-
1
-
-
79952232216
-
Global cancer statistics
-
Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011;61(2):69-90.
-
(2011)
CA Cancer J Clin
, vol.61
, Issue.2
, pp. 69-90
-
-
Jemal, A.1
Bray, F.2
Center, M.M.3
Ferlay, J.4
Ward, E.5
Forman, D.6
-
2
-
-
77955635233
-
Cancer statistics, 2010
-
Jemal A, Siegel R, Xu J, Ward E. Cancer statistics, 2010. CA Cancer J Clin. 2010;60(5):277-300.
-
(2010)
CA Cancer J Clin
, vol.60
, Issue.5
, pp. 277-300
-
-
Jemal, A.1
Siegel, R.2
Xu, J.3
Ward, E.4
-
3
-
-
56249109644
-
Gefitinib versus docetaxel in previously treated non-small-cell lung cancer (INTEREST): A randomised phase III trial
-
al
-
Kim ES, Hirsh V, Mok T, al. Gefitinib versus docetaxel in previously treated non-small-cell lung cancer (INTEREST): a randomised phase III trial. Lancet. 2008;372(9652):1809-1818.
-
(2008)
Lancet
, vol.372
, Issue.9652
, pp. 1809-1818
-
-
Kim, E.S.1
Hirsh, V.2
Mok, T.3
-
4
-
-
2342471392
-
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
-
Lynch TJ, Bell DW, Sordella R, et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med. 2004;350(21):2129-2139.
-
(2004)
N Engl J Med
, vol.350
, Issue.21
, pp. 2129-2139
-
-
Lynch, T.J.1
Bell, D.W.2
Sordella, R.3
-
5
-
-
2342624080
-
EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
-
Paez JG, Jänne PA, Lee JC, et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science. 2004;304(5676):1497-1500.
-
(2004)
Science
, vol.304
, Issue.5676
, pp. 1497-1500
-
-
Paez, J.G.1
Jänne, P.A.2
Lee, J.C.3
-
6
-
-
22044445517
-
Erlotinib in previously treated non-small-cell lung cancer
-
Shepherd FA, Rodrigues Pereira J, Ciuleanu T, et al. Erlotinib in previously treated non-small-cell lung cancer. N Engl J Med. 2005;353(2):123-132.
-
(2005)
N Engl J Med
, vol.353
, Issue.2
, pp. 123-132
-
-
Shepherd, F.A.1
Rodrigues Pereira, J.2
Ciuleanu, T.3
-
7
-
-
34547638047
-
Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer
-
Soda M, Choi YL, Enomoto M, et al. Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature. 2007;448(7153):561-566.
-
(2007)
Nature
, vol.448
, Issue.7153
, pp. 561-566
-
-
Soda, M.1
Choi, Y.L.2
Enomoto, M.3
-
8
-
-
78049425319
-
Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer
-
Kwak EL, Bang YJ, Camidge DR, et al. Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer. N Engl J Med. 2010;363(18):1693-1703.
-
(2010)
N Engl J Med
, vol.363
, Issue.18
, pp. 1693-1703
-
-
Kwak, E.L.1
Bang, Y.J.2
Camidge, D.R.3
-
9
-
-
58149382583
-
A mouse model for EML4-ALK-positive lung cancer
-
Soda M, Takada S, Takeuchi K, et al. A mouse model for EML4-ALK-positive lung cancer. Proc Natl Acad Sci U S A. 2008;105(50):19893-19897.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, Issue.50
, pp. 19893-19897
-
-
Soda, M.1
Takada, S.2
Takeuchi, K.3
-
10
-
-
0028198206
-
Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma
-
Morris SW, Kirstein MN, Valentine MB, et al. Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma. Science. 1994;263(5151):1281-1284.
-
(1994)
Science
, vol.263
, Issue.5151
, pp. 1281-1284
-
-
Morris, S.W.1
Kirstein, M.N.2
Valentine, M.B.3
-
11
-
-
80555139776
-
Identification of driver mutations in tumor specimens from 1,000 patients with lung adenocarcinoma: The NCI's Lung Cancer Mutation Consortium (LCMC)
-
Abstr
-
Kris MG, Johnson BE, Kwiatkowski DJ, et al. Identification of driver mutations in tumor specimens from 1,000 patients with lung adenocarcinoma: the NCI's Lung Cancer Mutation Consortium (LCMC). J Clin Oncol. 2011;29 Suppl:Abstr CRA7506.
-
(2011)
J Clin Oncol
, vol.29
, Issue.SUPPL.
