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Volumn 5, Issue SEP, 2015, Pages

Current status of CTCs as liquid biopsy in lung cancer and future directions

Author keywords

Circulating tumor cells; Liquid biopsy; Lung cancer; Non small cell lung cancer; Prognostic biomarkers; Review of literature; Small cell lung cancer

Indexed keywords

BIOPSY; CANCER PROGNOSIS; CELL SEPARATION; CIRCULATING TUMOR CELL; COPY NUMBER VARIATION; EARLY DIAGNOSIS; EPITHELIAL MESENCHYMAL TRANSITION; FLUORESCENCE IN SITU HYBRIDIZATION; GENE MUTATION; HUMAN; LUNG CANCER; METASTASIS; OVERALL SURVIVAL; PERSONALIZED MEDICINE; PREDICTION; PROGRESSION FREE SURVIVAL; REVIEW;

EID: 84944744413     PISSN: None     EISSN: 2234943X     Source Type: Journal    
DOI: 10.3389/fonc.2015.00209     Document Type: Review
Times cited : (48)

References (114)
  • 2
  • 3
    • 3142592957 scopus 로고    scopus 로고
    • Atlanta, GA: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health
    • Services USDoHaH. The Health Consequences of Smoking: A Report of the Surgeon General. Atlanta, GA: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health (2004).
    • (2004) The Health Consequences of Smoking: A Report of the Surgeon General
    • Services, U.S.DoHaH.1
  • 4
    • 7444234824 scopus 로고    scopus 로고
    • Gefitinib in patients with brain metastases from non-small-cell lung cancer: review of 15 clinical cases
    • Namba Y, Kijima T, Yokota S, Niinaka M, Kawamura S, Iwasaki T, et al. Gefitinib in patients with brain metastases from non-small-cell lung cancer: review of 15 clinical cases. Clin Lung Cancer (2004) 6(2):123-8. doi:10.3816/CLC.2004.n.026
    • (2004) Clin Lung Cancer , vol.6 , Issue.2 , pp. 123-128
    • Namba, Y.1    Kijima, T.2    Yokota, S.3    Niinaka, M.4    Kawamura, S.5    Iwasaki, T.6
  • 5
    • 79961108629 scopus 로고    scopus 로고
    • Reduced lung-cancer mortality with low-dose computed tomographic screening
    • Aberle DR, Adams AM, Berg CD, Black WC, Clapp JD, Fagerstrom RM, et al. Reduced lung-cancer mortality with low-dose computed tomographic screening. N Engl J Med (2011) 365(5):395-409. doi:10.1056/NEJMoa1102873
    • (2011) N Engl J Med , vol.365 , Issue.5 , pp. 395-409
    • Aberle, D.R.1    Adams, A.M.2    Berg, C.D.3    Black, W.C.4    Clapp, J.D.5    Fagerstrom, R.M.6
  • 7
    • 13844317894 scopus 로고    scopus 로고
    • EGFR mutation and resistance of non-small-cell lung cancer to gefitinib
    • Kobayashi S, Boggon TJ, Dayaram T, Janne PA, Kocher O, Meyerson M, et al. EGFR mutation and resistance of non-small-cell lung cancer to gefitinib. N Engl J Med (2005) 352(8):786-92. doi:10.1056/NEJMoa044238
    • (2005) N Engl J Med , vol.352 , Issue.8 , pp. 786-792
    • Kobayashi, S.1    Boggon, T.J.2    Dayaram, T.3    Janne, P.A.4    Kocher, O.5    Meyerson, M.6
  • 8
    • 34249075147 scopus 로고    scopus 로고
    • MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
    • Engelman JA, Zejnullahu K, Mitsudomi T, Song Y, Hyland C, Park JO, et al. MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science (2007) 316(5827):1039-43. doi:10.1126/science.1141478
    • (2007) Science , vol.316 , Issue.5827 , pp. 1039-1043
    • Engelman, J.A.1    Zejnullahu, K.2    Mitsudomi, T.3    Song, Y.4    Hyland, C.5    Park, J.O.6
  • 9
    • 84872017586 scopus 로고    scopus 로고
    • Circulating tumor cells: liquid biopsy of cancer
    • Alix-Panabieres C, Pantel K. Circulating tumor cells: liquid biopsy of cancer. Clin Chem (2013) 59(1):110-8. doi:10.1373/clinchem.2012.194258
    • (2013) Clin Chem , vol.59 , Issue.1 , pp. 110-118
    • Alix-Panabieres, C.1    Pantel, K.2
  • 10
    • 84906731563 scopus 로고    scopus 로고
    • Challenges in circulating tumour cell research
    • Alix-Panabieres C, Pantel K. Challenges in circulating tumour cell research. Nat Rev Cancer (2014) 14(9):623-31. doi:10.1038/nrc3820
    • (2014) Nat Rev Cancer , vol.14 , Issue.9 , pp. 623-631
    • Alix-Panabieres, C.1    Pantel, K.2
  • 11
    • 84896371874 scopus 로고    scopus 로고
    • Detection of circulating tumor DNA in early-and late-stage human malignancies
    • Bettegowda C, Sausen M, Leary RJ, Kinde I, Wang Y, Agrawal N, et al. Detection of circulating tumor DNA in early-and late-stage human malignancies. Sci Transl Med (2014) 6(224):224ra24. doi:10.1126/scitranslmed.3007094
    • (2014) Sci Transl Med , vol.6 , Issue.224
    • Bettegowda, C.1    Sausen, M.2    Leary, R.J.3    Kinde, I.4    Wang, Y.5    Agrawal, N.6
  • 12
    • 84891833170 scopus 로고    scopus 로고
    • Analysis of MicroRNAs in sputum to improve computed tomography for lung cancer diagnosis
    • Shen J, Liao J, Guarnera MA, Fang H, Cai L, Stass SA, et al. Analysis of MicroRNAs in sputum to improve computed tomography for lung cancer diagnosis. J Thorac Oncol (2014) 9(1):33-40. doi:10.1097/JTO.0000000000000025
    • (2014) J Thorac Oncol , vol.9 , Issue.1 , pp. 33-40
    • Shen, J.1    Liao, J.2    Guarnera, M.A.3    Fang, H.4    Cai, L.5    Stass, S.A.6
  • 13
    • 84898542288 scopus 로고    scopus 로고
    • Liquid biopsies: genotyping circulating tumor DNA
    • Diaz LA Jr, Bardelli A. Liquid biopsies: genotyping circulating tumor DNA. J Clin Oncol (2014) 32(6):579-86. doi:10.1200/JCO.2012.45.2011
    • (2014) J Clin Oncol , vol.32 , Issue.6 , pp. 579-586
    • Diaz, L.A.1    Bardelli, A.2
  • 14
    • 80053356340 scopus 로고    scopus 로고
    • Blood platelets contain tumor-derived RNA biomarkers
    • Nilsson RJ, Balaj L, Hulleman E, van Rijn S, Pegtel DM, Walraven M, et al. Blood platelets contain tumor-derived RNA biomarkers. Blood (2011) 118(13):3680-3. doi:10.1182/blood-2011-03-344408
    • (2011) Blood , vol.118 , Issue.13 , pp. 3680-3683
    • Nilsson, R.J.1    Balaj, L.2    Hulleman, E.3    van Rijn, S.4    Pegtel, D.M.5    Walraven, M.6
  • 16
    • 84898476658 scopus 로고    scopus 로고
    • Clinical validation of the detection of KRAS and BRAF mutations from circulating tumor DNA
    • Thierry AR, Mouliere F, El Messaoudi S, Mollevi C, Lopez-Crapez E, Rolet F, et al. Clinical validation of the detection of KRAS and BRAF mutations from circulating tumor DNA. Nat Med (2014) 20(4):430-5. doi:10.1038/nm.3511
    • (2014) Nat Med , vol.20 , Issue.4 , pp. 430-435
    • Thierry, A.R.1    Mouliere, F.2    El Messaoudi, S.3    Mollevi, C.4    Lopez-Crapez, E.5    Rolet, F.6
  • 17
    • 84884176329 scopus 로고    scopus 로고
    • Multiplex picodroplet digital PCR to detect KRAS mutations in circulating DNA from the plasma of colorectal cancer patients
    • Taly V, Pekin D, Benhaim L, Kotsopoulos SK, Le Corre D, Li X, et al. Multiplex picodroplet digital PCR to detect KRAS mutations in circulating DNA from the plasma of colorectal cancer patients. Clin Chem (2013) 59(12):1722-31. doi:10.1373/clinchem.2013.206359
    • (2013) Clin Chem , vol.59 , Issue.12 , pp. 1722-1731
    • Taly, V.1    Pekin, D.2    Benhaim, L.3    Kotsopoulos, S.K.4    Le Corre, D.5    Li, X.6
  • 18
    • 84885956968 scopus 로고    scopus 로고
    • Circulating tumor cells in pancreatic cancer patients: methods of detection and clinical implications
