Structural and evolutionary relationships of "AT-less" type I polyketide synthase ketosynthases

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 41, 2015, Pages 12693-12698

  Lohman, Jeremy R ^a   Ma, Ming ^a   Osipiuk, Jerzy ^b   Nocek, Boguslaw ^b   Kim, Youngchang ^b   Chang, Changsoo ^b   Cuff, Marianne ^b   Mack, Jamey ^b   Bigelow, Lance ^b   Li, Hui ^b   Endres, Michael ^b   Babnigg, Gyorgy ^b   Joachimiak, Andrzej ^b   Phillips, George N ^c   Shen, Ben ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b ARGONNE NATIONAL LABORATORY   (United States)

^c RICE UNIVERSITY   (United States)

Author keywords

Biosynthesis; Iso migrastatin; Leinamycin; Oxazolomycin; Secondary metabolism

Indexed keywords

ACYL CARRIER PROTEIN; ACYLTRANSFERASE LES TYPE I POLYKETIDE SYNTHASE KETOSYNTHASE; KETOSYNTHASE; POLYKETIDE SYNTHASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; CHEMICAL BOND; CONFERENCE PAPER; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; GENE CLUSTER; HIGH THROUGHPUT SEQUENCING; MOLECULAR DOCKING; MOLECULAR EVOLUTION; NONHUMAN; PHYLOGENY; PRIORITY JOURNAL; PROTEIN DOMAIN; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; CHEMISTRY; GENETICS; PROTEIN TERTIARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

CRYSTALLOGRAPHY, X-RAY; EVOLUTION, MOLECULAR; POLYKETIDE SYNTHASES; PROTEIN STRUCTURE, TERTIARY; SUBSTRATE SPECIFICITY;

EID: 84944104654     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1515460112     Document Type: Article

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