-
-
Kris, M.G.1
Johnson, B.E.2
Kwiatkowski, D.J.3
-
12
-
-
70350140489
-
Clinical activity observed in a phase I dose escalation trial of an oral c-met and ALK inhibitor, PF-02341066
-
Kwak EL, Camidge DR, Clark J, et al. Clinical activity observed in a phase I dose escalation trial of an oral c-met and ALK inhibitor, PF-02341066. J Clin Oncol. 2009;27 Suppl:148s.
-
(2009)
J Clin Oncol
, vol.27
, Issue.SUPPL.
-
-
Kwak, E.L.1
Camidge, D.R.2
Clark, J.3
-
13
-
-
69349083935
-
Unique clinicopathologic features characterize ALK rearranged lung adenocarcinoma in the western population
-
Rodig SJ, Mino-Kenudson M, Dacic S, et al. Unique clinicopathologic features characterize ALK rearranged lung adenocarcinoma in the western population. Clin Cancer Res. 2009;15(16):5216-5223.
-
(2009)
Clin Cancer Res
, vol.15
, Issue.16
, pp. 5216-5223
-
-
Rodig, S.J.1
Mino-Kenudson, M.2
Dacic, S.3
-
14
-
-
70349336416
-
Clinical features and outcome of patients with non small-cell lung cancer who harbor EML4-ALK
-
Shaw AT, Yeap BY, Mino-Kenudson M, et al. Clinical features and outcome of patients with non small-cell lung cancer who harbor EML4-ALK. J Clin Oncol. 2009;27(26):4247-4253.
-
(2009)
J Clin Oncol
, vol.27
, Issue.26
, pp. 4247-4253
-
-
Shaw, A.T.1
Yeap, B.Y.2
Mino-Kenudson, M.3
-
15
-
-
37549057005
-
The anaplastic lymphoma kinase in the pathogenesis of cancer
-
Chiarle R, Voena C, Ambrogio C, Piva R, Inghirami G. The anaplastic lymphoma kinase in the pathogenesis of cancer. Nat Rev Cancer. 2008;8(1):11-23.
-
(2008)
Nat Rev Cancer
, vol.8
, Issue.1
, pp. 11-23
-
-
Chiarle, R.1
Voena, C.2
Ambrogio, C.3
Piva, R.4
Inghirami, G.5
-
16
-
-
37549059613
-
Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma
-
Christensen JG, Zou HY, Arango ME, et al. Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma. Mol Cancer Ther. 2007;6(12 Pt 1):3314-3322.
-
(2007)
Mol Cancer Ther
, vol.6
, Issue.12 Part 1
, pp. 3314-3322
-
-
Christensen, J.G.1
Zou, H.Y.2
Arango, M.E.3
-
17
-
-
34249324494
-
An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms
-
Zou HY, Li Q, Lee JH, et al. An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms. Cancer Res. 2007;67(9):4408-4417.
-
(2007)
Cancer Res
, vol.67
, Issue.9
, pp. 4408-4417
-
-
Zou, H.Y.1
Li, Q.2
Lee, J.H.3
-
18
-
-
80052793410
-
A novel ALK secondary mutation and EGFR signaling cause resistance to ALK kinase inhibitors
-
Sasaki T, Koivunen J, Ogino A, et al. A novel ALK secondary mutation and EGFR signaling cause resistance to ALK kinase inhibitors. Cancer Res. 2011;71(18):6051-6060.
-
(2011)
Cancer Res
, vol.71
, Issue.18
, pp. 6051-6060
-
-
Sasaki, T.1
Koivunen, J.2
Ogino, A.3
-
19
-
-
78650950138
-
EGFR and EML4-ALK gene mutations in NSCLC: A case report of erlotinib-resistant patient with both concomitant mutations
-
Tiseo M, Gelsomino F, Boggiani D, et al. EGFR and EML4-ALK gene mutations in NSCLC: A case report of erlotinib-resistant patient with both concomitant mutations. Lung Cancer. 2011;71(2):241-243.