    • Tjensvoll K, Nordgard O, Smaaland R. Circulating tumor cells in pancreatic cancer patients: methods of detection and clinical implications. Int J Cancer (2014) 134(1):1-8. doi:10.1002/ijc.28134
    • (2014) Int J Cancer , vol.134 , Issue.1 , pp. 1-8
    • Tjensvoll, K.1    Nordgard, O.2    Smaaland, R.3
  • 19
    • 79955045007 scopus 로고    scopus 로고
    • Evaluation and prognostic significance of circulating tumor cells in patients with non-small-cell lung cancer
    • Krebs MG, Sloane R, Priest L, Lancashire L, Hou JM, Greystoke A, et al. Evaluation and prognostic significance of circulating tumor cells in patients with non-small-cell lung cancer. J Clin Oncol (2011) 29(12):1556-63. doi:10.1200/JCO.2010.28.7045
    • (2011) J Clin Oncol , vol.29 , Issue.12 , pp. 1556-1563
    • Krebs, M.G.1    Sloane, R.2    Priest, L.3    Lancashire, L.4    Hou, J.M.5    Greystoke, A.6
  • 20
    • 20144385756 scopus 로고    scopus 로고
    • Circulating tumor cells: a novel prognostic factor for newly diagnosed metastatic breast cancer
    • Cristofanilli M, Hayes DF, Budd GT, Ellis MJ, Stopeck A, Reuben JM, et al. Circulating tumor cells: a novel prognostic factor for newly diagnosed metastatic breast cancer. J Clin Oncol (2005) 23(7):1420-30. doi:10.1200/JCO.2005.08.140
    • (2005) J Clin Oncol , vol.23 , Issue.7 , pp. 1420-1430
    • Cristofanilli, M.1    Hayes, D.F.2    Budd, G.T.3    Ellis, M.J.4    Stopeck, A.5    Reuben, J.M.6
  • 21
    • 77953544034 scopus 로고    scopus 로고
    • Modeling the relationship between circulating tumour cells number and prognosis of metastatic breast cancer
    • Botteri E, Sandri MT, Bagnardi V, Munzone E, Zorzino L, Rotmensz N, et al. Modeling the relationship between circulating tumour cells number and prognosis of metastatic breast cancer. Breast Cancer Res Treat (2010) 122(1):211-7. doi:10.1007/s10549-009-0668-7
    • (2010) Breast Cancer Res Treat , vol.122 , Issue.1 , pp. 211-217
    • Botteri, E.1    Sandri, M.T.2    Bagnardi, V.3    Munzone, E.4    Zorzino, L.5    Rotmensz, N.6
  • 22
    • 42049099496 scopus 로고    scopus 로고
    • Detection of circulating tumor cells in patients with pancreatic cancer: a preliminary result
    • Kurihara T, Itoi T, Sofuni A, Itokawa F, Tsuchiya T, Tsuji S, et al. Detection of circulating tumor cells in patients with pancreatic cancer: a preliminary result. J Hepatobiliary Pancreat Surg (2008) 15(2):189-95. doi:10.1007/s00534-007-1250-5
    • (2008) J Hepatobiliary Pancreat Surg , vol.15 , Issue.2 , pp. 189-195
    • Kurihara, T.1    Itoi, T.2    Sofuni, A.3    Itokawa, F.4    Tsuchiya, T.5    Tsuji, S.6
  • 23
    • 70349969478 scopus 로고    scopus 로고
    • Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution
    • Shah SP, Morin RD, Khattra J, Prentice L, Pugh T, Burleigh A, et al. Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution. Nature (2009) 461(7265):809-U67. doi:10.1038/nature08489
    • (2009) Nature , vol.461 , Issue.7265 , pp. 809-813
    • Shah, S.P.1    Morin, R.D.2    Khattra, J.3    Prentice, L.4    Pugh, T.5    Burleigh, A.6
  • 25
    • 84887138426 scopus 로고    scopus 로고
    • Real-time liquid biopsy in cancer patients: fact or fiction?
    • Pantel K, Alix-Panabieres C. Real-time liquid biopsy in cancer patients: fact or fiction? Cancer Res (2013) 73(21):6384-8. doi:10.1158/0008-5472.CAN-13-2030
    • (2013) Cancer Res , vol.73 , Issue.21 , pp. 6384-6388
    • Pantel, K.1    Alix-Panabieres, C.2
  • 26
    • 84862705627 scopus 로고    scopus 로고
    • Circulating tumor cells in the diagnosis and management of pancreatic cancer
    • Cen P, Ni X, Yang J, Graham DY, Li M. Circulating tumor cells in the diagnosis and management of pancreatic cancer. Biochim Biophys Acta (2012) 1826(2):350-6. doi:10.1016/j.bbcan.2012.05.007
    • (2012) Biochim Biophys Acta , vol.1826 , Issue.2 , pp. 350-356
    • Cen, P.1    Ni, X.2    Yang, J.3    Graham, D.Y.4    Li, M.5
  • 27
    • 84920000942 scopus 로고    scopus 로고
    • Expansion of CTCs from early stage lung cancer patients using a microfluidic co-culture model
    • Zhang Z, Shiratsuchi H, Lin J, Chen GA, Reddy RM, Azizi E, et al. Expansion of CTCs from early stage lung cancer patients using a microfluidic co-culture model. Oncotarget (2014) 5(23):12383-97.
    • (2014) Oncotarget , vol.5 , Issue.23 , pp. 12383-12397
    • Zhang, Z.1    Shiratsuchi, H.2    Lin, J.3    Chen, G.A.4    Reddy, R.M.5    Azizi, E.6
  • 28
    • 4143094988 scopus 로고    scopus 로고
    • Circulating tumor cells, disease progression, and survival in metastatic breast cancer
    • Cristofanilli M, Budd GT, Ellis MJ, Stopeck A, Matera J, Miller MC, et al. Circulating tumor cells, disease progression, and survival in metastatic breast cancer. N Engl J Med (2004) 351(8):781-91. doi:10.1056/NEJMoa040766
    • (2004) N Engl J Med , vol.351 , Issue.8 , pp. 781-791
    • Cristofanilli, M.1    Budd, G.T.2    Ellis, M.J.3    Stopeck, A.4    Matera, J.5    Miller, M.C.6
  • 29
    • 27144495754 scopus 로고    scopus 로고
    • Detection of tumor cell dissemination in pancreatic ductal carcinoma patients by CK 20 RT-PCR indicates poor survival
    • Soeth E, Grigoleit U, Moellmann B, Roder C, Schniewind B, Kremer B, et al. Detection of tumor cell dissemination in pancreatic ductal carcinoma patients by CK 20 RT-PCR indicates poor survival. J Cancer Res Clin Oncol (2005) 131(10):669-76. doi:10.1007/s00432-005-0008-1
    • (2005) J Cancer Res Clin Oncol , vol.131 , Issue.10 , pp. 669-676
    • Soeth, E.1    Grigoleit, U.2    Moellmann, B.3    Roder, C.4    Schniewind, B.5    Kremer, B.6
  • 30
    • 84856411831 scopus 로고    scopus 로고
    • A pilot study to explore circulating tumour cells in pancreatic cancer as a novel biomarker
    • Khoja L, Backen A, Sloane R, Menasce L, Ryder D, Krebs M, et al. A pilot study to explore circulating tumour cells in pancreatic cancer as a novel biomarker. Br J Cancer (2012) 106(3):508-16. doi:10.1038/bjc.2011.545
    • (2012) Br J Cancer , vol.106 , Issue.3 , pp. 508-516
    • Khoja, L.1    Backen, A.2    Sloane, R.3    Menasce, L.4    Ryder, D.5    Krebs, M.6
  • 31
    • 33846934267 scopus 로고    scopus 로고
    • Detection of disseminated pancreatic cells by amplification of cytokeratin-19 with quantitative RT-PCR in blood, bone marrow and peritoneal lavage of pancreatic carcinoma patients
    • Hoffmann K, Kerner C, Wilfert W, Mueller M, Thiery J, Hauss J, et al. Detection of disseminated pancreatic cells by amplification of cytokeratin-19 with quantitative RT-PCR in blood, bone marrow and peritoneal lavage of pancreatic carcinoma patients. World J Gastroenterol (2007) 13(2):257-63. doi:10.3748/wjg.v13.i2.257
    • (2007) World J Gastroenterol , vol.13 , Issue.2 , pp. 257-263
    • Hoffmann, K.1    Kerner, C.2    Wilfert, W.3    Mueller, M.4    Thiery, J.5    Hauss, J.6
  • 32
    • 84856034107 scopus 로고    scopus 로고
    • Multimarker gene analysis of circulating tumor cells in pancreatic cancer patients: a feasibility study
    • de Albuquerque A, Kubisch I, Breier G, Stamminger G, Fersis N, Eichler A, et al. Multimarker gene analysis of circulating tumor cells in pancreatic cancer patients: a feasibility study. Oncology (2012) 82(1):3-10. doi:10.1159/000335479
