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Volumn 54, Issue , 2015, Pages 55-62

Simultaneous isolation and detection of circulating tumor cells with a microfluidic silicon-nanowire-array integrated with magnetic upconversion nanoprobes

Author keywords

Circulating tumor cells; Magnetic upconversion nanoparticles; Microchip; Silicon nanowire array

Indexed keywords

BIOLOGICAL ORGANS; BLOOD; CYTOLOGY; DIAGNOSIS; DISEASES; MAGNETIC NANOPARTICLES; MAGNETISM; MICROFLUIDICS; NANOWIRES; SILICON; SILICON COMPOUNDS; TUMORS;

EID: 84928013472     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2015.03.004     Document Type: Article
Times cited : (104)

References (44)
  • 1
    • 33751252276 scopus 로고    scopus 로고
    • Cancer metastasis: building a framework
    • Gupta G.P., Massagué J. Cancer metastasis: building a framework. Cell 2006, 127:679-695.
    • (2006) Cell , vol.127 , pp. 679-695
    • Gupta, G.P.1    Massagué, J.2
  • 2
    • 79953147370 scopus 로고    scopus 로고
    • Aperspective on cancer cell metastasis
    • Chaffer C.L., Weinberg R.A. Aperspective on cancer cell metastasis. Science 2011, 331:1559-1564.
    • (2011) Science , vol.331 , pp. 1559-1564
    • Chaffer, C.L.1    Weinberg, R.A.2
  • 3
    • 0036595629 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in tumour progression
    • Thiery J.P. Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2002, 2:442-454.
    • (2002) Nat Rev Cancer , vol.2 , pp. 442-454
    • Thiery, J.P.1
  • 4
    • 66149098947 scopus 로고    scopus 로고
    • Characterization of ERG, AR and PTEN gene status in circulating tumor cells from patients with castration-resistant prostate cancer
    • Attard G., Swennenhuis J.F., Olmos D., Reid A.H., Vickers E., A'Hern R., et al. Characterization of ERG, AR and PTEN gene status in circulating tumor cells from patients with castration-resistant prostate cancer. Cancer Res 2009, 69:2912-2918.
    • (2009) Cancer Res , vol.69 , pp. 2912-2918
    • Attard, G.1    Swennenhuis, J.F.2    Olmos, D.3    Reid, A.H.4    Vickers, E.5    A'Hern, R.6
  • 5
    • 49249130844 scopus 로고    scopus 로고
    • Relationship of circulating tumor cells to tumor response, progression-free survival, and overall survival in patients with metastatic colorectal cancer
    • Cohen S.J., Punt C.J., Iannotti N., Saidman B.H., Sabbath K.D., Gabrail N.Y., et al. Relationship of circulating tumor cells to tumor response, progression-free survival, and overall survival in patients with metastatic colorectal cancer. JClin Oncol 2008, 26:3213-3221.
    • (2008) JClin Oncol , vol.26 , pp. 3213-3221
    • Cohen, S.J.1    Punt, C.J.2    Iannotti, N.3    Saidman, B.H.4    Sabbath, K.D.5    Gabrail, N.Y.6
  • 6
    • 4143094988 scopus 로고    scopus 로고
    • Circulating tumor cells, disease progression, and survival in metastatic breast cancer
    • Cristofanilli M., Budd G.T., Ellis M.J., Stopeck A., Matera J., Miller M.C., et al. Circulating tumor cells, disease progression, and survival in metastatic breast cancer. NEngl J Med 2004, 351:781-791.
    • (2004) NEngl J Med , vol.351 , pp. 781-791
    • Cristofanilli, M.1    Budd, G.T.2    Ellis, M.J.3    Stopeck, A.4    Matera, J.5    Miller, M.C.6
  • 7
    • 58949088650 scopus 로고    scopus 로고
    • Circulating tumour cell (CTC) counts as intermediate end points in castration-resistant prostate cancer (CRPC): a single-centre experience
    • Olmos D., Arkenau H.-T., Ang J., Ledaki I., Attard G., Carden C., et al. Circulating tumour cell (CTC) counts as intermediate end points in castration-resistant prostate cancer (CRPC): a single-centre experience. Ann Oncol 2009, 20:27-33.
