-
1
-
-
54549091125
-
Systems biology: metabonomics
-
Nicholson, J.K. and Lindon, J.C. (2008) Systems biology: metabonomics. Nature, 455, 1054-1056.
-
(2008)
Nature
, vol.455
, pp. 1054-1056
-
-
Nicholson, J.K.1
Lindon, J.C.2
-
2
-
-
84867744660
-
Genetic variation in metabolic phenotypes: study designs and applications
-
Suhre, K. and Gieger, C. (2012) Genetic variation in metabolic phenotypes: study designs and applications. Nat. Rev. Genet., 13, 759-769.
-
(2012)
Nat. Rev. Genet.
, vol.13
, pp. 759-769
-
-
Suhre, K.1
Gieger, C.2
-
3
-
-
57149114936
-
Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum
-
Gieger, C., Geistlinger, L., Altmaier, E., Hrabe de Angelis, M., Kronenberg, F., Meitinger, T., Mewes, H.W., Wichmann, H.E., Weinberger, K.M., Adamski, J. et al. (2008) Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum. PLoS. Genet., 4, e1000282.
-
(2008)
PLoS. Genet.
, vol.4
-
-
Gieger, C.1
Geistlinger, L.2
Altmaier, E.3
Hrabe de Angelis, M.4
Kronenberg, F.5
Meitinger, T.6
Mewes, H.W.7
Wichmann, H.E.8
Weinberger, K.M.9
Adamski, J.10
-
4
-
-
84861810217
-
On the hypothesis-free testing of metabolite ratios in genome-wide and metabolome-wide association studies
-
Petersen, A.K., Krumsiek, J., Wagele, B., Theis, F.J., Wichmann, H.E., Gieger, C. and Suhre, K. (2012) On the hypothesis-free testing of metabolite ratios in genome-wide and metabolome-wide association studies. BMC Bioinformatics, 13, 120.
-
(2012)
BMC Bioinformatics
, vol.13
, pp. 120
-
-
Petersen, A.K.1
Krumsiek, J.2
Wagele, B.3
Theis, F.J.4
Wichmann, H.E.5
Gieger, C.6
Suhre, K.7
-
5
-
-
84929287746
-
Metabolic traits as intermediate phenotypes
-
In Suhre K. (ed). Springer New York
-
Kronenberg, F. (2012) Metabolic traits as intermediate phenotypes. In Suhre, K. (ed), Genetics Meets Metabolomics. Springer, New York, pp. 255-264.
-
(2012)
Genetics Meets Metabolomics
, pp. 255-264
-
-
Kronenberg, F.1
-
6
-
-
84876678696
-
Integrative genetic and metabolite profiling analysis suggests altered phosphatidylcholine metabolism in asthma
-
Ried, J.S., Baurecht, H., Stuckler, F., Krumsiek, J., Gieger, C., Heinrich, J., Kabesch, M., Prehn, C., Peters, A., Rodriguez, E. et al. (2013) Integrative genetic and metabolite profiling analysis suggests altered phosphatidylcholine metabolism in asthma. Allergy, 68, 629-636.
-
(2013)
Allergy
, vol.68
, pp. 629-636
-
-
Ried, J.S.1
Baurecht, H.2
Stuckler, F.3
Krumsiek, J.4
Gieger, C.5
Heinrich, J.6
Kabesch, M.7
Prehn, C.8
Peters, A.9
Rodriguez, E.10
-
7
-
-
73449117605
-
Genetic determinants of circulating sphingolipid concentrations in European populations
-
Hicks, A.A., Pramstaller, P.P., Johansson, A., Vitart, V., Rudan, I., Ugocsai, P., Aulchenko, Y., Franklin, C.S., Liebisch, G., Erdmann, J. et al. (2009) Genetic determinants of circulating sphingolipid concentrations in European populations. PLoSGenet., 5, e1000672.
-
(2009)
PLoSGenet.
, vol.5
-
-
Hicks, A.A.1
Pramstaller, P.P.2
Johansson, A.3
Vitart, V.4
Rudan, I.5
Ugocsai, P.6
Aulchenko, Y.7
Franklin, C.S.8
Liebisch, G.9
Erdmann, J.10
-
8
-
-
75749134031
-
A genome-wide perspective of genetic variation in human metabolism
-
Illig, T., Gieger, C., Zhai, G., Romisch-Margl, W., Wang-Sattler, R., Prehn, C., Altmaier, E., Kastenmuller, G., Kato, B.S., Mewes, H.W. et al. (2010) A genome-wide perspective of genetic variation in human metabolism. Nat. Genet., 42, 137-141.
-
(2010)
Nat. Genet.
, vol.42
, pp. 137-141
-
-
Illig, T.1
Gieger, C.2
Zhai, G.3
Romisch-Margl, W.4
Wang-Sattler, R.5
Prehn, C.6
Altmaier, E.7
Kastenmuller, G.8
Kato, B.S.9
Mewes, H.W.10
-
9
-
-
79957604338
-
A genome-wide association study of metabolic traits in human urine
-
Suhre, K., Wallaschofski, H., Raffler, J., Friedrich, N., Haring, R., Michael, K., Wasner, C., Krebs, A., Kronenberg, F., Chang, D. et al. (2011) A genome-wide association study of metabolic traits in human urine. Nat. Genet., 43, 565-569.
-
(2011)
Nat. Genet.
