADE SEROUS OVARIAN CANCER; HUMAN; MULTICENTER STUDY (TOPIC); NONHUMAN; OUTCOME ASSESSMENT; OVARY CANCER; PHASE 3 CLINICAL TRIAL (TOPIC); POINT MUTATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); RESEARCH PRIORITY; REVIEW; TUMOR MICROENVIRONMENT; CANCER GRADING; CYSTADENOCARCINOMA, SEROUS; FEMALE; MORTALITY; OVARIAN NEOPLASMS; PATHOLOGY; PROGNOSIS; SURVIVAL RATE;

EID: 84944871061     PISSN: 1474175X     EISSN: 14741768     Source Type: Journal    
DOI: 10.1038/nrc4019     Document Type: Review
Times cited : (864)

References (184)
  • 1
    • 80053168788 scopus 로고    scopus 로고
    • Rethinking ovarian cancer: Recommendations for improving outcomes
    • Vaughan, S. et al. Rethinking ovarian cancer: recommendations for improving outcomes. Nat. Rev. Cancer 11, 719-725 (2011).
    • (2011) Nat. Rev. Cancer , vol.11 , pp. 719-725
    • Vaughan, S.1
  • 2
    • 84877028141 scopus 로고    scopus 로고
    • Comprehensive molecular portraits of human breast tumours
    • The Cancer Genome Atlas Network. Comprehensive molecular portraits of human breast tumours. Nature 490, 61-70 (2012).
    • (2012) Nature , vol.490 , pp. 61-70
  • 3
    • 79957811258 scopus 로고    scopus 로고
    • STICS, SCOUTs and p53 signatures; A new language for pelvic serous carcinogenesis
    • Mehra, K. et al. STICS, SCOUTs and p53 signatures; a new language for pelvic serous carcinogenesis. Front. Biosci. (Elite Ed) 3, 625-634 (2011).
    • (2011) Front. Biosci. (Elite Ed) , vol.3 , pp. 625-634
    • Mehra, K.1
  • 4
    • 33846187651 scopus 로고    scopus 로고
    • A candidate precursor to serous carcinoma that originates in the distal fallopian tube
    • Lee, Y. et al. A candidate precursor to serous carcinoma that originates in the distal fallopian tube. J. Pathol. 211, 26-35 (2007).
    • (2007) J. Pathol. , vol.211 , pp. 26-35
    • Lee, Y.1
  • 5
    • 0035175430 scopus 로고    scopus 로고
    • Dysplastic changes in prophylactically removed Fallopian tubes of women predisposed to developing ovarian cancer
    • Piek, J. M. et al. Dysplastic changes in prophylactically removed Fallopian tubes of women predisposed to developing ovarian cancer. J. Pathol. 195, 451-456 (2001).
    • (2001) J. Pathol. , vol.195 , pp. 451-456
    • Piek, J.M.1
  • 6
    • 84925546922 scopus 로고    scopus 로고
    • Ovarian cancer risk after salpingectomy: A nationwide population-based study
    • Falconer, H., Yin, L., Gronberg, H. & Altman, D. Ovarian cancer risk after salpingectomy: a nationwide population-based study. J. Natl. Cancer Inst. 107 (2015).
    • (2015) J. Natl. Cancer Inst. , pp. 107
    • Falconer, H.1    Yin, L.2    Gronberg, H.3    Altman, D.4
  • 7
    • 84856041279 scopus 로고    scopus 로고
    • TP53 mutations in serous tubal intraepithelial carcinoma and concurrent pelvic high-grade serous carcinoma-evidence supporting the clonal relationship of the two lesions
    • Kuhn, E. et al. TP53 mutations in serous tubal intraepithelial carcinoma and concurrent pelvic high-grade serous carcinoma-evidence supporting the clonal relationship of the two lesions. J. Pathol. 226, 421-426 (2012).
    • (2012) J. Pathol. , vol.226 , pp. 421-426
    • Kuhn, E.1
  • 8
    • 33846624310 scopus 로고    scopus 로고
    • Intraepithelial carcinoma of the fimbria and pelvic serous carcinoma: Evidence for a causal relationship
    • Kindelberger, D. W. et al. Intraepithelial carcinoma of the fimbria and pelvic serous carcinoma: Evidence for a causal relationship. Am. J. Surg. Pathol. 31, 161-169 (2007).
    • (2007) Am. J. Surg. Pathol. , vol.31 , pp. 161-169
    • Kindelberger, D.W.1
  • 9
    • 84891937100 scopus 로고    scopus 로고
    • Transformation of the fallopian tube secretory epithelium leads to high-grade serous ovarian cancer in Brca;Tp53;Pten models
    • Perets, R. et al. Transformation of the fallopian tube secretory epithelium leads to high-grade serous ovarian cancer in Brca;Tp53;Pten models. Cancer Cell 24, 751-765 (2013).
    • (2013) Cancer Cell , vol.24 , pp. 751-765
    • Perets, R.1
  • 10
    • 84930419984 scopus 로고    scopus 로고
    • The ovary is an alternative site of origin for high-grade serous ovarian cancer in mice
    • Kim, J., Coffey, D. M., Ma, L. & Matzuk, M. M. The ovary is an alternative site of origin for high-grade serous ovarian cancer in mice. Endocrinology 156, 1975-1981 (2015).
    • (2015) Endocrinology , vol.156 , pp. 1975-1981
    • Kim, J.1    Coffey, D.M.2    Ma, L.3    Matzuk, M.M.4
  • 11
    • 84924071135 scopus 로고    scopus 로고
    • Evidence for a dualistic model of high-grade serous carcinoma: BRCA mutation status, histology, and tubal intraepithelial carcinoma
    • Howitt, B. E. et al. Evidence for a dualistic model of high-grade serous carcinoma: BRCA mutation status, histology, and tubal intraepithelial carcinoma. Am. J. Surg. Pathol. 39, 287-293 (2015).
    • (2015) Am. J. Surg. Pathol. , vol.39 , pp. 287-293
    • Howitt, B.E.1
  • 12
    • 80052414827 scopus 로고    scopus 로고
    • Immunohistochemical staining patterns of p53 can serve as a surrogate marker for TP53 mutations in ovarian carcinoma: An immunohistochemical and nucleotide sequencing analysis
    • Yemelyanova, A. et al. Immunohistochemical staining patterns of p53 can serve as a surrogate marker for TP53 mutations in ovarian carcinoma: an immunohistochemical and nucleotide sequencing analysis. Mod. Pathol. 24, 1248-1253 (2011).
    • (2011) Mod. Pathol. , vol.24 , pp. 1248-1253
    • Yemelyanova, A.1
  • 13
    • 77950965840 scopus 로고    scopus 로고
    • Driver mutations in TP53 are ubiquitous in high grade serous carcinoma of the ovary
    • Ahmed, A. A. et al. Driver mutations in TP53 are ubiquitous in high grade serous carcinoma of the ovary. J. Pathol. 221, 49-56 (2010).
    • (2010) J. Pathol. , vol.221 , pp. 49-56
    • Ahmed, A.A.1
  • 14
    • 79959838081 scopus 로고    scopus 로고
    • Integrated genomic analysis of ovarian cancer
    • The Cancer Genome Atlas Research Network. Integrated genomic analysis of ovarian cancer. Nature 474, 609-615 (2011).
    • (2011) Nature , vol.474 , pp. 609-615
  • 15
    • 84884997982 scopus 로고    scopus 로고
    • Emerging landscape of oncogenic signatures across human cancers
    • Ciriello, G. et al. Emerging landscape of oncogenic signatures across human cancers. Nat. Genet. 45, 1127-1133 (2013).
    • (2013) Nat. Genet. , vol.45 , pp. 1127-1133
    • Ciriello, G.1
  • 16
    • 84965085601 scopus 로고    scopus 로고
    • Combined image and genomic analysis of high-grade serous ovarian cancer reveals PTEN loss as a common driver event and prognostic classifier
    • Martins, F. C. et al. Combined image and genomic analysis of high-grade serous ovarian cancer reveals PTEN loss as a common driver event and prognostic classifier. Genome Biol. 15, 526 (2014).
    • (2014) Genome Biol. , vol.15 , pp. 526
    • Martins, F.C.1
  • 17
    • 84930638395 scopus 로고    scopus 로고
    • Whole-genome characterization of chemoresistant ovarian cancer
    • Patch, A. M. et al. Whole-genome characterization of chemoresistant ovarian cancer. Nature 521, 489-494 (2015).
    • (2015) Nature , vol.521 , pp. 489-494
    • Patch, A.M.1
  • 18
    • 77950974130 scopus 로고    scopus 로고
    • Development of a functional assay for homologous recombination status in primary cultures of epithelial ovarian tumor and correlation with sensitivity to poly(ADP-ribose) polymerase inhibitors
    • Mukhopadhyay, A. et al. Development of a functional assay for homologous recombination status in primary cultures of epithelial ovarian tumor and correlation with sensitivity to poly(ADP-ribose) polymerase inhibitors. Clin. Cancer Res. 16, 2344-2351 (2010).
    • (2010) Clin. Cancer Res. , vol.16 , pp. 2344-2351
    • Mukhopadhyay, A.1
  • 19
    • 84869210797 scopus 로고    scopus 로고
    • Clinicopathological features of homologous recombination-deficient epithelial ovarian cancers: Sensitivity to PARP inhibitors, platinum, and survival
    • Mukhopadhyay, A. et al. Clinicopathological features of homologous recombination-deficient epithelial ovarian cancers: sensitivity to PARP inhibitors, platinum, and survival. Cancer Res. 72, 5675-5682 (2012).
    • (2012) Cancer Res. , vol.72 , pp. 5675-5682
    • Mukhopadhyay, A.1
  • 20
    • 84864026311 scopus 로고    scopus 로고
    • BRCA mutation frequency and patterns of treatment response in BRCA mutation-positive women with ovarian cancer: A report from the Australian ovarian cancer study group
    • Alsop, K. et al. BRCA mutation frequency and patterns of treatment response in BRCA mutation-positive women with ovarian cancer: A report from the Australian Ovarian Cancer Study Group. J. Clin. Oncol. 30, 2654-2663 (2012).
    • (2012) J. Clin. Oncol. , vol.30 , pp. 2654-2663
    • Alsop, K.1
  • 21
    • 77955439715 scopus 로고    scopus 로고
    • Detection of inherited mutations for breast and ovarian cancer using genomic capture and massively parallel sequencing
    • Walsh, T. et al. Detection of inherited mutations for breast and ovarian cancer using genomic capture and massively parallel sequencing. Proc. Natl Acad. Sci. USA 107, 12629-12633 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 12629-12633
    • Walsh, T.1
  • 22
    • 67650471685 scopus 로고    scopus 로고
    • Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers
    • Fong, P. C. et al. Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. N. Engl. J. Med. 361, 123-134 (2009).