    • (2012) Oncology , vol.82 , Issue.1 , pp. 3-10
    • de Albuquerque, A.1    Kubisch, I.2    Breier, G.3    Stamminger, G.4    Fersis, N.5    Eichler, A.6
  • 33
    • 84859813987 scopus 로고    scopus 로고
    • Evaluation of circulating tumor cells and circulating tumor DNA in non-small cell lung cancer: association with clinical endpoints in a phase II clinical trial of pertuzumab and erlotinib
    • Punnoose EA, Atwal S, Liu W, Raja R, Fine BM, Hughes BG, et al. Evaluation of circulating tumor cells and circulating tumor DNA in non-small cell lung cancer: association with clinical endpoints in a phase II clinical trial of pertuzumab and erlotinib. Clin Cancer Res (2012) 18(8):2391-401. doi:10.1158/1078-0432.CCR-11-3148
    • (2012) Clin Cancer Res , vol.18 , Issue.8 , pp. 2391-2401
    • Punnoose, E.A.1    Atwal, S.2    Liu, W.3    Raja, R.4    Fine, B.M.5    Hughes, B.G.6
  • 34
    • 84893400818 scopus 로고    scopus 로고
    • Evaluation of circulating tumor cells and related events as prognostic factors and surrogate biomarkers in advanced NSCLC patients receiving first-line systemic treatment
    • Muinelo-Romay L, Vieito M, Abalo A, Nocelo MA, Baron F, Anido U, et al. Evaluation of circulating tumor cells and related events as prognostic factors and surrogate biomarkers in advanced NSCLC patients receiving first-line systemic treatment. Cancers (Basel) (2014) 6(1):153-65. doi:10.3390/cancers6010153
    • (2014) Cancers (Basel) , vol.6 , Issue.1 , pp. 153-165
    • Muinelo-Romay, L.1    Vieito, M.2    Abalo, A.3    Nocelo, M.A.4    Baron, F.5    Anido, U.6
  • 35
    • 72549116858 scopus 로고    scopus 로고
    • Circulating tumor cell as a diagnostic marker in primary lung cancer
    • Tanaka F, Yoneda K, Kondo N, Hashimoto M, Takuwa T, Matsumoto S, et al. Circulating tumor cell as a diagnostic marker in primary lung cancer. Clin Cancer Res (2009) 15(22):6980-6. doi:10.1158/1078-0432.CCR-09-1095
    • (2009) Clin Cancer Res , vol.15 , Issue.22 , pp. 6980-6986
    • Tanaka, F.1    Yoneda, K.2    Kondo, N.3    Hashimoto, M.4    Takuwa, T.5    Matsumoto, S.6
  • 36
    • 84858335921 scopus 로고    scopus 로고
    • Analysis of circulating tumor cells in patients with non-small cell lung cancer using epithelial marker-dependent and-independent approaches
    • Krebs MG, Hou JM, Sloane R, Lancashire L, Priest L, Nonaka D, et al. Analysis of circulating tumor cells in patients with non-small cell lung cancer using epithelial marker-dependent and-independent approaches. J Thorac Oncol (2012) 7(2):306-15. doi:10.1097/JTO.0b013e31823c5c16
    • (2012) J Thorac Oncol , vol.7 , Issue.2 , pp. 306-315
    • Krebs, M.G.1    Hou, J.M.2    Sloane, R.3    Lancashire, L.4    Priest, L.5    Nonaka, D.6
  • 37
    • 79951849235 scopus 로고    scopus 로고
    • Preoperative circulating tumor cell detection using the isolation by size of epithelial tumor cell method for patients with lung cancer is a new prognostic biomarker
    • Hofman V, Bonnetaud C, Ilie MI, Vielh P, Vignaud JM, Flejou JF, et al. Preoperative circulating tumor cell detection using the isolation by size of epithelial tumor cell method for patients with lung cancer is a new prognostic biomarker. Clin Cancer Res (2011) 17(4):827-35. doi:10.1158/1078-0432.CCR-10-0445
    • (2011) Clin Cancer Res , vol.17 , Issue.4 , pp. 827-835
    • Hofman, V.1    Bonnetaud, C.2    Ilie, M.I.3    Vielh, P.4    Vignaud, J.M.5    Flejou, J.F.6
  • 38
    • 84856971533 scopus 로고    scopus 로고
    • Fluid biopsy for circulating tumor cell identification in patients with early-and late-stage non-small cell lung cancer: a glimpse into lung cancer biology
    • Wendel M, Bazhenova L, Boshuizen R, Kolatkar A, Honnatti M, Cho EH, et al. Fluid biopsy for circulating tumor cell identification in patients with early-and late-stage non-small cell lung cancer: a glimpse into lung cancer biology. Phys Biol (2012) 9(1):016005. doi:10.1088/1478-3967/9/1/016005
    • (2012) Phys Biol , vol.9 , Issue.1
    • Wendel, M.1    Bazhenova, L.2    Boshuizen, R.3    Kolatkar, A.4    Honnatti, M.5    Cho, E.H.6
  • 39
    • 84891354380 scopus 로고    scopus 로고
    • Reproducible copy number variation patterns among single circulating tumor cells of lung cancer patients
    • Ni XH, Zhuo ML, Su Z, Duan JC, Gao Y, Wang ZJ, et al. Reproducible copy number variation patterns among single circulating tumor cells of lung cancer patients. P Natl Acad Sci U S A (2013) 110(52):21083-8. doi:10.1073/pnas.1320659110
    • (2013) P Natl Acad Sci U S A , vol.110 , Issue.52 , pp. 21083-21088
    • Ni, X.H.1    Zhuo, M.L.2    Su, Z.3    Duan, J.C.4    Gao, Y.5    Wang, Z.J.6
  • 40
    • 84883027282 scopus 로고    scopus 로고
    • Detection of circulating tumor cells harboring a unique ALK rearrangement in ALK-positive non-small-cell lung cancer
    • Pailler E, Adam J, Barthelemy A, Oulhen M, Auger N, Valent A, et al. Detection of circulating tumor cells harboring a unique ALK rearrangement in ALK-positive non-small-cell lung cancer. J Clin Oncol (2013) 31(18):2273-81. doi:10.1200/JCO.2012.44.5932
    • (2013) J Clin Oncol , vol.31 , Issue.18 , pp. 2273-2281
    • Pailler, E.1    Adam, J.2    Barthelemy, A.3    Oulhen, M.4    Auger, N.5    Valent, A.6
  • 41
    • 84943654057 scopus 로고    scopus 로고
    • High level of chromosomal instability in circulating tumor cells of ROS1-rearranged non-small-cell lung cancer
    • Pailler E, Auger N, Lindsay CR, Vielh P, Islas-Morris-Hernandez A, Borget I, et al. High level of chromosomal instability in circulating tumor cells of ROS1-rearranged non-small-cell lung cancer. Ann Oncol (2015) 26(7):1408-15. doi:10.1093/annonc/mdv165
    • (2015) Ann Oncol , vol.26 , Issue.7 , pp. 1408-1415
    • Pailler, E.1    Auger, N.2    Lindsay, C.R.3    Vielh, P.4    Islas-Morris-Hernandez, A.5    Borget, I.6
  • 42
    • 84905819148 scopus 로고    scopus 로고
    • Tumorigenicity and genetic profiling of circulating tumor cells in small-cell lung cancer
    • Hodgkinson CL, Morrow CJ, Li Y, Metcalf RL, Rothwell DG, Trapani F, et al. Tumorigenicity and genetic profiling of circulating tumor cells in small-cell lung cancer. Nat Med (2014) 20(8):897-903. doi:10.1038/nm.3600
    • (2014) Nat Med , vol.20 , Issue.8 , pp. 897-903
    • Hodgkinson, C.L.1    Morrow, C.J.2    Li, Y.3    Metcalf, R.L.4    Rothwell, D.G.5    Trapani, F.6
  • 43
    • 33847402612 scopus 로고    scopus 로고
    • Detection of circulating tumor cells in peripheral blood of patients with metastatic breast cancer: a validation study of the CellSearch system
    • Riethdorf S, Fritsche H, Muller V, Rau T, Schindlbeck C, Rack B, et al. Detection of circulating tumor cells in peripheral blood of patients with metastatic breast cancer: a validation study of the CellSearch system. Clin Cancer Res (2007) 13(3):920-8. doi:10.1158/1078-0432.CCR-06-1695
    • (2007) Clin Cancer Res , vol.13 , Issue.3 , pp. 920-928
    • Riethdorf, S.1    Fritsche, H.2    Muller, V.3    Rau, T.4    Schindlbeck, C.5    Rack, B.6
  • 44
    • 77954624770 scopus 로고    scopus 로고
    • Significance of circulating tumor cells detected by the CellSearch system in patients with metastatic breast colorectal and prostate cancer