    • (2009) Ann Oncol , vol.20 , pp. 27-33
    • Olmos, D.1    Arkenau, H.-T.2    Ang, J.3    Ledaki, I.4    Attard, G.5    Carden, C.6
  • 8
    • 6044259206 scopus 로고    scopus 로고
    • Tumor cells circulate in the peripheral blood of all major carcinomas but not in healthy subjects or patients with nonmalignant diseases
    • Allard W.J., Matera J., Miller M.C., Repollet M., Connelly M.C., Rao C., et al. Tumor cells circulate in the peripheral blood of all major carcinomas but not in healthy subjects or patients with nonmalignant diseases. Clin Cancer Res 2004, 10:6897-6904.
    • (2004) Clin Cancer Res , vol.10 , pp. 6897-6904
    • Allard, W.J.1    Matera, J.2    Miller, M.C.3    Repollet, M.4    Connelly, M.C.5    Rao, C.6
  • 9
    • 37549002543 scopus 로고    scopus 로고
    • Isolation of rare circulating tumour cells in cancer patients by microchip technology
    • Nagrath S., Sequist L.V., Maheswaran S., Bell D.W., Irimia D., Ulkus L., et al. Isolation of rare circulating tumour cells in cancer patients by microchip technology. Nature 2007, 450:1235-1239.
    • (2007) Nature , vol.450 , pp. 1235-1239
    • Nagrath, S.1    Sequist, L.V.2    Maheswaran, S.3    Bell, D.W.4    Irimia, D.5    Ulkus, L.6
  • 10
    • 78649872067 scopus 로고    scopus 로고
    • Isolation of circulating tumor cells using a microvortex-generating herringbone-chip
    • Stott S.L., Hsu C.-H., Tsukrov D.I., Yu M., Miyamoto D.T., Waltman B.A., et al. Isolation of circulating tumor cells using a microvortex-generating herringbone-chip. Proc Natl Acad Sci 2010, 107:18392-18397.
    • (2010) Proc Natl Acad Sci , vol.107 , pp. 18392-18397
    • Stott, S.L.1    Hsu, C.-H.2    Tsukrov, D.I.3    Yu, M.4    Miyamoto, D.T.5    Waltman, B.A.6
  • 11
    • 84875135107 scopus 로고    scopus 로고
    • Polymer nanofiber-embedded microchips for detection, isolation, and molecular analysis of single circulating melanoma cells
    • Hou S., Zhao L., Shen Q., Yu J., Ng C., Kong X., et al. Polymer nanofiber-embedded microchips for detection, isolation, and molecular analysis of single circulating melanoma cells. Angew Chem Int Ed 2013, 52:3379-3383.
    • (2013) Angew Chem Int Ed , vol.52 , pp. 3379-3383
    • Hou, S.1    Zhao, L.2    Shen, Q.3    Yu, J.4    Ng, C.5    Kong, X.6
  • 12
    • 0002438356 scopus 로고
    • Enquete permanent dans les centres anticancereaux
    • Denoix P. Enquete permanent dans les centres anticancereaux. Bull Inst Natl Hyg 1946, 1:70-75.
    • (1946) Bull Inst Natl Hyg , vol.1 , pp. 70-75
    • Denoix, P.1
  • 13
    • 46949084705 scopus 로고    scopus 로고
    • Highly efficient circulating tumor cell isolation from whole blood and label-free enumeration using polymer-based microfluidics with an integrated conductivity sensor
    • Adams A.A., Okagbare P.I., Feng J., Hupert M.L., Patterson D., Gottert J., et al. Highly efficient circulating tumor cell isolation from whole blood and label-free enumeration using polymer-based microfluidics with an integrated conductivity sensor. JAm Chem Soc 2008, 130:8633-8641.
    • (2008) JAm Chem Soc , vol.130 , pp. 8633-8641
    • Adams, A.A.1    Okagbare, P.I.2    Feng, J.3    Hupert, M.L.4    Patterson, D.5    Gottert, J.6
  • 14
    • 84887005212 scopus 로고    scopus 로고
    • Versatile immunomagnetic nanocarrier platform for capturing cancer cells
    • Wu C.-H., Huang Y.-Y., Chen P., Hoshino K., Liu H., Frenkel E.P., et al. Versatile immunomagnetic nanocarrier platform for capturing cancer cells. ACS Nano 2013, 7:8816-8823.
    • (2013) ACS Nano , vol.7 , pp. 8816-8823
    • Wu, C.-H.1    Huang, Y.-Y.2    Chen, P.3    Hoshino, K.4    Liu, H.5    Frenkel, E.P.6
  • 15
    • 84861150697 scopus 로고    scopus 로고
    • 2 nanofiber-based cell capture assay for detecting circulating tumor cells from colorectal and gastric cancer patients
    • 2 nanofiber-based cell capture assay for detecting circulating tumor cells from colorectal and gastric cancer patients. Adv Mater 2012, 24:2756-2760.