, vol.43
, pp. 565-569
-
-
Suhre, K.1
Wallaschofski, H.2
Raffler, J.3
Friedrich, N.4
Haring, R.5
Michael, K.6
Wasner, C.7
Krebs, A.8
Kronenberg, F.9
Chang, D.10
-
10
-
-
80052398214
-
Human metabolic individuality in biomedical and pharmaceutical research
-
Suhre, K., Shin, S.Y., Petersen, A.K., Mohney, R.P., Meredith, D., Wägele, B., Altmaier, E., CARDIoGRAM; Deloukas, P., Erdmann, J. et al. (2011) Human metabolic individuality in biomedical and pharmaceutical research. Nature, 477, 54-60.
-
(2011)
Nature
, vol.477
, pp. 54-60
-
-
Suhre, K.1
Shin, S.Y.2
Petersen, A.K.3
Mohney, R.P.4
Meredith, D.5
Wägele, B.6
Altmaier, E.7
Deloukas, P.8
Erdmann, J.9
-
11
-
-
80053456207
-
A genome-wide metabolic QTL analysis in Europeans implicates two loci shaped by recent positive selection
-
Nicholson, G., Rantalainen, M., Li, J.V., Maher, A.D., Malmodin, D., Ahmadi, K.R., Faber, J.H., Barrett, A., Min, J.L., Rayner, N.W. et al. (2011) A genome-wide metabolic QTL analysis in Europeans implicates two loci shaped by recent positive selection. PLoS Genet., 7, e1002270.
-
(2011)
PLoS Genet.
, vol.7
-
-
Nicholson, G.1
Rantalainen, M.2
Li, J.V.3
Maher, A.D.4
Malmodin, D.5
Ahmadi, K.R.6
Faber, J.H.7
Barrett, A.8
Min, J.L.9
Rayner, N.W.10
-
12
-
-
84857648463
-
Genome-wide association study identifies multiple loci influencing human serum metabolite levels
-
Kettunen, J., Tukiainen, T., Sarin, A.P., Ortega-Alonso, A., Tikkanen, E., Lyytikainen, L.P., Kangas, A.J., Soininen, P., Wurtz, P., Silander, K. et al. (2012) Genome-wide association study identifies multiple loci influencing human serum metabolite levels. Nat. Genet., 44, 269-276.
-
(2012)
Nat. Genet.
, vol.44
, pp. 269-276
-
-
Kettunen, J.1
Tukiainen, T.2
Sarin, A.P.3
Ortega-Alonso, A.4
Tikkanen, E.5
Lyytikainen, L.P.6
Kangas, A.J.7
Soininen, P.8
Wurtz, P.9
Silander, K.10
-
13
-
-
84859190557
-
Genome-wide association study identifies novel loci associated with circulating phosphoand sphingolipid concentrations
-
Demirkan, A., van Duijn, C.M., Ugocsai, P., Isaacs, A., Pramstaller, P.P., Liebisch, G., Wilson, J.F., Johansson, A., Rudan, I., Aulchenko, Y.S. et al. (2012) Genome-wide association study identifies novel loci associated with circulating phosphoand sphingolipid concentrations. PLoS Genet., 8, e1002490.
-
(2012)
PLoS Genet.
, vol.8
-
-
Demirkan, A.1
van Duijn, C.M.2
Ugocsai, P.3
Isaacs, A.4
Pramstaller, P.P.5
Liebisch, G.6
Wilson, J.F.7
Johansson, A.8
Rudan, I.9
Aulchenko, Y.S.10
-
14
-
-
84857684406
-
Detailed metabolic and genetic characterization reveals new associations for 30 known lipid loci
-
Tukiainen, T., Kettunen, J., Kangas, A.J., Lyytikainen, L.P., Soininen, P., Sarin, A.P., Tikkanen, E., O'Reilly, P.F., Savolainen, M.J., Kaski, K. et al. (2012) Detailed metabolic and genetic characterization reveals new associations for 30 known lipid loci. Hum. Mol. Genet., 21, 1444-1455.
-
(2012)
Hum. Mol. Genet.
, vol.21
, pp. 1444-1455
-
-
Tukiainen, T.1
Kettunen, J.2
Kangas, A.J.3
Lyytikainen, L.P.4
Soininen, P.5
Sarin, A.P.6
Tikkanen, E.7
O'Reilly, P.F.8
Savolainen, M.J.9
Kaski, K.10
-
15
-
-
84866156922
-
Novel loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis
-
Inouye, M., Ripatti, S., Kettunen, J., Lyytikainen, L.P., Oksala, N., Laurila, P.P., Kangas, A.J., Soininen, P., Savolainen, M.J., Viikari, J. et al. (2012) Novel loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis. PLoS Genet., 8, e1002907.
-
(2012)
PLoS Genet.
, vol.8
-
-
Inouye, M.1
Ripatti, S.2
Kettunen, J.3
Lyytikainen, L.P.4
Oksala, N.5
Laurila, P.P.6
Kangas, A.J.7
Soininen, P.8
Savolainen, M.J.9
Viikari, J.10
-
16
-
-
84868112190
-
Mining the unknown: a systems approach to metabolite identification combining genetic and metabolic information
-
Krumsiek, J., Suhre, K., Evans, A.M., Mitchell, M.W., Mohney, R.P., Milburn, M.V., Wagele, B., Romisch-Margl, W., Illig, T., Adamski, J. et al. (2012) Mining the unknown: a systems approach to metabolite identification combining genetic and metabolic information. PLoS Genet., 8, e1003005.
-
(2012)
PLoS Genet.