    • (2009) N. Engl. J. Med. , vol.361 , pp. 123-134
    • Fong, P.C.1
  • 23
    • 84859523588 scopus 로고    scopus 로고
    • Olaparib maintenance therapy in platinum-sensitive relapsed ovarian cancer
    • Ledermann, J. et al. Olaparib maintenance therapy in platinum-sensitive relapsed ovarian cancer. N. Engl. J. Med. 366, 1382-1392 (2012).
    • (2012) N. Engl. J. Med. , vol.366 , pp. 1382-1392
    • Ledermann, J.1
  • 24
    • 84929440309 scopus 로고    scopus 로고
    • Poly (adp-ribose) polymerase inhibitors: Recent advances and future development
    • Scott, C. L., Swisher, E. M. & Kaufmann, S. H. Poly (adp-ribose) polymerase inhibitors: recent advances and future development. J. Clin. Oncol. 33, 1397-1406 (2015).
    • (2015) J. Clin. Oncol. , vol.33 , pp. 1397-1406
    • Scott, C.L.1    Swisher, E.M.2    Kaufmann, S.H.3
  • 25
    • 84894267929 scopus 로고    scopus 로고
    • Cyclin E1 deregulation occurs early in secretory cell transformation to promote formation of fallopian tube-derived high-grade serous ovarian cancers
    • Karst, A. M. et al. Cyclin E1 deregulation occurs early in secretory cell transformation to promote formation of fallopian tube-derived high-grade serous ovarian cancers. Cancer Res. 74, 1141-1152 (2014).
    • (2014) Cancer Res. , vol.74 , pp. 1141-1152
    • Karst, A.M.1
  • 26
    • 78649751900 scopus 로고    scopus 로고
    • Amplicon-dependent CCNE1 expression is critical for clonogenic survival after cisplatin treatment and is correlated with 20q11 gain in ovarian cancer
    • Etemadmoghadam, D. et al. Amplicon-dependent CCNE1 expression is critical for clonogenic survival after cisplatin treatment and is correlated with 20q11 gain in ovarian cancer. PLoS ONE 5, e15498 (2010).
    • (2010) PLoS ONE , vol.5 , pp. e15498
    • Etemadmoghadam, D.1
  • 27
    • 52649085237 scopus 로고    scopus 로고
    • Novel molecular subtypes of serous and endometrioid ovarian cancer linked to clinical outcome
    • Tothill, R. W. et al. Novel molecular subtypes of serous and endometrioid ovarian cancer linked to clinical outcome. Clin. Cancer Res. 14, 5198-5208 (2008).
    • (2008) Clin. Cancer Res. , vol.14 , pp. 5198-5208
    • Tothill, R.W.1
  • 28
    • 84985034791 scopus 로고    scopus 로고
    • Prognostic and therapeutic relevance of molecular subtypes in high-grade serous ovarian cancer
    • Konecny, G. E. et al. Prognostic and therapeutic relevance of molecular subtypes in high-grade serous ovarian cancer. J. Natl. Cancer Inst. 106, dju249 (2014).
    • (2014) J. Natl. Cancer Inst. , vol.106 , pp. dju249
    • Konecny, G.E.1
  • 29
    • 81255157465 scopus 로고    scopus 로고
    • Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth
    • Nieman, K. M. et al. Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth. Nat. Med. 17, 1498-1503 (2011).
    • (2011) Nat. Med. , vol.17 , pp. 1498-1503
    • Nieman, K.M.1
  • 30
    • 84904265681 scopus 로고    scopus 로고
    • Hematogenous metastasis of ovarian cancer: Rethinking mode of spread
    • Pradeep, S. et al. Hematogenous metastasis of ovarian cancer: rethinking mode of spread. Cancer Cell 26, 77-91 (2014).
    • (2014) Cancer Cell , vol.26 , pp. 77-91
    • Pradeep, S.1
  • 31
    • 84873582060 scopus 로고    scopus 로고
    • Integrated analyses identify a master microRNA regulatory network for the mesenchymal subtype in serous ovarian cancer
    • Yang, D. et al. Integrated analyses identify a master microRNA regulatory network for the mesenchymal subtype in serous ovarian cancer. Cancer Cell 23, 186-199 (2013).
    • (2013) Cancer Cell , vol.23 , pp. 186-199
    • Yang, D.1
  • 32
    • 84878986540 scopus 로고    scopus 로고
    • A microRNA signature defines chemoresistance in ovarian cancer through modulation of angiogenesis
    • Vecchione, A. et al. A microRNA signature defines chemoresistance in ovarian cancer through modulation of angiogenesis. Proc. Natl Acad. Sci. USA 110, 9845-9850 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 9845-9850
    • Vecchione, A.1
  • 33
    • 84891883182 scopus 로고    scopus 로고
    • MicroRNA-181a has a critical role in ovarian cancer progression through the regulation of the epithelial-mesenchymal transition
    • Parikh, A. et al. microRNA-181a has a critical role in ovarian cancer progression through the regulation of the epithelial-mesenchymal transition. Nat. Commun. 5, 2977 (2014).
    • (2014) Nat. Commun. , vol.5 , pp. 2977
    • Parikh, A.1
  • 34
    • 0037448353 scopus 로고    scopus 로고
    • Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer
    • Zhang, L. et al. Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer. N. Engl. J. Med. 348, 203-213 (2003).
    • (2003) N. Engl. J. Med. , vol.348 , pp. 203-213
    • Zhang, L.1
  • 35
    • 84883372476 scopus 로고    scopus 로고
    • Type-specific cell line models for type-specific ovarian cancer research
    • Anglesio, M. S. et al. Type-specific cell line models for type-specific ovarian cancer research. PLoS ONE 8, e72162 (2013).
    • (2013) PLoS ONE , vol.8 , pp. e72162
    • Anglesio, M.S.1
  • 36
    • 84880291315 scopus 로고    scopus 로고
    • Evaluating cell lines as tumour models by comparison of genomic profiles
    • Domcke, S., Sinha, R., Levine, D. A., Sander, C. & Schultz, N. Evaluating cell lines as tumour models by comparison of genomic profiles. Nat. Commun. 4, 2126 (2013).
    • (2013) Nat. Commun. , vol.4 , pp. 2126
    • Domcke, S.1    Sinha, R.2    Levine, D.A.3    Sander, C.4    Schultz, N.5
  • 37
    • 84907197654 scopus 로고    scopus 로고
    • Ovarian cancer cell line panel (OCCP): Clinical importance of in vitro morphological subtypes
    • Beaufort, C. M. et al. Ovarian cancer cell line panel (OCCP): clinical importance of in vitro morphological subtypes. PLoS ONE 9, e103988 (2014).
    • (2014) PLoS ONE , vol.9 , pp. e103988
    • Beaufort, C.M.1
  • 38
    • 84897145705 scopus 로고    scopus 로고
    • The use of ovarian cancer cells from patients undergoing surgery to generate primary cultures capable of undergoing functional analysis
    • O'Donnell, R. et al. The use of ovarian cancer cells from patients undergoing surgery to generate primary cultures capable of undergoing functional analysis. PLoS ONE 9, e90604 (2014).
    • (2014) PLoS ONE , vol.9 , pp. e90604
    • O'Donnell, R.1
  • 39
    • 84935894028 scopus 로고    scopus 로고
    • Characterization of twenty-five ovarian tumour cell lines that phenocopy primary tumours
    • Ince, T. A. et al. Characterization of twenty-five ovarian tumour cell lines that phenocopy primary tumours. Nat. Commun. 6, 7419 (2015).
    • (2015) Nat. Commun. , vol.6 , pp. 7419
    • Ince, T.A.1
  • 40
    • 84923197615 scopus 로고    scopus 로고
    • Quantitative high throughput screening using a primary human three-dimensional organotypic culture predicts in vivo efficacy
    • Kenny, H. A. et al. Quantitative high throughput screening using a primary human three-dimensional organotypic culture predicts in vivo efficacy. Nat. Commun. 6, 6220 (2015).
    • (2015) Nat. Commun. , vol.6 , pp. 6220
    • Kenny, H.A.1
  • 41
    • 84907483668 scopus 로고    scopus 로고
    • Mesothelial cells promote early ovarian cancer metastasis through fibronectin secretion
    • Kenny, H. A. et al. Mesothelial cells promote early ovarian cancer metastasis through fibronectin secretion. J. Clin. Invest. 124, 4614-4628 (2014).
    • (2014) J. Clin. Invest. , vol.124 , pp. 4614-4628
    • Kenny, H.A.1
  • 42
    • 84866087898 scopus 로고    scopus 로고
    • Primary culture and immortalization of human fallopian tube secretory epithelial cells
    • Karst, A. M. & Drapkin, R. Primary culture and immortalization of human fallopian tube secretory epithelial cells. Nat. Protoc. 7, 1755-1764 (2012).
    • (2012) Nat. Protoc. , vol.7 , pp. 1755-1764
    • Karst, A.M.1    Drapkin, R.2
  • 43
    • 79956313481 scopus 로고    scopus 로고
    • Modeling high-grade serous ovarian carcinogenesis from the fallopian tube
    • Karst, A. M., Levanon, K. & Drapkin, R. Modeling high-grade serous ovarian carcinogenesis from the fallopian tube. Proc. Natl Acad. Sci. USA 108, 7547-7552 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 7547-7552
    • Karst, A.M.1    Levanon, K.2    Drapkin, R.3
  • 44
    • 80054795415 scopus 로고    scopus 로고
    • Molecular requirements for transformation of fallopian tube epithelial cells into serous carcinoma
    • Jazaeri, A. A. et al. Molecular requirements for transformation of fallopian tube epithelial cells into serous carcinoma. Neoplasia 13, 899-911 (2011).
    • (2011) Neoplasia , vol.13 , pp. 899-911
    • Jazaeri, A.A.1
  • 45
    • 84902349728 scopus 로고    scopus 로고
    • A genetically engineered ovarian cancer mouse model based on fallopian tube transformation mimics human high-grade serous carcinoma development
    • Sherman-Baust, C. A. et al. A genetically engineered ovarian cancer mouse model based on fallopian tube transformation mimics human high-grade serous carcinoma development. J. Pathol. 233, 228-237 (2014).
