Heterogeneity of anaplastic lymphoma kinase gene rearrangement in non-small-cell lung carcinomas: A comparative study between small biopsy and excision samples

Journal of Thoracic Oncology

Volumn 10, Issue 5, 2015, Pages 800-805

  Abe, Hideyuki ^a   Kawahara, Akihiko ^a   Azuma, Koichi ^b   Taira, Tomoki ^a   Takase, Yorihiko ^a   Fukumitsu, Chihiro ^a   Murata, Kazuya ^a   Yamaguchi, Tomohiko ^a   Akiba, Jun ^b   Ishii, Hidenobu ^b   Okamoto, Isamu ^c   Hoshino, Tomoaki ^b   Takamori, Shinzou ^b   Kage, Masayoshi ^a  

^a KURUME UNIVERSITY HOSPITAL   (Japan)

^b KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c KYUSHU UNIVERSITY HOSPITAL   (Japan)

Author keywords

Anaplastic lymphoma kinase; Biopsy sample; Crizotinib; Immunohistochemistry; In situ hybridization

Indexed keywords

CRIZOTINIB; ANAPLASTIC LYMPHOMA KINASE; PROTEIN TYROSINE KINASE;

ADULT; AGED; ANAPLASTIC LYMPHOMA KINASE GENE; ARTICLE; CANCER CHEMOTHERAPY; CANCER PATIENT; CANCER PROGNOSIS; CANCER SURGERY; CLINICAL ARTICLE; CLINICAL EVALUATION; CLINICAL OBSERVATION; CONTROLLED STUDY; EXCISION; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE REARRANGEMENT; GENETIC ASSOCIATION; GENETIC HETEROGENEITY; HUMAN; HUMAN TISSUE; LUNG BIOPSY; MALE; MIDDLE AGED; MULTIMODALITY CANCER THERAPY; NON SMALL CELL LUNG CANCER; PRIORITY JOURNAL; TREATMENT RESPONSE; TUMOR BIOPSY; TUMOR DIFFERENTIATION; TUMOR GENE; BIOPSY; CARCINOMA, NON-SMALL-CELL LUNG; COMPARATIVE STUDY; GENETICS; IMMUNOHISTOCHEMISTRY; LABORATORY DIAGNOSIS; LUNG; LUNG NEOPLASMS; PATHOLOGY;

ADULT; AGED; BIOPSY; CARCINOMA, NON-SMALL-CELL LUNG; FALSE NEGATIVE REACTIONS; FEMALE; GENE REARRANGEMENT; GENETIC HETEROGENEITY; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION, FLUORESCENCE; LUNG; LUNG NEOPLASMS; MALE; MIDDLE AGED; RECEPTOR PROTEIN-TYROSINE KINASES;

EID: 84938260368     PISSN: 15560864     EISSN: 15561380     Source Type: Journal    
DOI: 10.1097/JTO.0000000000000507     Document Type: Article

References (21)