    • Miller MC, Doyle GV, Terstappen LW. Significance of circulating tumor cells detected by the CellSearch system in patients with metastatic breast colorectal and prostate cancer. J Oncol (2010) 2010:617421. doi:10.1155/2010/617421
    • (2010) J Oncol , vol.2010
    • Miller, M.C.1    Doyle, G.V.2    Terstappen, L.W.3
  • 45
    • 84930639642 scopus 로고    scopus 로고
    • Combination of circulating tumor cells with serum carcinoembryonic antigen enhances clinical prediction of non-small cell lung cancer
    • Chen X, Wang X, He H, Liu Z, Hu JF, Li W. Combination of circulating tumor cells with serum carcinoembryonic antigen enhances clinical prediction of non-small cell lung cancer. PLoS One (2015) 10(5):e0126276. doi:10.1371/journal.pone.0126276
    • (2015) PLoS One , vol.10 , Issue.5
    • Chen, X.1    Wang, X.2    He, H.3    Liu, Z.4    Hu, J.F.5    Li, W.6
  • 46
    • 84885482664 scopus 로고    scopus 로고
    • Sensitive capture of circulating tumour cells by functionalized graphene oxide nanosheets
    • Yoon HJ, Kim TH, Zhang Z, Azizi E, Pham TM, Paoletti C, et al. Sensitive capture of circulating tumour cells by functionalized graphene oxide nanosheets. Nat Nanotechnol (2013) 8(10):735-41. doi:10.1038/nnano.2013.194
    • (2013) Nat Nanotechnol , vol.8 , Issue.10 , pp. 735-741
    • Yoon, H.J.1    Kim, T.H.2    Zhang, Z.3    Azizi, E.4    Pham, T.M.5    Paoletti, C.6
  • 47
    • 37549002543 scopus 로고    scopus 로고
    • Isolation of rare circulating tumour cells in cancer patients by microchip technology
    • Nagrath S, Sequist LV, Maheswaran S, Bell DW, Irimia D, Ulkus L, et al. Isolation of rare circulating tumour cells in cancer patients by microchip technology. Nature (2007) 450(7173):1235-9. doi:10.1038/nature06385
    • (2007) Nature , vol.450 , Issue.7173 , pp. 1235-1239
    • Nagrath, S.1    Sequist, L.V.2    Maheswaran, S.3    Bell, D.W.4    Irimia, D.5    Ulkus, L.6
  • 48
    • 78649872067 scopus 로고    scopus 로고
    • Isolation of circulating tumor cells using a microvortex-generating herringbone-chip
    • Stott SL, Hsu CH, Tsukrov DI, Yu M, Miyamoto DT, Waltman BA, et al. Isolation of circulating tumor cells using a microvortex-generating herringbone-chip. P Natl Acad Sci U S A (2010) 107(43):18392-7. doi:10.1073/pnas.1012539107
    • (2010) P Natl Acad Sci U S A , vol.107 , Issue.43 , pp. 18392-18397
    • Stott, S.L.1    Hsu, C.H.2    Tsukrov, D.I.3    Yu, M.4    Miyamoto, D.T.5    Waltman, B.A.6
  • 49
    • 84928013472 scopus 로고    scopus 로고
    • Simultaneous isolation and detection of circulating tumor cells with a microfluidic silicon-nanowire-array integrated with magnetic upconversion nanoprobes
    • Wang C, Ye M, Cheng L, Li R, Zhu W, Shi Z, et al. Simultaneous isolation and detection of circulating tumor cells with a microfluidic silicon-nanowire-array integrated with magnetic upconversion nanoprobes. Biomaterials (2015) 54:55-62. doi:10.1016/j.biomaterials.2015.03.004
    • (2015) Biomaterials , vol.54 , pp. 55-62
    • Wang, C.1    Ye, M.2    Cheng, L.3    Li, R.4    Zhu, W.5    Shi, Z.6
  • 51
    • 79751533744 scopus 로고    scopus 로고
    • 3D microfilter device for viable circulating tumor cell (CTC) enrichment from blood
    • Zheng S, Lin HK, Lu B, Williams A, Datar R, Cote RJ, et al. 3D microfilter device for viable circulating tumor cell (CTC) enrichment from blood. Biomed Microdevices (2011) 13(1):203-13. doi:10.1007/s10544-010-9485-3
    • (2011) Biomed Microdevices , vol.13 , Issue.1 , pp. 203-213
    • Zheng, S.1    Lin, H.K.2    Lu, B.3    Williams, A.4    Datar, R.5    Cote, R.J.6
  • 52
    • 77956881586 scopus 로고    scopus 로고
    • Application of a filtration-and isolation-by-size technique for the detection of circulating tumor cells in cutaneous melanoma
    • De Giorgi V, Pinzani P, Salvianti F, Panelos J, Paglierani M, Janowska A, et al. Application of a filtration-and isolation-by-size technique for the detection of circulating tumor cells in cutaneous melanoma. J Invest Dermatol (2010) 130(10):2440-7. doi:10.1038/jid.2010.141
    • (2010) J Invest Dermatol , vol.130 , Issue.10 , pp. 2440-2447
    • De Giorgi, V.1    Pinzani, P.2    Salvianti, F.3    Panelos, J.4    Paglierani, M.5    Janowska, A.6
  • 53
    • 79953251573 scopus 로고    scopus 로고
    • A new device for rapid isolation by size and characterization of rare circulating tumor cells
    • Desitter I, Guerrouahen BS, Benali-Furet N, Wechsler J, Janne PA, Kuang Y, et al. A new device for rapid isolation by size and characterization of rare circulating tumor cells. Anticancer Res (2011) 31(2):427-41.
    • (2011) Anticancer Res , vol.31 , Issue.2 , pp. 427-441
    • Desitter, I.1    Guerrouahen, B.S.2    Benali-Furet, N.3    Wechsler, J.4    Janne, P.A.5    Kuang, Y.6
  • 54
    • 84864233689 scopus 로고    scopus 로고
    • SSA-MOA: a novel CTC isolation platform using selective size amplification (SSA) and a multi-obstacle architecture (MOA) filter
    • Kim MS, Sim TS, Kim YJ, Kim SS, Jeong H, Park JM, et al. SSA-MOA: a novel CTC isolation platform using selective size amplification (SSA) and a multi-obstacle architecture (MOA) filter. Lab Chip (2012) 12(16):2874-80. doi:10.1039/c2lc40065k
    • (2012) Lab Chip , vol.12 , Issue.16 , pp. 2874-2880
    • Kim, M.S.1    Sim, T.S.2    Kim, Y.J.3    Kim, S.S.4    Jeong, H.5    Park, J.M.6
  • 55
    • 70350464298 scopus 로고    scopus 로고
    • Inertial microfluidics
    • Di Carlo D. Inertial microfluidics. Lab Chip (2009) 9(21):3038-46. doi:10.1039/b912547g
    • (2009) Lab Chip , vol.9 , Issue.21 , pp. 3038-3046
    • Di Carlo, D.1
  • 56
    • 41449109036 scopus 로고    scopus 로고
    • Equilibrium separation and filtration of particles using differential inertial focusing
    • Di Carlo D, Edd JF, Irimia D, Tompkins RG, Toner M. Equilibrium separation and filtration of particles using differential inertial focusing. Anal Chem (2008) 80(6):2204-11. doi:10.1021/ac702283m
    • (2008) Anal Chem , vol.80 , Issue.6 , pp. 2204-2211
    • Di Carlo, D.1    Edd, J.F.2    Irimia, D.3    Tompkins, R.G.4    Toner, M.5
  • 57
    • 84884524922 scopus 로고    scopus 로고
    • Highly sensitive enumeration of circulating tumor cells in lung cancer patients using a size-based filtration microfluidic chip
    • Huang T, Jia CP, Jun Y, Sun WJ, Wang WT, Zhang HL, et al. Highly sensitive enumeration of circulating tumor cells in lung cancer patients using a size-based filtration microfluidic chip. Biosens Bioelectron (2014) 51:213-8. doi:10.1016/j.bios.2013.07.044
    • (2014) Biosens Bioelectron , vol.51 , pp. 213-218
    • Huang, T.1    Jia, C.P.2    Jun, Y.3    Sun, W.J.4    Wang, W.T.5    Zhang, H.L.6
  • 58
    • 84879198321 scopus 로고    scopus 로고
    • Microcavity array system for size-based enrichment of circulating tumor cells from the blood of patients with small-cell lung cancer
    • Hosokawa M, Yoshikawa T, Negishi R, Yoshino T, Koh Y, Kenmotsu H, et al. Microcavity array system for size-based enrichment of circulating tumor cells from the blood of patients with small-cell lung cancer. Anal Chem (2013) 85(12):5692-8. doi:10.1021/ac400167x
