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Volumn 650, Issue 2-3, 2011, Pages 526-533

Inactivation of Nuclear Factor-κB by citrus flavanone hesperidin contributes to apoptosis and chemo-sensitizing effect in Ramos cells

Author keywords

Flavonoid; Hesperidin; IkappaB; NF kappaB; PPAR

Indexed keywords

DOXORUBICIN; HESPERIDIN; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

EID: 78651069319     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.10.053     Document Type: Article
Times cited : (53)

References (41)
  • 1
    • 0028980494 scopus 로고
    • P53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts
    • M.L. Agarwal, A. Agarwal, W.R. Taylor, and G.R. Stark p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts Proc. Natl Acad. Sci. USA 92 1995 8493 8497
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , pp. 8493-8497
    • Agarwal, M.L.1    Agarwal, A.2    Taylor, W.R.3    Stark, G.R.4
  • 2
    • 69549105653 scopus 로고    scopus 로고
    • Efficacy of the potential chemopreventive agent, hesperetin (citrus flavanone), on 1, 2-dimethylhydrazine induced colon carcinogenesis
    • S. Aranganathan, and N. Nalini Efficacy of the potential chemopreventive agent, hesperetin (citrus flavanone), on 1, 2-dimethylhydrazine induced colon carcinogenesis Food Chem. Toxicol. 47 2009 2594 2600
    • (2009) Food Chem. Toxicol. , vol.47 , pp. 2594-2600
    • Aranganathan, S.1    Nalini, N.2
  • 4
    • 0141863402 scopus 로고    scopus 로고
    • Overview of dietary flavonoids: Nomenclature, occurrence and intake
    • G.R. Beecher Overview of dietary flavonoids: nomenclature, occurrence and intake J. Nutr. 133 2003 3248S 3254S
    • (2003) J. Nutr. , vol.133
    • Beecher, G.R.1
  • 5
    • 0038653437 scopus 로고    scopus 로고
    • Hesperidin, a citrus flavonoid, inhibits bone loss and decreases serum and hepatic lipids in ovariectomized mice
    • H. Chiba, M. Uehara, J. Wu, X. Wang, R. Masuyama, K. Suzuki, K. Kanazawa, and Y. Ishimi Hesperidin, a citrus flavonoid, inhibits bone loss and decreases serum and hepatic lipids in ovariectomized mice J. Nutr. 133 2003 1892 1897
    • (2003) J. Nutr. , vol.133 , pp. 1892-1897
    • Chiba, H.1    Uehara, M.2    Wu, J.3    Wang, X.4    Masuyama, R.5    Suzuki, K.6    Kanazawa, K.7    Ishimi, Y.8
  • 8
    • 34250333058 scopus 로고    scopus 로고
    • NF-κB inhibition sensitizes to starvation-induced cell death in high-risk myelodysplastic syndrome and acute myeloid leukemia
    • DOI 10.1038/sj.onc.1210187, PII 1210187
    • C. Fabre, G. Carvalho, E. Tasdemir, T. Braun, L. Ades, J. Grosjean, S. Boehrer, D. Metivier, S. Souquere, G. Pierron, P. Fenaux, and G. Kroemer NF-kappaB inhibition sensitizes to starvation-induced cell death in high-risk myelodysplastic syndrome and acute myeloid leukemia Oncogene 26 2007 4071 4083 (Pubitemid 46920171)
    • (2007) Oncogene , vol.26 , Issue.28 , pp. 4071-4083
    • Fabre, C.1    Carvalho, G.2    Tasdemir, E.3    Braun, T.4    Ades, L.5    Grosjean, J.6    Boehrer, S.7    Metivier, D.8    Souquere, S.9    Pierron, G.10    Fenaux, P.11    Kroemer, G.12
  • 9
    • 28244442462 scopus 로고    scopus 로고
    • Apoptosis: A basic biological phenomenon with wide-ranging implications in human disease
