-
1
-
-
84881591682
-
Systemic cancer therapy: achievements and challenges that lie ahead
-
Palumbo MO, Kavan P, Miller WH Jr et al. Systemic cancer therapy: achievements and challenges that lie ahead. Front Pharmacol 2013;4: 57.
-
(2013)
Front Pharmacol
, vol.4
, pp. 57
-
-
Palumbo, M.O.1
Kavan, P.2
Miller, Jr.W.H.3
-
2
-
-
84856592577
-
Tumor control versus adverse events with targeted anticancer therapies
-
Keefe DM, Bateman EH. Tumor control versus adverse events with targeted anticancer therapies. Nat Rev Clin Oncol 2012; 9: 98-109.
-
(2012)
Nat Rev Clin Oncol
, vol.9
, pp. 98-109
-
-
Keefe, D.M.1
Bateman, E.H.2
-
3
-
-
84855466019
-
A phase 3 trial of bevacizumab in ovarian cancer
-
Perren TJ, Swart AM, Pfisterer J et al. A phase 3 trial of bevacizumab in ovarian cancer. N Engl J Med 2011; 365: 2484-2496.
-
(2011)
N Engl J Med
, vol.365
, pp. 2484-2496
-
-
Perren, T.J.1
Swart, A.M.2
Pfisterer, J.3
-
4
-
-
84861736119
-
OCEANS: a randomized, double-blind, placebo-controlled phase III trial of chemotherapy with or without bevacizumab in patients with platinum-sensitive recurrent epithelial ovarian, primary peritoneal, or fallopian tube cancer
-
Aghajanian C, Blank SV, Goff BA et al. OCEANS: a randomized, double-blind, placebo-controlled phase III trial of chemotherapy with or without bevacizumab in patients with platinum-sensitive recurrent epithelial ovarian, primary peritoneal, or fallopian tube cancer. J Clin Oncol 2012; 30: 2039-2045.
-
(2012)
J Clin Oncol
, vol.30
, pp. 2039-2045
-
-
Aghajanian, C.1
Blank, S.V.2
Goff, B.A.3
-
5
-
-
84880741126
-
The combination of intravenous bevacizumab and metronomic oral cyclophosphamide is an effective regimen for platinumresistant recurrent ovarian cancer
-
Barber EL, Zsiros E, Lurain JR et al. The combination of intravenous bevacizumab and metronomic oral cyclophosphamide is an effective regimen for platinumresistant recurrent ovarian cancer. J Gynecol Oncol 2013; 24: 258-264.
-
(2013)
J Gynecol Oncol
, vol.24
, pp. 258-264
-
-
Barber, E.L.1
Zsiros, E.2
Lurain, J.R.3
-
6
-
-
84899837376
-
Bevacizumab combined with chemotherapy for platinum-resistant recurrent ovarian cancer: the AURELIA openlabel randomized phase III trial
-
Pujade-Lauraine E, Hilpert F, Weber B et al. Bevacizumab combined with chemotherapy for platinum-resistant recurrent ovarian cancer: the AURELIA openlabel randomized phase III trial. J Clin Oncol 2014; 32: 1302-1308.
-
(2014)
J Clin Oncol
, vol.32
, pp. 1302-1308
-
-
Pujade-Lauraine, E.1
Hilpert, F.2
Weber, B.3
-
7
-
-
84888248795
-
Integrating bevacizumab into the management of epithelial ovarian cancer: the controversy of front-line versus recurrent disease
-
Monk BJ, Pujade-Lauraine E, Burger RA. Integrating bevacizumab into the management of epithelial ovarian cancer: the controversy of front-line versus recurrent disease. Ann Oncol 2013; 24(suppl 10): x53-x58.
-
(2013)
Ann Oncol
, vol.24
, pp. x53-x58
-
-
Monk, B.J.1
Pujade-Lauraine, E.2
Burger, R.A.3
-
8
-
-
84897132430
-
An updated meta-analysis of fatal adverse events caused by bevacizumab therapy in cancer patients
-
Huang H, Zheng Y, Zhu J et al. An updated meta-analysis of fatal adverse events caused by bevacizumab therapy in cancer patients. PLoS One 2014;9:e89960.
-
(2014)
PLoS One
, vol.9
, pp. e89960
-
-
Huang, H.1
Zheng, Y.2
Zhu, J.3
-
9
-
-
84866764407
-
Clinical utility of targeted treatments in the management of epithelial ovarian cancer
-
Twu C, Han ES. Clinical utility of targeted treatments in the management of epithelial ovarian cancer. Biologics 2012; 6: 233-244.
-
(2012)
Biologics
, vol.6
, pp. 233-244
-
-
Twu, C.1
Han, E.S.2
-
10
-
-
84880473776
-
Personalizing oncology: perspectives and prospects
-
Mendelsohn J. Personalizing oncology: perspectives and prospects. J Clin Oncol 2013; 31(15): 1904-1911.
-
(2013)
J Clin Oncol
, vol.31
, Issue.15
, pp. 1904-1911
-
-
Mendelsohn, J.1
-
11
-
-
84877280221
-
Momentum grows to make 'personalized' medicine more 'precise'
-
Katsnelson A. Momentum grows to make 'personalized' medicine more 'precise'. Nat Med 2013;19: 249.
-
(2013)
Nat Med
, vol.19
, pp. 249
-
-
Katsnelson, A.1
-
12
-
-
84855929701
-
Systems cancer medicine: towards realization of predictive, preventive, personalized and participatory (P4) medicine
-
Tian Q, Price ND, Hood L. Systems cancer medicine: towards realization of predictive, preventive, personalized and participatory (P4) medicine. J Intern Med 2012; 271: 111-121.
