Quinoline tricyclic derivatives. Design, synthesis and evaluation of the antiviral activity of three new classes of RNA-dependent RNA polymerase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 23, 2011, Pages 7070-7084

  Carta, Antonio ^a   Briguglio, Irene ^a   Piras, Sandra ^a   Corona, Paola ^a   Boatto, Giampiero ^a   Nieddu, Maria ^a   Giunchedi, Paolo ^a   Marongiu, Maria Elena ^b   Giliberti, Gabriele ^b   Iuliano, Filippo ^b   Blois, Sylvain ^b   Ibba, Cristina ^b   Busonera, Bernardetta ^b   La Colla, Paolo ^b  

^a UNIVERSITY OF SASSARI   (Italy)

^b UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

Flaviviridae; HCV; Imidazo 4,5 g quinolines; Pyrido 2,3 g quinoxalines; Triazolo 4,5 g quinolines

Indexed keywords

1 CHLORO 3 (4 CHLORO 1H TRIAZOLO[4,5 G]QUINOLIN 3 YL)PROPAN 2 ONE; 1 CHLORO 3 (4 CHLORO 3H TRIAZOLO[4,5 G]QUINOLIN 3 YL)PROPAN 2 ONE; 2 (2 METHOXYPHENYL) 3H IMIDAZO[4,5 G]QUINOLINE; 2 (3,4 DICHLOROPHENYL) 3H IMIDAZO[4,5 G]QUINOLINE; 2 (4 CHLOROPHENYL) 3H IMIDAZO[4,5 G]QUINOLINE; 2 (4 NITRONAPHTHALEN 1 YL) 3H IMIDAZO[4,5 G]QUINOLINE; 2 (BIPHENYL 4 YL) 3H IMIDAZO[4,5 G]QUINOLINE; 2 PHENYL 3H IMIDAZO[4,5 G]QUINOLINE; 2' METHYLCYTIDINE; 4 (4 CHLORO 3H IMIDAZO[4,5 G]QUINOLIN 2 YL)ANILINE; 4 CHLORO 2 (4 NITROPHENYL) 3H IMIDAZO[4,5 G]QUINOLINE; 4 CHLORO 2 CYCLOHEXYL 3H IMIDAZO[4,5 G]QUINOLINE; 4 CHLORO 2 PHENYL 3H IMIDAZO[4,5 G]QUINOLIN 8(5H) ONE; 4 CHLORO 2 PHENYL 3H IMIDAZO[4,5 G]QUINOLINE; 4 CHLORO 3 (CYCLOHEXYLMETHYL) 2 (4 NITROPHENYL) 3H IMIDAZO[4,5 G]QUINOLINE; 5 CHLORO 2 ETHYLPYRIDO[3,2 G]QUINOXALIN 3(4H) ONE; 5 CHLORO 2 ISOPROPYLPYRIDO[3,2 G]QUINOXALIN 3(4H) ONE; 5 CHLORO 2 PHENYLPYRIDO[3,2 G]QUINOXALIN 3(4H) ONE; 5 CHLORO 2,3 DIPHENYLPYRIDO[3,2 G]QUINOXALINE; 5 CHLORO 3 PHENYLPYRIDO[3,2 G]QUINOXALINE; ACICLOVIR; AZAURIDINE; EFAVIRENZ; IMIDAZOQUINOLINE DERIVATIVE; MYCOPHENOLIC ACID; PYRIDO[2,3 G]QUINOXALINE DERIVATIVE; QUINOLINE DERIVATIVE; RNA DIRECTED RNA POLYMERASE INHIBITOR; TRIAZOLO[4,5 G]QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; BOVINE DIARRHEA VIRUS; CONTROLLED STUDY; COXSACKIE VIRUS B; COXSACKIE VIRUS B5; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG SYNTHESIS; HEPATITIS C VIRUS; HERPES SIMPLEX VIRUS 1; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; MAMMALIAN ORTHOREOVIRUS; NONHUMAN; POLIOMYELITIS VIRUS 1; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; VACCINIA VIRUS; VESICULAR STOMATITIS VIRUS; YELLOW FEVER FLAVIVIRUS;

ANTIVIRAL AGENTS; ENZYME INHIBITORS; FLAVIVIRIDAE; HUMANS; MOLECULAR STRUCTURE; QUINOLINES; RNA REPLICASE; STRUCTURE-ACTIVITY RELATIONSHIP;

BOVINE VIRAL DIARRHEA VIRUS 1; DNA VIRUSES; FLAVIVIRIDAE; FLAVIVIRUS; HEPACIVIRUS; HEPATITIS C VIRUS; PESTIVIRUS; RICE STRIPE VIRUS; RNA VIRUSES;

EID: 80655146738     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.10.009     Document Type: Article

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