    • (2014) J. Pathol. , vol.233 , pp. 228-237
    • Sherman-Baust, C.A.1
  • 46
    • 84912101598 scopus 로고    scopus 로고
    • CRISPR-Cas9 knockin mice for genome editing and cancer modeling
    • Platt, R. J. et al. CRISPR-Cas9 knockin mice for genome editing and cancer modeling. Cell 159, 440-455 (2014).
    • (2014) Cell , vol.159 , pp. 440-455
    • Platt, R.J.1
  • 47
    • 84899475102 scopus 로고    scopus 로고
    • Molecular correlates of platinum response in human high-grade serous ovarian cancer patient-derived xenografts
    • Topp, M. D. et al. Molecular correlates of platinum response in human high-grade serous ovarian cancer patient-derived xenografts. Mol. Oncol. 8, 656-668 (2014).
    • (2014) Mol. Oncol. , vol.8 , pp. 656-668
    • Topp, M.D.1
  • 48
    • 84895814753 scopus 로고    scopus 로고
    • Tumorgrafts as in vivo surrogates for women with ovarian cancer
    • Weroha, S. J. et al. Tumorgrafts as in vivo surrogates for women with ovarian cancer. Clin. Cancer Res. 20, 1288-1297 (2014).
    • (2014) Clin. Cancer Res. , vol.20 , pp. 1288-1297
    • Weroha, S.J.1
  • 49
    • 84907966155 scopus 로고    scopus 로고
    • Using heterogeneity of the patient-derived xenograft model to identify the chemoresistant population in ovarian cancer
    • Dobbin, Z. C. et al. Using heterogeneity of the patient-derived xenograft model to identify the chemoresistant population in ovarian cancer. Oncotarget 5, 8750-8764 (2014).
    • (2014) Oncotarget , vol.5 , pp. 8750-8764
    • Dobbin, Z.C.1
  • 50
    • 84917706479 scopus 로고    scopus 로고
    • Patient-derived ovarian tumor xenografts recapitulate human clinicopathology and genetic alterations
    • Ricci, F. et al. Patient-derived ovarian tumor xenografts recapitulate human clinicopathology and genetic alterations. Cancer Res. 74, 6980-6990 (2014).
    • (2014) Cancer Res. , vol.74 , pp. 6980-6990
    • Ricci, F.1
  • 51
    • 84893637270 scopus 로고    scopus 로고
    • One mouse, one patient paradigm: New avatars of personalized cancer therapy
    • Malaney, P., Nicosia, S. V. & Dave, V. One mouse, one patient paradigm: New avatars of personalized cancer therapy. Cancer Lett. 344, 1-12 (2014).
    • (2014) Cancer Lett. , vol.344 , pp. 1-12
    • Malaney, P.1    Nicosia, S.V.2    Dave, V.3
  • 52
    • 79954582411 scopus 로고    scopus 로고
    • Humanized bone marrow mouse model as a preclinical tool to assess therapy-mediated hematotoxicity
    • Cai, S. et al. Humanized bone marrow mouse model as a preclinical tool to assess therapy-mediated hematotoxicity. Clin. Cancer Res. 17, 2195-2206 (2011).
    • (2011) Clin. Cancer Res. , vol.17 , pp. 2195-2206
    • Cai, S.1
  • 53
    • 84885092663 scopus 로고    scopus 로고
    • Distinct evolutionary trajectories of primary high-grade serous ovarian cancers revealed through spatial mutational profiling
    • Bashashati, A. et al. Distinct evolutionary trajectories of primary high-grade serous ovarian cancers revealed through spatial mutational profiling. J. Pathol. 231, 21-34 (2013).
    • (2013) J. Pathol. , vol.231 , pp. 21-34
    • Bashashati, A.1
  • 54
    • 84865137809 scopus 로고    scopus 로고
    • LRP1B deletion in high-grade serous ovarian cancers is associated with acquired chemotherapy resistance to liposomal doxorubicin
    • Cowin, P. A. et al. LRP1B deletion in high-grade serous ovarian cancers is associated with acquired chemotherapy resistance to liposomal doxorubicin. Cancer Res. 72, 4060-4073 (2012).
    • (2012) Cancer Res. , vol.72 , pp. 4060-4073
    • Cowin, P.A.1
  • 55
    • 77956344675 scopus 로고    scopus 로고
    • Genomic analysis of genetic heterogeneity and evolution in high-grade serous ovarian carcinoma
    • Cooke, S. L. et al. Genomic analysis of genetic heterogeneity and evolution in high-grade serous ovarian carcinoma. Oncogene 29, 4905-4913 (2010).
    • (2010) Oncogene , vol.29 , pp. 4905-4913
    • Cooke, S.L.1
  • 56
    • 84924359778 scopus 로고    scopus 로고
    • Spatial and temporal heterogeneity in high-grade serous ovarian cancer: A phylogenetic analysis
    • Schwarz, R. F. et al. Spatial and temporal heterogeneity in high-grade serous ovarian cancer: a phylogenetic analysis. PLoS Med. 12, e1001789 (2015).
    • (2015) PLoS Med. , vol.12 , pp. e1001789
    • Schwarz, R.F.1
  • 57
    • 84897954204 scopus 로고    scopus 로고
    • PyClone: Statistical inference of clonal population structure in cancer
    • Roth, A. et al. PyClone: statistical inference of clonal population structure in cancer. Nat. Methods 11, 396-398 (2014).
    • (2014) Nat. Methods , vol.11 , pp. 396-398
    • Roth, A.1
  • 58
    • 81355151361 scopus 로고    scopus 로고
    • DNA-PK mediates AKT activation and apoptosis inhibition in clinically acquired platinum resistance
    • Stronach, E. A. et al. DNA-PK mediates AKT activation and apoptosis inhibition in clinically acquired platinum resistance. Neoplasia 13, 1069-1080 (2011).
    • (2011) Neoplasia , vol.13 , pp. 1069-1080
    • Stronach, E.A.1
  • 59
    • 80051642095 scopus 로고    scopus 로고
    • Secondary somatic mutations restoring BRCA1/2 predict chemotherapy resistance in hereditary ovarian carcinomas
    • Norquist, B. et al. Secondary somatic mutations restoring BRCA1/2 predict chemotherapy resistance in hereditary ovarian carcinomas. J. Clin. Oncol. 29, 3008-3015 (2011).
    • (2011) J. Clin. Oncol. , vol.29 , pp. 3008-3015
    • Norquist, B.1
  • 60
    • 39849106300 scopus 로고    scopus 로고
    • Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers
    • Sakai, W. et al. Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers. Nature 451, 1116-1120 (2008).
    • (2008) Nature , vol.451 , pp. 1116-1120
    • Sakai, W.1
  • 61
    • 84944875118 scopus 로고    scopus 로고
    • Afuresertib (GSK2110183), an oral AKT kinase inhibitor, in combination with carboplatin and paclitaxel in recurrent ovarian cancer
    • Blagden, S. et al. Afuresertib (GSK2110183), an oral AKT kinase inhibitor, in combination with carboplatin and paclitaxel in recurrent ovarian cancer. Eur. J. Cancer 50, 7 (2014).
    • (2014) Eur. J. Cancer , vol.50 , pp. 7
    • Blagden, S.1
  • 62
    • 84903603624 scopus 로고    scopus 로고
    • DIRAS3 regulates the autophagosome initiation complex in dormant ovarian cancer cells
    • Lu, Z. et al. DIRAS3 regulates the autophagosome initiation complex in dormant ovarian cancer cells. Autophagy 10, 1071-1092 (2014).
    • (2014) Autophagy , vol.10 , pp. 1071-1092
    • Lu, Z.1
  • 63
    • 84877579861 scopus 로고    scopus 로고
    • Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA
    • Murtaza, M. et al. Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA. Nature 497, 108-112 (2013).
    • (2013) Nature , vol.497 , pp. 108-112
    • Murtaza, M.1
  • 64
    • 84928403539 scopus 로고    scopus 로고
    • Cancer: A most exceptional response
    • Marx, V. Cancer: A most exceptional response. Nature 520, 389-393 (2015).
    • (2015) Nature , vol.520 , pp. 389-393
    • Marx, V.1
  • 65
    • 84892164928 scopus 로고    scopus 로고
    • CD137 accurately identifies and enriches for naturally occurring tumor-reactive T cells in tumor
    • Ye, Q. et al. CD137 accurately identifies and enriches for naturally occurring tumor-reactive T cells in tumor. Clin. Cancer Res. 20, 44-55 (2014).
    • (2014) Clin. Cancer Res. , vol.20 , pp. 44-55
    • Ye, Q.1
  • 67
    • 84895835410 scopus 로고    scopus 로고
    • Surveillance of the tumor mutanome by T cells during progression from primary to recurrent ovarian cancer
    • Wick, D. A. et al. Surveillance of the tumor mutanome by T cells during progression from primary to recurrent ovarian cancer. Clin. Cancer Res. 20, 1125-1134 (2014).
    • (2014) Clin. Cancer Res. , vol.20 , pp. 1125-1134
    • Wick, D.A.1
  • 68
    • 84859158880 scopus 로고    scopus 로고
    • The CD47-SIRPα pathway in cancer immune evasion and potential therapeutic implications
    • Chao, M. P., Weissman, I. L. & Majeti, R. The CD47-SIRPα pathway in cancer immune evasion and potential therapeutic implications. Curr. Opin. Immunol. 24, 225-232 (2012).
    • (2012) Curr. Opin. Immunol. , vol.24 , pp. 225-232
    • Chao, M.P.1    Weissman, I.L.2    Majeti, R.3
  • 69
    • 70349746798 scopus 로고    scopus 로고
    • Role of the immunosuppressive enzyme indoleamine 2,3-dioxygenase in the progression of ovarian carcinoma
    • Inaba, T. et al. Role of the immunosuppressive enzyme indoleamine 2,3-dioxygenase in the progression of ovarian carcinoma. Gynecol. Oncol. 115, 185-192 (2009).
    • (2009) Gynecol. Oncol. , vol.115 , pp. 185-192
    • Inaba, T.1
  • 70
    • 84890284474 scopus 로고    scopus 로고
    • Therapeutic PD-1 pathway blockade augments with other modalities of immunotherapy T-cell function to prevent immune decline in ovarian cancer
    • Duraiswamy, J., Freeman, G. J. & Coukos, G. Therapeutic PD-1 pathway blockade augments with other modalities of immunotherapy T-cell function to prevent immune decline in ovarian cancer. Cancer Res. 73, 6900-6912 (2013).