, vol.8
-
-
Krumsiek, J.1
Suhre, K.2
Evans, A.M.3
Mitchell, M.W.4
Mohney, R.P.5
Milburn, M.V.6
Wagele, B.7
Romisch-Margl, W.8
Illig, T.9
Adamski, J.10
-
17
-
-
84872403982
-
Current status on genomemetabolome-wide associations: an opportunity in nutrition research
-
Montoliu, I., Genick, U., Ledda, M., Collino, S., Martin, F.P., le Coutre, J. and Rezzi, S. (2013) Current status on genomemetabolome-wide associations: an opportunity in nutrition research. Genes Nutr., 8, 19-27.
-
(2013)
Genes Nutr.
, vol.8
, pp. 19-27
-
-
Montoliu, I.1
Genick, U.2
Ledda, M.3
Collino, S.4
Martin, F.P.5
le Coutre, J.6
Rezzi, S.7
-
18
-
-
84873714655
-
Identification and MS-assisted interpretation of genetically influenced NMR signals in human plasma
-
Raffler, J., Romisch-Margl, W., Petersen, A.K., Pagel, P., Blochl, F., Hengstenberg, C., Illig, T., Meisinger, C., Stark, K., Wichmann, H.E. et al. (2013) Identification and MS-assisted interpretation of genetically influenced NMR signals in human plasma. Genome. Med., 5, 13.
-
(2013)
Genome. Med.
, vol.5
, pp. 13
-
-
Raffler, J.1
Romisch-Margl, W.2
Petersen, A.K.3
Pagel, P.4
Blochl, F.5
Hengstenberg, C.6
Illig, T.7
Meisinger, C.8
Stark, K.9
Wichmann, H.E.10
-
19
-
-
84873949476
-
A genome-wide assessment of variability in human serum metabolism
-
Hong, M.G., Karlsson, R., Magnusson, P.K., Lewis, M.R., Isaacs, W., Zheng, L.S., Xu, J., Gronberg, H., Ingelsson, E., Pawitan, Y. et al. (2013) A genome-wide assessment of variability in human serum metabolism. Hum. Mutat., 34, 515-524.
-
(2013)
Hum. Mutat.
, vol.34
, pp. 515-524
-
-
Hong, M.G.1
Karlsson, R.2
Magnusson, P.K.3
Lewis, M.R.4
Isaacs, W.5
Zheng, L.S.6
Xu, J.7
Gronberg, H.8
Ingelsson, E.9
Pawitan, Y.10
-
20
-
-
84879867981
-
A genome-wide association study of the human metabolome in a community-based cohort
-
Rhee, E.P., Ho, J.E., Chen, M.H., Shen, D., Cheng, S., Larson, M.G., Ghorbani, A., Shi, X., Helenius, I.T., O'Donnell, C.J. et al. (2013) A genome-wide association study of the human metabolome in a community-based cohort. Cell Metab., 18, 130-143.
-
(2013)
Cell Metab.
, vol.18
, pp. 130-143
-
-
Rhee, E.P.1
Ho, J.E.2
Chen, M.H.3
Shen, D.4
Cheng, S.5
Larson, M.G.6
Ghorbani, A.7
Shi, X.8
Helenius, I.T.9
O'Donnell, C.J.10
-
21
-
-
84901742293
-
Genome-wide association study of metabolic traits reveals novel gene-metabolite-disease links
-
Rueedi, R., Ledda, M., Nicholls, A.W., Salek, R.M., Marques-Vidal, P., Morya, E., Sameshima, K., Montoliu, I., Da Silva, L., Collino, S. et al. (2014) Genome-wide association study of metabolic traits reveals novel gene-metabolite-disease links. PLoS Genet., 10, e1004132.
-
(2014)
PLoS Genet.
, vol.10
-
-
Rueedi, R.1
Ledda, M.2
Nicholls, A.W.3
Salek, R.M.4
Marques-Vidal, P.5
Morya, E.6
Sameshima, K.7
Montoliu, I.8
Da Silva, L.9
Collino, S.10
-
22
-
-
84897399605
-
Genetic determinants influencing human serum metabolome among African Americans
-
Yu, B., Zheng, Y., Alexander, D., Morrison, A.C., Coresh, J. and Boerwinkle, E. (2014) Genetic determinants influencing human serum metabolome among African Americans. PLoS Genet., 10, e1004212.
-
(2014)
PLoS Genet.
, vol.10
-
-
Yu, B.1
Zheng, Y.2
Alexander, D.3
Morrison, A.C.4
Coresh, J.5
Boerwinkle, E.6
-
23
-
-
84901686870
-
An atlas of genetic influences on human blood metabolites
-
Shin, S.-Y., Fauman, E.B., Petersen, A.-K., Krumsiek, J., Santos, R., Huang, J., Arnold, M., Erte, I., Forgetta, V., Yang, T.-P. et al. (2014) An atlas of genetic influences on human blood metabolites. Nat. Genet., 46, 543-550.
-
(2014)
Nat. Genet.
, vol.46
, pp. 543-550
-
-
Shin, S.-Y.1
Fauman, E.B.2
Petersen, A.-K.3
Krumsiek, J.4
Santos, R.5
Huang, J.6
Arnold, M.7
Erte, I.8
Forgetta, V.9
Yang, T.-P.10
-
24
-
-
84991510620
-
Novel genetic associations with serum level metabolites identified by phenotype set enrichment analyses
-
Ried, J.S., Shin, S.Y., Krumsiek, J., Illig, T., Theis, F.J., Spector, T.D., Adamski, J., Wichmann, H.E., Strauch, K., Soranzo, N. et al. (2014) Novel genetic associations with serum level metabolites identified by phenotype set enrichment analyses. Hum. Mol. Genet., 23, 5847-5857.
