메뉴 건너뛰기




Volumn 56, Issue 4, 2003, Pages 446-457

Evolutionary affiliations within the superfamily of ketosynthases reflect complex pathway associations

Author keywords

Cyanobacteria; Ketosynthase; Nonribosomal peptide; Nonribosomal peptide synthetase; Polyketide; Polyketide synthase

Indexed keywords

CYANOGINOSIN; DINOPHYSISTOXIN 1; DOCOSAHEXAENOIC ACID; ICOSAPENTAENOIC ACID; KETOSYNTHASE; MEVINOLIN; OLIGONUCLEOTIDE; PEPTIDE SYNTHASE; POLYKETIDE; POLYKETIDE SYNTHASE; RAPAMYCIN; SERRAWETTIN W2; UNCLASSIFIED DRUG;

EID: 0037380334     PISSN: 00222844     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00239-002-2415-0     Document Type: Article
Times cited : (74)

References (47)
  • 1
    • 0033763409 scopus 로고    scopus 로고
    • A complex multienzyme system encoded by five polyketide synthase genes is involved in the biosynthesis of the 26-membered polyene macrolide pimaricin in Streptomyces natalensis
    • Aparicio JF, Fouces R, Mendes MV, Olivera N, Martin JF (2000) A complex multienzyme system encoded by five polyketide synthase genes is involved in the biosynthesis of the 26-membered polyene macrolide pimaricin in Streptomyces natalensis. Chem Biol 7:895-905
    • (2000) Chem Biol , vol.7 , pp. 895-905
    • Aparicio, J.F.1    Fouces, R.2    Mendes, M.V.3    Olivera, N.4    Martin, J.F.5
  • 2
    • 0032876464 scopus 로고    scopus 로고
    • Ketosynthase domain probes identify two subclasses of fungal polyketide synthase genes
    • Bingle LE, Simpson TJ, Lazarus CM (1999) Ketosynthase domain probes identify two subclasses of fungal polyketide synthase genes. Fungal Genet Biol 26:209-223
    • (1999) Fungal Genet Biol , vol.26 , pp. 209-223
    • Bingle, L.E.1    Simpson, T.J.2    Lazarus, C.M.3
  • 4
    • 0034047123 scopus 로고    scopus 로고
    • Biosynthesis of the polyene antifungal antibiotic nystatin in Streptomyces noursei ATCC 11455: Analysis of the gene cluster and deduction of the biosynthetic pathway
    • Brautaset T, Sekurova ON, Sletta H, Ellingsen TE, Strom AR, Valla S, Zotchev SB (2000) Biosynthesis of the polyene antifungal antibiotic nystatin in Streptomyces noursei ATCC 11455: Analysis of the gene cluster and deduction of the biosynthetic pathway. Chem Biol 7:395-403
    • (2000) Chem Biol , vol.7 , pp. 395-403
    • Brautaset, T.1    Sekurova, O.N.2    Sletta, H.3    Ellingsen, T.E.4    Strom, A.R.5    Valla, S.6    Zotchev, S.B.7
  • 6
    • 0030908912 scopus 로고    scopus 로고
    • A polyketide-synthase-like gene is involved in the synthesis of heterocyst glycolipids in Nostoc punctiforme strain ATCC 29133
    • Campbell EL, Cohen MF, Meeks JC (1997) A polyketide-synthase-like gene is involved in the synthesis of heterocyst glycolipids in Nostoc punctiforme strain ATCC 29133. Arch Microbiol 167:251-258
    • (1997) Arch Microbiol , vol.167 , pp. 251-258
    • Campbell, E.L.1    Cohen, M.F.2    Meeks, J.C.3
  • 7
    • 0026415106 scopus 로고
    • Modular organization of genes required for complex polyketide biosynthesis
    • Donadio S, Stayer MJ, McAlpine JB, Swanson SJ, Katz L (1991) Modular organization of genes required for complex polyketide biosynthesis. Science 252:675-679
    • (1991) Science , vol.252 , pp. 675-679
    • Donadio, S.1    Stayer, M.J.2    McAlpine, J.B.3    Swanson, S.J.4    Katz, L.5
  • 8
    • 0034796211 scopus 로고    scopus 로고
    • Hybrid peptide-polyketide natural products: Biosynthesis and prospects toward engineering natural molecules