    • (2013) Cancer Res. , vol.73 , pp. 6900-6912
    • Duraiswamy, J.1    Freeman, G.J.2    Coukos, G.3
  • 71
    • 84880757177 scopus 로고    scopus 로고
    • Deciphering and reversing tumor immune suppression
    • Motz, G. T. & Coukos, G. Deciphering and reversing tumor immune suppression. Immunity 39, 61-73 (2013).
    • (2013) Immunity , vol.39 , pp. 61-73
    • Motz, G.T.1    Coukos, G.2
  • 72
    • 34548798737 scopus 로고    scopus 로고
    • Relationship between B7-H4, regulatory T cells, and patient outcome in human ovarian carcinoma
    • Kryczek, I. et al. Relationship between B7-H4, regulatory T cells, and patient outcome in human ovarian carcinoma. Cancer Res. 67, 8900-8905 (2007).
    • (2007) Cancer Res. , vol.67 , pp. 8900-8905
    • Kryczek, I.1
  • 73
    • 84880706152 scopus 로고    scopus 로고
    • Oncology meets immunology: The cancer-immunity cycle
    • Chen, D. S. & Mellman, I. Oncology meets immunology: the cancer-immunity cycle. Immunity 39, 1-10 (2013).
    • (2013) Immunity , vol.39 , pp. 1-10
    • Chen, D.S.1    Mellman, I.2
  • 74
    • 84928761118 scopus 로고    scopus 로고
    • Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer
    • Rizvi, N. A. et al. Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer. Science 348, 124-128 (2015).
    • (2015) Science , vol.348 , pp. 124-128
    • Rizvi, N.A.1
  • 75
    • 84918828514 scopus 로고    scopus 로고
    • Genetic basis for clinical response to CTLA-4 blockade in melanoma
    • Snyder, A. et al. Genetic basis for clinical response to CTLA-4 blockade in melanoma. N. Engl. J. Med. 371, 2189-2199 (2014).
    • (2014) N. Engl. J. Med. , vol.371 , pp. 2189-2199
    • Snyder, A.1
  • 76
    • 84920962202 scopus 로고    scopus 로고
    • Molecular and genetic properties of tumors associated with local immune cytolytic activity
    • Rooney, M. S., Shukla, S. A., Wu, C. J., Getz, G. & Hacohen, N. Molecular and genetic properties of tumors associated with local immune cytolytic activity. Cell 160, 48-61 (2015).
    • (2015) Cell , vol.160 , pp. 48-61
    • Rooney, M.S.1    Shukla, S.A.2    Wu, C.J.3    Getz, G.4    Hacohen, N.5
  • 77
    • 84879878171 scopus 로고    scopus 로고
    • Nonequivalent gene expression and copy number alterations in high-grade serous ovarian cancers with BRCA1 and BRCA2 mutations
    • George, J. et al. Nonequivalent gene expression and copy number alterations in high-grade serous ovarian cancers with BRCA1 and BRCA2 mutations. Clin. Cancer Res. 19, 3474-3484 (2013).
    • (2013) Clin. Cancer Res. , vol.19 , pp. 3474-3484
    • George, J.1
  • 78
    • 84857555621 scopus 로고    scopus 로고
    • Morphologic patterns associated with BRCA1 and BRCA2 genotype in ovarian carcinoma
    • Soslow, R. A. et al. Morphologic patterns associated with BRCA1 and BRCA2 genotype in ovarian carcinoma. Mod. Pathol. 25, 625-636 (2012).
    • (2012) Mod. Pathol. , vol.25 , pp. 625-636
    • Soslow, R.A.1
  • 79
    • 84863836600 scopus 로고    scopus 로고
    • Prediction of BRCA1 germline mutation status in women with ovarian cancer using morphology-based criteria: Identification of a BRCA1 ovarian cancer phenotype
    • Fujiwara, M. et al. Prediction of BRCA1 germline mutation status in women with ovarian cancer using morphology-based criteria: identification of a BRCA1 ovarian cancer phenotype. Am. J. Surg. Pathol. 36, 1170-1177 (2012).
    • (2012) Am. J. Surg. Pathol. , vol.36 , pp. 1170-1177
    • Fujiwara, M.1
  • 80
    • 61349151645 scopus 로고    scopus 로고
    • Intraepithelial T cells and prognosis in ovarian carcinoma: Novel associations with stage, tumor type, and BRCA1 loss
    • Clarke, B. et al. Intraepithelial T cells and prognosis in ovarian carcinoma: novel associations with stage, tumor type, and BRCA1 loss. Mod. Pathol. 22, 393-402 (2009).
    • (2009) Mod. Pathol. , vol.22 , pp. 393-402
    • Clarke, B.1
  • 81
    • 80053950209 scopus 로고    scopus 로고
    • Association of BRCA1 and BRCA2 mutations with survival, chemotherapy sensitivity, and gene mutator phenotype in patients with ovarian cancer
    • Yang, D. et al. Association of BRCA1 and BRCA2 mutations with survival, chemotherapy sensitivity, and gene mutator phenotype in patients with ovarian cancer. JAMA 306, 1557-1565 (2011).
    • (2011) JAMA , vol.306 , pp. 1557-1565
    • Yang, D.1
  • 82
    • 84923166583 scopus 로고    scopus 로고
    • Aberrant recombination and repair during immunoglobulin class switching in BRCA1-deficient human B cells
    • Bjorkman, A. et al. Aberrant recombination and repair during immunoglobulin class switching in BRCA1-deficient human B cells. Proc. Natl Acad. Sci. USA 112, 2157-2162 (2015).
    • (2015) Proc. Natl Acad. Sci. USA , vol.112 , pp. 2157-2162
    • Bjorkman, A.1
  • 83
    • 84890280907 scopus 로고    scopus 로고
    • Towards the introduction of the 'Immunoscore' in the classification of malignant tumours
    • Galon, J. et al. Towards the introduction of the 'Immunoscore' in the classification of malignant tumours. J. Pathol. 232, 199-209 (2014).
    • (2014) J. Pathol. , vol.232 , pp. 199-209
    • Galon, J.1
  • 84
    • 84880704621 scopus 로고    scopus 로고
    • The continuum of cancer immunosurveillance: Prognostic, predictive, and mechanistic signatures
    • Galon, J., Angell, H. K., Bedognetti, D. & Marincola, F. M. The continuum of cancer immunosurveillance: prognostic, predictive, and mechanistic signatures. Immunity 39, 11-26 (2013).
    • (2013) Immunity , vol.39 , pp. 11-26
    • Galon, J.1    Angell, H.K.2    Bedognetti, D.3    Marincola, F.M.4
  • 85
    • 84890130945 scopus 로고    scopus 로고
    • Alterations of immune response of non-small cell lung cancer with azacytidine
    • Wrangle, J. et al. Alterations of immune response of non-small cell lung cancer with azacytidine. Oncotarget 4, 2067-2079 (2013).
    • (2013) Oncotarget , vol.4 , pp. 2067-2079
    • Wrangle, J.1
  • 86
    • 84896820241 scopus 로고    scopus 로고
    • Immune regulation by low doses of the DNA methyltransferase inhibitor 5-azacitidine in common human epithelial cancers
    • Li, H. et al. Immune regulation by low doses of the DNA methyltransferase inhibitor 5-azacitidine in common human epithelial cancers. Oncotarget 5, 587-598 (2014).
    • (2014) Oncotarget , vol.5 , pp. 587-598
    • Li, H.1
  • 87
    • 84919769943 scopus 로고    scopus 로고
    • The novel, small-molecule DNA methylation inhibitor SGI-110 as an ovarian cancer chemosensitizer
    • Fang, F. et al. The novel, small-molecule DNA methylation inhibitor SGI-110 as an ovarian cancer chemosensitizer. Clin. Cancer Res. 20, 6504-6516 (2014).
    • (2014) Clin. Cancer Res. , vol.20 , pp. 6504-6516
    • Fang, F.1
  • 88
    • 84903532856 scopus 로고    scopus 로고
    • Decitabine reactivated pathways in platinum resistant ovarian cancer
    • Fang, F. et al. Decitabine reactivated pathways in platinum resistant ovarian cancer. Oncotarget 5, 3579-3589 (2014).
    • (2014) Oncotarget , vol.5 , pp. 3579-3589
    • Fang, F.1
  • 89
    • 84860528199 scopus 로고    scopus 로고
    • Epigenetic resensitization to platinum in ovarian cancer
    • Matei, D. et al. Epigenetic resensitization to platinum in ovarian cancer. Cancer Res. 72, 2197-2205 (2012).
    • (2012) Cancer Res. , vol.72 , pp. 2197-2205
    • Matei, D.1
  • 90
    • 84862557227 scopus 로고    scopus 로고
    • CD20+ tumor-infiltrating lymphocytes have an atypical CD27-memory phenotype and together with CD8+ T cells promote favorable prognosis in ovarian cancer
    • Nielsen, J. S. et al. CD20+ tumor-infiltrating lymphocytes have an atypical CD27-memory phenotype and together with CD8+ T cells promote favorable prognosis in ovarian cancer. Clin. Cancer Res. 18, 3281-3292 (2012).
    • (2012) Clin. Cancer Res. , vol.18 , pp. 3281-3292
    • Nielsen, J.S.1
  • 91
    • 80052855899 scopus 로고    scopus 로고
    • Interleukin-6 as a therapeutic target in human ovarian cancer
    • Coward, J. et al. Interleukin-6 as a therapeutic target in human ovarian cancer. Clin. Cancer Res. 17, 6083-6096 (2011).
    • (2011) Clin. Cancer Res. , vol.17 , pp. 6083-6096
    • Coward, J.1
  • 92
    • 84885724091 scopus 로고    scopus 로고
    • Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer
    • Bindea, G. et al. Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer. Immunity 39, 782-795 (2013).
    • (2013) Immunity , vol.39 , pp. 782-795
    • Bindea, G.1
  • 93
    • 33749319703 scopus 로고    scopus 로고
    • Type, density, and location of immune cells within human colorectal tumors predict clinical outcome
    • Galon, J. et al. Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science 313, 1960-1964 (2006).
    • (2006) Science , vol.313 , pp. 1960-1964
    • Galon, J.1
  • 94
    • 84902178965 scopus 로고    scopus 로고
    • Mesenchymal gene program-expressing ovarian cancer spheroids exhibit enhanced mesothelial clearance
    • Davidowitz, R. A. et al. Mesenchymal gene program-expressing ovarian cancer spheroids exhibit enhanced mesothelial clearance. J. Clin. Invest. 124, 2611-2625 (2014).
    • (2014) J. Clin. Invest. , vol.124 , pp. 2611-2625
    • Davidowitz, R.A.1
  • 95
    • 80053169555 scopus 로고    scopus 로고
    • Ovarian cancer spheroids use myosin-generated force to clear the mesothelium
    • Iwanicki, M. P. et al. Ovarian cancer spheroids use myosin-generated force to clear the mesothelium. Cancer Discov. 1, 144-157 (2011).