    • (2012) Adv Mater , vol.24 , pp. 2756-2760
    • Zhang, N.1    Deng, Y.2    Tai, Q.3    Cheng, B.4    Zhao, L.5    Shen, Q.6
  • 16
    • 84885482664 scopus 로고    scopus 로고
    • Sensitive capture of circulating tumour cells by functionalized graphene oxide nanosheets
    • Yoon H.J., Kim T.H., Zhang Z., Azizi E., Pham T.M., Paoletti C., et al. Sensitive capture of circulating tumour cells by functionalized graphene oxide nanosheets. Nat Nanotechnol 2013, 8:735-741.
    • (2013) Nat Nanotechnol , vol.8 , pp. 735-741
    • Yoon, H.J.1    Kim, T.H.2    Zhang, Z.3    Azizi, E.4    Pham, T.M.5    Paoletti, C.6
  • 17
    • 84893442694 scopus 로고    scopus 로고
    • Quick-response magnetic nanospheres for rapid, efficient capture and sensitive detection of circulating tumor cells
    • Wen C.-Y., Wu L.-L., Zhang Z.-L., Liu Y.-L., Wei S.-Z., Hu J., et al. Quick-response magnetic nanospheres for rapid, efficient capture and sensitive detection of circulating tumor cells. ACS Nano 2013, 8:941-949.
    • (2013) ACS Nano , vol.8 , pp. 941-949
    • Wen, C.-Y.1    Wu, L.-L.2    Zhang, Z.-L.3    Liu, Y.-L.4    Wei, S.-Z.5    Hu, J.6
  • 18
    • 84900027235 scopus 로고    scopus 로고
    • Ultrasensitive telomerase activity detection in circulating tumor cells based on DNA metallization and sharp solid-state electrochemical techniques
    • Wu L., Wang J., Ren J., Qu X. Ultrasensitive telomerase activity detection in circulating tumor cells based on DNA metallization and sharp solid-state electrochemical techniques. Adv Funct Mater 2014, 24:2727-2733.
    • (2014) Adv Funct Mater , vol.24 , pp. 2727-2733
    • Wu, L.1    Wang, J.2    Ren, J.3    Qu, X.4
  • 19
    • 84908115631 scopus 로고    scopus 로고
    • Nanostructure embedded microchips for detection, isolation, and characterization of circulating tumor cells
    • Lin M., Chen J.-F., Lu Y.-T., Zhang Y., Song J., Hou S., et al. Nanostructure embedded microchips for detection, isolation, and characterization of circulating tumor cells. Acc Chem Res 2014, 47:2941-2950.
    • (2014) Acc Chem Res , vol.47 , pp. 2941-2950
    • Lin, M.1    Chen, J.-F.2    Lu, Y.-T.3    Zhang, Y.4    Song, J.5    Hou, S.6
  • 20
    • 84875176433 scopus 로고    scopus 로고
    • Capture and stimulated release of circulating tumor cells on polymer-grafted silicon nanostructures
    • Hou S., Zhao H., Zhao L., Shen Q., Wei K.S., Suh D.Y., et al. Capture and stimulated release of circulating tumor cells on polymer-grafted silicon nanostructures. Adv Mater 2013, 25:1547-1551.
    • (2013) Adv Mater , vol.25 , pp. 1547-1551
    • Hou, S.1    Zhao, H.2    Zhao, L.3    Shen, Q.4    Wei, K.S.5    Suh, D.Y.6
  • 21
    • 79952651278 scopus 로고    scopus 로고
    • Highly efficient capture of circulating tumor cells by using nanostructured silicon substrates with integrated chaotic micromixers
    • Wang S.T., Liu K., Liu J.A., Yu Z.T.F., Xu X.W., Zhao L.B., et al. Highly efficient capture of circulating tumor cells by using nanostructured silicon substrates with integrated chaotic micromixers. Angew Chem Int Ed 2011, 50:3084-3088.
    • (2011) Angew Chem Int Ed , vol.50 , pp. 3084-3088
    • Wang, S.T.1    Liu, K.2    Liu, J.A.3    Yu, Z.T.F.4    Xu, X.W.5    Zhao, L.B.6
  • 22
    • 84902665899 scopus 로고    scopus 로고
    • Upconversion nanoparticles: design, nanochemistry, and applications in theranostics
    • Chen G., Qiu H., Prasad P.N., Chen X. Upconversion nanoparticles: design, nanochemistry, and applications in theranostics. Chem Rev 2014, 114:5161-5214.