    • Du L, Sanchez C, Shen B (2001) Hybrid peptide-polyketide natural products: Biosynthesis and prospects toward engineering natural molecules. Metab Eng 3:78-95
    • (2001) Metab Eng , vol.3 , pp. 78-95
    • Du, L.1    Sanchez, C.2    Shen, B.3
  • 10
    • 0000461280 scopus 로고
    • Confidence limits on phylogenies: An approach using the bootstrap
    • Felsenstein J (1985) Confidence limits on phylogenies: An approach using the bootstrap. Evolution 39:166-170
    • (1985) Evolution , vol.39 , pp. 166-170
    • Felsenstein, J.1
  • 11
    • 0000122573 scopus 로고
    • PHYLIP. Phylogeny inference package
    • Felsenstein J (1989) PHYLIP. Phylogeny inference package. Cladistics 5:164-166
    • (1989) Cladistics , vol.5 , pp. 164-166
    • Felsenstein, J.1
  • 13
    • 0031035424 scopus 로고    scopus 로고
    • A locus coding for putative nonribosomal peptide/polyketide synthase functions is mutated in a swarming-defective Proteus mirabilis strain
    • Gaisser S, Hughes C (1997) A locus coding for putative nonribosomal peptide/polyketide synthase functions is mutated in a swarming-defective Proteus mirabilis strain. Mol Gen Genet 253:415-427
    • (1997) Mol Gen Genet , vol.253 , pp. 415-427
    • Gaisser, S.1    Hughes, C.2
  • 15
    • 0033574768 scopus 로고    scopus 로고
    • Dissecting and exploiting intermodular communication in polyketide synthases
    • Gokhale RS, Tsuji SY, Cane DE, Khosla C (1999) Dissecting and exploiting intermodular communication in polyketide synthases. Science 284:482-485
    • (1999) Science , vol.284 , pp. 482-485
    • Gokhale, R.S.1    Tsuji, S.Y.2    Cane, D.E.3    Khosla, C.4
  • 18
    • 0032473567 scopus 로고    scopus 로고
    • Crystal structure of beta-ketoacyl-acyl carrier protein synthase II from E. coli reveals the molecular architecture of condensing enzymes
    • Huang W, Jia J, Edwards P, Dehesh K, Schneider G, Lindqvist Y (1998) Crystal structure of beta-ketoacyl-acyl carrier protein synthase II from E. coli reveals the molecular architecture of condensing enzymes. EMBO J 17:1183-1191
    • (1998) EMBO J , vol.17 , pp. 1183-1191
    • Huang, W.1    Jia, J.2    Edwards, P.3    Dehesh, K.4    Schneider, G.5    Lindqvist, Y.6
  • 19
    • 0025107820 scopus 로고
    • Microviridin: A novel tricyclic depsipeptide from the toxic cyanobacterium Microcystis viridis
    • Ishituka M, Kusumi I, Kakisawa H, Kaya K, Watanabe M (1990) Microviridin: A novel tricyclic depsipeptide from the toxic cyanobacterium Microcystis viridis. J Am Chem Soc 112:8180-8182
    • (1990) J Am Chem Soc , vol.112 , pp. 8180-8182
    • Ishituka, M.1    Kusumi, I.2    Kakisawa, H.3    Kaya, K.4    Watanabe, M.5
  • 20
    • 0018792053 scopus 로고
    • Flavanone synthase from Petroselinum hortense, Molecular weight, subunit composition, size of messenger RNA, and absence of pantetheinyl residue
    • Kreuzaler F, Ragg H, Heller W, Tesch R, Witt I, Hammer D, Hahlbrock K (1979) Flavanone synthase from Petroselinum hortense. Molecular weight, subunit composition, size of messenger RNA, and absence of pantetheinyl residue. Eur J Biochem 99:89-96
    • (1979) Eur J Biochem , vol.99 , pp. 89-96
    • Kreuzaler, F.1    Ragg, H.2    Heller, W.3    Tesch, R.4    Witt, I.5    Hammer, D.6    Hahlbrock, K.7
  • 21
    • 0031755841 scopus 로고    scopus 로고
    • N-Acyl-L-homoserine lactone autoinducers control production of an extracellular lipopeptide biosurfactant required for swarming motility of Serratia liquefaciens MG1