-
(2012)
J Intern Med
, vol.271
, pp. 111-121
-
-
Tian, Q.1
Price, N.D.2
Hood, L.3
-
13
-
-
84865677954
-
Overcoming implementation challenges of personalized cancer therapy
-
Meric-Bernstam F, Mills GB. Overcoming implementation challenges of personalized cancer therapy. Nat Rev Clin Oncol 2012; 9: 542-548.
-
(2012)
Nat Rev Clin Oncol
, vol.9
, pp. 542-548
-
-
Meric-Bernstam, F.1
Mills, G.B.2
-
14
-
-
84874144193
-
Personalized cancer medicine: molecular diagnostics, predictive biomarkers, and drug resistance
-
Gonzalez de Castro D, Clarke PA, Al-Lazikani B, Workman P. Personalized cancer medicine: molecular diagnostics, predictive biomarkers, and drug resistance. Clin Pharmacol Ther 2013; 93: 252-259.
-
(2013)
Clin Pharmacol Ther
, vol.93
, pp. 252-259
-
-
Gonzalez de Castro, D.1
Clarke, P.A.2
Al-Lazikani, B.3
Workman, P.4
-
15
-
-
84875937242
-
Genotyping and genomic profiling of nonsmall- cell lung cancer: implications for current and future therapies
-
Li T, Kung HJ, Mack PC, Gandara DR. Genotyping and genomic profiling of nonsmall- cell lung cancer: implications for current and future therapies. J Clin Oncol 2013; 31: 1039-1049.
-
(2013)
J Clin Oncol
, vol.31
, pp. 1039-1049
-
-
Li, T.1
Kung, H.J.2
Mack, P.C.3
Gandara, D.R.4
-
16
-
-
84943736918
-
Dako Receives FDA Approval for use of EGFR PharmDx with Vectibix [Product Release]
-
King of Prussia, PA: Advance Healthcare Network for Laboratory. 5 October, 8 October 2014, date last accessed
-
Dako Receives FDA Approval for use of EGFR PharmDx with Vectibix [Product Release]. King of Prussia, PA: Advance Healthcare Network for Laboratory. 5 October 2006. http://laboratory-manager.advanceweb.com/Article/Dako-Receives-FDA-Approval-for-Use-of-EGFR-pharmDx-with-Vectibix.aspx (8 October 2014, date last accessed).
-
(2006)
-
-
-
17
-
-
84943775755
-
FDA Approval for Cetuximab [National Cancer Institute Web Site Announcement]
-
2102, Bethesda, MD: US National Institutes of Health/Food and Drug Administration; 6 July, 8 October 2014, date last accessed
-
FDA Approval for Cetuximab [National Cancer Institute Web Site Announcement]. Bethesda, MD: US National Institutes of Health/Food and Drug Administration; 6 July 2102. http://www.cancer.gov/cancertopics/druginfo/fda-cetuximab (8 October 2014, date last accessed).
-
-
-
-
19
-
-
80755181069
-
Prospective molecular marker analyses of EGFR and KRAS from a randomized, placebo-controlled study of erlotinib maintenance therapy in advanced non-small-cell lung cancer
-
Brugger W, Triller N, Blasinska-Morawiec M et al. Prospective molecular marker analyses of EGFR and KRAS from a randomized, placebo-controlled study of erlotinib maintenance therapy in advanced non-small-cell lung cancer. J Clin Oncol 2011; 29: 4113-4120.
-
(2011)
J Clin Oncol
, vol.29
, pp. 4113-4120
-
-
Brugger, W.1
Triller, N.2
Blasinska-Morawiec, M.3
-
20
-
-
69949162760
-
Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
-
Mok TS, Wu YL, Thongprasert S et al. Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N Engl J Med 2009; 361: 947-957.
-
(2009)
N Engl J Med
, vol.361
, pp. 947-957
-
-
Mok, T.S.1
Wu, Y.L.2
Thongprasert, S.3
-
21
-
-
84892575530
-
Targeted agents in non-small cell lung cancer therapy: what is there on the horizon?
-
Villaflor VM, Salgia R. Targeted agents in non-small cell lung cancer therapy: what is there on the horizon?. J Carcinog 2013;12: 7.
-
(2013)
J Carcinog
, vol.12
, pp. 7
-
-
Villaflor, V.M.1
Salgia, R.2
-
22
-
-
84876985187
-
Clinical use of crizotinib for the treatment of non-small cell lung cancer
-
Roberts PJ. Clinical use of crizotinib for the treatment of non-small cell lung cancer. Biologics 2013; 7: 91-101.
-
(2013)
Biologics
, vol.7
, pp. 91-101
-
-
Roberts, P.J.1
-
23
-
-
84858236146
-
Optimizing molecular-targeted therapies in ovarian cancer: the renewed surge of interest in ovarian cancer biomarkers and cell signaling pathways
-
Hiss D. Optimizing molecular-targeted therapies in ovarian cancer: the renewed surge of interest in ovarian cancer biomarkers and cell signaling pathways. J Oncol 2012;2012: 737981.
-
(2012)
J Oncol
, vol.2012
, pp. 737981
-
-
Hiss, D.1
-
24
-
-
84888030906
-
Utilizing the folate receptor for active targeting of cancer nanotherapeutics
-
Dec 7 [epub ahead of print]
-
Zwicke GL, Mansoori GA, Jeffery CJ. Utilizing the folate receptor for active targeting of cancer nanotherapeutics. Nano Rev 2012 Dec 7 [epub ahead of print], doi: 10.3402/nano.v3i0.18496.
-
(2012)
Nano Rev
-
-
Zwicke, G.L.1
Mansoori, G.A.2
Jeffery, C.J.3
-
25
-
-
84865992002
-
Antifolates in cancer therapy: structure, activity and mechanisms of drug resistance
-
Gonen N, Assaraf YG. Antifolates in cancer therapy: structure, activity and mechanisms of drug resistance. Drug Resist Updat 2012; 15: 183-210.