    • (2013) Anal Chem , vol.85 , Issue.12 , pp. 5692-5698
    • Hosokawa, M.1    Yoshikawa, T.2    Negishi, R.3    Yoshino, T.4    Koh, Y.5    Kenmotsu, H.6
  • 59
    • 84879529278 scopus 로고    scopus 로고
    • Size-based isolation of circulating tumor cells in lung cancer patients using a microcavity array system
    • Hosokawa M, Kenmotsu H, Koh Y, Yoshino T, Yoshikawa T, Naito T, et al. Size-based isolation of circulating tumor cells in lung cancer patients using a microcavity array system. PLoS One (2013) 8(6):e67466. doi:10.1371/journal.pone.0067466
    • (2013) PLoS One , vol.8 , Issue.6
    • Hosokawa, M.1    Kenmotsu, H.2    Koh, Y.3    Yoshino, T.4    Yoshikawa, T.5    Naito, T.6
  • 60
    • 84928719292 scopus 로고    scopus 로고
    • A microfluidic chip integrated with a high-density PDMS-based microfiltration membrane for rapid isolation and detection of circulating tumor cells
    • Fan X, Jia C, Yang J, Li G, Mao H, Jin Q, et al. A microfluidic chip integrated with a high-density PDMS-based microfiltration membrane for rapid isolation and detection of circulating tumor cells. Biosens Bioelectron (2015) 71:380-6. doi:10.1016/j.bios.2015.04.080
    • (2015) Biosens Bioelectron , vol.71 , pp. 380-386
    • Fan, X.1    Jia, C.2    Yang, J.3    Li, G.4    Mao, H.5    Jin, Q.6
  • 61
    • 79961170499 scopus 로고    scopus 로고
    • Circulating tumor cells: advances in detection methods, biological issues, and clinical relevance
    • Sun YF, Yang XR, Zhou J, Qiu SJ, Fan J, Xu Y. Circulating tumor cells: advances in detection methods, biological issues, and clinical relevance. J Cancer Res Clin Oncol (2011) 137(8):1151-73. doi:10.1007/s00432-011-0988-y
    • (2011) J Cancer Res Clin Oncol , vol.137 , Issue.8 , pp. 1151-1173
    • Sun, Y.F.1    Yang, X.R.2    Zhou, J.3    Qiu, S.J.4    Fan, J.5    Xu, Y.6
  • 63
    • 84876317732 scopus 로고    scopus 로고
    • High throughput capture of circulating tumor cells using an integrated microfluidic system
    • Liu ZB, Zhang W, Huang F, Feng HT, Shu WL, Xu XP, et al. High throughput capture of circulating tumor cells using an integrated microfluidic system. Biosens Bioelectron (2013) 47:113-9. doi:10.1016/j.bios.2013.03.017
    • (2013) Biosens Bioelectron , vol.47 , pp. 113-119
    • Liu, Z.B.1    Zhang, W.2    Huang, F.3    Feng, H.T.4    Shu, W.L.5    Xu, X.P.6
  • 64
    • 84875970076 scopus 로고    scopus 로고
    • Inertial focusing for tumor antigen-dependent and-independent sorting of rare circulating tumor cells
    • Ozkumur E, Shah AM, Ciciliano JC, Emmink BL, Miyamoto DT, Brachtel E, et al. Inertial focusing for tumor antigen-dependent and-independent sorting of rare circulating tumor cells. Sci Transl Med (2013) 5(179):179ra47. doi:10.1126/scitranslmed.3005616
    • (2013) Sci Transl Med , vol.5 , Issue.179
    • Ozkumur, E.1    Shah, A.M.2    Ciciliano, J.C.3    Emmink, B.L.4    Miyamoto, D.T.5    Brachtel, E.6
  • 65
    • 34548841925 scopus 로고    scopus 로고
    • Cellular separations: a review of new challenges in analytical chemistry
    • Pappas D, Wang K. Cellular separations: a review of new challenges in analytical chemistry. Anal Chim Acta (2007) 601(1):26-35. doi:10.1016/j.aca.2007.08.033
    • (2007) Anal Chim Acta , vol.601 , Issue.1 , pp. 26-35
    • Pappas, D.1    Wang, K.2
  • 66
    • 84920509099 scopus 로고    scopus 로고
    • Circulating tumor cell enumeration with a combination of epithelial cell adhesion molecule-and cell-surface vimentin-based methods for monitoring breast cancer therapeutic response
    • Satelli A, Brownlee Z, Mitra A, Meng QH, Li S. Circulating tumor cell enumeration with a combination of epithelial cell adhesion molecule-and cell-surface vimentin-based methods for monitoring breast cancer therapeutic response. Clin Chem (2015) 61(1):259-66. doi:10.1373/clinchem.2014.228122
    • (2015) Clin Chem , vol.61 , Issue.1 , pp. 259-266
    • Satelli, A.1    Brownlee, Z.2    Mitra, A.3    Meng, Q.H.4    Li, S.5
  • 67
    • 84924931514 scopus 로고    scopus 로고
    • Circulating tumor cell detection using a parallel flow micro-aperture chip system
    • Chang CL, Huang WF, Jalal SI, Chan BD, Mahmood A, Shahda S, et al. Circulating tumor cell detection using a parallel flow micro-aperture chip system. Lab Chip (2015) 15(7):1677-88. doi:10.1039/c5lc00100e
    • (2015) Lab Chip , vol.15 , Issue.7 , pp. 1677-1688
    • Chang, C.L.1    Huang, W.F.2    Jalal, S.I.3    Chan, B.D.4    Mahmood, A.5    Shahda, S.6
  • 68
    • 0033891393 scopus 로고    scopus 로고
    • Isolation by size of epithelial tumor cells: a new method for the immunomorphological and molecular characterization of circulatingtumor cells
    • Vona G, Sabile A, Louha M, Sitruk V, Romana S, Schutze K, et al. Isolation by size of epithelial tumor cells: a new method for the immunomorphological and molecular characterization of circulatingtumor cells. Am J Pathol (2000) 156(1):57-63. doi:10.1016/S0002-9440(10)64706-2
    • (2000) Am J Pathol , vol.156 , Issue.1 , pp. 57-63
    • Vona, G.1    Sabile, A.2    Louha, M.3    Sitruk, V.4    Romana, S.5    Schutze, K.6
  • 70
    • 84905814502 scopus 로고    scopus 로고
    • Circulating tumor microemboli diagnostics for patients with non-small-cell lung cancer
    • Carlsson A, Nair VS, Luttgen MS, Keu KV, Horng G, Vasanawala M, et al. Circulating tumor microemboli diagnostics for patients with non-small-cell lung cancer. J Thorac Oncol (2014) 9(8):1111-9. doi:10.1097/JTO.0000000000000235
    • (2014) J Thorac Oncol , vol.9 , Issue.8 , pp. 1111-1119
    • Carlsson, A.1    Nair, V.S.2    Luttgen, M.S.3    Keu, K.V.4    Horng, G.5    Vasanawala, M.6
  • 71
    • 84940720719 scopus 로고    scopus 로고
    • Aptamers selected to postoperative lung adenocarcinoma detect circulating tumor cells in human blood
    • Zamay GS, Kolovskaya OS, Zamay TN, Glazyrin YE, Krat AV, Zubkova O, et al. Aptamers selected to postoperative lung adenocarcinoma detect circulating tumor cells in human blood. Mol Ther (2015) 23(9):1486-96. doi:10.1038/mt.2015.108
    • (2015) Mol Ther , vol.23 , Issue.9 , pp. 1486-1496
    • Zamay, G.S.1    Kolovskaya, O.S.2    Zamay, T.N.3    Glazyrin, Y.E.4    Krat, A.V.5    Zubkova, O.6
  • 72
    • 84918804152 scopus 로고    scopus 로고
    • Tracking viable circulating tumor cells (CTCs) in the peripheral blood of non-small cell lung cancer (NSCLC) patients undergoing definitive radiation therapy: pilot study results
    • Dorsey JF, Kao GD, MacArthur KM, Ju M, Steinmetz D, Wileyto EP, et al. Tracking viable circulating tumor cells (CTCs) in the peripheral blood of non-small cell lung cancer (NSCLC) patients undergoing definitive radiation therapy: pilot study results. Cancer (2015) 121(1):139-49. doi:10.1002/cncr.28975
    • (2015) Cancer , vol.121 , Issue.1 , pp. 139-149
    • Dorsey, J.F.1    Kao, G.D.2    MacArthur, K.M.3    Ju, M.4    Steinmetz, D.5    Wileyto, E.P.6
  • 73
    • 84905680559 scopus 로고    scopus 로고
    • Prognostic significance of circulating tumor cells in advanced non-small cell lung cancer patients treated with docetaxel and gemcitabine