    • B. Fadeel, and S. Orrenius Apoptosis: a basic biological phenomenon with wide-ranging implications in human disease J. Intern. Med. 258 2005 479 517
    • (2005) J. Intern. Med. , vol.258 , pp. 479-517
    • Fadeel, B.1    Orrenius, S.2
  • 11
    • 0033593230 scopus 로고    scopus 로고
    • Bax-induced caspase activation and apoptosis via cytochrome c release from mitochondria is inhibitable by Bcl-xL
    • D.M. Finucane, E. Bossy-Wetzel, N.J. Waterhouse, T.G. Cotter, and D.R. Green Bax-induced caspase activation and apoptosis via cytochrome c release from mitochondria is inhibitable by Bcl-xL J. Biol. Chem. 274 1999 2225 2233
    • (1999) J. Biol. Chem. , vol.274 , pp. 2225-2233
    • Finucane, D.M.1    Bossy-Wetzel, E.2    Waterhouse, N.J.3    Cotter, T.G.4    Green, D.R.5
  • 12
    • 0028802897 scopus 로고
    • Nucleic acid dyes for detection of apoptosis in live cells
    • T. Frey Nucleic acid dyes for detection of apoptosis in live cells Cytometry 21 1995 265 274
    • (1995) Cytometry , vol.21 , pp. 265-274
    • Frey, T.1
  • 14
    • 0036283121 scopus 로고    scopus 로고
    • PPARs: Transcriptional effectors of fatty acids and their derivatives
    • A.K. Hihi, L. Michalik, and W. Wahli PPARs: transcriptional effectors of fatty acids and their derivatives Cell. Mol. Life Sci. 59 2002 790 798
    • (2002) Cell. Mol. Life Sci. , vol.59 , pp. 790-798
    • Hihi, A.K.1    Michalik, L.2    Wahli, W.3
  • 15
    • 33748291395 scopus 로고    scopus 로고
    • Modulation of the age-related nuclear factor-kappaB (NF-kappaB) pathway by hesperetin
    • J.Y. Kim, K.J. Jung, J.S. Choi, and H.Y. Chung Modulation of the age-related nuclear factor-kappaB (NF-kappaB) pathway by hesperetin Aging Cell 5 2006 401 411
    • (2006) Aging Cell , vol.5 , pp. 401-411
    • Kim, J.Y.1    Jung, K.J.2    Choi, J.S.3    Chung, H.Y.4
  • 16
    • 35448982383 scopus 로고    scopus 로고
    • Biology of PPAR gamma in cancer: A critical review on existing lacunae
    • A. Krishnan, S.A. Nair, and M.R. Pillai Biology of PPAR gamma in cancer: a critical review on existing lacunae Curr. Mol. Med. 7 2007 532 540
    • (2007) Curr. Mol. Med. , vol.7 , pp. 532-540
    • Krishnan, A.1    Nair, S.A.2    Pillai, M.R.3
  • 17
    • 0027285380 scopus 로고
    • P53 mutations increase resistance to ionizing radiation
    • J.M. Lee, and A. Bernstein p53 mutations increase resistance to ionizing radiation Proc. Natl Acad. Sci. USA 90 1993 5742 5746
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , pp. 5742-5746
    • Lee, J.M.1    Bernstein, A.2
  • 18
    • 77950465549 scopus 로고    scopus 로고
    • The inhibitory effect of hesperidin on tumor cell invasiveness occurs via suppression of activator protein 1 and nuclear factor-kappaB in human hepatocellular carcinoma cells
    • K.H. Lee, M.H. Yeh, S.T. Kao, C.M. Hung, C.J. Liu, Y.Y. Huang, and C.C. Yeh The inhibitory effect of hesperidin on tumor cell invasiveness occurs via suppression of activator protein 1 and nuclear factor-kappaB in human hepatocellular carcinoma cells Toxicol Lett 194 2010 42 49
    • (2010) Toxicol Lett , vol.194 , pp. 42-49