    • (2011) Cancer Discov. , vol.1 , pp. 144-157
    • Iwanicki, M.P.1
  • 96
    • 84882661249 scopus 로고    scopus 로고
    • TGF-β modulates ovarian cancer invasion by upregulating CAF-derived versican in the tumor microenvironment
    • Yeung, T. L. et al. TGF-β modulates ovarian cancer invasion by upregulating CAF-derived versican in the tumor microenvironment. Cancer Res. 73, 5016-5028 (2013).
    • (2013) Cancer Res. , vol.73 , pp. 5016-5028
    • Yeung, T.L.1
  • 97
    • 84893506505 scopus 로고    scopus 로고
    • A collagen-remodeling gene signature regulated by TGF-β signaling is associated with metastasis and poor survival in serous ovarian cancer
    • Cheon, D. J. et al. A collagen-remodeling gene signature regulated by TGF-β signaling is associated with metastasis and poor survival in serous ovarian cancer. Clin. Cancer Res. 20, 711-723 (2014).
    • (2014) Clin. Cancer Res. , vol.20 , pp. 711-723
    • Cheon, D.J.1
  • 98
    • 67149143399 scopus 로고    scopus 로고
    • Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer
    • Olive, K. P. et al. Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science 324, 1457-1461 (2009).
    • (2009) Science , vol.324 , pp. 1457-1461
    • Olive, K.P.1
  • 99
    • 36649034681 scopus 로고    scopus 로고
    • The extracellular matrix protein TGFBI induces microtubule stabilization and sensitizes ovarian cancers to paclitaxel
    • Ahmed, A. A. et al. The extracellular matrix protein TGFBI induces microtubule stabilization and sensitizes ovarian cancers to paclitaxel. Cancer Cell 12, 514-527 (2007).
    • (2007) Cancer Cell , vol.12 , pp. 514-527
    • Ahmed, A.A.1
  • 100
    • 84902469661 scopus 로고    scopus 로고
    • Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival
    • Ozdemir, B. C. et al. Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival. Cancer Cell 25, 719-734 (2014).
    • (2014) Cancer Cell , vol.25 , pp. 719-734
    • Ozdemir, B.C.1
  • 101
    • 84902435628 scopus 로고    scopus 로고
    • Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma
    • Rhim, A. D. et al. Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma. Cancer Cell 25, 735-747 (2014).
    • (2014) Cancer Cell , vol.25 , pp. 735-747
    • Rhim, A.D.1
  • 102
    • 17244373777 scopus 로고    scopus 로고
    • Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
    • Farmer, H. et al. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature 434, 917-921 (2005).
    • (2005) Nature , vol.434 , pp. 917-921
    • Farmer, H.1
  • 103
    • 84903547236 scopus 로고    scopus 로고
    • Olaparib maintenance therapy in patients with platinum-sensitive relapsed serous ovarian cancer: A preplanned retrospective analysis of outcomes by BRCA status in a randomised phase 2 trial
    • Ledermann, J. et al. Olaparib maintenance therapy in patients with platinum-sensitive relapsed serous ovarian cancer: a preplanned retrospective analysis of outcomes by BRCA status in a randomised phase 2 trial. Lancet Oncol. 15, 852-861 (2014).
    • (2014) Lancet Oncol. , vol.15 , pp. 852-861
    • Ledermann, J.1
  • 104
    • 84869079205 scopus 로고    scopus 로고
    • Patterns of genomic loss of heterozygosity predict homologous recombination repair defects in epithelial ovarian cancer
    • Abkevich, V. et al. Patterns of genomic loss of heterozygosity predict homologous recombination repair defects in epithelial ovarian cancer. Br. J. Cancer 107, 1776-1782 (2012).
    • (2012) Br. J. Cancer , vol.107 , pp. 1776-1782
    • Abkevich, V.1
  • 105
    • 84934313840 scopus 로고    scopus 로고
    • Results of ARIEL2: A phase 2 trial to prospectively identify ovarian cancer patients likely to respond to rucaparib using tumor genetic analysis
    • McNeish, I. A. et al. Results of ARIEL2: A phase 2 trial to prospectively identify ovarian cancer patients likely to respond to rucaparib using tumor genetic analysis. J. Clin. Oncol. 33, 5508 (2015).
    • (2015) J. Clin. Oncol. , vol.33 , pp. 5508
    • McNeish, I.A.1
  • 106
    • 39849097680 scopus 로고    scopus 로고
    • Resistance to therapy caused by intragenic deletion in BRCA2
    • Edwards, S. L. et al. Resistance to therapy caused by intragenic deletion in BRCA2. Nature 451, 1111-1115 (2008).
    • (2008) Nature , vol.451 , pp. 1111-1115
    • Edwards, S.L.1
  • 107
    • 84855466019 scopus 로고    scopus 로고
    • A phase 3 trial of bevacizumab in ovarian cancer
    • Perren, T. J. et al. A phase 3 trial of bevacizumab in ovarian cancer. N. Engl. J. Med. 365, 2484-2496 (2011).
    • (2011) N. Engl. J. Med. , vol.365 , pp. 2484-2496
    • Perren, T.J.1
  • 108
    • 84855425106 scopus 로고    scopus 로고
    • Incorporation of bevacizumab in the primary treatment of ovarian cancer
    • Burger, R. A. et al. Incorporation of bevacizumab in the primary treatment of ovarian cancer. N. Engl. J. Med. 365, 2473-2483 (2011).
    • (2011) N. Engl. J. Med. , vol.365 , pp. 2473-2483
    • Burger, R.A.1
  • 109
    • 84899837376 scopus 로고    scopus 로고
    • Bevacizumab combined with chemotherapy for platinum-resistant recurrent ovarian cancer: The AURELIA open-label randomized phase III trial
    • Pujade-Lauraine, E. et al. Bevacizumab combined with chemotherapy for platinum-resistant recurrent ovarian cancer: The AURELIA open-label randomized phase III trial. J. Clin. Oncol. 32, 1302-1308 (2014).
    • (2014) J. Clin. Oncol. , vol.32 , pp. 1302-1308
    • Pujade-Lauraine, E.1
  • 110
    • 84908355651 scopus 로고    scopus 로고
    • Ovarian cancer and antiangiogenic therapy: Caveat emptor
    • Oliver, K. E. & McGuire, W. P. Ovarian cancer and antiangiogenic therapy: caveat emptor. J. Clin. Oncol. 32, 3353-3356 (2014).
    • (2014) J. Clin. Oncol. , vol.32 , pp. 3353-3356
    • Oliver, K.E.1    McGuire, W.P.2
  • 111
    • 84873619713 scopus 로고    scopus 로고
    • Targeted anti-vascular therapies for ovarian cancer: Current evidence
    • Hall, M. et al. Targeted anti-vascular therapies for ovarian cancer: current evidence. Br. J. Cancer 108, 250-258 (2013).
    • (2013) Br. J. Cancer , vol.108 , pp. 250-258
    • Hall, M.1
  • 112
    • 84908319663 scopus 로고    scopus 로고
    • Molecular subgroup of high-grade serous ovarian cancer (HGSOC) as a predictor of outcome following bevacizumab
    • Gourley, G. et al. Molecular subgroup of high-grade serous ovarian cancer (HGSOC) as a predictor of outcome following bevacizumab. J. Clin. Oncol. 32, 5502 (2014).
    • (2014) J. Clin. Oncol. , vol.32 , pp. 5502
    • Gourley, G.1
  • 113
    • 84925457982 scopus 로고    scopus 로고
    • Anti-vascular therapies in ovarian cancer: Moving beyond anti-VEGF approaches
    • Choi, H. J. et al. Anti-vascular therapies in ovarian cancer: moving beyond anti-VEGF approaches. Cancer Metastasis Rev. 34, 19-40 (2015).
    • (2015) Cancer Metastasis Rev. , vol.34 , pp. 19-40
    • Choi, H.J.1
  • 114
    • 84874030601 scopus 로고    scopus 로고
    • Identification of FGFR4 as a potential therapeutic target for advanced-stage, high-grade serous ovarian cancer
    • Zaid, T. M. et al. Identification of FGFR4 as a potential therapeutic target for advanced-stage, high-grade serous ovarian cancer. Clin. Cancer Res. 19, 809-820 (2013).
    • (2013) Clin. Cancer Res. , vol.19 , pp. 809-820
    • Zaid, T.M.1
  • 115
    • 84908134454 scopus 로고    scopus 로고
    • Combination cediranib and olaparib versus olaparib alone for women with recurrent platinum-sensitive ovarian cancer: A randomised phase 2 study
    • Liu, J. F. et al. Combination cediranib and olaparib versus olaparib alone for women with recurrent platinum-sensitive ovarian cancer: a randomised phase 2 study. Lancet Oncol. 15, 1207-1214 (2014).
    • (2014) Lancet Oncol. , vol.15 , pp. 1207-1214
    • Liu, J.F.1
  • 116
    • 80051533002 scopus 로고    scopus 로고
    • The BATTLE trial: A bold step toward improving the efficiency of biomarker-based drug development
    • Rubin, E. H., Anderson, K. M. & Gause, C. K. The BATTLE trial: a bold step toward improving the efficiency of biomarker-based drug development. Cancer Discov. 1, 17-20 (2011).
    • (2011) Cancer Discov. , vol.1 , pp. 17-20
    • Rubin, E.H.1    Anderson, K.M.2    Gause, C.K.3
  • 117
    • 79961062492 scopus 로고    scopus 로고
    • Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer
    • Cheung, H. W. et al. Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer. Proc. Natl Acad. Sci. USA 108, 12372-12377 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 12372-12377
    • Cheung, H.W.1
  • 118
    • 84920423504 scopus 로고    scopus 로고
    • An in-tumor genetic screen reveals that the BET bromodomain protein, BRD4, is a potential therapeutic target in ovarian carcinoma
    • Baratta, M. G. et al. An in-tumor genetic screen reveals that the BET bromodomain protein, BRD4, is a potential therapeutic target in ovarian carcinoma. Proc. Natl Acad. Sci. USA 112, 232-237 (2015).
    • (2015) Proc. Natl Acad. Sci. USA , vol.112 , pp. 232-237
    • Baratta, M.G.1
  • 119
    • 84859169877 scopus 로고    scopus 로고
    • The cancer cell line Encyclopedia enables predictive modelling of anticancer drug sensitivity
    • Barretina, J. et al. The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature 483, 603-607 (2012).