-
(2014)
Hum. Mol. Genet.
, vol.23
, pp. 5847-5857
-
-
Ried, J.S.1
Shin, S.Y.2
Krumsiek, J.3
Illig, T.4
Theis, F.J.5
Spector, T.D.6
Adamski, J.7
Wichmann, H.E.8
Strauch, K.9
Soranzo, N.10
-
25
-
-
84924402386
-
Insight in genome-wide association of metabolite quantitative traits by exome sequence analyses
-
Demirkan, A., Henneman, P., Verhoeven, A., Dharuri, H., Amin, N., van Klinken, J.B., Karssen, L.C., de Vries, B., Meissner, A., Goraler, S. et al. (2015) Insight in genome-wide association of metabolite quantitative traits by exome sequence analyses. PLoS Genet., 11, e1004835.
-
(2015)
PLoS Genet.
, vol.11
-
-
Demirkan, A.1
Henneman, P.2
Verhoeven, A.3
Dharuri, H.4
Amin, N.5
van Klinken, J.B.6
Karssen, L.C.7
de Vries, B.8
Meissner, A.9
Goraler, S.10
-
26
-
-
84935910747
-
Genome wide association study identifies novel genetic variants contributing to variation in blood metabolite levels
-
Draisma, H.H., Pool, R., Kobl, M., Jansen, R., Petersen, A.K., Vaarhorst, A.A., Yet, I., Haller, T., Demirkan, A., Esko, T. et al. (2015) Genome wide association study identifies novel genetic variants contributing to variation in blood metabolite levels. Nat. Commun., 6, 7208.
-
(2015)
Nat. Commun.
, vol.6
, pp. 7208
-
-
Draisma, H.H.1
Pool, R.2
Kobl, M.3
Jansen, R.4
Petersen, A.K.5
Vaarhorst, A.A.6
Yet, I.7
Haller, T.8
Demirkan, A.9
Esko, T.10
-
27
-
-
84907222785
-
Genetic, anatomic, and clinical determinants of human serum sterol and vitamin D levels
-
Stiles, A.R., Kozlitina, J., Thompson, B.M., McDonald, J.G., King, K.S. and Russell, D.W. (2014) Genetic, anatomic, and clinical determinants of human serum sterol and vitamin D levels. Proc. Natl. Acad. Sci. USA, 111, E4006-E4014.
-
(2014)
Proc. Natl. Acad. Sci. USA
, vol.111
, pp. E4006-E4014
-
-
Stiles, A.R.1
Kozlitina, J.2
Thompson, B.M.3
McDonald, J.G.4
King, K.S.5
Russell, D.W.6
-
28
-
-
84961289830
-
Genome-wide association study of plasma levels of polychlorinated biphenyls disclose an association with the CYP2B6 gene in a population-based sample
-
Ng, E., Salihovic, S., Monica Lind, P., Mahajan, A., Syvanen, A.C., Axelsson, T., Ingelsson, E., Lindgren, C.M., van Bavel, B., Morris, A.P. et al. (2015) Genome-wide association study of plasma levels of polychlorinated biphenyls disclose an association with the CYP2B6 gene in a population-based sample. Environ. Res., 140, 95-101.
-
(2015)
Environ. Res.
, vol.140
, pp. 95-101
-
-
Ng, E.1
Salihovic, S.2
Monica Lind, P.3
Mahajan, A.4
Syvanen, A.C.5
Axelsson, T.6
Ingelsson, E.7
Lindgren, C.M.8
van Bavel, B.9
Morris, A.P.10
-
29
-
-
84878256943
-
Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes
-
Xie, W., Wood, A.R., Lyssenko, V., Weedon, M.N., Knowles, J.W., Alkayyali, S., Assimes, T.L., Quertermous, T., Abbasi, F., Paananen, J. et al. (2013) Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes. Diabetes, 62, 2141-2150.
-
(2013)
Diabetes
, vol.62
, pp. 2141-2150
-
-
Xie, W.1
Wood, A.R.2
Lyssenko, V.3
Weedon, M.N.4
Knowles, J.W.5
Alkayyali, S.6
Assimes, T.L.7
Quertermous, T.8
Abbasi, F.9
Paananen, J.10
-
30
-
-
84878092875
-
Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium
-
Wu, J.H., Lemaitre, R.N., Manichaikul, A., Guan, W., Tanaka, T., Foy, M., Kabagambe, E.K., Djousse, L., Siscovick, D., Fretts, A.M. et al. (2013) Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. Circ. Cardiovasc. Genet., 6, 171-183.
-
(2013)
Circ. Cardiovasc. Genet.
, vol.6
, pp. 171-183
-
-
Wu, J.H.1
Lemaitre, R.N.2
Manichaikul, A.3
Guan, W.4
Tanaka, T.5
Foy, M.6
Kabagambe, E.K.7
Djousse, L.8
Siscovick, D.9
Fretts, A.M.10
-
31
-
-
84860458015
-
A genome-wide association study of total bilirubin and cholelithiasis risk in sickle cell anemia
-
Ilton, J.N., Sebastiani, P., Solovieff, N., Hartley, S.W., Bhatnagar, P., Arking, D.E., Dworkis, D.A., Casella, J.F., Barron-Casella, E., Bean, C.J. et al. (2012) A genome-wide association study of total bilirubin and cholelithiasis risk in sickle cell anemia. PLoS One, 7, e34741.
