Identification of Lead Compounds as Inhibitors of STAT3: Design, Synthesis and Bioactivity

Molecular Informatics

Volumn 34, Issue 10, 2015, Pages 689-697

  Botta, Antonio ^a   Sirignano, Esther ^a   Popolo, Ada ^a   Saturnino, Carmela ^a   Terracciano, Stefania ^a   Foglia, Antonio ^a   Sinicropi, Maria Stefania ^b   Longo, Pasquale ^a   Di Micco, Simone ^a  

^a UNIVERSITY OF SALERNO   (Italy)

^b UNIVERSITY OF CALABRIA   (Italy)

Author keywords

1,4 dimethyl carbazoles; Antitumor compound; Molecular docking; STAT3; STAT3 inhibitor

Indexed keywords

1,4 DIMETHYL 9H CARBAZOLE; 1,4 DIMETHYL CARBAZOLE DERIVATIVE; 5,8 DIMETHYL 9H CARBAZOLE 3 SULFONAMIDE; 5,8 DIMETHYL 9H CARBAZOLE 3 SULFONYL CHLORIDE; 6 METHOXY 1,4 DIMETHYL 3 NITRO 9H CARBAZOLE; 6 METHOXY 1,4 DIMETHYL 9 ETHYL CARBAZOLE; 6 METHOXY 1,4,9 TRIMETHYL CARBAZOLE; ANTINEOPLASTIC AGENT; ETHYL 5,8 DIMETHYL 9H CARBAZOLE 3 NITRO CARBOXYLATE; PROTEIN INHIBITOR; STAT3 PROTEIN; STAT3 PROTEIN INHIBITOR; UNCLASSIFIED DRUG; CARBAZOLE DERIVATIVE; LEAD; STAT3 PROTEIN, HUMAN; TUMOR PROTEIN;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; CARCINOGENESIS; CHEMICAL MODIFICATION; COMPUTER AIDED DESIGN; CONTROLLED STUDY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; HELA CELL LINE; HUMAN; HUMAN CELL; MELANOMA CELL; PRIORITY JOURNAL; WESTERN BLOTTING; ANTAGONISTS AND INHIBITORS; CELL PROLIFERATION; CHEMISTRY; DRUG EFFECTS; METABOLISM; NEOPLASM; SYNTHESIS;

ANTINEOPLASTIC AGENTS; CARBAZOLES; CELL PROLIFERATION; HELA CELLS; HUMANS; LEAD; NEOPLASM PROTEINS; NEOPLASMS; STAT3 TRANSCRIPTION FACTOR;

EID: 84944354193     PISSN: 18681743     EISSN: 18681751     Source Type: Journal    
DOI: 10.1002/minf.201500043     Document Type: Article

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