-
(2011)
Lung Cancer
, vol.71
, Issue.2
, pp. 241-243
-
-
Tiseo, M.1
Gelsomino, F.2
Boggiani, D.3
-
20
-
-
84864231379
-
Comparison of reverse transcription-polymerase chain reaction, immunohistochemistry, and fluorescence in situ hybridization methodologies for detection of echinoderm microtubule-associated proteinlike 4-anaplastic lymphoma kinase fusion-positive non-small cell lung carcinoma: Implications for optimal clinical testing
-
Wallander ML, Geiersbach KB, Tripp SR, Layfield LJ. Comparison of reverse transcription-polymerase chain reaction, immunohistochemistry, and fluorescence in situ hybridization methodologies for detection of echinoderm microtubule-associated proteinlike 4-anaplastic lymphoma kinase fusion-positive non-small cell lung carcinoma: Implications for optimal clinical testing. Arch Pathol Lab Med. 2012;136(7):796-803.
-
(2012)
Arch Pathol Lab Med
, vol.136
, Issue.7
, pp. 796-803
-
-
Wallander, M.L.1
Geiersbach, K.B.2
Tripp, S.R.3
Layfield, L.J.4
-
21
-
-
81755161162
-
Concomitant EGFR mutation and EML4-ALK gene fusion in non-small cell lung cancer
-
Yang J, Zhang X, Su J, et al. Concomitant EGFR mutation and EML4-ALK gene fusion in non-small cell lung cancer. J Clin Oncol. 2011;29(Suppl 15):10517.
-
(2011)
J Clin Oncol
, vol.29
, Issue.SUPPL. 15
, pp. 10517
-
-
Yang, J.1
Zhang, X.2
Su, J.3
-
22
-
-
78349237453
-
Optimizing the detection of lung cancer patients harboring anaplastic lymphoma kinase (ALK) gene rearrangements potentially suitable for ALK inhibitor treatment
-
Camidge DR, Kono SA, Flacco A, et al. Optimizing the detection of lung cancer patients harboring anaplastic lymphoma kinase (ALK) gene rearrangements potentially suitable for ALK inhibitor treatment. Clin Cancer Res. 2010;16(22):5581-5590.
-
(2010)
Clin Cancer Res
, vol.16
, Issue.22
, pp. 5581-5590
-
-
Camidge, D.R.1
Kono, S.A.2
Flacco, A.3
-
23
-
-
77954399760
-
Fusion of EML4 and ALK is associated with development of lung adenocarcinomas lacking EGFR and KRAS mutations and is correlated with ALK expression
-
Zhang X, Zhang S, Yang X, et al. Fusion of EML4 and ALK is associated with development of lung adenocarcinomas lacking EGFR and KRAS mutations and is correlated with ALK expression. Mol Cancer. 2010;9:188.
-
(2010)
Mol Cancer
, vol.9
, pp. 188
-
-
Zhang, X.1
Zhang, S.2
Yang, X.3
-
24
-
-
80052492099
-
Progression-free survival (PFS) from a Phase I study of crizotinib (PF-02341066) in patients with ALK-positive non-small cell lung cancer (NSCLC)
-
Camidge DR, Bang Y, Kwak EL, et al. Progression-free survival (PFS) from a Phase I study of crizotinib (PF-02341066) in patients with ALK-positive non-small cell lung cancer (NSCLC). J Clin Oncol. 2011;29(Suppl 15):2501.
-
(2501)
J Clin Oncol
, vol.29
, Issue.SUPPL. 15
, pp. 2011
-
-
Camidge, D.R.1
Bang, Y.2
Kwak, E.L.3
-
25
-
-
80051780280
-
Initial phase II results with crizotinib in advanced ALK-positive non-small cell lung cancer (NSCLC): Profile 1005
-
Abstr 7514
-
Crino L, Crinò L, Kim D, et al. Initial phase II results with crizotinib in advanced ALK-positive non-small cell lung cancer (NSCLC): Profile 1005. J Clin Oncol. 2011;29 Suppl:Abstr 7514.
-
(2011)
J Clin Oncol
, vol.29
, Issue.SUPPL.
-
-
Crino, L.1
Crinò, L.2
Kim, D.3
-
26
-
-
84876975376
-
-
Xalkori [crizotinib, package insert]. New York, NY: Pfizer Inc
-
Xalkori [crizotinib, package insert]. New York, NY: Pfizer Inc; 2011.
-
(2011)
-
-
-
27
-
-
84865431278
-
Results of a global phase II study with crizotinib in advanced ALK-positive non-small cell lung cancer (NSCLC)
-
Abstr 7533
-
Kim DW, Ahn MJ, Shi Y, et al. Results of a global phase II study with crizotinib in advanced ALK-positive non-small cell lung cancer (NSCLC). J Clin Oncol. 2012;30 Suppl:Abstr 7533.
-
(2012)
J Clin Oncol
, vol.30
, Issue.SUPPL.