    • Lee, K.H.1    Yeh, M.H.2    Kao, S.T.3    Hung, C.M.4    Liu, C.J.5    Huang, Y.Y.6    Yeh, C.C.7
  • 19
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
    • T. Mosmann Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays J. Immunol. Meth. 65 1983 55 63
    • (1983) J. Immunol. Meth. , vol.65 , pp. 55-63
    • Mosmann, T.1
  • 20
    • 0036245961 scopus 로고    scopus 로고
    • Human B lymphocytes and B lymphomas express PPAR-gamma and are killed by PPAR-gamma agonists
    • J. Padilla, E. Leung, and R.P. Phipps Human B lymphocytes and B lymphomas express PPAR-gamma and are killed by PPAR-gamma agonists Clin. Immunol. 103 2002 22 33
    • (2002) Clin. Immunol. , vol.103 , pp. 22-33
    • Padilla, J.1    Leung, E.2    Phipps, R.P.3
  • 21
    • 0035093490 scopus 로고    scopus 로고
    • Interactive effect of hesperidin and vitamin e supplements on cholesterol metabolism in high cholesterol-fed rats
    • Y.B. Park, K.M. Do, S.H. Bok, M.K. Lee, T.S. Jeong, and M.S. Choi Interactive effect of hesperidin and vitamin E supplements on cholesterol metabolism in high cholesterol-fed rats Int. J. Vitam. Nutr. Res. 71 2001 36 44
    • (2001) Int. J. Vitam. Nutr. Res. , vol.71 , pp. 36-44
    • Park, Y.B.1    Do, K.M.2    Bok, S.H.3    Lee, M.K.4    Jeong, T.S.5    Choi, M.S.6
  • 22
    • 33750685296 scopus 로고    scopus 로고
    • [6]-Gingerol induces cell cycle arrest and cell death of mutant p53-expressing pancreatic cancer cells
    • Y.J. Park, J. Wen, S. Bang, S.W. Park, and S.Y. Song [6]-Gingerol induces cell cycle arrest and cell death of mutant p53-expressing pancreatic cancer cells Yonsei Med. J. 47 2006 688 697
    • (2006) Yonsei Med. J. , vol.47 , pp. 688-697
    • Park, Y.J.1    Wen, J.2    Bang, S.3    Park, S.W.4    Song, S.Y.5
  • 23
    • 37349110272 scopus 로고    scopus 로고
    • Apoptotic effect of hesperidin through caspase3 activation in human colon cancer cells, SNU-C4
    • H.J. Park, M.J. Kim, E. Ha, and J.H. Chung Apoptotic effect of hesperidin through caspase3 activation in human colon cancer cells, SNU-C4 Phytomedicine 15 2008 147 151
    • (2008) Phytomedicine , vol.15 , pp. 147-151
    • Park, H.J.1    Kim, M.J.2    Ha, E.3    Chung, J.H.4
  • 24
    • 72449199438 scopus 로고    scopus 로고
    • Bioactive compounds from Mexican lime (Citrus aurantifolia) juice induce apoptosis in human pancreatic cells
    • J.R. Patil, K.N. Chidambara Murthy, G.K. Jayaprakasha, M.B. Chetti, and B.S. Patil Bioactive compounds from Mexican lime (Citrus aurantifolia) juice induce apoptosis in human pancreatic cells J. Agric. Food Chem. 57 2009 10933 10942
    • (2009) J. Agric. Food Chem. , vol.57 , pp. 10933-10942
    • Patil, J.R.1    Chidambara Murthy, K.N.2    Jayaprakasha, G.K.3    Chetti, M.B.4    Patil, B.S.5
  • 25
    • 13544263219 scopus 로고    scopus 로고
    • 15-Deoxy-delta 12, 14-prostaglandin J2 induces apoptosis in human malignant B cells: An effect associated with inhibition of NF-kappa B activity and down-regulation of antiapoptotic proteins
    • R. Piva, P. Gianferretti, A. Ciucci, R. Taulli, G. Belardo, and M.G. Santoro 15-Deoxy-delta 12, 14-prostaglandin J2 induces apoptosis in human malignant B cells: an effect associated with inhibition of NF-kappa B activity and down-regulation of antiapoptotic proteins Blood 105 2005 1750 1758