    • Juan O, Vidal J, Gisbert R, Munoz J, Macia S, Gomez-Codina J. Prognostic significance of circulating tumor cells in advanced non-small cell lung cancer patients treated with docetaxel and gemcitabine. Clin Transl Oncol (2014) 16(7):637-43. doi:10.1007/s12094-013-1128-8
    • (2014) Clin Transl Oncol , vol.16 , Issue.7 , pp. 637-643
    • Juan, O.1    Vidal, J.2    Gisbert, R.3    Munoz, J.4    Macia, S.5    Gomez-Codina, J.6
  • 74
    • 0037385741 scopus 로고    scopus 로고
    • Tumour cells in the tumour draining vein of patients with non-small cell lung cancer: detection rate and clinical significance
    • Sienel W, Seen-Hibler R, Mutschler W, Pantel K, Passlick B. Tumour cells in the tumour draining vein of patients with non-small cell lung cancer: detection rate and clinical significance. Eur J Cardio-Thorac (2003) 23(4):451-6. doi:10.1016/S1010-7940(02)00865-5
    • (2003) Eur J Cardio-Thorac , vol.23 , Issue.4 , pp. 451-456
    • Sienel, W.1    Seen-Hibler, R.2    Mutschler, W.3    Pantel, K.4    Passlick, B.5
  • 75
    • 84901438631 scopus 로고    scopus 로고
    • Significant increase in circulating tumour cells in pulmonary venous blood during surgical manipulation in patients with primary lung cancer
    • Hashimoto M, Tanaka F, Yoneda K, Takuwa T, Matsumoto S, Okumura Y, et al. Significant increase in circulating tumour cells in pulmonary venous blood during surgical manipulation in patients with primary lung cancer. Interact Cardiovasc Thorac Surg (2014) 18(6):775-83. doi:10.1093/icvts/ivu048
    • (2014) Interact Cardiovasc Thorac Surg , vol.18 , Issue.6 , pp. 775-783
    • Hashimoto, M.1    Tanaka, F.2    Yoneda, K.3    Takuwa, T.4    Matsumoto, S.5    Okumura, Y.6
  • 76
    • 84878179999 scopus 로고    scopus 로고
    • Significance of tumour vessel invasion in determining the morphology of isolated tumour cells in the pulmonary vein in non-small-cell lung cancer
    • Funaki S, Sawabata N, Abulaiti A, Nakagiri T, Shintani Y, Inoue M, et al. Significance of tumour vessel invasion in determining the morphology of isolated tumour cells in the pulmonary vein in non-small-cell lung cancer. Eur J Cardiothorac Surg (2013) 43(6):1126-30. doi:10.1093/ejcts/ezs553
    • (2013) Eur J Cardiothorac Surg , vol.43 , Issue.6 , pp. 1126-1130
    • Funaki, S.1    Sawabata, N.2    Abulaiti, A.3    Nakagiri, T.4    Shintani, Y.5    Inoue, M.6
  • 77
    • 84937725844 scopus 로고    scopus 로고
    • Circulating tumour cells in patients with lung cancer undergoing endobronchial cryotherapy
    • Chudasama D, Rice A, Soppa G, Anikin V. Circulating tumour cells in patients with lung cancer undergoing endobronchial cryotherapy. Cryobiology (2015) 71(1):161-3. doi:10.1016/j.cryobiol.2015.06.001
    • (2015) Cryobiology , vol.71 , Issue.1 , pp. 161-163
    • Chudasama, D.1    Rice, A.2    Soppa, G.3    Anikin, V.4
  • 78
    • 84929012563 scopus 로고    scopus 로고
    • Classification of circulating tumor cells by epithelial-mesenchymal transition markers
    • Wu S, Liu S, Liu Z, Huang J, Pu X, Li J, et al. Classification of circulating tumor cells by epithelial-mesenchymal transition markers. PLoS One (2015) 10(4):e0123976. doi:10.1371/journal.pone.0123976
    • (2015) PLoS One , vol.10 , Issue.4
    • Wu, S.1    Liu, S.2    Liu, Z.3    Huang, J.4    Pu, X.5    Li, J.6
  • 79
    • 84927150847 scopus 로고    scopus 로고
    • Individual profiling of circulating tumor cell composition in patients with non-small cell lung cancer receiving platinum based treatment
    • Nel I, Jehn U, Gauler T, Hoffmann AC. Individual profiling of circulating tumor cell composition in patients with non-small cell lung cancer receiving platinum based treatment. Transl Lung Cancer Res (2014) 3(2):100-6. doi:10.3978/j.issn.2218-6751.2014.03.05
    • (2014) Transl Lung Cancer Res , vol.3 , Issue.2 , pp. 100-106
    • Nel, I.1    Jehn, U.2    Gauler, T.3    Hoffmann, A.C.4
  • 81
    • 84856862054 scopus 로고    scopus 로고
    • Clinical significance and molecular characteristics of circulating tumor cells and circulating tumor microemboli in patients with small-cell lung cancer
    • Hou JM, Krebs MG, Lancashire L, Sloane R, Backen A, Swain RK, et al. Clinical significance and molecular characteristics of circulating tumor cells and circulating tumor microemboli in patients with small-cell lung cancer. J Clin Oncol (2012) 30(5):525-32. doi:10.1200/JCO.2010.33.3716
    • (2012) J Clin Oncol , vol.30 , Issue.5 , pp. 525-532
    • Hou, J.M.1    Krebs, M.G.2    Lancashire, L.3    Sloane, R.4    Backen, A.5    Swain, R.K.6
  • 82
    • 84987958770 scopus 로고    scopus 로고
    • A multicenter pilot study examining the role of circulating tumor cells as a blood-based tumor marker in patients with extensive small-cell lung cancer
    • Huang CH, Wick JA, Sittampalam GS, Nirmalanandhan VS, Ganti AK, Neupane PC, et al. A multicenter pilot study examining the role of circulating tumor cells as a blood-based tumor marker in patients with extensive small-cell lung cancer. Front Oncol (2014) 4:271. doi:10.3389/fonc.2014.00271
    • (2014) Front Oncol , vol.4 , pp. 271
    • Huang, C.H.1    Wick, J.A.2    Sittampalam, G.S.3    Nirmalanandhan, V.S.4    Ganti, A.K.5    Neupane, P.C.6
  • 83
    • 84900829967 scopus 로고    scopus 로고
    • Using multiplexed assays of oncogenic drivers in lung cancers to select targeted drugs
    • Kris MG, Johnson BE, Berry LD, Kwiatkowski DJ, Iafrate AJ, Wistuba II, et al. Using multiplexed assays of oncogenic drivers in lung cancers to select targeted drugs. JAMA (2014) 311(19):1998-2006. doi:10.1001/jama.2014.3741
    • (2014) JAMA , vol.311 , Issue.19 , pp. 1998-2006
    • Kris, M.G.1    Johnson, B.E.2    Berry, L.D.3    Kwiatkowski, D.J.4    Iafrate, A.J.5    Wistuba, I.I.6
  • 84
    • 84905029258 scopus 로고    scopus 로고
    • Comprehensive molecular profiling of lung adenocarcinoma
    • Cancer Genome Atlas Research Network. Comprehensive molecular profiling of lung adenocarcinoma. Nature (2014) 511(7511):543-50. doi:10.1038/nature13385
    • (2014) Nature , vol.511 , Issue.7511 , pp. 543-550
  • 85
    • 84866894408 scopus 로고    scopus 로고
    • Comprehensive genomic characterization of squamous cell lung cancers
    • Cancer Genome Atlas Research Network. Comprehensive genomic characterization of squamous cell lung cancers. Nature (2012) 489(7417):519-25. doi:10.1038/nature11404
    • (2012) Nature , vol.489 , Issue.7417 , pp. 519-525
  • 86
    • 84938260368 scopus 로고    scopus 로고
    • Heterogeneity of anaplastic lymphoma kinase gene rearrangement in non-small-cell lung carcinomas: a comparative study between small biopsy and excision samples
    • Abe H, Kawahara A, Azuma K, Taira T, Takase Y, Fukumitsu C, et al. Heterogeneity of anaplastic lymphoma kinase gene rearrangement in non-small-cell lung carcinomas: a comparative study between small biopsy and excision samples. J Thorac Oncol (2015) 10(5):800-5. doi:10.1097/JTO.0000000000000507
    • (2015) J Thorac Oncol , vol.10 , Issue.5 , pp. 800-805
    • Abe, H.1    Kawahara, A.2    Azuma, K.3    Taira, T.4    Takase, Y.5    Fukumitsu, C.6
  • 87
    • 84923014763 scopus 로고    scopus 로고