-
-
Kim, D.W.1
Ahn, M.J.2
Shi, Y.3
-
28
-
-
84866934606
-
Activity and safety of crizotinib in patients with ALK-positive non-small-cell lung cancer: Updated results from a Phase 1study
-
Camidge DR, Bang YJ, Kwak EL, et al. Activity and safety of crizotinib in patients with ALK-positive non-small-cell lung cancer: updated results from a Phase 1study. Lancet Oncol. 2012;13(10):1011-1019.
-
(2012)
Lancet Oncol
, vol.13
, Issue.10
, pp. 1011-1019
-
-
Camidge, D.R.1
Bang, Y.J.2
Kwak, E.L.3
-
29
-
-
84877000526
-
Phase III study of crizotinib versus pemetrexed or docetaxel chemotherapy in patients with advanced ALK-positive non-small cell lung cancer (NSCLC) (PROFILE 1007). Abstract LBA1 presented at the Annual Congress of the European Society for Medical Oncology, Vienna, Austria
-
Shaw AT, Kim DW, Nakagawa K, et al. Phase III study of crizotinib versus pemetrexed or docetaxel chemotherapy in patients with advanced ALK-positive non-small cell lung cancer (NSCLC) (PROFILE 1007). Abstract LBA1 presented at the Annual Congress of the European Society for Medical Oncology, Vienna, Austria, September 28-October 2, 2012.
-
(2012)
September 28-October
, pp. 2
-
-
Shaw, A.T.1
Kim, D.W.2
Nakagawa, K.3
-
31
-
-
57349113565
-
Multiplex reverse transcription-PCR screening for EML4-ALK fusion transcripts
-
Takeuchi K, Choi YL, Soda M, et al. Multiplex reverse transcription-PCR screening for EML4-ALK fusion transcripts. Clin Cancer Res. 2008;14(20):6618-6624.
-
(2008)
Clin Cancer Res
, vol.14
, Issue.20
, pp. 6618-6624
-
-
Takeuchi, K.1
Choi, Y.L.2
Soda, M.3
-
32
-
-
78650472876
-
Treatment of lung cancer with an ALK inhibitor after EML4-ALK fusion gene detection using endobronchial ultrasound-guided transbronchial needle aspiration
-
Nakajima T, Kimura H, Takeuchi K, et al. Treatment of lung cancer with an ALK inhibitor after EML4-ALK fusion gene detection using endobronchial ultrasound-guided transbronchial needle aspiration. J Thorac Oncol. 2010;5(12):2041-2043.
-
(2010)
J Thorac Oncol
, vol.5
, Issue.12
, pp. 2041-2043
-
-
Nakajima, T.1
Kimura, H.2
Takeuchi, K.3
-
33
-
-
48549098388
-
Identification of novel isoforms of the EML4-ALK transforming gene in non-small cell lung cancer
-
Choi YL, Takeuchi K, Soda M, et al. Identification of novel isoforms of the EML4-ALK transforming gene in non-small cell lung cancer. Cancer Res. 2008;68(13):4971-4976.
-
(2008)
Cancer Res
, vol.68
, Issue.13
, pp. 4971-4976
-
-
Choi, Y.L.1
Takeuchi, K.2
Soda, M.3
-
34
-
-
77649091118
-
A novel, highly sensitive antibody allows for the routine detection of ALK-rearranged lung adenocarcinomas by standard immunohistochemistry
-
Mino-Kenudson M, Chirieac LR, Law K, et al. A novel, highly sensitive antibody allows for the routine detection of ALK-rearranged lung adenocarcinomas by standard immunohistochemistry. Clin Cancer Res. 2010;16(5):1561-1571.
-
(2010)
Clin Cancer Res
, vol.16
, Issue.5
, pp. 1561-1571
-
-
Mino-Kenudson, M.1
Chirieac, L.R.2
Law, K.3
-
35
-
-
59649127007
-
EML4-ALK rearrangement in non-small cell lung cancer and non-tumor lung tissues
-
Martelli MP, Sozzi G, Hernandez L, et al. EML4-ALK rearrangement in non-small cell lung cancer and non-tumor lung tissues. Am J Pathol. 2009;174(2):661-670.
-
(2009)
Am J Pathol
, vol.174
, Issue.2
, pp. 661-670
-
-
Martelli, M.P.1
Sozzi, G.2
Hernandez, L.3
-
36
-
-
63949086127
-
KIF5B-ALK, a novel fusion oncokinase identified by an immunohistochemistry-based diagnostic system for ALK-positive lung cancer
-
Takeuchi K, Choi YL, Togashi Y, et al. KIF5B-ALK, a novel fusion oncokinase identified by an immunohistochemistry-based diagnostic system for ALK-positive lung cancer. Clin Cancer Res. 2009;15(9):3143-3149.