    • (2014) Chem Rev , vol.114 , pp. 5161-5214
    • Chen, G.1    Qiu, H.2    Prasad, P.N.3    Chen, X.4
  • 23
    • 84924559595 scopus 로고    scopus 로고
    • Current advances in lanthanide ion (Ln 3+)-based upconversion nanomaterials for drug delivery
    • Yang D., Hou Z., Cheng Z., Li C., Lin J. Current advances in lanthanide ion (Ln 3+)-based upconversion nanomaterials for drug delivery. Chem Soc Rev 2015, 10.1039/C4CS00155A.
    • (2015) Chem Soc Rev
    • Yang, D.1    Hou, Z.2    Cheng, Z.3    Li, C.4    Lin, J.5
  • 24
    • 84918822932 scopus 로고    scopus 로고
    • Enhancing luminescence in lanthanide-doped upconversion nanoparticles
    • Han S., Deng R., Xie X., Liu X. Enhancing luminescence in lanthanide-doped upconversion nanoparticles. Angew Chem Int Ed 2014, 53:11702-11715.
    • (2014) Angew Chem Int Ed , vol.53 , pp. 11702-11715
    • Han, S.1    Deng, R.2    Xie, X.3    Liu, X.4
  • 25
    • 84878364571 scopus 로고    scopus 로고
    • Lanthanide-doped upconverting luminescent nanoparticle platforms for optical imaging-guided drug delivery and therapy
    • Shen J., Zhao L., Han G. Lanthanide-doped upconverting luminescent nanoparticle platforms for optical imaging-guided drug delivery and therapy. Adv Drug Deliv Rev 2013, 65:744-755.
    • (2013) Adv Drug Deliv Rev , vol.65 , pp. 744-755
    • Shen, J.1    Zhao, L.2    Han, G.3
  • 26
    • 84862908692 scopus 로고    scopus 로고
    • Upconversion nanophosphors for small-animal imaging
    • Zhou J., Liu Z., Li F. Upconversion nanophosphors for small-animal imaging. Chem Soc Rev 2012, 41:1323-1349.
    • (2012) Chem Soc Rev , vol.41 , pp. 1323-1349
    • Zhou, J.1    Liu, Z.2    Li, F.3
  • 27
    • 84859811743 scopus 로고    scopus 로고
    • Towards whole-body imaging at the single cell level using ultra-sensitive stem cell labeling with oligo-arginine modified upconversion nanoparticles
    • Wang C., Cheng L., Xu H., Liu Z. Towards whole-body imaging at the single cell level using ultra-sensitive stem cell labeling with oligo-arginine modified upconversion nanoparticles. Biomaterials 2012, 33:4872-4881.
    • (2012) Biomaterials , vol.33 , pp. 4872-4881
    • Wang, C.1    Cheng, L.2    Xu, H.3    Liu, Z.4
  • 28
    • 84872286216 scopus 로고    scopus 로고
    • Multifunctional upconversion nanoparticles for dual-modal imaging-guided stem cell therapy under remote magnetic control
    • Cheng L., Wang C., Ma X., Wang Q., Cheng Y., Wang H., et al. Multifunctional upconversion nanoparticles for dual-modal imaging-guided stem cell therapy under remote magnetic control. Adv Funct Mater 2013, 23:272-280.
    • (2013) Adv Funct Mater , vol.23 , pp. 272-280
    • Cheng, L.1    Wang, C.2    Ma, X.3    Wang, Q.4    Cheng, Y.5    Wang, H.6
  • 29
    • 85027929595 scopus 로고    scopus 로고
    • Aptamer-conjugated upconversion nanoprobes assisted by magnetic separation for effective isolation and sensitive detection of circulating tumor cells
    • Fang S., Wang C., Xiang J., Cheng L., Song X.J., Xu L.G., et al. Aptamer-conjugated upconversion nanoprobes assisted by magnetic separation for effective isolation and sensitive detection of circulating tumor cells. Nano Res 2014, 7:1327-1336.