    • (2012) Nature , vol.483 , pp. 603-607
    • Barretina, J.1
  • 120
    • 84898402897 scopus 로고    scopus 로고
    • Multiplexed ion beam imaging of human breast tumors
    • Angelo, M. et al. Multiplexed ion beam imaging of human breast tumors. Nat. Med. 20, 436-442 (2014).
    • (2014) Nat. Med. , vol.20 , pp. 436-442
    • Angelo, M.1
  • 121
    • 0037440042 scopus 로고    scopus 로고
    • Evaluation of monoclonal humanized anti-HER2 antibody, trastuzumab, in patients with recurrent or refractory ovarian or primary peritoneal carcinoma with overexpression of HER2: A phase II trial of the gynecologic oncology group
    • Bookman, M. A., Darcy, K. M., Clarke-Pearson, D., Boothby, R. A. & Horowitz, I. R. Evaluation of monoclonal humanized anti-HER2 antibody, trastuzumab, in patients with recurrent or refractory ovarian or primary peritoneal carcinoma with overexpression of HER2: a phase II trial of the Gynecologic Oncology Group. J. Clin. Oncol. 21, 283-290 (2003).
    • (2003) J. Clin. Oncol. , vol.21 , pp. 283-290
    • Bookman, M.A.1    Darcy, K.M.2    Clarke-Pearson, D.3    Boothby, R.A.4    Horowitz, I.R.5
  • 122
    • 84865746086 scopus 로고    scopus 로고
    • The OPCML tumor suppressor functions as a cell surface repressor-adaptor, negatively regulating receptor tyrosine kinases in epithelial ovarian cancer
    • McKie, A. B. et al. The OPCML tumor suppressor functions as a cell surface repressor-adaptor, negatively regulating receptor tyrosine kinases in epithelial ovarian cancer. Cancer Discov. 2, 156-171 (2012).
    • (2012) Cancer Discov. , vol.2 , pp. 156-171
    • McKie, A.B.1
  • 123
    • 84875740314 scopus 로고    scopus 로고
    • Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal
    • Gao, J. et al. Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci. Signal 6, pl1 (2013).
    • (2013) Sci. Signal , vol.6 , pp. pl1
    • Gao, J.1
  • 124
    • 84866002291 scopus 로고    scopus 로고
    • The cBio cancer genomics portal: An open platform for exploring multidimensional cancer genomics data
    • Cerami, E. et al. The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. Cancer Discov. 2, 401-404 (2012).
    • (2012) Cancer Discov. , vol.2 , pp. 401-404
    • Cerami, E.1
  • 125
    • 84899635792 scopus 로고    scopus 로고
    • Small cell carcinoma of the ovary, hypercalcemic type, displays frequent inactivating germline and somatic mutations in SMARCA4
    • Ramos, P. et al. Small cell carcinoma of the ovary, hypercalcemic type, displays frequent inactivating germline and somatic mutations in SMARCA4. Nat. Genet. 46, 427-429 (2014).
    • (2014) Nat. Genet. , vol.46 , pp. 427-429
    • Ramos, P.1
  • 126
    • 79957917044 scopus 로고    scopus 로고
    • Aldehyde dehydrogenase in combination with CD133 defines angiogenic ovarian cancer stem cells that portend poor patient survival
    • Silva, I. A. et al. Aldehyde dehydrogenase in combination with CD133 defines angiogenic ovarian cancer stem cells that portend poor patient survival. Cancer Res. 71, 3991-4001 (2011).
    • (2011) Cancer Res. , vol.71 , pp. 3991-4001
    • Silva, I.A.1
  • 127
    • 84939152538 scopus 로고    scopus 로고
    • β-catenin-regulated ALDH1A1 is a target in ovarian cancer spheroids
    • Condello, S. et al. β-catenin-regulated ALDH1A1 is a target in ovarian cancer spheroids. Oncogene 34, 2297-2308 (2015).
    • (2015) Oncogene , vol.34 , pp. 2297-2308
    • Condello, S.1
  • 128
    • 84907043116 scopus 로고    scopus 로고
    • Epigenetic targeting of ovarian cancer stem cells
    • Wang, Y. et al. Epigenetic targeting of ovarian cancer stem cells. Cancer Res. 74, 4922-4936 (2014).
    • (2014) Cancer Res. , vol.74 , pp. 4922-4936
    • Wang, Y.1
  • 129
    • 84914140232 scopus 로고    scopus 로고
    • Ovarian cancer stem cells express ROR1, which can be targeted for anti-cancer-stem-cell therapy
    • Zhang, S. et al. Ovarian cancer stem cells express ROR1, which can be targeted for anti-cancer-stem-cell therapy. Proc. Natl Acad. Sci. USA 111, 17266-17271 (2014).
    • (2014) Proc. Natl Acad. Sci. USA , vol.111 , pp. 17266-17271
    • Zhang, S.1
  • 130
    • 84864029167 scopus 로고    scopus 로고
    • Cracking open window of opportunity trials
    • Kalinsky, K. & Hershman, D. L. Cracking open window of opportunity trials. J. Clin. Oncol. 30, 2573-2575 (2012).
    • (2012) J. Clin. Oncol. , vol.30 , pp. 2573-2575
    • Kalinsky, K.1    Hershman, D.L.2
  • 131
    • 79251584663 scopus 로고    scopus 로고
    • Early versus delayed treatment of relapsed ovarian cancer
    • Rustin, G., van der Burg, M., Griffin, C., Qian, W. & Swart, A. M. Early versus delayed treatment of relapsed ovarian cancer. Lancet 377, 380-381 (2011).
    • (2011) Lancet , vol.377 , pp. 380-381
    • Rustin, G.1    Van Der-Burg, M.2    Griffin, C.3    Qian, W.4    Swart, A.M.5
  • 132
    • 84931564561 scopus 로고    scopus 로고
    • Factors influencing ovulation and the risk of ovarian cancer in BRCA1 and BRCA2 mutation carriers
    • Kotsopoulos, J. et al. Factors influencing ovulation and the risk of ovarian cancer in BRCA1 and BRCA2 mutation carriers. Int. J. Cancer 137, 1136-1146 (2014).
    • (2014) Int. J. Cancer , vol.137 , pp. 1136-1146
    • Kotsopoulos, J.1
  • 133
    • 84893873955 scopus 로고    scopus 로고
    • Aspirin, nonaspirin nonsteroidal anti-inflammatory drug, and acetaminophen use and risk of invasive epithelial ovarian cancer: A pooled analysis in the ovarian cancer association consortium
    • Trabert, B. et al. Aspirin, nonaspirin nonsteroidal anti-inflammatory drug, and acetaminophen use and risk of invasive epithelial ovarian cancer: a pooled analysis in the Ovarian Cancer Association Consortium. J. Natl. Cancer Inst. 106, djt431 (2014).
    • (2014) J. Natl. Cancer Inst. , vol.106 , pp. djt431
    • Trabert, B.1
  • 134
  • 135
    • 84872978681 scopus 로고    scopus 로고
    • Metformin intake is associated with better survival in ovarian cancer: A case-control study
    • Kumar, S. et al. Metformin intake is associated with better survival in ovarian cancer: a case-control study. Cancer 119, 555-562 (2013).
    • (2013) Cancer , vol.119 , pp. 555-562
    • Kumar, S.1
  • 136
    • 84920777915 scopus 로고    scopus 로고
    • Metformin inhibits ovarian cancer growth and increases sensitivity to paclitaxel in mouse models
    • Lengyel, E. et al. Metformin inhibits ovarian cancer growth and increases sensitivity to paclitaxel in mouse models. Am. J. Obstet. Gynecol. 212, e1-479.e10 (2014).
    • (2014) Am. J. Obstet. Gynecol. , vol.212 , pp. e1-e10
    • Lengyel, E.1
  • 137
    • 84929515264 scopus 로고    scopus 로고
    • Menopausal hormone use and ovarian cancer risk: Individual participant meta-analysis of 52 epidemiological studies
    • Collaborative Group on Epidemiological Studies of Ovarian Cancer. Menopausal hormone use and ovarian cancer risk: individual participant meta-analysis of 52 epidemiological studies. Lancet 385, 1835-1842 (2015).
    • (2015) Lancet , vol.385 , pp. 1835-1842
  • 138
    • 84860157091 scopus 로고    scopus 로고
    • Ovarian cancer and body size: Individual participant meta-analysis including 25,157 women with ovarian cancer from 47 epidemiological studies
    • Collaborative Group on Epidemiological Studies of Ovarian Cancer. Ovarian cancer and body size: individual participant meta-analysis including 25,157 women with ovarian cancer from 47 epidemiological studies. PLoS Med. 9, e1001200 (2012).
    • (2012) PLoS Med. , vol.9 , pp. e1001200
  • 139
    • 84878880984 scopus 로고    scopus 로고
    • Disparities in ovarian cancer care quality and survival according to race and socioeconomic status
    • Bristow, R. E. et al. Disparities in ovarian cancer care quality and survival according to race and socioeconomic status. J. Natl Cancer Inst. 105, 823-832 (2013).
    • (2013) J. Natl Cancer Inst. , vol.105 , pp. 823-832
    • Bristow, R.E.1
  • 140
    • 84873742602 scopus 로고    scopus 로고
    • Characteristics of women with ovarian carcinoma who have BRCA1 and BRCA2 mutations not identified by clinical testing
    • Norquist, B. M. et al. Characteristics of women with ovarian carcinoma who have BRCA1 and BRCA2 mutations not identified by clinical testing. Gynecol. Oncol. 128, 483-487 (2013).
    • (2013) Gynecol. Oncol. , vol.128 , pp. 483-487
    • Norquist, B.M.1
  • 141
    • 84904764472 scopus 로고    scopus 로고
    • Underestimation of risk of a BRCA1 or BRCA2 mutation in women with high-grade serous ovarian cancer by BRCAPRO: A multi-institution study
    • Daniels, M. S. et al. Underestimation of risk of a BRCA1 or BRCA2 mutation in women with high-grade serous ovarian cancer by BRCAPRO: a multi-institution study. J. Clin. Oncol. 32, 1249-1255 (2014).
    • (2014) J. Clin. Oncol. , vol.32 , pp. 1249-1255
    • Daniels, M.S.1
  • 142
    • 84864276664 scopus 로고    scopus 로고
    • Germline BRCA1 and BRCA2 mutations in ovarian cancer: Utility of a histology-based referral strategy
    • Schrader, K. A. et al. Germline BRCA1 and BRCA2 mutations in ovarian cancer: utility of a histology-based referral strategy. Obstet. Gynecol. 120, 235-240 (2012).
