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Volumn 114, Issue 8, 2015, Pages 1123-1131

Black elderberry extract attenuates inflammation and metabolic dysfunction in diet-induced obese mice

Author keywords

Black elderberry extract; Diet induced obese mice; Inflammation; Insulin resistance; Molecular nutrition; Obesity

Indexed keywords

ACYL COENZYME A DEHYDROGENASE; ACYL COENZYME A OXIDASE; ADIPOCYTE PROTEIN 2; ADIPONECTIN; ALANINE AMINOTRANSFERASE; ANTIINFLAMMATORY AGENT; BLACK ELDERBERRY EXTRACT; CD68 ANTIGEN; CELL PROTEIN; CHOLESTEROL; COLLAGEN TYPE 6; COLLAGEN TYPE 6 ALPHA3; FATTY ACID SYNTHASE; INSULIN; INTERLEUKIN 6; LIPOPROTEIN LIPASE; MONOCYTE CHEMOTACTIC PROTEIN 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA 2; PLANT EXTRACT; PLASMINOGEN ACTIVATOR INHIBITOR 1; RESISTIN; TRANSFORMING GROWTH FACTOR BETA; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CCL2 PROTEIN, MOUSE; FAT INTAKE; LARD; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

EID: 84944151659     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114515002962     Document Type: Article
Times cited : (57)

References (38)
  • 1
    • 33750695093 scopus 로고    scopus 로고
    • World Health Organization no. 311. (accessed May. 2015
    • World Health Organization (2015) Obesity and overweight, fact sheet no. 311. http://www.who.int/mediacentre/factsheets/ fs311/en (accessed May 2015).
    • (2015) Obesity and Overweight, Fact Sheet
  • 2
    • 0037422846 scopus 로고    scopus 로고
    • Obesity in adulthood and its consequences for life expectancy: A lifetable analysis
    • Peeters A, Barendregt JJ, Willekens F, et al. (2003) Obesity in adulthood and its consequences for life expectancy: a lifetable analysis. Ann Intern Med 138, 24-32.
    • (2003) Ann Intern Med , vol.138 , pp. 24-32
    • Peeters, A.1    Barendregt, J.J.2    Willekens, F.3
  • 3
    • 0032742418 scopus 로고    scopus 로고
    • The disease burden associated with overweight and obesity
    • Must A, Spadano J, Coakley EH, et al. (1999) The disease burden associated with overweight and obesity. JAMA 282, 1523-1529.
    • (1999) JAMA , vol.282 , pp. 1523-1529
    • Must, A.1    Spadano, J.2    Coakley, E.H.3
  • 5
    • 33845866857 scopus 로고    scopus 로고
    • Inflammation and metabolic disorders
    • Hotamisligil GS (2006) Inflammation and metabolic disorders. Nature 444, 860-867.
    • (2006) Nature , vol.444 , pp. 860-867
    • Hotamisligil, G.S.1
  • 6
    • 42449097289 scopus 로고    scopus 로고
    • Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes
    • Guilherme A, Virbasius JV, Puri V, et al. (2008) Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes. Nat Rev Mol Cell Biol 9, 367-377.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 367-377
    • Guilherme, A.1    Virbasius, J.V.2    Puri, V.3
  • 7
    • 84892638292 scopus 로고    scopus 로고
    • Intakes of anthocyanins and flavones are associated with biomarkers of insulin resistance and inflammation in women
    • Jennings A, Welch AA, Spector T, et al. (2014) Intakes of anthocyanins and flavones are associated with biomarkers of insulin resistance and inflammation in women. J Nutr 144, 202-208.
    • (2014) J Nutr , vol.144 , pp. 202-208
    • Jennings, A.1    Welch, A.A.2    Spector, T.3
  • 8
    • 39749188825 scopus 로고    scopus 로고
    • Cyanidin 3-glucoside protects 3T3-L1 adipocytes against H2O2- or TNF-Alphainduced insulin resistance by inhibiting c-Jun NH2-Terminal kinase activation
    • Guo H, Ling W, Wang Q, et al. (2008) Cyanidin 3-glucoside protects 3T3-L1 adipocytes against H2O2- or TNF-Alphainduced insulin resistance by inhibiting c-Jun NH2-Terminal kinase activation. Biochem Pharmacol 75, 1393-1401.
