The detection of EpCAM+ and EpCAM- circulating tumor cells

Scientific Reports

Volumn 5, Issue , 2015, Pages

  De Wit, Sanne ^a   Van Dalum, Guus ^a   Lenferink, Aufried T M ^a   Tibbe, Arjan G J ^b   Hiltermann, T Jeroen N ^c   Groen, Harry J M ^c   Van Rijn, Cees J M ^d   Terstappen, Leon W M M ^a  

^a UNIVERSITY OF TWENTE   (Netherlands)

^b VyCAP   (Netherlands)

^c UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^d WAGENINGEN UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CELL ADHESION MOLECULE; EPCAM PROTEIN, HUMAN; EPITHELIAL CELL ADHESION MOLECULE; KERATIN; TUMOR ANTIGEN; TUMOR MARKER;

ADULT; AGED; CASE CONTROL STUDY; FEMALE; FLOW CYTOMETRY; FOLLOW UP; HUMAN; KAPLAN MEIER METHOD; LUNG NEOPLASMS; MALE; METABOLISM; METASTASIS; MIDDLE AGED; MORTALITY; PATHOLOGY; PROCEDURES; PROGNOSIS; TUMOR CELL LINE; TUMOR EMBOLISM; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, NEOPLASM; BIOMARKERS, TUMOR; CASE-CONTROL STUDIES; CELL ADHESION MOLECULES; CELL LINE, TUMOR; EPITHELIAL CELL ADHESION MOLECULE; FEMALE; FLOW CYTOMETRY; FOLLOW-UP STUDIES; HUMANS; KAPLAN-MEIER ESTIMATE; KERATINS; LUNG NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM METASTASIS; NEOPLASTIC CELLS, CIRCULATING; PROGNOSIS;

EID: 84937417243     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep12270     Document Type: Article

References (30)

1. Racila, E. et al. Detection and characterization of carcinoma cells in the blood. Proc. Natl. Acad. Sci. USA. 95, 4589-4594 (1998).
2. Cristofanilli, M. & Budd, G. Circulating tumor cells, disease progression, and survival in metastatic breast cancer. Engl. J. Med. 351, 781-791 (2004).
3. De Bono, J. S. et al. Circulating tumor cells predict survival benefit from treatment in metastatic castration-resistant prostate cancer. Clin. cancer Res. 14, 6302-9 (2008).
4. Cohen, S. J. et al. Relationship of Circulating Tumor Cells to Tumor Response, Progression-Free Survival, and Overall Survival in Patients With Metastatic Colorectal Cancer. J. Clin. Oncol. 26, 3213-3221 (2008).
5. Hiltermann, T. J. N. et al. Circulating tumor cells in small-cell lung cancer: a predictive and prognostic factor. Ann. Oncol. 23, 2937-42 (2012).
6. Krebs, M. M. G. et al. Evaluation and prognostic significance of circulating tumor cells in patients with non-small-cell lung cancer. J. Clin. Oncol. 29, 1556-63 (2011).
7. Matsusaka, S. et al. Circulating tumor cells as a surrogate marker for determining response to chemotherapy in patients with advanced gastric cancer. Cancer Sci. 101, 1067-71 (2010).
8. Rao, C. et al. Circulating melanoma cells and survival in metastatic melanoma. Int. J. Oncol. 38, 755-60 (2011).
9. Gazzaniga, P. et al. Prognostic value of circulating tumor cells in nonmuscle invasive bladder cancer: a CellSearch analysis. Ann. Oncol. 23, 2352-6 (2012).
10. Allard, W. J. et al. Tumor cells circulate in the peripheral blood of all major carcinomas but not in healthy subjects or patients with nonmalignant diseases. Clin. cancer Res. 10, 6897-904 (2004).
11. Coumans, F. A. W., Ligthart, S. T., Uhr, J. W. & Terstappen, L. W. M. M. Challenges in the Enumeration and Phenotyping of CTC. Clin. cancer Res. 18, 5711-8 (2012).
12. Herlyn, D. et al. Efficient selection of human tumor growth-inhibiting monoclonal antibodies. J. Immunol. Methods 73, 157-167 (1984).
13. Stahel, R., Gilks, W., Lehmann, H. & Schenker, T. Third international workshop on lung tumor and differentiation antigens: overview of the results of the central data analysis. Int. J. cancer 57, 6-26 (1994).
14. Rao, C. G. et al. Expression of epithelial cell adhesion molecule in carcinoma cells present in blood and primary and metastatic tumors. Int. J. Oncol. 27, 49-57 (2005).
15. Van Dalum, G. et al. Importance of circulating tumor cells in newly diagnosed colorectal cancer. Int. J. Oncol. 46, 1361-1368 (2015).
16. Van Dalum, G. et al. Circulating tumor cells before and during follow-up after breast cancer surgery. Int. J. Oncol. 46, 407-413 (2014).
17. Rosenberg, R. et al. Comparison of two density gradient centrifugation systems for the enrichment of disseminated tumor cells in blood. Cytometry 49, 150-8 (2002).
18. Hsieh, H. Ben et al. High speed detection of circulating tumor cells. Biosens. Bioelectron. 21, 1893-9 (2006).
19. Nagrath, S. et al. Isolation of rare circulating tumour cells in cancer patients by microchip technology. Nature 450, 1235-9 (2007).
20. Lin, H. K. et al. Portable filter-based microdevice for detection and characterization of circulating tumor cells. Clin. Cancer Res. 16, 5011-8 (2010).
21. Stott, S. L. et al. Isolation of circulating tumor cells using a microvortex-generating herringbone-chip. Proc. Natl. Acad. Sci. USA. 107, 18392-7 (2010).
22. Williams, A. et al. Reporting the capture efficiency of a filter-based microdevice: a CTC is not a CTC unless it is CD45 negative-letter. Clin. Cancer Res. 17, 3050-3050 (2011).
23. Khoja, L. et al. A pilot study to explore circulating tumour cells in pancreatic cancer as a novel biomarker. Br. J. Cancer 106, 508-16 (2012).
24. Krebs, M. G. et al. Analysis of circulating tumor cells in patients with non-small cell lung cancer using epithelial markerdependent and-independent approaches. J. Thorac. Oncol. 7, 306-15 (2012).
25. Hou, H. W. et al. Isolation and retrieval of circulating tumor cells using centrifugal forces. Sci. Rep. 3, 1259 (2013).
26. Adams, D. L. et al. The systematic study of circulating tumor cell isolation using lithographic microfilters. RSC Adv. 4, 4334 (2014).
27. Adams, D. L. et al. Circulating giant macrophages as a potential biomarker of solid tumors. Proc. Natl. Acad. Sci. USA. 111, 3514-9 (2014).
28. Coumans, F. A. W., van Dalum, G., Beck, M. & Terstappen, L. W. M. M. Filter characteristics influencing circulating tumor cell enrichment from whole blood. PLoS One 8, e61770 (2013).
29. Coumans, F. A. W., van Dalum, G., Beck, M. & Terstappen, L. W. M. M. Filtration parameters influencing circulating tumor cell enrichment from whole blood. PLoS One 8, e61774 (2013).
30. Ligthart, S. T. et al. Unbiased and automated identification of a circulating tumour cell definition that associates with overall survival. PLoS One 6, e27419 (2011).