-
(2012)
Drug Resist Updat
, vol.15
, pp. 183-210
-
-
Gonen, N.1
Assaraf, Y.G.2
-
26
-
-
0029818146
-
Folate receptors
-
Antony AC. Folate receptors. Annu Rev Nutr 1996; 16: 501-521.
-
(1996)
Annu Rev Nutr
, vol.16
, pp. 501-521
-
-
Antony, A.C.1
-
27
-
-
32944463897
-
Role of folate receptor genes in reproduction and related cancers
-
Elnakat H, Ratnam M. Role of folate receptor genes in reproduction and related cancers. Front Biosci 2006; 11: 506-519.
-
(2006)
Front Biosci
, vol.11
, pp. 506-519
-
-
Elnakat, H.1
Ratnam, M.2
-
28
-
-
79960481261
-
Mechanisms of membrane transport of folates into cells and across epithelia
-
Zhao R, op-Bove N, Visentin M, Goldman ID. Mechanisms of membrane transport of folates into cells and across epithelia. Annu Rev Nutr 2011; 31: 177-201.
-
(2011)
Annu Rev Nutr
, vol.31
, pp. 177-201
-
-
Zhao, R.1
op-Bove, N.2
Visentin, M.3
Goldman, I.D.4
-
29
-
-
0028301752
-
Differential regulation of folate receptor isoforms in normal and malignant tissues in vivo and in established cell lines. Physiologic and clinical implications
-
Ross JF, Chaudhuri PK, Ratnam M. Differential regulation of folate receptor isoforms in normal and malignant tissues in vivo and in established cell lines. Physiologic and clinical implications. Cancer 1994; 73: 2432-2443.
-
(1994)
Cancer
, vol.73
, pp. 2432-2443
-
-
Ross, J.F.1
Chaudhuri, P.K.2
Ratnam, M.3
-
30
-
-
33947362046
-
The folate receptor: what does it promise in tissuetargeted therapeutics?
-
Salazar MD, Ratnam M. The folate receptor: what does it promise in tissuetargeted therapeutics?. Cancer Metastasis Rev 2007; 26: 141-152.
-
(2007)
Cancer Metastasis Rev
, vol.26
, pp. 141-152
-
-
Salazar, M.D.1
Ratnam, M.2
-
31
-
-
84899471338
-
Juno is the egg Izumo receptor and is essential for mammalian fertilization
-
Bianchi E, Doe B, Goulding D, Wright GJ. Juno is the egg Izumo receptor and is essential for mammalian fertilization. Nature 2014; 508: 483-487.
-
(2014)
Nature
, vol.508
, pp. 483-487
-
-
Bianchi, E.1
Doe, B.2
Goulding, D.3
Wright, G.J.4
-
32
-
-
84864259555
-
Folate receptor alpha expression in lung cancer: diagnostic and prognostic significance
-
O'Shannessy DJ, Yu G, Smale R et al. Folate receptor alpha expression in lung cancer: diagnostic and prognostic significance. Oncotarget 2012; 3: 414-425.
-
(2012)
Oncotarget
, vol.3
, pp. 414-425
-
-
O'Shannessy, D.J.1
Yu, G.2
Smale, R.3
-
33
-
-
40649096363
-
Immunohistochemical expression of folate receptor alpha in colorectal carcinoma: patterns and biological significance
-
Shia J, Klimstra DS, Nitzkorski JR et al. Immunohistochemical expression of folate receptor alpha in colorectal carcinoma: patterns and biological significance. Hum Pathol 2008; 39: 498-505.
-
(2008)
Hum Pathol
, vol.39
, pp. 498-505
-
-
Shia, J.1
Klimstra, D.S.2
Nitzkorski, J.R.3
-
34
-
-
33745204461
-
The role of folate receptor alpha in cancer development, progression and treatment: cause, consequence or innocent bystander?
-
Kelemen LE. The role of folate receptor alpha in cancer development, progression and treatment: cause, consequence or innocent bystander?. Int J Cancer 2006; 119: 243-250.
-
(2006)
Int J Cancer
, vol.119
, pp. 243-250
-
-
Kelemen, L.E.1
-
35
-
-
84862209448
-
A novel splice variant of folate receptor 4 predominantly expressed in regulatory T cells
-
Tian Y, Wu G, Xing JC et al. A novel splice variant of folate receptor 4 predominantly expressed in regulatory T cells. BMC Immunol 2012;13: 30.
-
(2012)
BMC Immunol
, vol.13
, pp. 30
-
-
Tian, Y.1
Wu, G.2
Xing, J.C.3
-
36
-
-
0024006840
-
Influence on immunoreactive folate-binding proteins of extracellular folate concentration in cultured human cells
-
Kane MA, Elwood PC, Portillo RM et al. Influence on immunoreactive folate-binding proteins of extracellular folate concentration in cultured human cells. J Clin Invest 1988; 81: 1398-1406.
-
(1988)
J Clin Invest
, vol.81
, pp. 1398-1406
-
-
Kane, M.A.1
Elwood, P.C.2
Portillo, R.M.3
-
37
-
-
0033960584
-
Interaction of folate receptor with signaling molecules lyn and G(alpha)(i-3) in detergent-resistant complexes from the ovary carcinoma cell line IGROV1
-
Miotti S, Bagnoli M, Tomassetti A et al. Interaction of folate receptor with signaling molecules lyn and G(alpha)(i-3) in detergent-resistant complexes from the ovary carcinoma cell line IGROV1. J Cell Sci 2000; 113(Pt 2): 349-357.