    • (2005) Blood , vol.105 , pp. 1750-1758
    • Piva, R.1    Gianferretti, P.2    Ciucci, A.3    Taulli, R.4    Belardo, G.5    Santoro, M.G.6
  • 26
    • 0036400016 scopus 로고    scopus 로고
    • Dietary flavonoids: Bioavailability, metabolic effects, and safety
    • J.A. Ross, and C.M. Kasum Dietary flavonoids: bioavailability, metabolic effects, and safety Annu. Rev. Nutr. 22 2002 19 34
    • (2002) Annu. Rev. Nutr. , vol.22 , pp. 19-34
    • Ross, J.A.1    Kasum, C.M.2
  • 28
    • 37849027240 scopus 로고    scopus 로고
    • Novel PPAR-gamma agonists identified from a natural product library: A virtual screening, induced-fit docking and biological assay study
    • N.K. Salam, T.H. Huang, B.P. Kota, M.S. Kim, Y. Li, and D.E. Hibbs Novel PPAR-gamma agonists identified from a natural product library: a virtual screening, induced-fit docking and biological assay study Chem. Biol. Drug Des. 71 2008 57 70
    • (2008) Chem. Biol. Drug Des. , vol.71 , pp. 57-70
    • Salam, N.K.1    Huang, T.H.2    Kota, B.P.3    Kim, M.S.4    Li, Y.5    Hibbs, D.E.6
  • 30
    • 33747383912 scopus 로고    scopus 로고
    • Troglitazone sensitizes tumor cells to TRAIL-induced apoptosis via down-regulation of FLIP and Survivin
    • K. Schultze, B. Bock, A. Eckert, L. Oevermann, D. Ramacher, O. Wiestler, and W. Roth Troglitazone sensitizes tumor cells to TRAIL-induced apoptosis via down-regulation of FLIP and Survivin Apoptosis 11 2006 1503 1512
    • (2006) Apoptosis , vol.11 , pp. 1503-1512
    • Schultze, K.1    Bock, B.2    Eckert, A.3    Oevermann, L.4    Ramacher, D.5    Wiestler, O.6    Roth, W.7
  • 31
    • 13944280963 scopus 로고    scopus 로고
    • Thiazolidenediones mediate apoptosis in prostate cancer cells in part through inhibition of Bcl-xL/Bcl-2 functions independently of PPARgamma
    • C.W. Shiau, C.C. Yang, S.K. Kulp, K.F. Chen, C.S. Chen, and J.W. Huang Thiazolidenediones mediate apoptosis in prostate cancer cells in part through inhibition of Bcl-xL/Bcl-2 functions independently of PPARgamma Cancer Res. 65 2005 1561 1569
    • (2005) Cancer Res. , vol.65 , pp. 1561-1569
    • Shiau, C.W.1    Yang, C.C.2    Kulp, S.K.3    Chen, K.F.4    Chen, C.S.5    Huang, J.W.6
  • 32
    • 33644755512 scopus 로고    scopus 로고
    • Down-regulating constitutive activation of the NF-kappaB canonical pathway overcomes the resistance of cutaneous T-cell lymphoma to apoptosis
    • A. Sors, F. Jean-Louis, C. Pellet, L. Laroche, L. Dubertret, G. Courtois, H. Bachelez, and L. Michel Down-regulating constitutive activation of the NF-kappaB canonical pathway overcomes the resistance of cutaneous T-cell lymphoma to apoptosis Blood 107 2006 2354 2363
    • (2006) Blood , vol.107 , pp. 2354-2363
    • Sors, A.1    Jean-Louis, F.2    Pellet, C.3    Laroche, L.4    Dubertret, L.5    Courtois, G.6    Bachelez, H.7    Michel, L.8
  • 33
    • 52049095036 scopus 로고    scopus 로고
    • New insights into NF-kappaB regulation and function
    • S.C. Sun, and S.C. Ley New insights into NF-kappaB regulation and function Trends Immunol. 29 2008 469 478
    • (2008) Trends Immunol. , vol.29 , pp. 469-478