-
(2009)
Clin Cancer Res
, vol.15
, Issue.9
, pp. 3143-3149
-
-
Takeuchi, K.1
Choi, Y.L.2
Togashi, Y.3
-
37
-
-
81755188353
-
Asymptomatic profound sinus bradycardia (heart rate # 45) in non-small cell lung cancer patients treated with crizotinib
-
Ou SH, Azada M, Dy J, Stiber JA. Asymptomatic profound sinus bradycardia (heart rate # 45) in non-small cell lung cancer patients treated with crizotinib. J Thorac Oncol. 2011;6(12):2135-2137.
-
(2011)
J Thorac Oncol
, vol.6
, Issue.12
, pp. 2135-2137
-
-
Ou, S.H.1
Azada, M.2
Dy, J.3
Stiber, J.A.4
-
38
-
-
78049426513
-
ALK Lung Cancer Study Group. EML4-ALK mutations in lung cancer that confer resistance to ALK inhibitors
-
Choi YL, Soda M, Yamashita Y, et al; ALK Lung Cancer Study Group. EML4-ALK mutations in lung cancer that confer resistance to ALK inhibitors. N Engl J Med. 2010;363(18):1734-1739.
-
(2010)
N Engl J Med
, vol.363
, Issue.18
, pp. 1734-1739
-
-
Choi, Y.L.1
Soda, M.2
Yamashita, Y.3
-
39
-
-
84856990335
-
Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non-small cell lung cancer
-
Doebele RC, Pilling AB, Aisner DL, et al. Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non-small cell lung cancer. Clin Cancer Res. 2012;18(5):1472-1482.
-
(2012)
Clin Cancer Res
, vol.18
, Issue.5
, pp. 1472-1482
-
-
Doebele, R.C.1
Pilling, A.B.2
Aisner, D.L.3
-
40
-
-
79956318797
-
Therapeutic strategies to overcome crizotinib resistance in non-small cell lung cancers harboring the fusion oncogene EML4-ALK
-
Katayama R, Khan TM, Benes C, et al. Therapeutic strategies to overcome crizotinib resistance in non-small cell lung cancers harboring the fusion oncogene EML4-ALK. Proc Natl Acad Sci U S A. 2011;108(18):7535-7540.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, Issue.18
, pp. 7535-7540
-
-
Katayama, R.1
Khan, T.M.2
Benes, C.3
-
41
-
-
84856999699
-
Mechanisms of acquired crizotinib resistance in ALK-rearranged lung cancers
-
Katayama R, Shaw AT, Khan TM, et al. Mechanisms of acquired crizotinib resistance in ALK-rearranged lung cancers. Sci Transl Med. 2012;4(120):120ra17.
-
(2012)
Sci Transl Med
, vol.4
, Issue.120
-
-
Katayama, R.1
Shaw, A.T.2
Khan, T.M.3
-
42
-
-
78649475696
-
The neuroblastoma-associated F1174L ALK mutation causes resistance to an ALK kinase inhibitor in ALK-translocated cancers
-
Sasaki T, Okuda K, Zheng W, et al. The neuroblastoma-associated F1174L ALK mutation causes resistance to an ALK kinase inhibitor in ALK-translocated cancers. Cancer Res. 2010;70(24):10038-10043.
-
(2010)
Cancer Res
, vol.70
, Issue.24
, pp. 10038-10043
-
-
Sasaki, T.1
Okuda, K.2
Zheng, W.3
-
43
-
-
84869211206
-
Activation of HER family signaling as a mechanism of acquired resistance to ALK inhibitors in EML4-ALK-positive non-small cell lung cancer
-
Tanizaki J, Okamoto I, Okabe T, et al. Activation of HER family signaling as a mechanism of acquired resistance to ALK inhibitors in EML4-ALK-positive non-small cell lung cancer. Clin Cancer Res. 2012;18(22):6219-6226.
-
(2012)
Clin Cancer Res
, vol.18
, Issue.22
, pp. 6219-6226
-
-
Tanizaki, J.1
Okamoto, I.2
Okabe, T.3
-
44
-
-
0035800507
-
Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification
-
Gorre ME, Mohammed M, Ellwood K, et al. Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification. Science. 2001;293(5531):876-880.