    • (2008) Biochem Pharmacol , vol.75 , pp. 1393-1401
    • Guo, H.1    Ling, W.2    Wang, Q.3
  • 9
    • 84864134648 scopus 로고    scopus 로고
    • Cyanidin-3-O-betaglucoside, a typical anthocyanin, exhibits antilipolytic effects in 3T3-L1 adipocytes during hyperglycemia: Involvement of FoxO1-mediated transcription of adipose triglyceride lipase
    • Guo H, Guo J, Jiang X, et al. (2012) Cyanidin-3-O-betaglucoside, a typical anthocyanin, exhibits antilipolytic effects in 3T3-L1 adipocytes during hyperglycemia: involvement of FoxO1-mediated transcription of adipose triglyceride lipase. Food Chem Toxicol 50, 3040-3047.
    • (2012) Food Chem Toxicol , vol.50 , pp. 3040-3047
    • Guo, H.1    Guo, J.2    Jiang, X.3
  • 10
    • 80052903790 scopus 로고    scopus 로고
    • Cyanidin-3-Obeta-glucoside and protocatechuic acid exert insulin-like effects by upregulating PPARgamma activity in human omental adipocytes
    • Scazzocchio B, Vari R, Filesi C, et al. (2011) Cyanidin-3-Obeta-glucoside and protocatechuic acid exert insulin-like effects by upregulating PPARgamma activity in human omental adipocytes. Diabetes 60, 2234-2244.
    • (2011) Diabetes , vol.60 , pp. 2234-2244
    • Scazzocchio, B.1    Vari, R.2    Filesi, C.3
  • 11
    • 84858290692 scopus 로고    scopus 로고
    • Cyanidin 3-glucoside attenuates obesity-Associated insulin resistance and hepatic steatosis in high-fat diet-fed and db/db mice via the transcription factor FoxO1
    • Guo H, Xia M, Zou T, et al. (2012) Cyanidin 3-glucoside attenuates obesity-Associated insulin resistance and hepatic steatosis in high-fat diet-fed and db/db mice via the transcription factor FoxO1. J Nutr Biochem 23, 349-360.
    • (2012) J Nutr Biochem , vol.23 , pp. 349-360
    • Guo, H.1    Xia, M.2    Zou, T.3
  • 12
    • 35348964129 scopus 로고    scopus 로고
    • Cyanidin 3-glucoside ameliorates hyperglycemia and insulin sensitivity due to down-regulation of retinol binding protein 4 expression in diabetic mice
    • Sasaki R, Nishimura N, Hoshino H, et al. (2007) Cyanidin 3-glucoside ameliorates hyperglycemia and insulin sensitivity due to down-regulation of retinol binding protein 4 expression in diabetic mice. Biochem Pharmacol 74, 1619-1627.
    • (2007) Biochem Pharmacol , vol.74 , pp. 1619-1627
    • Sasaki, R.1    Nishimura, N.2    Hoshino, H.3
  • 13
    • 84921497880 scopus 로고    scopus 로고
    • Purified anthocyanins from bilberry and black currant attenuate hepatic mitochondrial dysfunction and steatohepatitis in mice with methionine and choline deficiency
    • Tang X, Shen T, Jiang X, et al. (2015) Purified anthocyanins from bilberry and black currant attenuate hepatic mitochondrial dysfunction and steatohepatitis in mice with methionine and choline deficiency. J Agric Food Chem 63, 552-561.
    • (2015) J Agric Food Chem , vol.63 , pp. 552-561
    • Tang, X.1    Shen, T.2    Jiang, X.3
  • 14
    • 34548062593 scopus 로고    scopus 로고
    • Anthocyanins inhibit nuclear factor-kappaB activation in monocytes and reduce plasma concentrations of pro-inflammatory mediators in healthy adults
    • Karlsen A, Retterstol L, Laake P, et al. (2007) Anthocyanins inhibit nuclear factor-kappaB activation in monocytes and reduce plasma concentrations of pro-inflammatory mediators in healthy adults. J Nutr 137, 1951-1954.