-
(2012)
PLoS One
, vol.7
-
-
Ilton, J.N.1
Sebastiani, P.2
Solovieff, N.3
Hartley, S.W.4
Bhatnagar, P.5
Arking, D.E.6
Dworkis, D.A.7
Casella, J.F.8
Barron-Casella, E.9
Bean, C.J.10
-
32
-
-
84858337105
-
UGT1A1 is a major locus influencing bilirubin levels in African Americans
-
Chen, G., Ramos, E., Adeyemo, A., Shriner, D., Zhou, J., Doumatey, A.P., Huang, H., Erdos, M.R., Gerry, N.P., Herbert, A. et al. (2012) UGT1A1 is a major locus influencing bilirubin levels in African Americans. Eur. J. Hum. Genet., 20, 463-468.
-
(2012)
Eur. J. Hum. Genet.
, vol.20
, pp. 463-468
-
-
Chen, G.1
Ramos, E.2
Adeyemo, A.3
Shriner, D.4
Zhou, J.5
Doumatey, A.P.6
Huang, H.7
Erdos, M.R.8
Gerry, N.P.9
Herbert, A.10
-
33
-
-
77956154650
-
Genome-wide association of serum bilirubin levels in Korean population
-
Kang, T.W., Kim, H.J., Ju, H., Kim, J.H., Jeon, Y.J., Lee, H.C., Kim, K.K., Kim, J.W., Lee, S., Kim, J.Y. et al. (2010) Genome-wide association of serum bilirubin levels in Korean population. Hum. Mol. Genet., 19, 3672-3678.
-
(2010)
Hum. Mol. Genet.
, vol.19
, pp. 3672-3678
-
-
Kang, T.W.1
Kim, H.J.2
Ju, H.3
Kim, J.H.4
Jeon, Y.J.5
Lee, H.C.6
Kim, K.K.7
Kim, J.W.8
Lee, S.9
Kim, J.Y.10
-
34
-
-
67649838598
-
Genome-wide association metaanalysis for total serum bilirubin levels
-
Johnson, A.D., Kavousi, M., Smith, A.V., Chen, M.H., Dehghan, A., Aspelund, T., Lin, J.P., van Duijn, C.M., Harris, T.B., Cupples, L.A. et al. (2009) Genome-wide association metaanalysis for total serum bilirubin levels. Hum. Mol. Genet., 18, 2700-2710.
-
(2009)
Hum. Mol. Genet.
, vol.18
, pp. 2700-2710
-
-
Johnson, A.D.1
Kavousi, M.2
Smith, A.V.3
Chen, M.H.4
Dehghan, A.5
Aspelund, T.6
Lin, J.P.7
van Duijn, C.M.8
Harris, T.B.9
Cupples, L.A.10
-
35
-
-
67651056502
-
Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations
-
Kolz, M., Johnson, T., Sanna, S., Teumer, A., Vitart, V., Perola, M., Mangino, M., Albrecht, E., Wallace, C., Farrall, M. et al. (2009) Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations. PLoS Genet., 5, e1000504.
-
(2009)
PLoS Genet.
, vol.5
-
-
Kolz, M.1
Johnson, T.2
Sanna, S.3
Teumer, A.4
Vitart, V.5
Perola, M.6
Mangino, M.7
Albrecht, E.8
Wallace, C.9
Farrall, M.10
-
36
-
-
41449093735
-
SLC2A9 influences uric acid concentrations with pronounced sex-specific effects
-
Doring, A., Gieger, C., Mehta, D., Gohlke, H., Prokisch, H., Coassin, S., Fischer, G., Henke, K., Klopp, N., Kronenberg, F. et al. (2008) SLC2A9 influences uric acid concentrations with pronounced sex-specific effects. Nat. Genet., 40, 430-436.
-
(2008)
Nat. Genet.
, vol.40
, pp. 430-436
-
-
Doring, A.1
Gieger, C.2
Mehta, D.3
Gohlke, H.4
Prokisch, H.5
Coassin, S.6
Fischer, G.7
Henke, K.8
Klopp, N.9
Kronenberg, F.10
-
37
-
-
57049083981
-
Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study
-
Dehghan, A., Kottgen, A., Yang, Q., Hwang, S.J., Kao, W.L., Rivadeneira, F., Boerwinkle, E., Levy, D., Hofman, A., Astor, B.C. et al. (2008) Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study. Lancet, 372, 1953-1961.
-
(2008)
Lancet
, vol.372
, pp. 1953-1961
-
-
Dehghan, A.1
Kottgen, A.2
Yang, Q.3
Hwang, S.J.4
Kao, W.L.5
Rivadeneira, F.6
Boerwinkle, E.7
Levy, D.8
Hofman, A.9
Astor, B.C.10
-
38
-
-
84947899575
-
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations
-
Kottgen, A., Albrecht, E., Teumer, A., Vitart, V., Krumsiek, J., Hundertmark, C., Pistis, G., Ruggiero, D., O'Seaghdha, C.M., Haller, T. et al. (2013) Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nat. Genet., 45, 145-154.
-
(2013)
Nat. Genet.
