Synthesis, pharmacological evaluation, and σ1 receptor interaction analysis of hydroxyethyl substituted piperazines

Journal of Medicinal Chemistry

Volumn 57, Issue 7, 2014, Pages 2884-2894

  Weber, Frauke ^a   Brune, Stefanie ^a   Korpis, Katharina ^b   Bednarski, Patrick J ^b   Laurini, Erik ^c   Dal Col, Valentina ^c   Pricl, Sabrina ^c   Schepmann, Dirk ^a   Wünsch, Bernhard ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b UNIVERSITY OF GREIFSWALD   (Germany)

^c UNIVERSITY OF TRIESTE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

(S)2 [4 (CYCLOHEXYLMETHYL) 1 (NAPHTHALEN 2 YLMETHYL)PIPERAZIN 2 YL]ETHANOL; (S)METHYL 2 [4 (CYCLOHEXYLMETHYL) 1 (NAPHTHALEN 2 YLMETHYL) 3,6 DIOXO PIPERAZIN 2 YL]ACETATE; ASPARTIC ACID; CHEMICAL COMPOUND; DIMETHYL(S) 2 AMINOBUTANEDIOATE HYDROCHLORIDE; DIMETHYL(S) 2 [2 CHLORO N(NAPHTHALEN 2 YLMETHYL)ACETYLAMINO]BUTANEDIOATE; HYDROXYETHYL; PIPERAZINE DERIVATIVE; SIGMA 1 OPIATE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; BINDING AFFINITY; CANCER CELL CULTURE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL GROWTH; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; GUINEA PIG; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IC 50; MOLECULAR INTERACTION; MOLECULAR MODEL; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RPMI 8226 CELL; THIN LAYER CHROMATOGRAPHY; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BRAIN; CHROMATOGRAPHY, THIN LAYER; GUINEA PIGS; HUMANS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MOLECULAR STRUCTURE; NEOPLASMS; PIPERAZINES; PROTEIN BINDING; RECEPTORS, SIGMA; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 84898444903     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm401707t     Document Type: Article

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