-
(2000)
J Cell Sci
, vol.113
, pp. 349-357
-
-
Miotti, S.1
Bagnoli, M.2
Tomassetti, A.3
-
38
-
-
0027442379
-
Gene transfection and expression of the ovarian carcinoma marker folate binding protein on NIH/3T3 cells increases cell growth in vitro and in vivo
-
Bottero F, Tomassetti A, Canevari S et al. Gene transfection and expression of the ovarian carcinoma marker folate binding protein on NIH/3T3 cells increases cell growth in vitro and in vivo. Cancer Res 1993; 53: 5791-5796.
-
(1993)
Cancer Res
, vol.53
, pp. 5791-5796
-
-
Bottero, F.1
Tomassetti, A.2
Canevari, S.3
-
39
-
-
0038684626
-
Reversion of transformed phenotype in ovarian cancer cells by intracellular expression of anti folate receptor antibodies
-
Figini M, Ferri R, Mezzanzanica D et al. Reversion of transformed phenotype in ovarian cancer cells by intracellular expression of anti folate receptor antibodies. Gene Ther 2003; 10: 1018-1025.
-
(2003)
Gene Ther
, vol.10
, pp. 1018-1025
-
-
Figini, M.1
Ferri, R.2
Mezzanzanica, D.3
-
40
-
-
12344303295
-
Antisense oligonucleotides targeted to the human alpha folate receptor inhibit breast cancer cell growth and sensitize the cells to doxorubicin treatment
-
Jhaveri MS, Rait AS, Chung KN et al. Antisense oligonucleotides targeted to the human alpha folate receptor inhibit breast cancer cell growth and sensitize the cells to doxorubicin treatment. Mol Cancer Ther 2004; 3: 1505-1512.
-
(2004)
Mol Cancer Ther
, vol.3
, pp. 1505-1512
-
-
Jhaveri, M.S.1
Rait, A.S.2
Chung, K.N.3
-
41
-
-
84890016561
-
The antitumor activity of the human FOLR1-specific monoclonal antibody, farletuzumab, in an ovarian cancer mouse model is mediated by antibody-dependent cellular cytotoxicity
-
Lin J, Spidel JL, Maddage CJ et al. The antitumor activity of the human FOLR1-specific monoclonal antibody, farletuzumab, in an ovarian cancer mouse model is mediated by antibody-dependent cellular cytotoxicity. Cancer Biol Ther 2013; 14: 1032-1038.
-
(2013)
Cancer Biol Ther
, vol.14
, pp. 1032-1038
-
-
Lin, J.1
Spidel, J.L.2
Maddage, C.J.3
-
42
-
-
84862808121
-
Serous ovarian carcinoma patients with high alpha-folate receptor had reducing survival and cytotoxic chemo-response
-
Chen YL, Chang MC, Huang CY et al. Serous ovarian carcinoma patients with high alpha-folate receptor had reducing survival and cytotoxic chemo-response. Mol Oncol 2012; 6: 360-369.
-
(2012)
Mol Oncol
, vol.6
, pp. 360-369
-
-
Chen, Y.L.1
Chang, M.C.2
Huang, C.Y.3
-
43
-
-
84879073124
-
Folate receptor alpha (FRA) expression remains unchanged in epithelial ovarian and endometrial cancer after chemotherapy
-
Despierre E, Lambrechts S, Leunen K et al. Folate receptor alpha (FRA) expression remains unchanged in epithelial ovarian and endometrial cancer after chemotherapy. Gynecol Oncol 2013; 130: 192-199.
-
(2013)
Gynecol Oncol
, vol.130
, pp. 192-199
-
-
Despierre, E.1
Lambrechts, S.2
Leunen, K.3
-
44
-
-
84866144174
-
The effect of chemotherapy on expression of folate receptor-alpha in ovarian cancer
-
Crane LM, Arts HJ, van OM et al. The effect of chemotherapy on expression of folate receptor-alpha in ovarian cancer. Cell Oncol 2012; 35: 9-18.
-
(2012)
Cell Oncol
, vol.35
, pp. 9-18
-
-
Crane, L.M.1
Arts, H.J.2
van, O.M.3
-
45
-
-
0031944910
-
Expression of folate binding protein as a prognostic factor for response to platinum-containing chemotherapy and survival in human ovarian cancer
-
Toffoli G, Russo A, Gallo A et al. Expression of folate binding protein as a prognostic factor for response to platinum-containing chemotherapy and survival in human ovarian cancer. Int J Cancer 1998; 79: 121-126.
-
(1998)
Int J Cancer
, vol.79
, pp. 121-126
-
-
Toffoli, G.1
Russo, A.2
Gallo, A.3
-
46
-
-
84892736321
-
Interobserver agreement and assay reproducibility of folate receptor alpha expression in lung adenocarcinoma: a prognostic marker and potential therapeutic target
-
Bremer RE, Scoggin TS, Somers EB et al. Interobserver agreement and assay reproducibility of folate receptor alpha expression in lung adenocarcinoma: a prognostic marker and potential therapeutic target. Arch Pathol Lab Med 2013; 137(12): 1747-1752.
-
(2013)
Arch Pathol Lab Med
, vol.137
, Issue.12
, pp. 1747-1752
-
-
Bremer, R.E.1
Scoggin, T.S.2
Somers, E.B.3
-
47
-
-
34547108108
-
Folate receptor overexpression is associated with poor outcome in breast cancer
-
Hartmann LC, Keeney GL, Lingle WL et al. Folate receptor overexpression is associated with poor outcome in breast cancer. Int J Cancer 2007; 121: 938-942.