, vol.45
, pp. 145-154
-
-
Kottgen, A.1
Albrecht, E.2
Teumer, A.3
Vitart, V.4
Krumsiek, J.5
Hundertmark, C.6
Pistis, G.7
Ruggiero, D.8
O'Seaghdha, C.M.9
Haller, T.10
-
39
-
-
84894572651
-
Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality
-
Seppala, I., Kleber, M.E., Lyytikainen, L.P., Hernesniemi, J.A., Makela, K.M., Oksala, N., Laaksonen, R., Pilz, S., Tomaschitz, A., Silbernagel, G. et al. (2014) Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality. Eur. Heart J., 35, 524-531.
-
(2014)
Eur. Heart J.
, vol.35
, pp. 524-531
-
-
Seppala, I.1
Kleber, M.E.2
Lyytikainen, L.P.3
Hernesniemi, J.A.4
Makela, K.M.5
Oksala, N.6
Laaksonen, R.7
Pilz, S.8
Tomaschitz, A.9
Silbernagel, G.10
-
40
-
-
84892392892
-
Genome-wide association study identifies 3 genomic loci significantly associated with serum levels of homoarginine: the AtheroRemo Consortium
-
Kleber, M.E., Seppala, I., Pilz, S., Hoffmann, M.M., Tomaschitz, A., Oksala, N., Raitoharju, E., Lyytikainen, L.P., Makela, K.M., Laaksonen, R. et al. (2013) Genome-wide association study identifies 3 genomic loci significantly associated with serum levels of homoarginine: the AtheroRemo Consortium. Circ. Cardiovasc. Genet., 6, 505-513.
-
(2013)
Circ. Cardiovasc. Genet.
, vol.6
, pp. 505-513
-
-
Kleber, M.E.1
Seppala, I.2
Pilz, S.3
Hoffmann, M.M.4
Tomaschitz, A.5
Oksala, N.6
Raitoharju, E.7
Lyytikainen, L.P.8
Makela, K.M.9
Laaksonen, R.10
-
41
-
-
77951768942
-
Genetic loci influencing kidney function and chronic kidney disease
-
Chambers, J.C., Zhang, W., Lord, G.M., van der Harst, P., Lawlor, D.A., Sehmi, J.S., Gale, D.P., Wass, M.N., Ahmadi, K. R., Bakker, S.J. et al. (2010) Genetic loci influencing kidney function and chronic kidney disease. Nat. Genet., 42, 373-375.
-
(2010)
Nat. Genet.
, vol.42
, pp. 373-375
-
-
Chambers, J.C.1
Zhang, W.2
Lord, G.M.3
van der Harst, P.4
Lawlor, D.A.5
Sehmi, J.S.6
Gale, D.P.7
Wass, M.N.8
Ahmadi, K.R.9
Bakker, S.J.10
-
42
-
-
84901640509
-
Genetic regulation of mouse liver metabolite levels
-
Ghazalpour, A., Bennett, B.J., Shih, D., Che, N., Orozco, L., Pan, C., Hagopian, R., He, A., Kayne, P., Yang, W.P. et al. (2014) Genetic regulation of mouse liver metabolite levels. Mol. Syst. Biol., 10, 730.
-
(2014)
Mol. Syst. Biol.
, vol.10
, pp. 730
-
-
Ghazalpour, A.1
Bennett, B.J.2
Shih, D.3
Che, N.4
Orozco, L.5
Pan, C.6
Hagopian, R.7
He, A.8
Kayne, P.9
Yang, W.P.10
-
43
-
-
84903595019
-
Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism
-
Chen, W., Gao, Y., Xie, W., Gong, L., Lu, K., Wang, W., Li, Y., Liu, X., Zhang, H., Dong, H. et al. (2014) Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism. Nat. Genet., 46, 714-721.
-
(2014)
Nat. Genet.
, vol.46
, pp. 714-721
-
-
Chen, W.1
Gao, Y.2
Xie, W.3
Gong, L.4
Lu, K.5
Wang, W.6
Li, Y.7
Liu, X.8
Zhang, H.9
Dong, H.10
-
44
-
-
84876148784
-
HMDB 3.0-The Human Metabolome Database in 2013
-
Wishart, D.S., Jewison, T., Guo, A.C., Wilson, M., Knox, C., Liu, Y., Djoumbou, Y., Mandal, R., Aziat, F., Dong, E. et al. (2013) HMDB 3.0-The Human Metabolome Database in 2013. Nucleic Acids Res., 41, D801-D807.
-
(2013)
Nucleic Acids Res.
, vol.41
, pp. D801-D807
-
-
Wishart, D.S.1
Jewison, T.2
Guo, A.C.3
Wilson, M.4
Knox, C.5
Liu, Y.6
Djoumbou, Y.7
Mandal, R.8
Aziat, F.9
Dong, E.10
-
45
-
-
84937053500
-
Non-additive effects of genes in human metabolomics
-
Tsepilov, Y.A., Shin, S.Y., Soranzo, N., Spector, T.D., Prehn, C., Adamski, J., Kastenmuller, G., Wang-Sattler, R., Strauch, K., Gieger, C. et al. (2015) Non-additive effects of genes in human metabolomics. Genetics, 200, 707-718.
-
(2015)
Genetics
, vol.200
, pp. 707-718
-
-
Tsepilov, Y.A.1
Shin, S.Y.2
Soranzo, N.3
Spector, T.D.4
Prehn, C.5
Adamski, J.6
Kastenmuller, G.7
Wang-Sattler, R.8
Strauch, K.9
Gieger, C.10
-
46
-
-
79251567361
-
Gaussian graphical modeling reconstructs pathway reactions from high-throughput metabolomics data
-
Krumsiek, J., Suhre, K., Illig, T., Adamski, J. and Theis, F.J. (2011) Gaussian graphical modeling reconstructs pathway reactions from high-throughput metabolomics data. BMC Syst. Biol., 5, 21.
