Integrative genetic and metabolite profiling analysis suggests altered phosphatidylcholine metabolism in asthma

Allergy: European Journal of Allergy and Clinical Immunology

Volumn 68, Issue 5, 2013, Pages 629-636

  Ried, J S ^a   Baurecht, H ^b   Stuckler F ^a   Krumsiek, J ^a   Gieger, C ^a   Heinrich, J ^a   Kabesch, M ^c   Prehn, C ^a   Peters, A ^a   Rodriguez, E ^b   Schulz, H ^a   Strauch, K ^a,d   Suhre, K ^a,d,e   Wang Sattler, R ^a   Wichmann, H E ^a,d,f   Theis, F J ^a,g   Illig, T ^a,h   Adamski, J ^a,g   Weidinger, S ^b  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

^b UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^c UNIVERSITY HOSPITAL REGENSBURG   (Germany)

^d UNIVERSITY OF MUNICH   (Germany)

^e WEILL CORNELL MEDICAL COLLEGE   (Qatar)

^f LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^g TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^h HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

asthma; genetics; lipids; metabolomics

Indexed keywords

LYSOPHOSPHATIDYLCHOLINE; MED24 PROTEIN; PHOSPHATIDYLCHOLINE; PROTEIN VARIANT; PSMD3 PROTEIN; UNCLASSIFIED DRUG;

ADULT; AGED; ALLELE; ARTICLE; ASTHMA; CASE REPORT; CONTROLLED STUDY; DIET RESTRICTION; ELECTROSPRAY MASS SPECTROMETRY; GENE EXPRESSION PROFILING; GENE LOCUS; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; HUMAN; LIPID BLOOD LEVEL; MAJOR CLINICAL STUDY; METABOLIC DISORDER; METABOLITE; METABOLOMICS; PHOSPHOLIPID METABOLISM; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; TANDEM MASS SPECTROMETRY;

ADULT; AGED; AGED, 80 AND OVER; ALLELES; ASTHMA; CROSS-SECTIONAL STUDIES; FEMALE; GENE EXPRESSION PROFILING; GENETIC LOCI; GENOTYPE; HUMANS; MALE; METABOLOME; MIDDLE AGED; ODDS RATIO; PHOSPHATIDYLCHOLINES; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84876678696     PISSN: 01054538     EISSN: 13989995     Source Type: Journal    
DOI: 10.1111/all.12110     Document Type: Article

References (30)