-
(2007)
Int J Cancer
, vol.121
, pp. 938-942
-
-
Hartmann, L.C.1
Keeney, G.L.2
Lingle, W.L.3
-
48
-
-
84928651145
-
Evidence for a time-dependent association between FOLR1 expression and survival from ovarian carcinoma: implications for clinical testing. An Ovarian Tumour Tissue Analysis consortium study
-
Kobel M, Madore J, Ramus SJ et al. Evidence for a time-dependent association between FOLR1 expression and survival from ovarian carcinoma: implications for clinical testing. An Ovarian Tumour Tissue Analysis consortium study. Br J Cancer 2014; 111(12): 2297-2307.
-
(2014)
Br J Cancer
, vol.111
, Issue.12
, pp. 2297-2307
-
-
Kobel, M.1
Madore, J.2
Ramus, S.J.3
-
49
-
-
52549083788
-
Tumor detection using folate receptor-targeted imaging agents
-
Sega EI, Low PS. Tumor detection using folate receptor-targeted imaging agents. Cancer Metastasis Rev 2008; 27: 655-664.
-
(2008)
Cancer Metastasis Rev
, vol.27
, pp. 655-664
-
-
Sega, E.I.1
Low, P.S.2
-
50
-
-
84897372062
-
Profile of vintafolide (EC145) and its use in the treatment of platinum-resistant ovarian cancer
-
Luyckx M, Votino R, Squifflet JL, Baurain JF. Profile of vintafolide (EC145) and its use in the treatment of platinum-resistant ovarian cancer. Int J Womens Health 2014; 6: 351-358.
-
(2014)
Int J Womens Health
, vol.6
, pp. 351-358
-
-
Luyckx, M.1
Votino, R.2
Squifflet, J.L.3
Baurain, J.F.4
-
51
-
-
84890541361
-
Statistical and practical considerations for clinical evaluation of predictive biomarkers
-
Polley MY, Freidlin B, Korn EL et al. Statistical and practical considerations for clinical evaluation of predictive biomarkers. J Natl Cancer Inst 2013; 105: 1677-1683.
-
(2013)
J Natl Cancer Inst
, vol.105
, pp. 1677-1683
-
-
Polley, M.Y.1
Freidlin, B.2
Korn, E.L.3
-
52
-
-
14644392093
-
Folate receptor expression in carcinomas and normal tissues determined by a quantitative radioligand binding assay
-
Parker N, Turk MJ, Westrick E et al. Folate receptor expression in carcinomas and normal tissues determined by a quantitative radioligand binding assay. Anal Biochem 2005; 338: 284-293.
-
(2005)
Anal Biochem
, vol.338
, pp. 284-293
-
-
Parker, N.1
Turk, M.J.2
Westrick, E.3
-
53
-
-
67651108570
-
Functional folate receptor alpha is elevated in the blood of ovarian cancer patients
-
Basal E, Eghbali-Fatourechi GZ, Kalli KR et al. Functional folate receptor alpha is elevated in the blood of ovarian cancer patients. PLoS One 2009;4: e6292.
-
(2009)
PLoS One
, vol.4
, pp. e6292
-
-
Basal, E.1
Eghbali-Fatourechi, G.Z.2
Kalli, K.R.3
-
54
-
-
84876073350
-
Serum folate receptor alpha, mesothelin and megakaryocyte potentiating factor in ovarian cancer: association to disease stage and grade and comparison to CA125 and HE4
-
O'Shannessy DJ, Somers EB, Palmer LM et al. Serum folate receptor alpha, mesothelin and megakaryocyte potentiating factor in ovarian cancer: association to disease stage and grade and comparison to CA125 and HE4. J Ovarian Res 2013;6: 29.
-
(2013)
J Ovarian Res
, vol.6
, pp. 29
-
-
O'Shannessy, D.J.1
Somers, E.B.2
Palmer, L.M.3
-
55
-
-
84889566486
-
Prognostic significance of FRA expression in epithelial cancers using AQUA® technology
-
O'Shannessy DJ, Gustavson M, Chandrasekaran LK et al. Prognostic significance of FRA expression in epithelial cancers using AQUA® technology. Biomark Med 2013; 7: 933-946.
-
(2013)
Biomark Med
, vol.7
, pp. 933-946
-
-
O'Shannessy, D.J.1
Gustavson, M.2
Chandrasekaran, L.K.3
-
56
-
-
39149083739
-
Expression status of folate receptor alpha is significantly correlated with prognosis in non-small-cell lung cancers
-
Iwakiri S, Sonobe M, Nagai S et al. Expression status of folate receptor alpha is significantly correlated with prognosis in non-small-cell lung cancers. Ann Surg Oncol 2008; 15: 889-899.
-
(2008)
Ann Surg Oncol
, vol.15
, pp. 889-899
-
-
Iwakiri, S.1
Sonobe, M.2
Nagai, S.3
-
57
-
-
84863393080
-
Intratumor heterogeneity and branched evolution revealed by multiregion sequencing
-
Gerlinger M, Rowan AJ, Horswell S et al. Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N Engl J Med 2012; 366:883-892.
-
(2012)
N Engl J Med
, vol.366
, pp. 883-892
-
-
Gerlinger, M.1
Rowan, A.J.2
Horswell, S.3
-
58
-
-
84875884456
-
Cellular heterogeneity and molecular evolution in cancer
-
Almendro V, Marusyk A, Polyak K. Cellular heterogeneity and molecular evolution in cancer. Annu Rev Pathol 2013; 8: 277-302.
-
(2013)
Annu Rev Pathol
, vol.8
, pp. 277-302
-
-
Almendro, V.1
Marusyk, A.2
Polyak, K.3
-
59
-
-
84924359778
-
Spatial and temporal heterogeneity in highgrade serous ovarian cancer: a phylogenetic analysis
-
Schwarz RF, Ng CK, Cooke SL et al. Spatial and temporal heterogeneity in highgrade serous ovarian cancer: a phylogenetic analysis. PLoS Med 2015;12:e1001789.