    • Lindum PW, Anthoni U, Christophersen C, Eberl L, Molin S, Givskov M (1998) N-Acyl-L-homoserine lactone autoinducers control production of an extracellular lipopeptide biosurfactant required for swarming motility of Serratia liquefaciens MG1. J Bacteriol 180:6384-6388
    • (1998) J Bacteriol , vol.180 , pp. 6384-6388
    • Lindum, P.W.1    Anthoni, U.2    Christophersen, C.3    Eberl, L.4    Molin, S.5    Givskov, M.6
  • 22
    • 0030580449 scopus 로고    scopus 로고
    • Aeruginosins 102-A and B, new thrombin inhibitors from the cyanobacterium Microcystis viridis (NIES-102)
    • Matsuda H, Okino T, Murakami M, Yamaguchi K (1996) Aeruginosins 102-A and B, new thrombin inhibitors from the cyanobacterium Microcystis viridis (NIES-102). Tetrahedron 52:14501-14506
    • (1996) Tetrahedron , vol.52 , pp. 14501-14506
    • Matsuda, H.1    Okino, T.2    Murakami, M.3    Yamaguchi, K.4
  • 23
    • 0033515090 scopus 로고    scopus 로고
    • Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products
    • McDaniel R, Thamchaipenet A, Gustafsson C, Fu H, Betlach M, Ashley G (1999) Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products. Proc Natl Acad Sci USA 96:1846-1851
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 1846-1851
    • McDaniel, R.1    Thamchaipenet, A.2    Gustafsson, C.3    Fu, H.4    Betlach, M.5    Ashley, G.6
  • 25
    • 0035868628 scopus 로고    scopus 로고
    • On the presence of peptide synthetase and polyketide synthase genes in the cyanobacterial genus Nodularia
    • Moffitt MC, Neilan BA (2001) On the presence of peptide synthetase and polyketide synthase genes in the cyanobacterial genus Nodularia. FEMS Microbiol Lett 196:207-214
    • (2001) FEMS Microbiol Lett , vol.196 , pp. 207-214
    • Moffitt, M.C.1    Neilan, B.A.2
  • 27
    • 0031043482 scopus 로고    scopus 로고
    • Structural organization of a multifunctional polyketide synthase involved in the biosynthesis of the macrolide immunosuppressant FK506
    • Motamedi H, Cai SJ, Shafiee A, Elliston KO (1997) Structural organization of a multifunctional polyketide synthase involved in the biosynthesis of the macrolide immunosuppressant FK506. Eur J Biochem 244:74-80
    • (1997) Eur J Biochem , vol.244 , pp. 74-80
    • Motamedi, H.1    Cai, S.J.2    Shafiee, A.3    Elliston, K.O.4
  • 28
    • 0028236160 scopus 로고
    • Aeruginosin 298-A, a thrombin and trypsin inhibitor from the blue-green alga Microcystis aerusinosa (N1ES-298)
    • Murakami M, Okita Y, Matsuda H, Okino T, Yamaguchi K (1994) Aeruginosin 298-A, a thrombin and trypsin inhibitor from the blue-green alga Microcystis aerusinosa (N1ES-298). Tetrahedron Lett 35:3129-3132
    • (1994) Tetrahedron Lett , vol.35 , pp. 3129-3132
    • Murakami, M.1    Okita, Y.2    Matsuda, H.3    Okino, T.4    Yamaguchi, K.5
  • 29
    • 0028871685 scopus 로고
    • Genetic diversity and phylogeny of toxic cyanobacteria determined by DNA polymorphisms within the phycocyanin locus
    • Neilan BA, Jacobs D, Goodman AE (1995) Genetic diversity and phylogeny of toxic cyanobacteria determined by DNA polymorphisms within the phycocyanin locus. Appl Environ Microbiol 61:3875-3883
    • (1995) Appl Environ Microbiol , vol.61 , pp. 3875-3883
    • Neilan, B.A.1    Jacobs, D.2    Goodman, A.E.3
  • 31
    • 0029091489 scopus 로고
    • New microviridins, elatase inhibitors from the blue-green alga Microcystis aeruginosa
    • Okino T, Matsuda H, Murakami M, Yamaguchi K (1995) New microviridins, elatase inhibitors from the blue-green alga Microcystis aeruginosa. Tetrahedron Lett 51:10679-10686
    • (1995) Tetrahedron Lett , vol.51 , pp. 10679-10686