1. Moffatt MF, Kabesch M, Liang L, Dixon AL, Strachan D, Heath S, et al. Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature 2007; 448: 470-473. (Pubitemid 47123521)
2. Hancock DB, Romieu I, Shi M, Sienra-Monge JJ, Wu H, Chiu GY, et al. Genome-wide association study implicates chromosome 9q21.31 as a susceptibility locus for asthma in mexican children. PLoS Genet 2009; 5: e1000623.
3. Gudbjartsson DF, Bjornsdottir US, Halapi E, Helgadottir A, Sulem P, Jonsdottir GM, et al. Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. Nat Genet 2009; 41: 342-347.
4. Himes BE, Hunninghake GM, Baurley JW, Rafaels NM, Sleiman P, Strachan DP, et al. Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene. Am J Hum Genet 2009; 84: 581-593.
5. Sleiman PM, Flory J, Imielinski M, Bradfield JP, Annaiah K, Willis-Owen SA, et al. Variants of DENND1B associated with asthma in children. N Engl J Med 2010; 362: 36-44.
6. DeWan AT, Triche EW, Xu X, Hsu LI, Zhao C, Belanger K, et al. PDE11A associations with asthma: results of a genome-wide association scan. J Allergy Clin Immunol 2010; 126: 871-873 e879.
7. Mathias RA, Grant AV, Rafaels N, Hand T, Gao L, Vergara C, et al. A genome-wide association study on African-ancestry populations for asthma. J Allergy Clin Immunol 2010; 125: 336-346 e334.
8. Ferreira MA, McRae AF, Medland SE, Nyholt DR, Gordon SD, Wright MJ, et al. Association between ORMDL3, IL1RL1 and a deletion on chromosome 17q21 with asthma risk in Australia. Eur J Hum Genet 2011; 19: 458-464.
9. Li X, Howard TD, Zheng SL, Haselkorn T, Peters SP, Meyers DA, et al. Genome-wide association study of asthma identifies RAD50-IL13 and HLA-DR/DQ regions. J Allergy Clin Immunol 2010; 125: 328-335 e311.
10. Moffatt MF, Gut IG, Demenais F, Strachan DP, Bouzigon E, Heath S, et al. A large-scale, consortium-based genomewide association study of asthma. N Engl J Med 2010; 363: 1211-1221.
11. Torgerson DG, Ampleford EJ, Chiu GY, Gauderman WJ, Gignoux CR, Graves PE, et al. Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. Nat Genet 2011; 43: 887-892.
12. Cookson W, Liang L, Abecasis G, Moffatt M, Lathrop M,. Mapping complex disease traits with global gene expression. Nat Rev Genet 2009; 10: 184-194.
13. Adamski J,. Genome-wide association studies with metabolomics. Genome Med 2012; 4: 34.
14. Mittelstrass K, Ried JS, Yu Z, Krumsiek J, Gieger C, Prehn C, et al. Discovery of sexual dimorphisms in metabolic and genetic biomarkers. PLoS Genet 2011; 7: e1002215.
15. Illig T, Gieger C, Zhai G, Romisch-Margl W, Wang-Sattler R, Prehn C, et al. A genome-wide perspective of genetic variation in human metabolism. Nat Genet 2010; 42: 137-141.
16. Gieger C, Geistlinger L, Altmaier E, Hrabe de Angelis M, Kronenberg F, Meitinger T, et al. Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum. PLoS Genet 2008; 4: e1000282.
17. Suhre K, Shin SY, Petersen AK, Mohney RP, Meredith D, Wagele B, et al. Human metabolic individuality in biomedical and pharmaceutical research. Nature 2011; 477: 54-60.
18. Wichmann HE, Gieger C, Illig T,. KORA-gen-resource for population genetics, controls and a broad spectrum of disease phenotypes. Gesundheitswesen 2005; 67 (Suppl 1): S26-S30.
19. Menn P, Heinrich J, Huber RM, Jorres RA, John J, Karrasch S, et al. Direct medical costs of COPD-an excess cost approach based on two population-based studies. Respir Med 2012; 106: 540-548.
20. Marchini J, Howie B,. Genotype imputation for genome-wide association studies. Nat Rev Genet 2010; 11: 499-511.
21. Gieger C, Radhakrishnan A, Cvejic A, Tang W, Porcu E, Pistis G, et al. New gene functions in megakaryopoiesis and platelet formation. Nature 2011; 480: 201-208.
22. Krumsiek J, Suhre K, Illig T, Adamski J, Theis FJ,. Gaussian graphical modeling reconstructs pathway reactions from high-throughput metabolomics data. BMC Syst Biol 2011; 5: 21.
23. Luster AD, Tager AM,. T-cell trafficking in asthma: lipid mediators grease the way. Nat Rev Immunol 2004; 4: 711-724. (Pubitemid 39223077)
24. Breslow DK, Collins SR, Bodenmiller B, Aebersold R, Simons K, Shevchenko A, et al. Orm family proteins mediate sphingolipid homeostasis. Nature 2010; 463: 1048-1053.
25. Cottrell L, Neal WA, Ice C, Perez MK, Piedimonte G,. Metabolic abnormalities in children with asthma. Am J Respir Crit Care Med 2011; 183: 441-448.
26. Almstrand AC, Josefson M, Bredberg A, Lausmaa J, Sjovall P, Larsson P, et al. TOF-SIMS analysis of exhaled particles from patients with asthma and healthy controls. Eur Respir J 2012; 39: 59-66.
27. Lundstrom SL, Yang J, Kallberg HJ, Thunberg S, Gafvelin G, Haeggstrom JZ, et al. Allergic asthmatics show divergent lipid mediator profiles from healthy controls both at baseline and following birch pollen provocation. PLoS ONE 2012; 7: e33780.
28. Kettunen J, Tukiainen T, Sarin AP, Ortega-Alonso A, Tikkanen E, Lyytikainen LP, et al. Genome-wide association study identifies multiple loci influencing human serum metabolite levels. Nat Genet 2012; 44: 269-276.
29. Saude EJ, Skappak CD, Regush S, Cook K, Ben-Zvi A, Becker A, et al. Metabolomic profiling of asthma: diagnostic utility of urine nuclear magnetic resonance spectroscopy. J Allergy Clin Immunol 2011; 127: 757-764 e751-756.
30. Wang TJ, Larson MG, Vasan RS, Cheng S, Rhee EP, McCabe E, et al. Metabolite profiles and the risk of developing diabetes. Nat Med 2011; 17: 448-453.