-
(2015)
PLoS Med
, vol.12
, pp. e1001789
-
-
Schwarz, R.F.1
Ng, C.K.2
Cooke, S.L.3
-
60
-
-
0036862058
-
Synthesis and biological evaluation of EC20: a new folate-derived, (99 m)Tc-based radiopharmaceutical
-
Leamon CP, Parker MA, Vlahov IR et al. Synthesis and biological evaluation of EC20: a new folate-derived, (99 m)Tc-based radiopharmaceutical. Bioconjug Chem 2002; 13: 1200-1210.
-
(2002)
Bioconjug Chem
, vol.13
, pp. 1200-1210
-
-
Leamon, C.P.1
Parker, M.A.2
Vlahov, I.R.3
-
61
-
-
44849127008
-
Exploratory study of 99mTc-EC20 imaging for identifying patients with folate receptor-positive solid tumors
-
Fisher RE, Siegel BA, Edell SL et al. Exploratory study of 99mTc-EC20 imaging for identifying patients with folate receptor-positive solid tumors. J Nucl Med 2008; 49: 899-906.
-
(2008)
J Nucl Med
, vol.49
, pp. 899-906
-
-
Fisher, R.E.1
Siegel, B.A.2
Edell, S.L.3
-
62
-
-
0032892065
-
Receptor-mediated targeting of 67Gadeferoxamine- folate to folate-receptor-positive human KB tumor xenografts
-
Mathias CJ, Wang S, Low PS et al. Receptor-mediated targeting of 67Gadeferoxamine- folate to folate-receptor-positive human KB tumor xenografts. Nucl Med Biol 1999; 26: 23-25.
-
(1999)
Nucl Med Biol
, vol.26
, pp. 23-25
-
-
Mathias, C.J.1
Wang, S.2
Low, P.S.3
-
63
-
-
0030611096
-
Design and synthesis of [111In]DTPA-folate for use as a tumor-targeted radiopharmaceutical
-
Wang S, Luo J, Lantrip DA et al. Design and synthesis of [111In]DTPA-folate for use as a tumor-targeted radiopharmaceutical. Bioconjug Chem 1997; 8:673-679.
-
(1997)
Bioconjug Chem
, vol.8
, pp. 673-679
-
-
Wang, S.1
Luo, J.2
Lantrip, D.A.3
-
64
-
-
0032588840
-
99mTc-HYNIC-folate: a novel receptor-based targeted radiopharmaceutical for tumor imaging
-
Guo W, Hinkle GH, Lee RJ. 99mTc-HYNIC-folate: a novel receptor-based targeted radiopharmaceutical for tumor imaging. J Nucl Med 1999; 40:1563-1569.
-
(1999)
J Nucl Med
, vol.40
, pp. 1563-1569
-
-
Guo, W.1
Hinkle, G.H.2
Lee, R.J.3
-
65
-
-
0038621645
-
Evaluation of 111In-DTPA-folate as a receptor-targeted diagnostic agent for ovarian cancer: initial clinical results
-
Siegel BA, Dehdashti F, Mutch DG et al. Evaluation of 111In-DTPA-folate as a receptor-targeted diagnostic agent for ovarian cancer: initial clinical results. J Nucl Med 2003; 44: 700-707.
-
(2003)
J Nucl Med
, vol.44
, pp. 700-707
-
-
Siegel, B.A.1
Dehdashti, F.2
Mutch, D.G.3
-
66
-
-
80053989452
-
Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-alpha targeting: first inhuman results
-
van Dam GM, Themelis G, Crane LM et al. Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-alpha targeting: first inhuman results. Nat Med 2011; 17: 1315-1319.
-
(2011)
Nat Med
, vol.17
, pp. 1315-1319
-
-
van Dam, G.M.1
Themelis, G.2
Crane, L.M.3
-
67
-
-
84901248961
-
Development and preclinical evaluation of new (124)I-folate conjugates for PET imaging of folate receptorpositive tumors
-
AlJammaz I, Al-Otaibi B, Al-Rumayan F et al. Development and preclinical evaluation of new (124)I-folate conjugates for PET imaging of folate receptorpositive tumors. Nucl Med Biol 2014; 41: 457-463.
-
(2014)
Nucl Med Biol
, vol.41
, pp. 457-463
-
-
AlJammaz, I.1
Al-Otaibi, B.2
Al-Rumayan, F.3
-
68
-
-
84914163404
-
The co-development of a folate receptor targeted drug conjugate vintafolide (EC145) and a folate receptor targeted imaging agent 99mTc-etarfolatide (EC20) in the treatment of advanced adenocarcinoma NSCLC
-
Edelman MJ, Bonomi P, Harb W et al. The co-development of a folate receptor targeted drug conjugate vintafolide (EC145) and a folate receptor targeted imaging agent 99mTc-etarfolatide (EC20) in the treatment of advanced adenocarcinoma NSCLC. J Thorac Oncol 2012; 7(suppl 1): S63.
-
(2012)
J Thorac Oncol
, vol.7
, pp. S63
-
-
Edelman, M.J.1
Bonomi, P.2
Harb, W.3
-
69
-
-
84897043920
-
Phase II study of treatment of advanced ovarian cancer with folate-receptor-targeted therapeutic (vintafolide) and companion SPECT-based imaging agent (99mTc-etarfolatide)
-
Morris RT, Joyrich RN, Naumann RW et al. Phase II study of treatment of advanced ovarian cancer with folate-receptor-targeted therapeutic (vintafolide) and companion SPECT-based imaging agent (99mTc-etarfolatide). Ann Oncol 2014; 25: 852-858.
