Genome-wide association study of plasma levels of polychlorinated biphenyls disclose an association with the CYP2B6 gene in a population-based sample

Environmental Research

Volumn 140, Issue , 2015, Pages 95-101

  Ng, Esther ^a   Salihovic, Samira ^b   Monica Lind, P ^b   Mahajan, Anubha ^a   Syvänen, Anne Christine ^b   Axelsson, Tomas ^b   Ingelsson, Erik ^b   Lindgren, Cecilia M ^a   van Bavel, Bert ^c   Morris, Andrew P ^a,d   Lind, Lars ^b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UPPSALA UNIVERSITY   (Sweden)

^c ÖREBRO UNIVERSITY   (Sweden)

^d UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

Cytochrome P450; Genome wide association studies; Metabolism; Pollutants; Polychlorinated biphenyls; Single nucleotide polymorphisms

Indexed keywords

2,2',3',4,4',5 HEXACHLOROBIPHENYL; 2,2',3',4,4',5,5' HEPTACHLOROBIPHENYL; 2,2',3,3',4,4',5,5' OCTACHLOROBIPHENYL; 2,2',3,3',4,4',5,5',6 NONACHLOROBIPHENYL; 2,2',3,3',4,4',5,5',6,6' DECACHLOROBIPHENYL; 2,2',4,4',5 PENTACHLOROBIPHENYL; 2,2',4,4',5,5' HEXACHLOROBIPHENYL; 2,3',4,4',5 PENTACHLOROBIPHENYL; 2,3,3',4,4', PENTACHLOROBIPHENYL; 2,3,3',4,4',5,5' HEPTACHLOROBIPHENYL; 3,3',4,4',5 PENTACHLOROBIPHENYL; 3,3',4,4',5,5' HEXACHLOROBIPHENYL; CYTOCHROME P450 2B6; DNA; POLYCHLORINATED BIPHENYL; UNCLASSIFIED DRUG;

ANTHROPOGENIC EFFECT; CHROMOSOME; COHORT ANALYSIS; GAS CHROMATOGRAPHY; GENE EXPRESSION; HEALTH IMPACT; METABOLISM; PCB; REGRESSION ANALYSIS; TOXICITY;

AGED; ARTICLE; CHROMOSOME 19Q; COHORT ANALYSIS; CONTROLLED STUDY; DNA MICROARRAY; FEMALE; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENE MAPPING; GENETIC ASSOCIATION; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; MASS FRAGMENTOGRAPHY; MASS SPECTROMETRY; METABOLISM; MICROARRAY ANALYSIS; PLEIOTROPY; PRIORITY JOURNAL; SAMPLING; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; SWEDEN; BLOOD; ENVIRONMENTAL EXPOSURE; GENETICS;

SWEDEN;

AGED; COHORT STUDIES; CYTOCHROME P-450 CYP2B6; ENVIRONMENTAL EXPOSURE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GENOME-WIDE ASSOCIATION STUDY; HUMANS; POLYCHLORINATED BIPHENYLS; POLYMORPHISM, SINGLE NUCLEOTIDE; SWEDEN;

EID: 84961289830     PISSN: 00139351     EISSN: 10960953     Source Type: Journal    
DOI: 10.1016/j.envres.2015.03.022     Document Type: Article

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