-
(2001)
Science
, vol.293
, Issue.5531
, pp. 876-880
-
-
Gorre, M.E.1
Mohammed, M.2
Ellwood, K.3
-
45
-
-
18244371651
-
Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain
-
Pao W, Miller VA, Politi KA, et al. Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PLoS Med. 2005;2(3):e73.
-
(2005)
PLoS Med
, vol.2
, Issue.3
-
-
Pao, W.1
Miller, V.A.2
Politi, K.A.3
-
46
-
-
21144439000
-
Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib
-
Kwak EL, Sordella R, Bell DW, et al. Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib. Proc Natl Acad Sci U S A. 2005;102(21):7665-7670.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, Issue.21
, pp. 7665-7670
-
-
Kwak, E.L.1
Sordella, R.2
Bell, D.W.3
-
47
-
-
57749188299
-
Targeting cancer with small molecule kinase inhibitors
-
Zhang J, Yang PL, Gray NS. Targeting cancer with small molecule kinase inhibitors. Nat Rev Cancer. 2009;9(1):28-39.
-
(2009)
Nat Rev Cancer
, vol.9
, Issue.1
, pp. 28-39
-
-
Zhang, J.1
Yang, P.L.2
Gray, N.S.3
-
48
-
-
79960250811
-
Insights into ALK-driven cancers revealed through development of novel ALK tyrosine kinase inhibitors
-
Lovly CM, Heuckmann JM, de Stanchina E, et al. Insights into ALK-driven cancers revealed through development of novel ALK tyrosine kinase inhibitors. Cancer Res. 2011;71(14):4920-4931.
-
(2011)
Cancer Res
, vol.71
, Issue.14
, pp. 4920-4931
-
-
Lovly, C.M.1
Heuckmann, J.M.2
de Stanchina, E.3
-
49
-
-
79955964568
-
CH5424802, a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant
-
Sakamoto H, Tsukaguchi T, Hiroshima S, et al. CH5424802, a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant. Cancer Cell. 2011;19(5):679-690.
-
(2011)
Cancer Cell
, vol.19
, Issue.5
, pp. 679-690
-
-
Sakamoto, H.1
Tsukaguchi, T.2
Hiroshima, S.3
-
50
-
-
78649973178
-
Inhibition of ALK, PI3K/MEK, and HSP90 in murine lung adenocarcinoma induced by EML4-ALK fusion oncogene
-
Chen Z, Sasaki T, Tan X, et al. Inhibition of ALK, PI3K/MEK, and HSP90 in murine lung adenocarcinoma induced by EML4-ALK fusion oncogene. Cancer Res. 2010;70(23):9827-9836.
-
(2010)
Cancer Res
, vol.70
, Issue.23
, pp. 9827-9836
-
-
Chen, Z.1
Sasaki, T.2
Tan, X.3
-
51
-
-
84855457952
-
Hsp90 molecular chaperone inhibitors: Are we there yet?
-
Neckers L, Workman P. Hsp90 molecular chaperone inhibitors: are we there yet? Clin Cancer Res. 2012;18(1):64-76.
-
(2012)
Clin Cancer Res
, vol.18
, Issue.1
, pp. 64-76
-
-
Neckers, L.1
Workman, P.2
-
52
-
-
84876977183
-
The GALAXY trial (NCT01348126): A randomized IIB/III study of ganetespib (STA-9090) in combination with docetaxel versus docetaxel alone in subjects with stage IIIB or IV NSCLC
-
Goss GD, et al. The GALAXY trial (NCT01348126): a randomized IIB/III study of ganetespib (STA-9090) in combination with docetaxel versus docetaxel alone in subjects with stage IIIB or IV NSCLC. J Clin Oncol. 2012;30(Suppl 15):TPS7613.
-
(2012)
J Clin Oncol
, vol.30
, Issue.SUPPL. 15
-
-
Goss, G.D.1
-
53
-
-
79951885125
-
Activity of IPI-504, a novel heat-shock protein 90 inhibitor, in patients with molecularly defined non-small-cell lung cancer
-
Sequist LV, Gettinger S, Senzer NN, et al. Activity of IPI-504, a novel heat-shock protein 90 inhibitor, in patients with molecularly defined non-small-cell lung cancer. J Clin Oncol. 2010;28(33):4953-4960.