    • Assessment of EGFR mutations in circulating tumor cell preparations from NSCLC patients by next generation sequencing: toward a real-time liquid biopsy for treatment
    • Marchetti A, Del Grammastro M, Felicioni L, Malatesta S, Filice G, Centi I, et al. Assessment of EGFR mutations in circulating tumor cell preparations from NSCLC patients by next generation sequencing: toward a real-time liquid biopsy for treatment. PLoS One (2014) 9(8):e103883. doi:10.1371/journal.pone.0103883
    • (2014) PLoS One , vol.9 , Issue.8
    • Marchetti, A.1    Del Grammastro, M.2    Felicioni, L.3    Malatesta, S.4    Filice, G.5    Centi, I.6
  • 88
    • 84904605266 scopus 로고    scopus 로고
    • Development of a highly sensitive and specific method for detection of circulating tumor cells harboring somatic mutations in non-small-cell lung cancer patients
    • Breitenbuecher F, Hoffarth S, Worm K, Cortes-Incio D, Gauler TC, Kohler J, et al. Development of a highly sensitive and specific method for detection of circulating tumor cells harboring somatic mutations in non-small-cell lung cancer patients. PLoS One (2014) 9(1):e85350. doi:10.1371/journal.pone.0085350
    • (2014) PLoS One , vol.9 , Issue.1
    • Breitenbuecher, F.1    Hoffarth, S.2    Worm, K.3    Cortes-Incio, D.4    Gauler, T.C.5    Kohler, J.6
  • 89
    • 81855208762 scopus 로고    scopus 로고
    • Quantitative detection of EGFR mutations in circulating tumor DNA derived from lung adenocarcinomas
    • Taniguchi K, Uchida J, Nishino K, Kumagai T, Okuyama T, Okami J, et al. Quantitative detection of EGFR mutations in circulating tumor DNA derived from lung adenocarcinomas. Clin Cancer Res (2011) 17(24):7808-15. doi:10.1158/1078-0432.CCR-11-1712
    • (2011) Clin Cancer Res , vol.17 , Issue.24 , pp. 7808-7815
    • Taniguchi, K.1    Uchida, J.2    Nishino, K.3    Kumagai, T.4    Okuyama, T.5    Okami, J.6
  • 90
    • 84928349617 scopus 로고    scopus 로고
    • Clinical utility of circulating tumor cells in ALK-positive non-small-cell lung cancer
    • Faugeroux V, Pailler E, Auger N, Taylor M, Farace F. Clinical utility of circulating tumor cells in ALK-positive non-small-cell lung cancer. Front Oncol (2014) 4:281. doi:10.3389/fonc.2014.00281
    • (2014) Front Oncol , vol.4 , pp. 281
    • Faugeroux, V.1    Pailler, E.2    Auger, N.3    Taylor, M.4    Farace, F.5
  • 91
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • Thiery JP, Acloque H, Huang RY, Nieto MA. Epithelial-mesenchymal transitions in development and disease. Cell (2009) 139(5):871-90. doi:10.1016/j.cell.2009.11.007
    • (2009) Cell , vol.139 , Issue.5 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 92
    • 46949102805 scopus 로고    scopus 로고
    • Mechanisms of malignant progression
    • Weinberg RA. Mechanisms of malignant progression. Carcinogenesis (2008) 29(6):1092-5. doi:10.1093/carcin/bgn104
    • (2008) Carcinogenesis , vol.29 , Issue.6 , pp. 1092-1095
    • Weinberg, R.A.1
  • 93
    • 84856088337 scopus 로고    scopus 로고
    • EMT and dissemination precede pancreatic tumor formation
    • Rhim AD, Mirek ET, Aiello NM, Maitra A, Bailey JM, McAllister F, et al. EMT and dissemination precede pancreatic tumor formation. Cell (2012) 148(1-2):349-61. doi:10.1016/j.cell.2011.11.025
    • (2012) Cell , vol.148 , Issue.1-2 , pp. 349-361
    • Rhim, A.D.1    Mirek, E.T.2    Aiello, N.M.3    Maitra, A.4    Bailey, J.M.5    McAllister, F.6
  • 94
    • 84910008796 scopus 로고    scopus 로고
    • "Sentinel" circulating tumor cells allow early diagnosis of lung cancer in patients with chronic obstructive pulmonary disease
    • Ilie M, Hofman V, Long-Mira E, Selva E, Vignaud JM, Padovani B, et al. "Sentinel" circulating tumor cells allow early diagnosis of lung cancer in patients with chronic obstructive pulmonary disease. PLoS One (2014) 9(10):e111597. doi:10.1371/journal.pone.0111597
    • (2014) PLoS One , vol.9 , Issue.10
    • Ilie, M.1    Hofman, V.2    Long-Mira, E.3    Selva, E.4    Vignaud, J.M.5    Padovani, B.6
  • 95
    • 84919902906 scopus 로고    scopus 로고
    • Effect of circulating tumor cells combined with negative enrichment and CD45-FISH identification in diagnosis, therapy monitoring and prognosis of primary lung cancer
    • Chen YY, Xu GB. Effect of circulating tumor cells combined with negative enrichment and CD45-FISH identification in diagnosis, therapy monitoring and prognosis of primary lung cancer. Med Oncol (2014) 31(12):240. doi:10.1007/s12032-014-0240-0
    • (2014) Med Oncol , vol.31 , Issue.12 , pp. 240
    • Chen, Y.Y.1    Xu, G.B.2
  • 96
    • 84891724501 scopus 로고    scopus 로고
    • Folate receptor-positive circulating tumor cells as a novel diagnostic biomarker in non-small cell lung cancer
    • Yu Y, Chen Z, Dong J, Wei P, Hu R, Zhou C, et al. Folate receptor-positive circulating tumor cells as a novel diagnostic biomarker in non-small cell lung cancer. Transl Oncol (2013) 6(6):697-702. doi:10.1593/tlo.13535
    • (2013) Transl Oncol , vol.6 , Issue.6 , pp. 697-702
    • Yu, Y.1    Chen, Z.2    Dong, J.3    Wei, P.4    Hu, R.5    Zhou, C.6
  • 97
    • 84891954473 scopus 로고    scopus 로고
    • Quantification of rare circulating tumor cells in non-small cell lung cancer by ligand-targeted PCR
    • Lou J, Ben S, Yang G, Liang X, Wang X, Ni S, et al. Quantification of rare circulating tumor cells in non-small cell lung cancer by ligand-targeted PCR. PLoS One (2013) 8(12):e80458. doi:10.1371/journal.pone.0080458
    • (2013) PLoS One , vol.8 , Issue.12
    • Lou, J.1    Ben, S.2    Yang, G.3    Liang, X.4    Wang, X.5    Ni, S.6
  • 98
    • 84930925279 scopus 로고    scopus 로고
    • Circulating tumor cells in diagnosing lung cancer: clinical and morphologic analysis
    • Fiorelli A, Accardo M, Carelli E, Angioletti D, Santini M, Di Domenico M. Circulating tumor cells in diagnosing lung cancer: clinical and morphologic analysis. Ann Thorac Surg (2015) 99(6):1899-905. doi:10.1016/j.athoracsur.2014.11.049
    • (2015) Ann Thorac Surg , vol.99 , Issue.6 , pp. 1899-1905
    • Fiorelli, A.1    Accardo, M.2    Carelli, E.3    Angioletti, D.4    Santini, M.5    Di Domenico, M.6
  • 99
    • 84877726784 scopus 로고    scopus 로고
    • The identification and characterization of breast cancer CTCs competent for brain metastasis
    • Zhang L, Ridgway LD, Wetzel MD, Ngo J, Yin W, Kumar D, et al. The identification and characterization of breast cancer CTCs competent for brain metastasis. Sci Transl Med (2013) 5(180):180ra48. doi:10.1126/scitranslmed.3005109
    • (2013) Sci Transl Med , vol.5 , Issue.180
    • Zhang, L.1    Ridgway, L.D.2    Wetzel, M.D.3    Ngo, J.4    Yin, W.5    Kumar, D.6
  • 100
    • 84904121066 scopus 로고    scopus 로고
    • Cancer therapy. Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility
    • Yu M, Bardia A, Aceto N, Bersani F, Madden MW, Donaldson MC, et al. Cancer therapy. Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility. Science (2014) 345(6193):216-20. doi:10.1126/science.1253533
    • (2014) Science , vol.345 , Issue.6193 , pp. 216-220
    • Yu, M.1    Bardia, A.2    Aceto, N.3    Bersani, F.4    Madden, M.W.5    Donaldson, M.C.6
  • 101
    • 84928698890 scopus 로고    scopus 로고
