Iso-migrastatin, migrastatin, and dorrigocin production in streptomyces platensis NRRL 18993 is governed by a single biosynthetic machinery featuring an acyltransferase-less type I polyketide synthase

Journal of Biological Chemistry

Volumn 284, Issue 43, 2009, Pages 29746-29756

  Lim, Si Kyu ^a   Ju, Jianhua ^a   Zazopoulos, Emmanuel ^b   Jiang, Hui ^a   Seo, Jeong Woo ^a   Chen, Yihua ^a   Feng, Zhiyang ^a   Rajski, Scott R ^a   Farnet, Chris M ^b   Shen, Ben ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b Thallion Pharmaceuticals Inc   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CANDIDATE GENES; GENE INACTIVATION; HUMAN CANCER; IN-VIVO; OPEN READING FRAME; PLATENSIS; POLYKETIDE SYNTHASES; POLYKETIDES; POTENT INHIBITOR; REGULATORY PROTEIN; STREPTOMYCES PLATENSIS; THIOESTERASES; TUMOR CELL MIGRATION; TYPE II;

BIOCHEMISTRY; BIOINFORMATICS; BIOSYNTHESIS; CATALYSTS; CELL MEMBRANES; CYTOLOGY; ENZYMES; GENES; MACHINERY;

PLANTS (BOTANY);

ACYLTRANSFERASE; DORRIGOCIN; GLUTARIMIDE; ISOMIGRASTATIN; MIGRASTATIN; POLYKETIDE; POLYKETIDE SYNTHASE; THIOL ESTER HYDROLASE; UNCLASSIFIED DRUG;

ARTICLE; BIOINFORMATICS; CARBON NUCLEAR MAGNETIC RESONANCE; CELL MIGRATION; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME SYNTHESIS; GENE CLUSTER; GENE INACTIVATION; GENETIC ANALYSIS; INHIBITION KINETICS; MOLECULAR CLONING; MUTAGENESIS; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; STREPTOMYCES; STREPTOMYCES PLATENSIS; TUMOR CELL;

BASE SEQUENCE; GENE DELETION; GENOME, BACTERIAL; MACROLIDES; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; OPEN READING FRAMES; PIPERIDONES; POLYKETIDE SYNTHASES; STREPTOMYCES;

STREPTOMYCES PLATENSIS;

EID: 70350353075     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.046805     Document Type: Article

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