Hesperidin inhibits HeLa cell proliferation through apoptosis mediated by endoplasmic reticulum stress pathways and cell cycle arrest

BMC Cancer

Volumn 15, Issue 1, 2015, Pages

  Wang, Yaoxian ^a   Yu, Hui ^a   Zhang, Jin ^a   Gao, Jing ^a   Ge, Xin ^b   Lou, Ge ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

^b HEILONGJIANG PROVINCIAL HOSPITAL   (China)

Author keywords

Apoptosis; Cell cycle arrest; ER stress; HeLa cells; Hesperidin; MMP; ROS

Indexed keywords

CASPASE; CYCLIN D1; CYCLIN DEPENDENT KINASE 2; CYCLIN E; CYTOCHROME C; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; HESPERIDIN; REACTIVE OXYGEN METABOLITE; APOPTOSIS INDUCING FACTOR; CALCIUM; CASPASE 3; CCNE1 PROTEIN, HUMAN; CDK2 PROTEIN, HUMAN; DDIT3 PROTEIN, HUMAN; HEAT SHOCK PROTEIN; MOLECULAR CHAPERONE GRP78; ONCOPROTEIN;

APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CELL CYCLE ARREST; CELL PROLIFERATION; CELL VIABILITY; CHROMATIN CONDENSATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA FRAGMENTATION; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; G1 PHASE CELL CYCLE CHECKPOINT; HELA CELL LINE; HT 29 CELL LINE; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MTT ASSAY; PROTEIN EXPRESSION; CELL CULTURE; CELL CYCLE CHECKPOINT; DRUG EFFECTS; HT-29 CELL LINE; METABOLISM; SIGNAL TRANSDUCTION;

APOPTOSIS; APOPTOSIS INDUCING FACTOR; CALCIUM; CASPASE 3; CELL CYCLE CHECKPOINTS; CELL PROLIFERATION; CELLS, CULTURED; CYCLIN D1; CYCLIN E; CYCLIN-DEPENDENT KINASE 2; CYTOCHROMES C; DNA FRAGMENTATION; ENDOPLASMIC RETICULUM STRESS; HEAT-SHOCK PROTEINS; HELA CELLS; HESPERIDIN; HT29 CELLS; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; ONCOGENE PROTEINS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR CHOP;

EID: 84944065622     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/s12885-015-1706-y     Document Type: Article

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