Protein engineering of improved prolyl endopeptidases for celiac sprue therapy

Protein Engineering, Design and Selection

Volumn 21, Issue 12, 2008, Pages 699-707

  Ehren, Jennifer ^a   Govindarajan, Sridhar ^c   Morón, Belén ^b   Minshull, Jeremy ^c   Khosla, Chaitan ^a,b  

^a Stanford University   (United States)

^b STANFORD UNIVERSITY   (United States)

^c DNA20 Inc   (United States)

Author keywords

Celiac sprue; Prolyl endopeptidase

Indexed keywords

AMINES; BIOCHEMICAL ENGINEERING; BIOLOGICAL MATERIALS; CONCENTRATION (PROCESS); DETOXIFICATION; GENETIC ENGINEERING; LEARNING SYSTEMS; PROTEINS;

CELIAC SPRUE; CELIAC SPRUES; FIRST PRINCIPLES; GASTRIC CONDITIONS; GLUTEN PEPTIDES; HYDROPHOBIC RESIDUES; ITERATIVE DESIGNS; MACHINE LEARNING ALGORITHMS; PROLYL ENDOPEPTIDASE; PROLYL ENDOPEPTIDASES; PROTEIN ENGINEERINGS; PROTEIN STRUCTURES; SPECIFIC ACTIVITIES; SPHINGOMONAS; TOXIC EFFECTS; WHEAT BREADS;

LEARNING ALGORITHMS;

PEPSIN A; PROLYL ENDOPEPTIDASE;

ARTICLE; CELIAC DISEASE; COMPUTER MODEL; ENZYME ACTIVITY; ENZYME STABILITY; HYDROPHOBICITY; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN ENGINEERING; SPHINGOMONAS;

ALGORITHMS; AMINO ACID SEQUENCE; ARTIFICIAL INTELLIGENCE; CELIAC DISEASE; GLUTENS; MODELS, MOLECULAR; MUTATION; PROTEIN CONFORMATION; PROTEIN ENGINEERING; SERINE ENDOPEPTIDASES; SPHINGOMONAS;

NOVOSPHINGOBIUM CAPSULATUM; TRITICUM AESTIVUM;

EID: 56549128445     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzn050     Document Type: Article

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