-
(2011)
BMC Syst. Biol.
, vol.5
, pp. 21
-
-
Krumsiek, J.1
Suhre, K.2
Illig, T.3
Adamski, J.4
Theis, F.J.5
-
47
-
-
34447519008
-
Fifty years of research on the plasma kallikrein-kinin system: from protein structure and function to cell biology and in-vivo pathophysiology
-
Sainz, I.M., Pixley, R.A. and Colman, R.W. (2007) Fifty years of research on the plasma kallikrein-kinin system: from protein structure and function to cell biology and in-vivo pathophysiology. Thromb. Haemost., 98, 77-83.
-
(2007)
Thromb. Haemost.
, vol.98
, pp. 77-83
-
-
Sainz, I.M.1
Pixley, R.A.2
Colman, R.W.3
-
48
-
-
84927747554
-
SNiPA: an interactive, genetic variant-centered annotation browser
-
Arnold, M., Raffler, J., Pfeufer, A., Suhre, K. and Kastenmuller, G. (2015) SNiPA: an interactive, genetic variant-centered annotation browser. Bioinformatics, 31, 1334-1336.
-
(2015)
Bioinformatics
, vol.31
, pp. 1334-1336
-
-
Arnold, M.1
Raffler, J.2
Pfeufer, A.3
Suhre, K.4
Kastenmuller, G.5
-
49
-
-
84906026482
-
Using gene expression to improve the power of genome-wide association analysis
-
Ho, Y.Y., Baechler, E.C., Ortmann, W., Behrens, T.W., Graham, R.R., Bhangale, T.R. and Pan, W. (2014) Using gene expression to improve the power of genome-wide association analysis. Hum. Hered., 78, 94-103.
-
(2014)
Hum. Hered.
, vol.78
, pp. 94-103
-
-
Ho, Y.Y.1
Baechler, E.C.2
Ortmann, W.3
Behrens, T.W.4
Graham, R.R.5
Bhangale, T.R.6
Pan, W.7
-
50
-
-
84908377437
-
AGXT2: a promiscuous aminotransferase
-
Rodionov, R.N., Jarzebska, N., Weiss, N. and Lentz, S.R. (2014) AGXT2: a promiscuous aminotransferase. Trends Pharmacol. Sci., 35, 575-582.
-
(2014)
Trends Pharmacol. Sci.
, vol.35
, pp. 575-582
-
-
Rodionov, R.N.1
Jarzebska, N.2
Weiss, N.3
Lentz, S.R.4
-
51
-
-
0027463290
-
Identity of ?-3-aminoisobutyrate-pyruvate aminotransferase with alanine-glyoxylate aminotransferase 2
-
Kontani, Y., Kaneko, M., Kikugawa, M., Fujimoto, S. and Tamaki, N. (1993) Identity of ?-3-aminoisobutyrate-pyruvate aminotransferase with alanine-glyoxylate aminotransferase 2. Biochim. Biophys. Acta., 1156, 161-166.
-
(1993)
Biochim. Biophys. Acta.
, vol.1156
, pp. 161-166
-
-
Kontani, Y.1
Kaneko, M.2
Kikugawa, M.3
Fujimoto, S.4
Tamaki, N.5
-
52
-
-
0345910237
-
Family studies on the urinary excretion of beta-aminoisobutyric acid
-
Harris, H. (1953) Family studies on the urinary excretion of beta-aminoisobutyric acid. Ann. Eugen., 18, 43-49.
-
(1953)
Ann. Eugen.
, vol.18
, pp. 43-49
-
-
Harris, H.1
-
53
-
-
0000279797
-
beta-Aminoisobutyric acid (alpha-methyl-beta-alanine); a new amino-acid obtained from human urine
-
Crumpler, H.R., Dent, C.E., Harris, H. and Westall, R.G. (1951) beta-Aminoisobutyric acid (alpha-methyl-beta-alanine); a new amino-acid obtained from human urine. Nature, 167, 307-308.
-
(1951)
Nature
, vol.167
, pp. 307-308
-
-
Crumpler, H.R.1
Dent, C.E.2
Harris, H.3
Westall, R.G.4
-
54
-
-
84896124147
-
Alanine-glyoxylate aminotransferase 2 (AGXT2) polymorphisms have considerable impact on methylarginine and beta-aminoisobutyrate metabolism in healthy volunteers
-
Kittel, A., Muller, F., Konig, J., Mieth, M., Sticht, H., Zolk, O., Kralj, A., Heinrich, M.R., Fromm, M.F. and Maas, R. (2014) Alanine-glyoxylate aminotransferase 2 (AGXT2) polymorphisms have considerable impact on methylarginine and beta-aminoisobutyrate metabolism in healthy volunteers. PLoS One, 9, e88544.
-
(2014)
PLoS One
, vol.9
-
-
Kittel, A.1
Muller, F.2
Konig, J.3
Mieth, M.4
Sticht, H.5
Zolk, O.6
Kralj, A.7
Heinrich, M.R.8
Fromm, M.F.9
Maas, R.10
-
55
-
-
84901260638
-
Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid
-
Nguyen, L.N., Ma, D., Shui, G., Wong, P., Cazenave-Gassiot, A., Zhang, X., Wenk, M.R., Goh, E.L. and Silver, D.L. (2014) Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid. Nature, 509, 503-506.