    • (2012) Obstet. Gynecol. , vol.120 , pp. 235-240
    • Schrader, K.A.1
  • 143
    • 84905666270 scopus 로고    scopus 로고
    • The contribution of deleterious germline mutations in BRCA1, BRCA2 and the mismatch repair genes to ovarian cancer in the population
    • Song, H. et al. The contribution of deleterious germline mutations in BRCA1, BRCA2 and the mismatch repair genes to ovarian cancer in the population. Hum. Mol. Genet. 23, 4703-4709 (2014).
    • (2014) Hum. Mol. Genet. , vol.23 , pp. 4703-4709
    • Song, H.1
  • 144
    • 84893470371 scopus 로고    scopus 로고
    • Germline and somatic mutations in homologous recombination genes predict platinum response and survival in ovarian, fallopian tube, and peritoneal carcinomas
    • Pennington, K. P. et al. Germline and somatic mutations in homologous recombination genes predict platinum response and survival in ovarian, fallopian tube, and peritoneal carcinomas. Clin. Cancer Res. 20, 764-775 (2014).
    • (2014) Clin. Cancer Res. , vol.20 , pp. 764-775
    • Pennington, K.P.1
  • 145
    • 84922477275 scopus 로고    scopus 로고
    • Cost-effectiveness of population screening for BRCA mutations in Ashkenazi jewish women compared with family history-based testing
    • Manchanda, R. et al. Cost-effectiveness of population screening for BRCA mutations in Ashkenazi jewish women compared with family history-based testing. J. Natl Cancer Inst. 107, 380 (2015).
    • (2015) J. Natl Cancer Inst. , vol.107 , pp. 380
    • Manchanda, R.1
  • 146
    • 84930452193 scopus 로고    scopus 로고
    • Population testing for cancer predisposing BRCA1/BRCA2 mutations in the Ashkenazi-Jewish community: A randomized controlled trial
    • Manchanda, R. et al. Population testing for cancer predisposing BRCA1/BRCA2 mutations in the Ashkenazi-Jewish community: a randomized controlled trial. J. Natl Cancer Inst. 107, 379 (2015).
    • (2015) J. Natl Cancer Inst. , vol.107 , pp. 379
    • Manchanda, R.1
  • 147
    • 77951521419 scopus 로고    scopus 로고
    • Evaluating women with ovarian cancer for BRCA1 and BRCA2 mutations: Missed opportunities
    • Meyer, L. A. et al. Evaluating women with ovarian cancer for BRCA1 and BRCA2 mutations: missed opportunities. Obstet. Gynecol. 115, 945-952 (2010).
    • (2010) Obstet. Gynecol. , vol.115 , pp. 945-952
    • Meyer, L.A.1
  • 148
    • 84860320440 scopus 로고    scopus 로고
    • Germline RAD51C mutations confer susceptibility to ovarian cancer
    • Loveday, C. et al. Germline RAD51C mutations confer susceptibility to ovarian cancer. Nat. Genet. 44, 475-476 (2012).
    • (2012) Nat. Genet. , vol.44 , pp. 475-476
    • Loveday, C.1
  • 149
    • 80052264429 scopus 로고    scopus 로고
    • Germline mutations in RAD51D confer susceptibility to ovarian cancer
    • Loveday, C. et al. Germline mutations in RAD51D confer susceptibility to ovarian cancer. Nat. Genet. 43, 879-882 (2011).
    • (2011) Nat. Genet. , vol.43 , pp. 879-882
    • Loveday, C.1
  • 150
    • 77951720395 scopus 로고    scopus 로고
    • Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene
    • Meindl, A. et al. Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene. Nat. Genet. 42, 410-414 (2010).
    • (2010) Nat. Genet. , vol.42 , pp. 410-414
    • Meindl, A.1
  • 151
    • 80054973810 scopus 로고    scopus 로고
    • Mutations in BRIP1 confer high risk of ovarian cancer
    • Rafnar, T. et al. Mutations in BRIP1 confer high risk of ovarian cancer. Nat. Genet. 43, 1104-1107 (2011).
    • (2011) Nat. Genet. , vol.43 , pp. 1104-1107
    • Rafnar, T.1
  • 152
    • 84929171835 scopus 로고    scopus 로고
    • Identification of six new susceptibility loci for invasive epithelial ovarian cancer
    • Kuchenbaecker, K. B. et al. Identification of six new susceptibility loci for invasive epithelial ovarian cancer. Nat. Genet. 47, 164-171 (2015).
    • (2015) Nat. Genet. , vol.47 , pp. 164-171
    • Kuchenbaecker, K.B.1
  • 153
    • 84875411563 scopus 로고    scopus 로고
    • Biopsychological stress factors in BRCA mutation carriers
    • Wenzel, L. et al. Biopsychological stress factors in BRCA mutation carriers. Psychosomatics 53, 582-590 (2012).
    • (2012) Psychosomatics , vol.53 , pp. 582-590
    • Wenzel, L.1
  • 154
    • 84878594735 scopus 로고    scopus 로고
    • Biomarkers, the molecular gaze and the transformation of cancer survivorship
    • Bell, K. Biomarkers, the molecular gaze and the transformation of cancer survivorship. Biosocieties 8, 124-143 (2013).
    • (2013) Biosocieties , vol.8 , pp. 124-143
    • Bell, K.1
  • 155
    • 84872107151 scopus 로고    scopus 로고
    • Prophylactic salpingectomy and delayed oophorectomy as an alternative for BRCA mutation carriers
    • Kwon, J. S. et al. Prophylactic salpingectomy and delayed oophorectomy as an alternative for BRCA mutation carriers. Obstet. Gynecol. 121, 14-24 (2013).
    • (2013) Obstet. Gynecol. , vol.121 , pp. 14-24
    • Kwon, J.S.1
  • 156
    • 84899751361 scopus 로고    scopus 로고
    • Opportunistic salpingectomy: Uptake, risks, and complications of a regional initiative for ovarian cancer prevention
    • 471
    • McAlpine, J. N. et al. Opportunistic salpingectomy: uptake, risks, and complications of a regional initiative for ovarian cancer prevention. Am. J. Obstet. Gynecol. 210, 471 e1-11 (2014).
    • (2014) Am. J. Obstet. Gynecol. , vol.210 , pp. e1-11
    • McAlpine, J.N.1
  • 157
    • 84927948853 scopus 로고    scopus 로고
    • Population distribution of lifetime risk of ovarian cancer in the United States
    • Pearce, C. L. et al. Population distribution of lifetime risk of ovarian cancer in the United States. Cancer Epidemiol. Biomarkers Prev. 24, 671-676 (2015).
    • (2015) Cancer Epidemiol. Biomarkers Prev. , vol.24 , pp. 671-676
    • Pearce, C.L.1
  • 158
    • 79958036419 scopus 로고    scopus 로고
    • Effect of screening on ovarian cancer mortality: The prostate, lung, colorectal and ovarian (PLCO) Cancer screening randomized controlled trial
    • Buys, S. S. et al. Effect of screening on ovarian cancer mortality: the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Randomized Controlled Trial. JAMA 305, 2295-2303 (2011).
    • (2011) JAMA , vol.305 , pp. 2295-2303
    • Buys, S.S.1
  • 159
    • 84930654984 scopus 로고    scopus 로고
    • Risk algorithm using serial biomarker measurements doubles the number of screen-detected cancers compared with a single-threshold rule in the United Kingdom collaborative trial of ovarian cancer screening
    • Menon, U. et al. Risk algorithm using serial biomarker measurements doubles the number of screen-detected cancers compared with a single-threshold rule in the United Kingdom collaborative trial of ovarian cancer screening. J. Clin. Oncol. 33, 2062-2071 (2015).
    • (2015) J. Clin. Oncol. , vol.33 , pp. 2062-2071
    • Menon, U.1
  • 160
    • 84924940396 scopus 로고    scopus 로고
    • Does aggressive surgery improve outcomes? Interaction between preoperative disease burden and complex surgery in patients with advanced-stage ovarian cancer: An analysis of GOG 182
    • Horowitz, N. S. et al. Does aggressive surgery improve outcomes? interaction between preoperative disease burden and complex surgery in patients with advanced-stage ovarian cancer: an analysis of GOG 182. J. Clin. Oncol. 33, 937-943 (2015).
    • (2015) J. Clin. Oncol. , vol.33 , pp. 937-943
    • Horowitz, N.S.1
  • 161
    • 84894028183 scopus 로고    scopus 로고
    • Ovarian cancer screening-current status, future directions
    • Menon, U., Griffin, M. & Gentry-Maharaj, A. Ovarian cancer screening-current status, future directions. Gynecol. Oncol. 132, 490-495 (2014).
    • (2014) Gynecol. Oncol. , vol.132 , pp. 490-495
    • Menon, U.1    Griffin, M.2    Gentry-Maharaj, A.3
  • 162
    • 84873389024 scopus 로고    scopus 로고
    • Longitudinal screening algorithm that incorporates change over time in CA125 levels identifies ovarian cancer earlier than a single-threshold rule
    • Drescher, C. W. et al. Longitudinal screening algorithm that incorporates change over time in CA125 levels identifies ovarian cancer earlier than a single-threshold rule. J. Clin. Oncol. 31, 387-392 (2013).
    • (2013) J. Clin. Oncol. , vol.31 , pp. 387-392
    • Drescher, C.W.1
  • 163
    • 84861746437 scopus 로고    scopus 로고
    • Noninvasive identification and monitoring of cancer mutations by targeted deep sequencing of plasma DNA
    • Forshew, T. et al. Noninvasive identification and monitoring of cancer mutations by targeted deep sequencing of plasma DNA. Sci. Transl Med. 4, 136ra68 (2012).
    • (2012) Sci. Transl Med. , vol.4 , pp. 136ra68
    • Forshew, T.1
  • 164
    • 84872329672 scopus 로고    scopus 로고
    • Evaluation of DNA from the Papanicolaou test to detect ovarian and endometrial cancers
    • Kinde, I. et al. Evaluation of DNA from the Papanicolaou test to detect ovarian and endometrial cancers. Sci. Transl Med. 5, 167ra4 (2013).
    • (2013) Sci. Transl Med. , vol.5 , pp. 167ra4
    • Kinde, I.1
  • 165
    • 79951579305 scopus 로고    scopus 로고
    • Autofluorescence imaging can identify preinvasive or clinically occult lesions in fallopian tube epithelium: A promising step towards screening and early detection
    • McAlpine, J. N. et al. Autofluorescence imaging can identify preinvasive or clinically occult lesions in fallopian tube epithelium: a promising step towards screening and early detection. Gynecol. Oncol. 120, 385-392 (2011).
