Engineering of Kuma030: A Gliadin Peptidase That Rapidly Degrades Immunogenic Gliadin Peptides in Gastric Conditions

Journal of the American Chemical Society

Volumn 137, Issue 40, 2015, Pages 13106-13113

  Wolf, Clancey ^a   Siegel, Justin B ^b   Tinberg, Christine ^a   Camarca, Alessandra ^c   Gianfrani, Carmen ^d   Paski, Shirley ^e   Guan, Rongjin ^f   Montelione, Gaetano ^f   Baker, David ^a   Pultz, Ingrid S ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c CNR   (Italy)

^d INSTITUTE OF PROTEIN BIOCHEMISTRY   (Italy)

^e UNIVERSITY OF WASHINGTON MEDICAL CENTER   (United States)

^f RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEINS; T-CELLS;

CELIAC DISEASE; GASTRIC CONDITIONS; GASTRIC DIGESTIONS; HOMOLOGOUS PROTEINS; INTESTINAL INFLAMMATION; ORAL ADMINISTRATION; T-CELL RESPONSE; TOXIC THRESHOLDS;

PATIENT TREATMENT;

GLIADIN; KUMA 030; PEPTIDASE; TRIPEPTIDE; UNCLASSIFIED DRUG; PEPTIDE HYDROLASE;

AMINO ACID SEQUENCE; ARTICLE; BARLEY; CELIAC DISEASE; CHEMICAL ENGINEERING; CONTROLLED STUDY; DIGESTION; ENZYME ACTIVE SITE; HUMAN; HUMAN CELL; IMMUNOGENICITY; MOLECULAR MODEL; RYE; T LYMPHOCYTE; CELL CULTURE; CHEMISTRY; METABOLISM; MOLECULAR GENETICS; STOMACH;

AMINO ACID SEQUENCE; CATALYTIC DOMAIN; CELLS, CULTURED; GLIADIN; HUMANS; MOLECULAR SEQUENCE DATA; PEPTIDE HYDROLASES; STOMACH;

EID: 84944262891     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/jacs.5b08325     Document Type: Article

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