-
(2014)
Ann Oncol
, vol.25
, pp. 852-858
-
-
Morris, R.T.1
Joyrich, R.N.2
Naumann, R.W.3
-
70
-
-
84866625235
-
Multicenter trial of EC145 in advanced, folatereceptor positive adenocarcinoma of the lung
-
Edelman MJ, Harb WA, Pal SE et al. Multicenter trial of EC145 in advanced, folatereceptor positive adenocarcinoma of the lung. J Thorac Oncol 2012; 7:1618-1621.
-
(2012)
J Thorac Oncol
, vol.7
, pp. 1618-1621
-
-
Edelman, M.J.1
Harb, W.A.2
Pal, S.E.3
-
71
-
-
84891854386
-
PRECEDENT: a randomized phase II trial comparing vintafolide (EC145) and pegylated liposomal doxorubicin (PLD) in combination versus PLD alone in patients with platinum-resistant ovarian cancer
-
Naumann RW, Coleman RL, Burger RA et al. PRECEDENT: a randomized phase II trial comparing vintafolide (EC145) and pegylated liposomal doxorubicin (PLD) in combination versus PLD alone in patients with platinum-resistant ovarian cancer. J Clin Oncol 2013; 31: 4400-4406.
-
(2013)
J Clin Oncol
, vol.31
, pp. 4400-4406
-
-
Naumann, R.W.1
Coleman, R.L.2
Burger, R.A.3
-
72
-
-
84901327650
-
Imaging the folate receptor on cancer cells with 99mTc-etarfolatide: properties, clinical use, and future potential of folate receptor imaging
-
Maurer AH, Elsinga P, Fanti S et al. Imaging the folate receptor on cancer cells with 99mTc-etarfolatide: properties, clinical use, and future potential of folate receptor imaging. J Nucl Med 2014; 55: 701-704.
-
(2014)
J Nucl Med
, vol.55
, pp. 701-704
-
-
Maurer, A.H.1
Elsinga, P.2
Fanti, S.3
-
73
-
-
84859727702
-
EC145: a novel targeted agent for adenocarcinoma of the lung
-
Pribble P, Edelman MJ. EC145: a novel targeted agent for adenocarcinoma of the lung. Expert Opin Investig Drugs 2012; 21: 755-761.
-
(2012)
Expert Opin Investig Drugs
, vol.21
, pp. 755-761
-
-
Pribble, P.1
Edelman, M.J.2
-
74
-
-
34249321972
-
Preclinical evaluation of EC145, a folatevinca alkaloid conjugate
-
Reddy JA, Dorton R, Westrick E et al. Preclinical evaluation of EC145, a folatevinca alkaloid conjugate. Cancer Res 2007; 67: 4434-4442.
-
(2007)
Cancer Res
, vol.67
, pp. 4434-4442
-
-
Reddy, J.A.1
Dorton, R.2
Westrick, E.3
-
75
-
-
84877579319
-
Farletuzumab (a monoclonal antibody against folate receptor alpha) in relapsed platinum-sensitive ovarian cancer
-
Armstrong DK, White AJ, Weil SC et al. Farletuzumab (a monoclonal antibody against folate receptor alpha) in relapsed platinum-sensitive ovarian cancer. Gynecol Oncol 2013; 129: 452-458.
-
(2013)
Gynecol Oncol
, vol.129
, pp. 452-458
-
-
Armstrong, D.K.1
White, A.J.2
Weil, S.C.3
-
77
-
-
84920938950
-
Immunotherapy targeting folate receptor induces cell death associated with autophagy in ovarian cancer
-
Wen Y, Graybill WS, Previs RA et al. Immunotherapy targeting folate receptor induces cell death associated with autophagy in ovarian cancer. Clin Cancer Res 2015; 21: 448-459.
-
(2015)
Clin Cancer Res
, vol.21
, pp. 448-459
-
-
Wen, Y.1
Graybill, W.S.2
Previs, R.A.3
-
78
-
-
29244449017
-
BGC 945, a novel tumor-selective thymidylate synthase inhibitor targeted to alpha-folate receptor-overexpressing tumors
-
Gibbs DD, Theti DS, Wood N et al. BGC 945, a novel tumor-selective thymidylate synthase inhibitor targeted to alpha-folate receptor-overexpressing tumors. Cancer Res 2005; 65: 11721-11728.
-
(2005)
Cancer Res
, vol.65
, pp. 11721-11728
-
-
Gibbs, D.D.1
Theti, D.S.2
Wood, N.3
-
79
-
-
84863483737
-
Farletuzumab, an anti-folate receptor alpha antibody, does not block binding of folate or anti-folates to receptor nor does it alter the potency of anti-folates in vitro
-
Kamen BA, Smith AK. Farletuzumab, an anti-folate receptor alpha antibody, does not block binding of folate or anti-folates to receptor nor does it alter the potency of anti-folates in vitro. Cancer Chemother Pharmacol 2012; 70: 113-120.
-
(2012)
Cancer Chemother Pharmacol
, vol.70
, pp. 113-120
-
-
Kamen, B.A.1
Smith, A.K.2
-
80
-
-
84962222791
-
Eisai Announces Results of Phase III Study of Anticancer Agent Farletuzumab in Patients with Relapsed Platinum-Sensitive Ovarian Cancer [News Release]
-
Tokyo, Japan: Eisai Co., Ltd. 11 January, 8 October 2014, date last accessed
-
Eisai Announces Results of Phase III Study of Anticancer Agent Farletuzumab in Patients with Relapsed Platinum-Sensitive Ovarian Cancer [News Release]. Tokyo, Japan: Eisai Co., Ltd. 11 January 2013. http://www.eisai.com/news/news201305.html (8 October 2014, date last accessed).