    • (2007) J Nutr , vol.137 , pp. 1951-1954
    • Karlsen, A.1    Retterstol, L.2    Laake, P.3
  • 15
    • 84884162151 scopus 로고    scopus 로고
    • Anti-inflammatory effect of purified dietary anthocyanin in adults with hypercholesterolemia: A randomized controlled trial
    • Zhu Y, Ling W, Guo H, et al. (2013) Anti-inflammatory effect of purified dietary anthocyanin in adults with hypercholesterolemia: a randomized controlled trial. Nutr Metab Cardiovasc Dis 23, 843-849.
    • (2013) Nutr Metab Cardiovasc Dis , vol.23 , pp. 843-849
    • Zhu, Y.1    Ling, W.2    Guo, H.3
  • 16
    • 77951281689 scopus 로고    scopus 로고
    • Systematic analysis of the content of 502 polyphenols in 452 foods and beverages: An application of the phenol-explorer database
    • Perez-Jimenez J, Neveu V, Vos F, et al. (2010) Systematic analysis of the content of 502 polyphenols in 452 foods and beverages: an application of the phenol-explorer database. J Agric Food Chem 58, 4959-4969.
    • (2010) J Agric Food Chem , vol.58 , pp. 4959-4969
    • Perez-Jimenez, J.1    Neveu, V.2    Vos, F.3
  • 17
    • 11144234817 scopus 로고    scopus 로고
    • Characterization of anthocyanins and proanthocyanidins in some cultivars of Ribes, Aronia, and Sambucus and their antioxidant capacity
    • Wu X, Gu L, Prior RL, et al. (2004) Characterization of anthocyanins and proanthocyanidins in some cultivars of Ribes, Aronia, and Sambucus and their antioxidant capacity. J Agric Food Chem 52, 7846-7856.
    • (2004) J Agric Food Chem , vol.52 , pp. 7846-7856
    • Wu, X.1    Gu, L.2    Prior, R.L.3
  • 18
    • 84927626701 scopus 로고    scopus 로고
    • Anthocyanin-rich black elderberry extract improves markers of HDL function and reduces aortic cholesterol in hyperlipidemic mice
    • Farrell N, Norris G, Lee SG, et al. (2015) Anthocyanin-rich black elderberry extract improves markers of HDL function and reduces aortic cholesterol in hyperlipidemic mice. Food Funct 6, 1278-1287.
    • (2015) Food Funct , vol.6 , pp. 1278-1287
    • Farrell, N.1    Norris, G.2    Lee, S.G.3
  • 20
    • 33745512076 scopus 로고    scopus 로고
    • Concentrations of anthocyanins in common foods in the United States and estimation of normal consumption
    • Wu X, Beecher GR, Holden JM, et al. (2006) Concentrations of anthocyanins in common foods in the United States and estimation of normal consumption. J Agric Food Chem 54, 4069-4075.
    • (2006) J Agric Food Chem , vol.54 , pp. 4069-4075
    • Wu, X.1    Beecher, G.R.2    Holden, J.M.3
  • 21
    • 0021813187 scopus 로고
    • Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
    • Matthews DR, Hosker JP, Rudenski AS, et al. (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28, 412-419.
    • (1985) Diabetologia , vol.28 , pp. 412-419
    • Matthews, D.R.1    Hosker, J.P.2    Rudenski, A.S.3
  • 22
    • 13844281685 scopus 로고    scopus 로고
    • Bioavailability and bioefficacy of polyphenols in humans i Review of 97 bioavailability studies
    • Manach C, Williamson G, Morand C, et al. (2005) Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am J Clin Nutr 81, 230S-242SS.
    • (2005) Am J Clin Nutr , vol.81 , pp. 230S-242SS
    • Manach, C.1    Williamson, G.2    Morand, C.3
  • 23
    • 33750455858 scopus 로고    scopus 로고
    • Consumption of flavonoid-rich foods and increased plasma antioxidant capacity in humans: Cause, consequence, or epiphenomenon?