-
(2014)
Nature
, vol.509
, pp. 503-506
-
-
Nguyen, L.N.1
Ma, D.2
Shui, G.3
Wong, P.4
Cazenave-Gassiot, A.5
Zhang, X.6
Wenk, M.R.7
Goh, E.L.8
Silver, D.L.9
-
56
-
-
84925285086
-
A decade of innovation in pharmaceutical R and D: the Chorus model
-
Owens, P.K., Raddad, E., Miller, J.W., Stille, J.R., Olovich, K.G., Smith, N.V., Jones, R.S. and Scherer, J.C. (2015) A decade of innovation in pharmaceutical R and D: the Chorus model. Nat. Rev. Drug Discov., 14, 17-28.
-
(2015)
Nat. Rev. Drug Discov.
, vol.14
, pp. 17-28
-
-
Owens, P.K.1
Raddad, E.2
Miller, J.W.3
Stille, J.R.4
Olovich, K.G.5
Smith, N.V.6
Jones, R.S.7
Scherer, J.C.8
-
57
-
-
84881315517
-
Validating therapeutic targets through human genetics
-
Plenge, R.M., Scolnick, E.M. and Altshuler, D. (2013) Validating therapeutic targets through human genetics. Nat. Rev. Drug Discov., 12, 581-594.
-
(2013)
Nat. Rev. Drug Discov.
, vol.12
, pp. 581-594
-
-
Plenge, R.M.1
Scolnick, E.M.2
Altshuler, D.3
-
58
-
-
84885018609
-
Systematic identification of trans eQTLs as putative drivers of known disease associations
-
Westra, H.J., Peters, M.J., Esko, T., Yaghootkar, H., Schurmann, C., Kettunen, J., Christiansen, M.W., Fairfax, B.P., Schramm, K., Powell, J.E. et al. (2013) Systematic identification of trans eQTLs as putative drivers of known disease associations. Nat. Genet., 45, 1238-1243.
-
(2013)
Nat. Genet.
, vol.45
, pp. 1238-1243
-
-
Westra, H.J.1
Peters, M.J.2
Esko, T.3
Yaghootkar, H.4
Schurmann, C.5
Kettunen, J.6
Christiansen, M.W.7
Fairfax, B.P.8
Schramm, K.9
Powell, J.E.10
-
59
-
-
44949201115
-
A genome-wide association study identifies protein quantitative trait loci (pQTLs)
-
Melzer, D., Perry, J.R., Hernandez, D., Corsi, A.M., Stevens, K., Rafferty, I., Lauretani, F., Murray, A., Gibbs, J.R., Paolisso, G. et al. (2008) A genome-wide association study identifies protein quantitative trait loci (pQTLs). PLoS Genet., 4, e1000072.
-
(2008)
PLoS Genet.
, vol.4
-
-
Melzer, D.1
Perry, J.R.2
Hernandez, D.3
Corsi, A.M.4
Stevens, K.5
Rafferty, I.6
Lauretani, F.7
Murray, A.8
Gibbs, J.R.9
Paolisso, G.10
-
60
-
-
84975742481
-
Genomics meets glycomics-the first GWAS study of humanN-glycomeidentifiesHNF1alpha as amaster regulator of plasma protein fucosylation
-
Lauc, G., Essafi, A., Huffman, J.E., Hayward, C., Knezevic, A., Kattla, J.J., Polasek, O., Gornik, O., Vitart, V., Abrahams, J.L. et al. (2010) Genomics meets glycomics-the first GWAS study of humanN-glycomeidentifiesHNF1alpha as amaster regulator of plasma protein fucosylation. PLoS Genet., 6, e1001256.
-
(2010)
PLoS Genet.
, vol.6
-
-
Lauc, G.1
Essafi, A.2
Huffman, J.E.3
Hayward, C.4
Knezevic, A.5
Kattla, J.J.6
Polasek, O.7
Gornik, O.8
Vitart, V.9
Abrahams, J.L.10
-
61
-
-
84897372328
-
Epigenetics meets metabolomics: an epigenome-wide association study with blood serum metabolic traits
-
Petersen, A.K., Zeilinger, S., Kastenmuller, G., Romisch-Margl, W., Brugger, M., Peters, A., Meisinger, C., Strauch, K., Hengstenberg, C., Pagel, P. et al. (2014) Epigenetics meets metabolomics: an epigenome-wide association study with blood serum metabolic traits. Hum. Mol. Genet., 23, 534-545.
-
(2014)
Hum. Mol. Genet.
, vol.23
, pp. 534-545
-
-
Petersen, A.K.1
Zeilinger, S.2
Kastenmuller, G.3
Romisch-Margl, W.4
Brugger, M.5
Peters, A.6
Meisinger, C.7
Strauch, K.8
Hengstenberg, C.9
Pagel, P.10
-
62
-
-
84937790219
-
The human blood metabolome-transcriptome interface
-
Bartel, J., Krumsiek, J., Schramm, K., Adamski, J., Gieger, C., Herder, C., Carstensen, M., Peters, A., Rathmann, W., Roden, M. et al. (2015) The human blood metabolome-transcriptome interface. PLoS Genet., 11, e1005274.
-
(2015)
PLoS Genet.
, vol.11
-
-
Bartel, J.1
Krumsiek, J.2
Schramm, K.3
Adamski, J.4
Gieger, C.5
Herder, C.6
Carstensen, M.7
Peters, A.8
Rathmann, W.9
Roden, M.10
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