1. Soda M, Takada S, Takeuchi K, A mouse model for EML4-ALK-positive lung cancer. Proc Natl Acad Sci USA 2008 105 19893 19897
2. Takeuchi K, Choi YL, Togashi Y, KIF5B-ALK, a novel fusion oncokinase identified by an immunohistochemistry-based diagnostic system for ALK-positive lung cancer. Clin Cancer Res 2009 15 3143 3149
3. Solomon B, Varella-Garcia M, Camidge DR., ALK gene rearrangements: a new therapeutic target in a molecularly defined subset of non-small cell lung cancer. J Thorac Oncol 2009 4 1450 1454
4. Rodig SJ, Mino-Kenudson M, Dacic S, Unique clinicopathologic features characterize ALK-rearranged lung adenocarcinoma in the western population. Clin Cancer Res 2009 15 5216 5223
5. Peters S, Taron M, Bubendorf L, Blackhall F, Stahel R., Treatment and detection of ALK-rearranged NSCLC. Lung Cancer 2013 81 145 154
6. Lindeman NI, Cagle PT, Beasley MB, Molecular testing guideline for selection of lung cancer patients for EGFR and ALK tyrosine kinase inhibitors: guideline from the College of American Pathologists, International Association for the Study of Lung Cancer, and Association for Molecular Pathology. J Thorac Oncol 2013 8 823 859
7. Zhou J, Zhao J, Sun K, Accurate and economical detection of ALK positive lung adenocarcinoma with semiquantitative immunohistochemical screening. PLoS One 2014 9 e92828
8. Cabillic F, Gros A, Dugay F, Parallel FISH and immunohistochemical studies of ALK status in 3244 non-small-cell lung cancers reveal major discordances. J Thorac Oncol 2014 9 295 306
9. Yi ES, Boland JM, Maleszewski JJ, Correlation of IHC and FISH for ALK gene rearrangement in non-small cell lung carcinoma: IHC score algorithm for FISH. J Thorac Oncol 2011 6 459 465
10. Selinger CI, Rogers TM, Russell PA, Testing for ALK rearrangement in lung adenocarcinoma: a multicenter comparison of immunohistochemistry and fluorescent in situ hybridization. Mod Pathol 2013 26 1545 1553
11. Kawahara A, Akiba J, Abe H, Eml4-alk-positive lung adenocarcinoma with signet-ring cells. Diagn Cytopathol 2014 42 460 463
12. Akiba J, Kawahara A, Abe H, Evaluation of immunohistochemistry using two different antibodies and procedures for primary lung adenocarcinoma harboring anaplastic lymphoma kinase rearrangement. Oncol Lett 2014 8 2155 2159
13. Nishino M, Klepeis VE, Yeap BY, Histologic and cytomorphologic features of ALK-rearranged lung adenocarcinomas. Mod Pathol 2012 25 1462 1472
14. Camidge DR, Kono SA, Flacco A, Optimizing the detection of lung cancer patients harboring anaplastic lymphoma kinase (ALK) gene rearrangements potentially suitable for ALK inhibitor treatment. Clin Cancer Res 2010 16 5581 5590
15. Camidge DR, Theodoro M, Maxson DA, Correlations between the percentage of tumor cells showing an anaplastic lymphoma kinase (ALK) gene rearrangement, ALK signal copy number, and response to crizotinib therapy in ALK fluorescence in situ hybridization-positive nonsmall cell lung cancer. Cancer 2012 118 4486 4494
16. Proietti A, Alì G, Pelliccioni S, Anaplastic lymphoma kinase gene rearrangements in cytological samples of non-small cell lung cancer: comparison with histological assessment. Cancer Cytopathol 2014 122 445 453
17. To KF, Tong JH, Yeung KS, Detection of ALK rearrangement by immunohistochemistry in lung adenocarcinoma and the identification of a novel EML4-ALK variant. J Thorac Oncol 2013 8 883 891
18. McLeer-Florin A, Moro-Sibilot D, Melis A, Dual IHC and FISH testing for ALK gene rearrangement in lung adenocarcinomas in a routine practice: a French study. J Thorac Oncol 2012 7 348 354
19. Rakha EA, Starczynski J, Lee AH, Ellis IO., The updated ASCO/CAP guideline recommendations for HER2 testing in the management of invasive breast cancer: a critical review of their implications for routine practice. Histopathology 2014 64 609 615
20. Yamashita-Kashima Y, Shu S, Yorozu K, Importance of formalin fixing conditions for HER2 testing in gastric cancer: immunohistochemical staining and fluorescence in situ hybridization. Gastric Cancer 2014 17 638 647
21. Le Quesne J, Maurya M, Yancheva SG, A comparison of immunohistochemical assays and FISH in detecting the ALK translocation in diagnostic histological and cytological lung tumor material. J Thorac Oncol 2014 9 769 774