-
(2013)
-
-
-
81
-
-
84904278154
-
Phase 3 double-blind, placebo-controlled study of weekly farletuzumab with carboplatin/taxane in subjects with platinum sensitive ovarian cancer in first relapse
-
Vergote I, Armstrong D. Phase 3 double-blind, placebo-controlled study of weekly farletuzumab with carboplatin/taxane in subjects with platinum sensitive ovarian cancer in first relapse. Int J Gynecol Cancer 2013; 23(8 suppl): 11.
-
(2013)
Int J Gynecol Cancer
, vol.23
, Issue.8 SUPPL
, pp. 11
-
-
Vergote, I.1
Armstrong, D.2
-
82
-
-
84925456254
-
Role of the folate receptor in ovarian cancer treatment: evidence, mechanism, and clinical implications
-
Vergote IB, Marth C, Coleman RL. Role of the folate receptor in ovarian cancer treatment: evidence, mechanism, and clinical implications. Cancer Metastasis Rev 2015; 34: 41-52.
-
(2015)
Cancer Metastasis Rev
, vol.34
, pp. 41-52
-
-
Vergote, I.B.1
Marth, C.2
Coleman, R.L.3
-
83
-
-
0032729175
-
Comparison of IgE and IgG antibodydependent cytotoxicity in vitro and in a SCID mouse xenograft model of ovarian carcinoma
-
Gould HJ, Mackay GA, Karagiannis SN et al. Comparison of IgE and IgG antibodydependent cytotoxicity in vitro and in a SCID mouse xenograft model of ovarian carcinoma. Eur J Immunol 1999; 29: 3527-3537.
-
(1999)
Eur J Immunol
, vol.29
, pp. 3527-3537
-
-
Gould, H.J.1
Mackay, G.A.2
Karagiannis, S.N.3
-
84
-
-
0037730341
-
Activity of human monocytes in IgE antibody-dependent surveillance and killing of ovarian tumor cells
-
Karagiannis SN, Wang Q, East N et al. Activity of human monocytes in IgE antibody-dependent surveillance and killing of ovarian tumor cells. Eur J Immunol 2003; 33: 1030-1040.
-
(2003)
Eur J Immunol
, vol.33
, pp. 1030-1040
-
-
Karagiannis, S.N.1
Wang, Q.2
East, N.3
-
86
-
-
80052966648
-
Harnessing engineered antibodies of the IgE class to combat malignancy: initial assessment of FcvarepsilonRI-mediated basophil activation by a tumour-specific IgE antibody to evaluate the risk of type I hypersensitivity
-
Rudman SM, Josephs DH, Cambrook H et al. Harnessing engineered antibodies of the IgE class to combat malignancy: initial assessment of FcvarepsilonRI-mediated basophil activation by a tumour-specific IgE antibody to evaluate the risk of type I hypersensitivity. Clin Exp Allergy 2011; 41: 1400-1413.
-
(2011)
Clin Exp Allergy
, vol.41
, pp. 1400-1413
-
-
Rudman, S.M.1
Josephs, D.H.2
Cambrook, H.3
-
88
-
-
34447131647
-
Comparative preclinical activity of the folate-targeted Vinca alkaloid conjugates EC140 and EC145
-
Leamon CP, Reddy JA, Vlahov IR et al. Comparative preclinical activity of the folate-targeted Vinca alkaloid conjugates EC140 and EC145. Int J Cancer 2007; 121: 1585-1592.
-
(2007)
Int J Cancer
, vol.121
, pp. 1585-1592
-
-
Leamon, C.P.1
Reddy, J.A.2
Vlahov, I.R.3
-
89
-
-
33747349484
-
Design and regioselective synthesis of a new generation of targeted chemotherapeutic. Part 1: EC145, a folic acid conjugate of desacetylvinblastine monohydrazide
-
Vlahov IR, Santhapuram HK, Kleindl PJ et al. Design and regioselective synthesis of a new generation of targeted chemotherapeutic. Part 1: EC145, a folic acid conjugate of desacetylvinblastine monohydrazide. Bioorg Med Chem Lett 2006; 16: 5093-5096.
-
(2006)
Bioorg Med Chem Lett
, vol.16
, pp. 5093-5096
-
-
Vlahov, I.R.1
Santhapuram, H.K.2
Kleindl, P.J.3
-
90
-
-
84863946983
-
Engineering folate-drug conjugates to target cancer: from chemistry to clinic
-
Vlahov IR, Leamon CP. Engineering folate-drug conjugates to target cancer: from chemistry to clinic. Bioconjug Chem 2012; 23: 1357-1369.
-
(2012)
Bioconjug Chem
, vol.23
, pp. 1357-1369
-
-
Vlahov, I.R.1
Leamon, C.P.2
-
91
-
-
84869444058
-
Phase I study of folate conjugate EC145 (Vintafolide) in patients with refractory solid tumors
-
LoRusso PM, Edelman MJ, Bever SL et al. Phase I study of folate conjugate EC145 (Vintafolide) in patients with refractory solid tumors. J Clin Oncol 2012; 30: 4011-4016.
-
(2012)
J Clin Oncol
, vol.30
, pp. 4011-4016
-
-
LoRusso, P.M.1
Edelman, M.J.2
Bever, S.L.3
-
92
-
-
84931395636
-
TARGET: a randomized phase II trial comparing vintafolide versus vintafolide plus docetaxel, versus docetaxel alone in second-line treatment of folate-receptor-positive non-small cell lung cancer patients
-
LBA40PR
-
Hanna N, Juhasz E, Cainap C. TARGET: a randomized phase II trial comparing vintafolide versus vintafolide plus docetaxel, versus docetaxel alone in second-line treatment of folate-receptor-positive non-small cell lung cancer patients. Ann Oncol 2014; 25(suppl 5): v1-v41. LBA40PR.
-
(2014)
Ann Oncol
, vol.25
, pp. v1-v41
-
-
Hanna, N.1
Juhasz, E.2
Cainap, C.3
|