    • Establishment and characterization of a cell line from human circulating colon cancer cells
    • Cayrefourcq L, Mazard T, Joosse S, Solassol J, Ramos J, Assenat E, et al. Establishment and characterization of a cell line from human circulating colon cancer cells. Cancer Res (2015) 75(5):892-901. doi:10.1158/0008-5472.CAN-14-2613
    • (2015) Cancer Res , vol.75 , Issue.5 , pp. 892-901
    • Cayrefourcq, L.1    Mazard, T.2    Joosse, S.3    Solassol, J.4    Ramos, J.5    Assenat, E.6
  • 102
    • 84863654659 scopus 로고    scopus 로고
    • Beyond counting tumor cells
    • Kling J. Beyond counting tumor cells. Nat Biotechnol (2012) 30(7):578-80. doi:10.1038/nbt.2295
    • (2012) Nat Biotechnol , vol.30 , Issue.7 , pp. 578-580
    • Kling, J.1
  • 103
    • 79551693066 scopus 로고    scopus 로고
    • Circulating tumor cells: approaches to isolation and characterization
    • Yu M, Stott S, Toner M, Maheswaran S, Haber DA. Circulating tumor cells: approaches to isolation and characterization. J Cell Biol (2011) 192(3):373-82. doi:10.1083/jcb.201010021
    • (2011) J Cell Biol , vol.192 , Issue.3 , pp. 373-382
    • Yu, M.1    Stott, S.2    Toner, M.3    Maheswaran, S.4    Haber, D.A.5
  • 104
    • 84873811988 scopus 로고    scopus 로고
    • Circulating breast tumor cells exhibit dynamic changes in epithelial and mesenchymal composition
    • Yu M, Bardia A, Wittner BS, Stott SL, Smas ME, Ting DT, et al. Circulating breast tumor cells exhibit dynamic changes in epithelial and mesenchymal composition. Science (2013) 339(6119):580-4. doi:10.1126/science.1228522
    • (2013) Science , vol.339 , Issue.6119 , pp. 580-584
    • Yu, M.1    Bardia, A.2    Wittner, B.S.3    Stott, S.L.4    Smas, M.E.5    Ting, D.T.6
  • 105
    • 84877865227 scopus 로고    scopus 로고
    • Complex tumor genomes inferred from single circulating tumor cells by array-CGH and next-generation sequencing
    • Heitzer E, Auer M, Gasch C, Pichler M, Ulz P, Hoffmann EM, et al. Complex tumor genomes inferred from single circulating tumor cells by array-CGH and next-generation sequencing. Cancer Res (2013) 73(10):2965-75. doi:10.1158/0008-5472.CAN-12-4140
    • (2013) Cancer Res , vol.73 , Issue.10 , pp. 2965-2975
    • Heitzer, E.1    Auer, M.2    Gasch, C.3    Pichler, M.4    Ulz, P.5    Hoffmann, E.M.6
  • 106
    • 77956268304 scopus 로고    scopus 로고
    • Circulating tumour cells in cancer patients: challenges and perspectives
    • Pantel K, Alix-Panabieres C. Circulating tumour cells in cancer patients: challenges and perspectives. Trends Mol Med (2010) 16(9):398-406. doi:10.1016/j.molmed.2010.07.001
    • (2010) Trends Mol Med , vol.16 , Issue.9 , pp. 398-406
    • Pantel, K.1    Alix-Panabieres, C.2
  • 107
    • 84883375246 scopus 로고    scopus 로고
    • Capture of viable circulating tumor cells in the liver of colorectal cancer patients
    • Deneve E, Riethdorf S, Ramos J, Nocca D, Coffy A, Daures JP, et al. Capture of viable circulating tumor cells in the liver of colorectal cancer patients. Clin Chem (2013) 59(9):1384-92. doi:10.1373/clinchem.2013.202846
    • (2013) Clin Chem , vol.59 , Issue.9 , pp. 1384-1392
    • Deneve, E.1    Riethdorf, S.2    Ramos, J.3    Nocca, D.4    Coffy, A.5    Daures, J.P.6
  • 108
    • 57649110602 scopus 로고    scopus 로고
    • Clinical significance of circulating tumor cells detected by an invasion assay in peripheral blood of patients with ovarian cancer
    • Fan T, Zhao Q, Chen JJ, Chen WT, Pearl ML. Clinical significance of circulating tumor cells detected by an invasion assay in peripheral blood of patients with ovarian cancer. Gynecol Oncol (2009) 112(1):185-91. doi:10.1016/j.ygyno.2008.09.021
    • (2009) Gynecol Oncol , vol.112 , Issue.1 , pp. 185-191
    • Fan, T.1    Zhao, Q.2    Chen, J.J.3    Chen, W.T.4    Pearl, M.L.5
  • 109
    • 84880270290 scopus 로고    scopus 로고
    • Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay
    • Baccelli I, Schneeweiss A, Riethdorf S, Stenzinger A, Schillert A, Vogel V, et al. Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay. Nat Biotechnol (2013) 31(6):539-U143. doi:10.1038/nbt.2576
    • (2013) Nat Biotechnol , vol.31 , Issue.6 , pp. 539-U143
    • Baccelli, I.1    Schneeweiss, A.2    Riethdorf, S.3    Stenzinger, A.4    Schillert, A.5    Vogel, V.6
  • 110
    • 84864285223 scopus 로고    scopus 로고
    • RNA sequencing of pancreatic circulating tumour cells implicates WNT signalling in metastasis
    • Yu M, Ting DT, Stott SL, Wittner BS, Ozsolak F, Paul S, et al. RNA sequencing of pancreatic circulating tumour cells implicates WNT signalling in metastasis. Nature (2012) 487(7408):510-3. doi:10.1038/nature11217
    • (2012) Nature , vol.487 , Issue.7408 , pp. 510-513
    • Yu, M.1    Ting, D.T.2    Stott, S.L.3    Wittner, B.S.4    Ozsolak, F.5    Paul, S.6
  • 111
    • 84907414338 scopus 로고    scopus 로고
    • Single-cell RNA sequencing identifies extracellular matrix gene expression by pancreatic circulating tumor cells
    • Ting DT, Wittner BS, Ligorio M, Vincent Jordan N, Shah AM, Miyamoto DT, et al. Single-cell RNA sequencing identifies extracellular matrix gene expression by pancreatic circulating tumor cells. Cell Rep (2014) 8(6):1905-18. doi:10.1016/j.celrep.2014.08.029
    • (2014) Cell Rep , vol.8 , Issue.6 , pp. 1905-1918
    • Ting, D.T.1    Wittner, B.S.2    Ligorio, M.3    Vincent Jordan, N.4    Shah, A.M.5    Miyamoto, D.T.6
  • 112
    • 84923351687 scopus 로고    scopus 로고
    • Limited genomic heterogeneity of circulating melanoma cells in advanced stage patients
    • Ruiz C, Li JL, Luttgen MS, Kolatkar A, Kendall JT, Flores E, et al. Limited genomic heterogeneity of circulating melanoma cells in advanced stage patients. Phys Biol (2015) 12(1):016008. doi:10.1088/1478-3975/12/1/016008
    • (2015) Phys Biol , vol.12 , Issue.1
    • Ruiz, C.1    Li, J.L.2    Luttgen, M.S.3    Kolatkar, A.4    Kendall, J.T.5    Flores, E.6
  • 113
    • 62649158232 scopus 로고    scopus 로고
    • Isolating highly enriched populations of circulating epithelial cells and other rare cells from blood using a magnetic sweeper device
    • Talasaz AH, Powell AA, Huber DE, Berbee JG, Roh KH, Yu W, et al. Isolating highly enriched populations of circulating epithelial cells and other rare cells from blood using a magnetic sweeper device. P Natl Acad Sci U S A (2009) 106(10):3970-5. doi:10.1073/pnas.0813188106
    • (2009) P Natl Acad Sci U S A , vol.106 , Issue.10 , pp. 3970-3975
    • Talasaz, A.H.1    Powell, A.A.2    Huber, D.E.3    Berbee, J.G.4    Roh, K.H.5    Yu, W.6
  • 114
    • 84876240481 scopus 로고    scopus 로고
    • Prognostic value of cancer stem cells, epithelial-mesenchymal transition and circulating tumor cells in lung cancer
    • Pirozzi G, Tirino V, Camerlingo R, La Rocca A, Martucci N, Scognamiglio G, et al. Prognostic value of cancer stem cells, epithelial-mesenchymal transition and circulating tumor cells in lung cancer. Oncol Rep (2013) 29(5):1763-8. doi:10.3892/or.2013.2294
    • (2013) Oncol Rep , vol.29 , Issue.5 , pp. 1763-1768
    • Pirozzi, G.1    Tirino, V.2    Camerlingo, R.3    La Rocca, A.4    Martucci, N.5    Scognamiglio, G.6


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