    • (2014) Nano Res , vol.7 , pp. 1327-1336
    • Fang, S.1    Wang, C.2    Xiang, J.3    Cheng, L.4    Song, X.J.5    Xu, L.G.6
  • 30
    • 84858789825 scopus 로고    scopus 로고
    • Facile preparation of multifunctional upconversion nanoprobes for multimodal imaging and dual-targeted photothermal therapy
    • Cheng L., Yang K., Li Y., Chen J., Wang C., Shao M., et al. Facile preparation of multifunctional upconversion nanoprobes for multimodal imaging and dual-targeted photothermal therapy. Angew Chem 2011, 123:7523-7528.
    • (2011) Angew Chem , vol.123 , pp. 7523-7528
    • Cheng, L.1    Yang, K.2    Li, Y.3    Chen, J.4    Wang, C.5    Shao, M.6
  • 31
    • 0028350104 scopus 로고
    • Ep-CAM: a human epithelial antigen is a homophilic cell-cell adhesion molecule
    • Litvinov S.V., Velders M.P., Bakker H., Fleuren G.J., Warnaar S.O. Ep-CAM: a human epithelial antigen is a homophilic cell-cell adhesion molecule. JCell Biol 1994, 125:437-446.
    • (1994) JCell Biol , vol.125 , pp. 437-446
    • Litvinov, S.V.1    Velders, M.P.2    Bakker, H.3    Fleuren, G.J.4    Warnaar, S.O.5
  • 32
    • 79952633419 scopus 로고    scopus 로고
    • Enhanced signals and fast nucleic acid hybridization by microfluidic chaotic mixing
    • Liu J., Williams B.A., Gwirtz R.M., Wold B.J., Quake S. Enhanced signals and fast nucleic acid hybridization by microfluidic chaotic mixing. Angew Chem 2006, 118:3700-3705.
    • (2006) Angew Chem , vol.118 , pp. 3700-3705
    • Liu, J.1    Williams, B.A.2    Gwirtz, R.M.3    Wold, B.J.4    Quake, S.5
  • 33
    • 84896958955 scopus 로고    scopus 로고
    • Emerging role of nanomaterials in circulating tumor cell isolation and analysis
    • Yoon H.J., Kozminsky M., Nagrath S. Emerging role of nanomaterials in circulating tumor cell isolation and analysis. ACS Nano 2014, 8:1995-2017.
    • (2014) ACS Nano , vol.8 , pp. 1995-2017
    • Yoon, H.J.1    Kozminsky, M.2    Nagrath, S.3
  • 34
    • 78049282862 scopus 로고    scopus 로고
    • Multiplexed protein detection using antibody-conjugated microbead arrays in a microfabricated electrophoretic device
    • Barbee K.D., Hsiao A.P., Roller E.E., Huang X. Multiplexed protein detection using antibody-conjugated microbead arrays in a microfabricated electrophoretic device. Lab Chip 2010, 10:3084-3093.
    • (2010) Lab Chip , vol.10 , pp. 3084-3093
    • Barbee, K.D.1    Hsiao, A.P.2    Roller, E.E.3    Huang, X.4
  • 35
    • 70449103171 scopus 로고    scopus 로고
    • Three-dimensional nanostructured substrates toward efficient capture of circulating tumor cells
    • Wang S.T., Wang H., Jiao J., Chen K.J., Owens G.E., Kamei K.I., et al. Three-dimensional nanostructured substrates toward efficient capture of circulating tumor cells. Angew Chem Int Ed 2009, 48:8970-8973.
    • (2009) Angew Chem Int Ed , vol.48 , pp. 8970-8973
    • Wang, S.T.1    Wang, H.2    Jiao, J.3    Chen, K.J.4    Owens, G.E.5    Kamei, K.I.6
  • 36
    • 84896951591 scopus 로고    scopus 로고
    • Three-dimensional nano-biointerface as a new platform for guiding cell fate
    • Liu X., Wang S. Three-dimensional nano-biointerface as a new platform for guiding cell fate. Chem Soc Rev 2014, 43:2385-2401.
    • (2014) Chem Soc Rev , vol.43 , pp. 2385-2401
    • Liu, X.1    Wang, S.2
  • 37
    • 71749117352 scopus 로고    scopus 로고
    • Excellent photocatalysis of HF-treated silicon nanowires
    • Shao M., Cheng L., Zhang X., Ma D.D.D., Lee S.-t. Excellent photocatalysis of HF-treated silicon nanowires. JAm Chem Soc 2009, 131:17738-17739.