-
(2010)
J Clin Oncol
, vol.28
, Issue.33
, pp. 4953-4960
-
-
Sequist, L.V.1
Gettinger, S.2
Senzer, N.N.3
-
54
-
-
82555180241
-
An open-label Phase II study of the Hsp90 inhibitor ganetespib (STA-9090) as monotherapy in patients with advanced non-small cell lung cancer (NSCLC)
-
Abstr 7500
-
Wong K, Koczywas M, Goldman JW, et al. An open-label Phase II study of the Hsp90 inhibitor ganetespib (STA-9090) as monotherapy in patients with advanced non-small cell lung cancer (NSCLC). J Clin Oncol. 2011;29 Suppl:Abstr 7500.
-
(2011)
J Clin Oncol
, vol.29
, Issue.SUPPL.
-
-
Wong, K.1
Koczywas, M.2
Goldman, J.W.3
-
55
-
-
84866930352
-
Combined PI3K/mTOR and MEK inhibition provides broad antitumor activity in faithful murine cancer models
-
Roberts PJ, Usary JE, Darr DB, et al. Combined PI3K/mTOR and MEK inhibition provides broad antitumor activity in faithful murine cancer models. Clin Cancer Res. 2012;18(19):5290-5303.
-
(2012)
Clin Cancer Res
, vol.18
, Issue.19
, pp. 5290-5303
-
-
Roberts, P.J.1
Usary, J.E.2
Darr, D.B.3
-
56
-
-
0037402509
-
Fusion of FIG to the receptor tyrosine kinase ROS in a glioblastoma with an interstitial del(6)(q21q21)
-
Charest A, Lane K, McMahon K, et al. Fusion of FIG to the receptor tyrosine kinase ROS in a glioblastoma with an interstitial del(6)(q21q21). Genes Chromosomes Cancer. 2003;37(1):58-71.
-
(2003)
Genes Chromosomes Cancer
, vol.37
, Issue.1
, pp. 58-71
-
-
Charest, A.1
Lane, K.2
McMahon, K.3
-
57
-
-
79251579592
-
Survey of tyrosine kinase signaling reveals ROS kinase fusions in human cholangiocarcinoma
-
Gu TL, Deng X, Huang F, et al. Survey of tyrosine kinase signaling reveals ROS kinase fusions in human cholangiocarcinoma. PLoS One. 2011;6(1):e15640.
-
(2011)
PLoS One
, vol.6
, Issue.1
-
-
Gu, T.L.1
Deng, X.2
Huang, F.3
-
58
-
-
0024852378
-
Characterization of the ros1-gene products expressed in human glioblastoma cell lines
-
Sharma S, Birchmeier C, Nikawa J, O'Neill K, Rodgers L, Wigler M. Characterization of the ros1-gene products expressed in human glioblastoma cell lines. Oncogene Res. 1989;5(2):91-100.
-
(1989)
Oncogene Res
, vol.5
, Issue.2
, pp. 91-100
-
-
Sharma, S.1
Birchmeier, C.2
Nikawa, J.3
O'Neill, K.4
Rodgers, L.5
Wigler, M.6
-
59
-
-
36849065315
-
Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer
-
Rikova K, Guo A, Zeng Q, et al. Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell. 2007;131(6):1190-1203.
-
(2007)
Cell
, vol.131
, Issue.6
, pp. 1190-1203
-
-
Rikova, K.1
Guo, A.2
Zeng, Q.3
-
60
-
-
84865089246
-
Analysis of receptor tyrosine kinase ROS1-positive tumors in non-small cell lung cancer: Identification of a FIG-ROS1 fusion
-
Rimkunas VM, Crosby KE, Li D, et al. Analysis of receptor tyrosine kinase ROS1-positive tumors in non-small cell lung cancer: identification of a FIG-ROS1 fusion. Clin Cancer Res. 2012;18(16):4449-4457.
-
(2012)
Clin Cancer Res
, vol.18
, Issue.16
, pp. 4449-4457
-
-
Rimkunas, V.M.1
Crosby, K.E.2
Li, D.3
-
61
-
-
84857985225
-
RET, ROS1 and ALK fusions in lung cancer
-
Takeuchi K, Soda M, Togashi Y, et al. RET, ROS1 and ALK fusions in lung cancer. Nat Med. 2012;18(3):378-381.
-
(2012)
Nat Med
, vol.18
, Issue.3
, pp. 378-381
-
-
Takeuchi, K.1
Soda, M.2
Togashi, Y.3
-
62
-
-
84863338079
-
ROS1 rearrangements define a unique molecular class of lung cancers
-
Bergethon K, Shaw AT, Ou SH, et al. ROS1 rearrangements define a unique molecular class of lung cancers. J Clin Oncol. 2012;30(8):863-870.