    • Okino, T.1    Matsuda, H.2    Murakami, M.3    Yamaguchi, K.4
  • 32
    • 0032211974 scopus 로고    scopus 로고
    • Identification of a Mycobacterium tuberculosis gene cluster encoding the biosynthetic enzymes for assembly of the virulence-conferring siderophore mycobactin
    • Quadri LE, Sello J, Keating TA, Weinreb PH, Walsh CT (1998) Identification of a Mycobacterium tuberculosis gene cluster encoding the biosynthetic enzymes for assembly of the virulence-conferring siderophore mycobactin. Chem Biol 5:631-645
    • (1998) Chem Biol , vol.5 , pp. 631-645
    • Quadri, L.E.1    Sello, J.2    Keating, T.A.3    Weinreb, P.H.4    Walsh, C.T.5
  • 33
    • 0032849891 scopus 로고    scopus 로고
    • Polyketides from dinoflagellates: Origins, pharmacology and biosynthesis
    • Rein KS, Borrone J (1999) Polyketides from dinoflagellates: Origins, pharmacology and biosynthesis. Comp Biochem Physiol B Biochem Mol Biol 124:117-131
    • (1999) Comp Biochem Physiol B Biochem Mol Biol , vol.124 , pp. 117-131
    • Rein, K.S.1    Borrone, J.2
  • 34
    • 0028791886 scopus 로고
    • A 2-amino-2-butenoic acid (Dhb)-conraining microcystin isolated from Oscillatoria agardhii
    • Sano T, Kaya K (1995) A 2-amino-2-butenoic acid (Dhb)-conraining microcystin isolated from Oscillatoria agardhii. Tetrahedron Lett 36:8603-8606
    • (1995) Tetrahedron Lett , vol.36 , pp. 8603-8606
    • Sano, T.1    Kaya, K.2
  • 36
    • 0030690924 scopus 로고    scopus 로고
    • A study of iterative type II polyketide synthases, using bacterial genes cloned from soil DNA: A means to access and use genes from uncultured microorganisms
    • Seow KT, Meurer G, Gerlitz M, Wendt-Pienkowski E, Hutchinson CR, Davies J (1997) A study of iterative type II polyketide synthases, using bacterial genes cloned from soil DNA: A means to access and use genes from uncultured microorganisms. J Bacteriol 179:7360-7368
    • (1997) J Bacteriol , vol.179 , pp. 7360-7368
    • Seow, K.T.1    Meurer, G.2    Gerlitz, M.3    Wendt-Pienkowski, E.4    Hutchinson, C.R.5    Davies, J.6
  • 37
    • 0034094917 scopus 로고    scopus 로고
    • Cloning, characterization and heterologous expression of a polyketide synthase and P-450 oxidase involved in the biosynthesis of the antibiotic oleandomycin
    • Shah S, Xue Q, Tang L, Carney JR, Betlach M, McDaniel R (2000) Cloning, characterization and heterologous expression of a polyketide synthase and P-450 oxidase involved in the biosynthesis of the antibiotic oleandomycin. J Antibiot (Tokyo) 53:502-508
    • (2000) J Antibiot (Tokyo) , vol.53 , pp. 502-508
    • Shah, S.1    Xue, Q.2    Tang, L.3    Carney, J.R.4    Betlach, M.5    McDaniel, R.6
  • 38
    • 0032830741 scopus 로고    scopus 로고
    • Bleomycin biosynthesis in Streptomyces verticillus ATCC 15003: A model of hybrid peptide and polyketide biosynthesis
    • Shen B, Du LC, Sanchez C, Chen M, Edwards DJ (1999) Bleomycin biosynthesis in Streptomyces verticillus ATCC 15003: A model of hybrid peptide and polyketide biosynthesis. Bioorganic Chem 27:155-171
    • (1999) Bioorganic Chem , vol.27 , pp. 155-171
    • Shen, B.1    Du, L.C.2    Sanchez, C.3    Chen, M.4    Edwards, D.J.5
  • 40
    • 0035913715 scopus 로고    scopus 로고
    • Multiple hybrid polyketide synthase/non-ribosomal peptide synthetase gene clusters in the myxobacterium Stigmatella aurantiaca
    • Silakowski B, Kunze B, Muller R (2001) Multiple hybrid polyketide synthase/non-ribosomal peptide synthetase gene clusters in the myxobacterium Stigmatella aurantiaca. Gene 275:233-240
