Synthesis, Pim kinase inhibitory potencies and in vitro antiproliferative activities of diversely substituted pyrrolo[2,3-a]carbazoles

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 18, 2010, Pages 6865-6873

  Akué Gédu, Rufine ^a,b   Nauton, Lionel ^a,b   Théry, Vincent ^a,b   Bain, Jenny ^c   Cohen, Philip ^c   Anizon, Fabrice ^a,b   Moreau, Pascale ^a,b  

^a UNIVERSITÉ CLERMONT AUVERGNE   (France)

^b CNRS   (France)

^c UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

In vitro antiproliferative activities; Kinase inhibitors; PIM inhibitors; Pyrrolo 2,3 a carbazoles

Indexed keywords

6 BROMO 1,10 DIHYDROPYRROLO[2,3 A]CARBAZOLE 3 CARBALDEHYDE; CARBAZOLE DERIVATIVE; PROTEIN KINASE PIM 1; PROTEIN KINASE PIM 2; PROTEIN KINASE PIM 3; PROTEIN SERINE THREONINE KINASE; PROTEIN SERINE THREONINE KINASE INHIBITOR; PYROLO[2,3 A]CARBAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; FIBROBLAST; HUMAN; HUMAN CELL; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANTINEOPLASTIC AGENTS; BINDING SITES; CARBAZOLES; CELL LINE; COMPUTER SIMULATION; HUMANS; PROTEIN KINASE INHIBITORS; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-PIM-1;

EID: 77956344582     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.07.036     Document Type: Article

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