    • (2009) JAm Chem Soc , vol.131 , pp. 17738-17739
    • Shao, M.1    Cheng, L.2    Zhang, X.3    Ma, D.D.D.4    Lee, S.-T.5
  • 38
    • 84876485145 scopus 로고    scopus 로고
    • Specific capture and release of circulating tumor cells using aptamer-modified nanosubstrates
    • Shen Q.L., Xu L., Zhao L.B., Wu D.X., Fan Y.S., Zhou Y.L., et al. Specific capture and release of circulating tumor cells using aptamer-modified nanosubstrates. Adv Mater 2013, 25:2368-2373.
    • (2013) Adv Mater , vol.25 , pp. 2368-2373
    • Shen, Q.L.1    Xu, L.2    Zhao, L.B.3    Wu, D.X.4    Fan, Y.S.5    Zhou, Y.L.6
  • 39
    • 84876491890 scopus 로고    scopus 로고
    • High-purity prostate circulating tumor cell isolation by a polymer nanofiber-embedded microchip for whole exome sequencing
    • Zhao L., Lu Y.T., Li F., Wu K., Hou S., Yu J., et al. High-purity prostate circulating tumor cell isolation by a polymer nanofiber-embedded microchip for whole exome sequencing. Adv Mater 2013, 25:2897-2902.
    • (2013) Adv Mater , vol.25 , pp. 2897-2902
    • Zhao, L.1    Lu, Y.T.2    Li, F.3    Wu, K.4    Hou, S.5    Yu, J.6
  • 40
    • 84878237164 scopus 로고    scopus 로고
    • Dual-responsive surfaces modified with phenylboronic acid-containing polymer brush to reversibly capture and release cancer cells
    • Liu H., Li Y., Sun K., Fan J., Zhang P., Meng J., et al. Dual-responsive surfaces modified with phenylboronic acid-containing polymer brush to reversibly capture and release cancer cells. JAm Chem Soc 2013, 135:7603-7609.
    • (2013) JAm Chem Soc , vol.135 , pp. 7603-7609
    • Liu, H.1    Li, Y.2    Sun, K.3    Fan, J.4    Zhang, P.5    Meng, J.6
  • 41
    • 84922516888 scopus 로고    scopus 로고
    • An electroactive biotin-doped polypyrrole substrate that immobilizes and releases EpCAM-positive cancer cells
    • Jeon S., Moon J.M., Lee E.S., Kim Y.H., Cho Y. An electroactive biotin-doped polypyrrole substrate that immobilizes and releases EpCAM-positive cancer cells. Angew Chem 2014, 126:4685-4690.
    • (2014) Angew Chem , vol.126 , pp. 4685-4690
    • Jeon, S.1    Moon, J.M.2    Lee, E.S.3    Kim, Y.H.4    Cho, Y.5
  • 42
    • 4143074922 scopus 로고    scopus 로고
    • EpCAM is overexpressed in breast cancer and is a potential target for breast cancer gene therapy
    • Osta W.A., Chen Y., Mikhitarian K., Mitas M., Salem M., Hannun Y.A., et al. EpCAM is overexpressed in breast cancer and is a potential target for breast cancer gene therapy. Cancer Res 2004, 64:5818-5824.
    • (2004) Cancer Res , vol.64 , pp. 5818-5824
    • Osta, W.A.1    Chen, Y.2    Mikhitarian, K.3    Mitas, M.4    Salem, M.5    Hannun, Y.A.6
  • 43
    • 80052190496 scopus 로고    scopus 로고
    • Circulating tumor cells in breast cancer: detection systems, molecular characterization, and future challenges
    • Lianidou E.S., Markou A. Circulating tumor cells in breast cancer: detection systems, molecular characterization, and future challenges. Clin Chem 2011, 57:1242-1255.
    • (2011) Clin Chem , vol.57 , pp. 1242-1255
    • Lianidou, E.S.1    Markou, A.2
  • 44
    • 65849240762 scopus 로고    scopus 로고
    • Enrichment with anti-cytokeratin alone or combined with anti-EpCAM antibodies significantly increases the sensitivity for circulating tumor cell detection in metastatic breast cancer patients
    • Deng G., Herrler M., Burgess D., Manna E., Krag D., Burke J.F. Enrichment with anti-cytokeratin alone or combined with anti-EpCAM antibodies significantly increases the sensitivity for circulating tumor cell detection in metastatic breast cancer patients. Breast Cancer Res 2008, 10:R69.
    • (2008) Breast Cancer Res , vol.10 , pp. R69
    • Deng, G.1    Herrler, M.2    Burgess, D.3    Manna, E.4    Krag, D.5    Burke, J.F.6


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