    • (2001) Gene , vol.275 , pp. 233-240
    • Silakowski, B.1    Kunze, B.2    Muller, R.3
  • 41
    • 0033452637 scopus 로고    scopus 로고
    • Isolation of clustered genes that are notably homologous to the eicosapentaenoic acid biosynthesis gene cluster from the docosahexaenoic acid-producing bacterium Vibrio marinus strain MP-1
    • Tanaka M, Ueno A, Kawasaki K, Yumoto I, Ohgiya S, Hoshino T, Ishizaki K, Okuyama H, Morita N (1999) Isolation of clustered genes that are notably homologous to the eicosapentaenoic acid biosynthesis gene cluster from the docosahexaenoic acid-producing bacterium Vibrio marinus strain MP-1. Biotechnol Lett 21:939-945
    • (1999) Biotechnol Lett , vol.21 , pp. 939-945
    • Tanaka, M.1    Ueno, A.2    Kawasaki, K.3    Yumoto, I.4    Ohgiya, S.5    Hoshino, T.6    Ishizaki, K.7    Okuyama, H.8    Morita, N.9
  • 42
    • 0027968068 scopus 로고
    • CLUSTAL W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
    • Thompson JD, Higgins DG, Gibson TJ (1994) CLUSTAL W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res 22:4673-4680
    • (1994) Nucleic Acids Res , vol.22 , pp. 4673-4680
    • Thompson, J.D.1    Higgins, D.G.2    Gibson, T.J.3
  • 43
    • 0033780306 scopus 로고    scopus 로고
    • Structural organization of microcystin biosynthesis in Microcystis aeruginosa PCC 7806: An integrated peptide-polyketide synthetase system
    • Tillett D, Dittmann E, Erhard M, von Dohren H, Borner T, Neilan BA (2000) Structural organization of microcystin biosynthesis in Microcystis aeruginosa PCC 7806: An integrated peptide-polyketide synthetase system. Chem Biol 7:753-764
    • (2000) Chem Biol , vol.7 , pp. 753-764
    • Tillett, D.1    Dittmann, E.2    Erhard, M.3    Von Dohren, H.4    Borner, T.5    Neilan, B.A.6
  • 44
    • 0033533388 scopus 로고    scopus 로고
    • Conversion of a β-ketoacyl synthase to a malonyl decarboxylase by replacement of the active-site cysteine with glutamine
    • Witkowski A, Joshi AK, Lindqvist Y, Smith S (1999) Conversion of a β-ketoacyl synthase to a malonyl decarboxylase by replacement of the active-site cysteine with glutamine. Biochemistry 38:11643-11650
    • (1999) Biochemistry , vol.38 , pp. 11643-11650
    • Witkowski, A.1    Joshi, A.K.2    Lindqvist, Y.3    Smith, S.4
  • 45
    • 0035861496 scopus 로고    scopus 로고
    • The genome of the natural genetic engineer Agrobacterium tumefacians
    • Wood DW, Setubal JC, Kaul R, et al. (2001) The genome of the natural genetic engineer Agrobacterium tumefacians. Science 294:2317-2323
    • (2001) Science , vol.294 , pp. 2317-2323
    • Wood, D.W.1    Setubal, J.C.2    Kaul, R.3
  • 46
    • 0034643859 scopus 로고    scopus 로고
    • The FK520 gene cluster of Streptomyces hygroscopicus var. ascomyceticus (ATCC 14891) contains genes for biosynthesis of unusual polyketide extender units
    • Wu K, Chung L, Revill WP, Katz L, Reeves CD (2000) The FK520 gene cluster of Streptomyces hygroscopicus var. ascomyceticus (ATCC 14891) contains genes for biosynthesis of unusual polyketide extender units. Gene 251:81-90
    • (2000) Gene , vol.251 , pp. 81-90
    • Wu, K.1    Chung, L.2    Revill, W.P.3    Katz, L.4    Reeves, C.D.5
  • 47
    • 0029926287 scopus 로고    scopus 로고
    • Production of eicosapentaenoic acid from marine bacteria
    • Yazawa K (1996) Production of eicosapentaenoic acid from marine bacteria. Lipids 31:S297-S300
    • (1996) Lipids , vol.31
    • Yazawa, K.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.