    • Lotito SB & Frei B (2006) Consumption of flavonoid-rich foods and increased plasma antioxidant capacity in humans: cause, consequence, or epiphenomenon?. Free Radic Biol Med 41, 1727-1746.
    • (2006) Free Radic Biol Med , vol.41 , pp. 1727-1746
    • Lotito, S.B.1    Frei, B.2
  • 24
    • 84876912589 scopus 로고    scopus 로고
    • Human metabolism and elimination of the anthocyanin, cyanidin-3-glucoside: A (13)C-Tracer study
    • Czank C, Cassidy A, Zhang Q, et al. (2013) Human metabolism and elimination of the anthocyanin, cyanidin-3-glucoside: a (13)C-Tracer study. Am J Clin Nutr 97, 995-1003.
    • (2013) Am J Clin Nutr , vol.97 , pp. 995-1003
    • Czank, C.1    Cassidy, A.2    Zhang, Q.3
  • 25
    • 34548399951 scopus 로고    scopus 로고
    • Protocatechuic acid is the major human metabolite of cyanidin-glucosides
    • Vitaglione P, Donnarumma G, Napolitano A, et al. (2007) Protocatechuic acid is the major human metabolite of cyanidin-glucosides. J Nutr 137, 2043-2048.
    • (2007) J Nutr , vol.137 , pp. 2043-2048
    • Vitaglione, P.1    Donnarumma, G.2    Napolitano, A.3
  • 26
    • 34547492488 scopus 로고    scopus 로고
    • PPARgamma activation primes human monocytes into alternative M2 macrophages with anti-inflammatory properties
    • Bouhlel MA, Derudas B, Rigamonti E, et al. (2007) PPARgamma activation primes human monocytes into alternative M2 macrophages with anti-inflammatory properties. Cell Metab 6, 137-143.
    • (2007) Cell Metab , vol.6 , pp. 137-143
    • Bouhlel, M.A.1    Derudas, B.2    Rigamonti, E.3
  • 27
    • 78649652068 scopus 로고    scopus 로고
    • Adipose tissue macrophages in insulin-resistant subjects are associated with collagen VI and fibrosis and demonstrate alternative activation
    • Spencer M, Yao-Borengasser A, Unal R, et al. (2010) Adipose tissue macrophages in insulin-resistant subjects are associated with collagen VI and fibrosis and demonstrate alternative activation. Am J Physiol Endocrinol Metab 299, E1016-E1027.
    • (2010) Am J Physiol Endocrinol Metab , vol.299 , pp. E1016-E1027
    • Spencer, M.1    Yao-Borengasser, A.2    Unal, R.3
  • 28
    • 34347354309 scopus 로고    scopus 로고
    • Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance
    • Odegaard JI, Ricardo-Gonzalez RR, Goforth MH, et al. (2007) Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance. Nature 447, 1116-1120.
    • (2007) Nature , vol.447 , pp. 1116-1120
    • Odegaard, J.I.1    Ricardo-Gonzalez, R.R.2    Goforth, M.H.3
  • 29
    • 0033779575 scopus 로고    scopus 로고
    • Influence of alternatively and classically activated macrophages on fibrogenic activities of human fibroblasts
    • Song E, Ouyang N, Horbelt M, et al. (2000) Influence of alternatively and classically activated macrophages on fibrogenic activities of human fibroblasts. Cell Immunol 204, 19-28.
    • (2000) Cell Immunol , vol.204 , pp. 19-28
    • Song, E.1    Ouyang, N.2    Horbelt, M.3
  • 30
    • 0035907240 scopus 로고    scopus 로고
    • Identification of novel TGF-beta /Smad gene targets in dermal fibroblasts using a combined cDNA microarray/promoter transactivation approach
    • Verrecchia F, Chu ML & Mauviel A (2001) Identification of novel TGF-beta /Smad gene targets in dermal fibroblasts using a combined cDNA microarray/promoter transactivation approach. J Biol Chem 276, 17058-17062.