    • Sun, S.C.1    Ley, S.C.2
  • 34
    • 0032403126 scopus 로고    scopus 로고
    • IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs
    • I. Tamm, Y. Wang, E. Sausville, D.A. Scudiero, N. Vigna, T. Oltersdorf, and J.C. Reed IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs Cancer Res. 58 1998 5315 5320
    • (1998) Cancer Res. , vol.58 , pp. 5315-5320
    • Tamm, I.1    Wang, Y.2    Sausville, E.3    Scudiero, D.A.4    Vigna, N.5    Oltersdorf, T.6    Reed, J.C.7
  • 35
    • 0028990125 scopus 로고
    • Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase
    • M. Tewari, L.T. Quan, K. O'Rourke, S. Desnoyers, Z. Zeng, D.R. Beidler, G.G. Poirier, G.S. Salvesen, and V.M. Dixit Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase Cell 81 1995 801 809
    • (1995) Cell , vol.81 , pp. 801-809
    • Tewari, M.1    Quan, L.T.2    O'Rourke, K.3    Desnoyers, S.4    Zeng, Z.5    Beidler, D.R.6    Poirier, G.G.7    Salvesen, G.S.8    Dixit, V.M.9
  • 36
    • 0035989516 scopus 로고    scopus 로고
    • Polyphenol antioxidants in citrus juices: In vitro and in vivo studies relevant to heart disease
    • J.A. Vinson, X. Liang, J. Proch, B.A. Hontz, J. Dancel, and N. Sandone Polyphenol antioxidants in citrus juices: in vitro and in vivo studies relevant to heart disease Adv. Exp. Med. Biol. 505 2002 113 122
    • (2002) Adv. Exp. Med. Biol. , vol.505 , pp. 113-122
    • Vinson, J.A.1    Liang, X.2    Proch, J.3    Hontz, B.A.4    Dancel, J.5    Sandone, N.6
  • 37
    • 43549100859 scopus 로고    scopus 로고
    • A gut feeling of the PXR, PPAR and NF-kappaB connection
    • W. Wahli A gut feeling of the PXR, PPAR and NF-kappaB connection J. Intern. Med. 263 2008 613 619
    • (2008) J. Intern. Med. , vol.263 , pp. 613-619
    • Wahli, W.1
  • 39
    • 21644479440 scopus 로고    scopus 로고
    • Antioxidant activity of the flavonoid hesperidin in chemical and biological systems
    • P.K. Wilmsen, D.S. Spada, and M. Salvador Antioxidant activity of the flavonoid hesperidin in chemical and biological systems J. Agric. Food Chem. 53 2005 4757 4761
    • (2005) J. Agric. Food Chem. , vol.53 , pp. 4757-4761
    • Wilmsen, P.K.1    Spada, D.S.2    Salvador, M.3
  • 40
    • 40949141088 scopus 로고    scopus 로고
    • Short-term effects of glucosyl hesperidin and hesperetin on blood pressure and vascular endothelial function in spontaneously hypertensive rats
    • M. Yamamoto, A. Suzuki, and T. Hase Short-term effects of glucosyl hesperidin and hesperetin on blood pressure and vascular endothelial function in spontaneously hypertensive rats J. Nutr. Sci. Vitaminol. (Tokyo) 54 2008 95 98
    • (2008) J. Nutr. Sci. Vitaminol. (Tokyo) , vol.54 , pp. 95-98
    • Yamamoto, M.1    Suzuki, A.2    Hase, T.3
  • 41
    • 57549084878 scopus 로고    scopus 로고
    • Citrus fruit flavonoids influence on neutrophil apoptosis and oxidative metabolism
    • M. Zielinska-Przyjemska, and E. Ignatowicz Citrus fruit flavonoids influence on neutrophil apoptosis and oxidative metabolism Phytother. Res. 22 2008 1557 1562
    • (2008) Phytother. Res. , vol.22 , pp. 1557-1562
    • Zielinska-Przyjemska, M.1    Ignatowicz, E.2


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