    • (2011) Gynecol. Oncol. , vol.120 , pp. 385-392
    • McAlpine, J.N.1
  • 166
    • 84895826704 scopus 로고    scopus 로고
    • Ultrasound molecular imaging in a human CD276 expression-modulated murine ovarian cancer model
    • Lutz, A. M. et al. Ultrasound molecular imaging in a human CD276 expression-modulated murine ovarian cancer model. Clin. Cancer Res. 20, 1313-1322 (2014).
    • (2014) Clin. Cancer Res. , vol.20 , pp. 1313-1322
    • Lutz, A.M.1
  • 167
    • 0032980903 scopus 로고    scopus 로고
    • Survival impact of surgical cytoreduction in stage IV epithelial ovarian cancer
    • Bristow, R. E., Montz, F. J., Lagasse, L. D., Leuchter, R. S. & Karlan, B. Y. Survival impact of surgical cytoreduction in stage IV epithelial ovarian cancer. Gynecol. Oncol. 72, 278-287 (1999).
    • (1999) Gynecol. Oncol. , vol.72 , pp. 278-287
    • Bristow, R.E.1    Montz, F.J.2    Lagasse, L.D.3    Leuchter, R.S.4    Karlan, B.Y.5
  • 168
    • 63449129599 scopus 로고    scopus 로고
    • Role of surgical outcome as prognostic factor in advanced epithelial ovarian cancer: A combined exploratory analysis of 3 prospectively randomized phase 3 multicenter trials: By the Arbeitsgemeinschaft Gynaekologische Onkologie Studiengruppe Ovarialkarzinom (AGO-OVAR) and the Groupe d'Investigateurs Nationaux Pour les Etudes des Cancers de l'Ovaire (GINECO)
    • du Bois, A. et al. Role of surgical outcome as prognostic factor in advanced epithelial ovarian cancer: a combined exploratory analysis of 3 prospectively randomized phase 3 multicenter trials: by the Arbeitsgemeinschaft Gynaekologische Onkologie Studiengruppe Ovarialkarzinom (AGO-OVAR) and the Groupe d'Investigateurs Nationaux Pour les Etudes des Cancers de l'Ovaire (GINECO). Cancer 115, 1234-1244 (2009).
    • (2009) Cancer , vol.115 , pp. 1234-1244
    • Du Bois, A.1
  • 169
    • 77956285631 scopus 로고    scopus 로고
    • Neoadjuvant chemotherapy or primary surgery in stage IIIC or IV ovarian cancer
    • Vergote, I. et al. Neoadjuvant chemotherapy or primary surgery in stage IIIC or IV ovarian cancer. N. Engl. J. Med. 363, 943-953 (2010).
    • (2010) N. Engl. J. Med. , vol.363 , pp. 943-953
    • Vergote, I.1
  • 170
    • 55949128032 scopus 로고    scopus 로고
    • A statement for extensive primary cytoreductive surgery in advanced ovarian cancer
    • Naik, R., Edmondson, R. J., Galaal, K., Hatem, M. H. & Godfrey, K. A. A statement for extensive primary cytoreductive surgery in advanced ovarian cancer. BJOG 115, 1713-1714 (2008).
    • (2008) BJOG , vol.115 , pp. 1713-1714
    • Naik, R.1    Edmondson, R.J.2    Galaal, K.3    Hatem, M.H.4    Godfrey, K.A.5
  • 171
    • 84943362394 scopus 로고    scopus 로고
    • Artificial intelligence systems as prognostic and predictive tools in ovarian cancer
    • Enshaei, A., Robson, C. N. & Edmondson, R. J. Artificial intelligence systems as prognostic and predictive tools in ovarian cancer. Ann. Surg. Oncol. 22, 3970-3975 (2015).
    • (2015) Ann. Surg. Oncol. , vol.22 , pp. 3970-3975
    • Enshaei, A.1    Robson, C.N.2    Edmondson, R.J.3
  • 172
    • 84884902788 scopus 로고    scopus 로고
    • Which patients benefit most from primary surgery or neoadjuvant chemotherapy in stage IIIC or IV ovarian cancer? An exploratory analysis of the European Organisation for Research and Treatment of Cancer 55971 randomised trial
    • van Meurs, H. S. et al. Which patients benefit most from primary surgery or neoadjuvant chemotherapy in stage IIIC or IV ovarian cancer? An exploratory analysis of the European Organisation for Research and Treatment of Cancer 55971 randomised trial. Eur. J. Cancer 49, 3191-3201 (2013).
    • (2013) Eur. J. Cancer , vol.49 , pp. 3191-3201
    • Van Meurs, H.S.1
  • 173
    • 84902460514 scopus 로고    scopus 로고
    • Risk prediction for late-stage ovarian cancer by meta-analysis of 1525 patient samples
    • Riester, M. et al. Risk prediction for late-stage ovarian cancer by meta-analysis of 1525 patient samples. J. Natl Cancer Inst. 106, dju048 (2014).
    • (2014) J. Natl Cancer Inst. , vol.106 , pp. dju048
    • Riester, M.1
  • 174
    • 84925940428 scopus 로고    scopus 로고
    • A framework for a personalized surgical approach to ovarian cancer
    • Nick, A. M., Coleman, R. L., Ramirez, P. T. & Sood, A. K. A framework for a personalized surgical approach to ovarian cancer. Nat. Rev. Clin. Oncol. 12, 239-245 (2015).
    • (2015) Nat. Rev. Clin. Oncol. , vol.12 , pp. 239-245
    • Nick, A.M.1    Coleman, R.L.2    Ramirez, P.T.3    Sood, A.K.4
  • 175
    • 79956096959 scopus 로고    scopus 로고
    • Prospective validation study of a predictive score for operability of recurrent ovarian cancer: The Multicenter Intergroup Study DESKTOP II. A project of the AGO Kommission OVAR, AGO Study Group, NOGGO, AGO-Austria, and MITO
    • Harter, P. et al. Prospective validation study of a predictive score for operability of recurrent ovarian cancer: the Multicenter Intergroup Study DESKTOP II. A project of the AGO Kommission OVAR, AGO Study Group, NOGGO, AGO-Austria, and MITO. Int. J. Gynecol. Cancer 21, 289-295 (2011).
    • (2011) Int. J. Gynecol. Cancer , vol.21 , pp. 289-295
    • Harter, P.1
  • 176
    • 33845657404 scopus 로고    scopus 로고
    • Surgery in recurrent ovarian cancer: The Arbeitsgemeinschaft Gynaekologische Onkologie (AGO) DESKTOP OVAR trial
    • Harter, P. et al. Surgery in recurrent ovarian cancer: the Arbeitsgemeinschaft Gynaekologische Onkologie (AGO) DESKTOP OVAR trial. Ann. Surg. Oncol. 13, 1702-1710 (2006).
    • (2006) Ann. Surg. Oncol. , vol.13 , pp. 1702-1710
    • Harter, P.1
  • 177
    • 84875221407 scopus 로고    scopus 로고
    • Value of tertiary cytoreductive surgery in epithelial ovarian cancer: An international multicenter evaluation
    • Fotopoulou, C. et al. Value of tertiary cytoreductive surgery in epithelial ovarian cancer: an international multicenter evaluation. Ann. Surg. Oncol. 20, 1348-1354 (2013).
    • (2013) Ann. Surg. Oncol. , vol.20 , pp. 1348-1354
    • Fotopoulou, C.1
  • 178
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan, D. & Weinberg, R. A. Hallmarks of cancer: the next generation. Cell 144, 646-674 (2011).
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 179
    • 33846421673 scopus 로고    scopus 로고
    • Congenital hypothyroid female pax8-deficient mice are infertile despite thyroid hormone replacement therapy
    • Mittag, J., Winterhager, E., Bauer, K. & Grummer, R. Congenital hypothyroid female pax8-deficient mice are infertile despite thyroid hormone replacement therapy. Endocrinology 148, 719-725 (2007).
    • (2007) Endocrinology , vol.148 , pp. 719-725
    • Mittag, J.1    Winterhager, E.2    Bauer, K.3    Grummer, R.4
  • 180
    • 79959310044 scopus 로고    scopus 로고
    • Expression of PAX8 in normal and neoplastic tissues: A comprehensive immunohistochemical study
    • Tacha, D., Zhou, D. & Cheng, L. Expression of PAX8 in normal and neoplastic tissues: a comprehensive immunohistochemical study. Appl. Immunohistochem Mol. Morphol. 19, 293-299 (2011).
    • (2011) Appl. Immunohistochem Mol. Morphol. , vol.19 , pp. 293-299
    • Tacha, D.1    Zhou, D.2    Cheng, L.3
  • 181
    • 77951822119 scopus 로고    scopus 로고
    • PAX8 reliably distinguishes ovarian serous tumors from malignant mesothelioma
    • Laury, A. R. et al. PAX8 reliably distinguishes ovarian serous tumors from malignant mesothelioma. Am. J. Surg. Pathol. 34, 627-635 (2010).
    • (2010) Am. J. Surg. Pathol. , vol.34 , pp. 627-635
    • Laury, A.R.1
  • 182
    • 84903542932 scopus 로고    scopus 로고
    • CPTAC Assay portal: A repository of targeted proteomic assays
    • Whiteaker, J. R. et al. CPTAC Assay Portal: a repository of targeted proteomic assays. Nat. Methods 11, 703-704 (2014).
    • (2014) Nat. Methods , vol.11 , pp. 703-704
    • Whiteaker, J.R.1
  • 183
    • 85069238577 scopus 로고    scopus 로고
    • Succinate dehydrogenase inhibition leads to epithelial-mesenchymal transition and reprogrammed carbon metabolism
    • Aspuria, P. J. et al. Succinate dehydrogenase inhibition leads to epithelial-mesenchymal transition and reprogrammed carbon metabolism. Cancer Metab. 2, 21 (2014).
    • (2014) Cancer Metab. , vol.2 , pp. 21
    • Aspuria, P.J.1
  • 184
    • 80052576079 scopus 로고    scopus 로고
    • Stathmin 1, a marker of PI3K pathway activation and regulator of microtubule dynamics, is expressed in early pelvic serous carcinomas
    • Karst, A. M. et al. Stathmin 1, a marker of PI3K pathway activation and regulator of microtubule dynamics, is expressed in early pelvic serous carcinomas. Gynecol. Oncol. 123, 5-12 (2011).
    • (2011) Gynecol. Oncol. , vol.123 , pp. 5-12
    • Karst, A.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.