    • (2001) J Biol Chem , vol.276 , pp. 17058-17062
    • Verrecchia, F.1    Chu, M.L.2    Mauviel, A.3
  • 31
    • 84908432350 scopus 로고    scopus 로고
    • Insulin resistance is associated with MCP1-mediated macrophage accumulation in skeletal muscle in mice and humans
    • Patsouris D, Cao JJ, Vial G, et al. (2014) Insulin resistance is associated with MCP1-mediated macrophage accumulation in skeletal muscle in mice and humans. PLOS ONE 9, e110653.
    • (2014) PLOS ONE , vol.9 , pp. e110653
    • Patsouris, D.1    Cao, J.J.2    Vial, G.3
  • 32
    • 84882731713 scopus 로고    scopus 로고
    • Interleukin-6 myokine signaling in skeletal muscle: A doubleedged sword?
    • Munoz-Canoves P, Scheele C, Pedersen BK, et al. (2013) Interleukin-6 myokine signaling in skeletal muscle: a doubleedged sword?. FEBS J 280, 4131-4148.
    • (2013) FEBS J , vol.280 , pp. 4131-4148
    • Munoz-Canoves, P.1    Scheele, C.2    Pedersen, B.K.3
  • 33
    • 0036152683 scopus 로고    scopus 로고
    • Interleukin-6-deficient mice develop mature-onset obesity
    • Wallenius V, Wallenius K, Ahren B, et al. (2002) Interleukin-6-deficient mice develop mature-onset obesity. Nat Med 8, 75-79.
    • (2002) Nat Med , vol.8 , pp. 75-79
    • Wallenius, V.1    Wallenius, K.2    Ahren, B.3
  • 34
    • 33750859187 scopus 로고    scopus 로고
    • Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-Activated protein kinase
    • Carey AL, Steinberg GR, Macaulay SL, et al. (2006) Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-Activated protein kinase. Diabetes 55, 2688-2697.
    • (2006) Diabetes , vol.55 , pp. 2688-2697
    • Carey, A.L.1    Steinberg, G.R.2    Macaulay, S.L.3
  • 35
    • 34249682779 scopus 로고    scopus 로고
    • Interleukin-6 directly increases glucose metabolism in resting human skeletal muscle
    • Glund S, Deshmukh A, Long YC, et al. (2007) Interleukin-6 directly increases glucose metabolism in resting human skeletal muscle. Diabetes 56, 1630-1637.
    • (2007) Diabetes , vol.56 , pp. 1630-1637
    • Glund, S.1    Deshmukh, A.2    Long, Y.C.3
  • 36
    • 0025098765 scopus 로고
    • Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy
    • Shulman GI, Rothman DL, Jue T, et al. (1990) Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy. N Engl J Med 322, 223-228.
    • (1990) N Engl J Med , vol.322 , pp. 223-228
    • Shulman, G.I.1    Rothman, D.L.2    Jue, T.3
  • 37
    • 67749132533 scopus 로고    scopus 로고
    • Dietary blueberry attenuates whole-body insulin resistance in high fat-fed mice by reducing adipocyte death and its inflammatory sequelae
    • DeFuria J, Bennett G, Strissel KJ, et al. (2009) Dietary blueberry attenuates whole-body insulin resistance in high fat-fed mice by reducing adipocyte death and its inflammatory sequelae. J Nutr 139, 1510-1516.
    • (2009) J Nutr , vol.139 , pp. 1510-1516
    • DeFuria, J.1    Bennett, G.2    Strissel, K.J.3
  • 38
    • 84871602044 scopus 로고    scopus 로고
    • Differential effects of grape powder and its extract on glucose tolerance and chronic inflammation in high-fat-fed obese mice
    • Chuang CC, Shen W, Chen H, et al. (2012) Differential effects of grape powder and its extract on glucose tolerance and chronic inflammation in high-fat-fed obese mice. J Agric Food Chem 60, 12458-12468.
    • (2012) J Agric Food Chem , vol.60 , pp. 12458-12468
    • Chuang, C.C.1    Shen, W.2    Chen, H.3


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