-
(2012)
J Clin Oncol
, vol.30
, Issue.8
, pp. 863-870
-
-
Bergethon, K.1
Shaw, A.T.2
Ou, S.H.3
-
63
-
-
84862846839
-
Preclinical rationale for use of the clinically available multitargeted tyrosine kinase inhibitor crizotinib in ROS1-translocated lung cancer
-
Yasuda H, et al. Preclinical rationale for use of the clinically available multitargeted tyrosine kinase inhibitor crizotinib in ROS1-translocated lung cancer. J Thorac Oncol. 2012;7(7):p. 1086-1090.
-
(2012)
J Thorac Oncol
, vol.7
, Issue.7
, pp. 1086-1090
-
-
Yasuda, H.1
-
64
-
-
44849126091
-
Genomic alterations of anaplastic lymphoma kinase may sensitize tumors to anaplastic lymphoma kinase inhibitors
-
McDermott U, et al. Genomic alterations of anaplastic lymphoma kinase may sensitize tumors to anaplastic lymphoma kinase inhibitors. Cancer Res. 2008;68(9):p. 3389-3395.
-
(2008)
Cancer Res
, vol.68
, Issue.9
, pp. 3389-3395
-
-
McDermott, U.1
-
65
-
-
84865092224
-
Clinical activity of crizotinib in advanced non-small cell lung cancer (NSCLC) harboring ROS1 gene rearrangement
-
Shaw AT, et al., Clinical activity of crizotinib in advanced non-small cell lung cancer (NSCLC) harboring ROS1 gene rearrangement. ASCO Meeting Abstracts. 2012;30(15_suppl):p. 7508.
-
(2012)
ASCO Meeting Abstracts
, vol.30
, Issue.15 SUPPL
, pp. 7508
-
-
Shaw, A.T.1
-
66
-
-
84858341589
-
MET signaling: Novel targeted inhibition and its clinical development in lung cancer
-
Feng Y, Thiagarajan PS, Ma PC. MET signaling: novel targeted inhibition and its clinical development in lung cancer. J Thorac Oncol. 2012;7(2):p. 459-467.
-
(2012)
J Thorac Oncol
, vol.7
, Issue.2
, pp. 459-467
-
-
Feng, Y.1
Thiagarajan, P.S.2
Ma, P.C.3
-
67
-
-
0038724909
-
c-Met: Structure, functions and potential for therapeutic inhibition
-
Ma PC, et al. c-Met: structure, functions and potential for therapeutic inhibition. Cancer Metastasis Rev. 2003;22(4):p. 309-325.
-
(2003)
Cancer Metastasis Rev
, vol.22
, Issue.4
, pp. 309-325
-
-
Ma, P.C.1
-
68
-
-
81755165799
-
Clinical implications of high MET gene dosage in non-small cell lung cancer patients without previous tyrosine kinase inhibitor treatment
-
Chen YT, et al. Clinical implications of high MET gene dosage in non-small cell lung cancer patients without previous tyrosine kinase inhibitor treatment. J Thorac Oncol. 2011;6(12):p. 2027-2035.
-
(2011)
J Thorac Oncol
, vol.6
, Issue.12
, pp. 2027-2035
-
-
Chen, Y.T.1
-
69
-
-
84862777005
-
Correlation between MET gene copy number by silver in situ hybridization and protein expression by immunohistochemistry in non-small cell lung cancer
-
Dziadziuszko R, et al. Correlation between MET gene copy number by silver in situ hybridization and protein expression by immunohistochemistry in non-small cell lung cancer. J Thorac Oncol. 2012;7(2):p. 340-347.
-
(2012)
J Thorac Oncol
, vol.7
, Issue.2
, pp. 340-347
-
-
Dziadziuszko, R.1
-
70
-
-
84863229341
-
High MET copy number and MET overexpression: Poor outcome in non-small cell lung cancer patients
-
Park, S., et al., High MET copy number and MET overexpression: poor outcome in non-small cell lung cancer patients. Histol Histopathol, 2012. 27(2): p. 197-207.
-
(2012)
Histol Histopathol
, vol.27
, Issue.2
, pp. 197-207
-
-
Park, S.1
-
71
-
-
84907047245
-
Biomarkers that currently affect clinical practice: EGFR, ALK, MET, KRAS
-
Vincent MD, et al., Biomarkers that currently affect clinical practice: EGFR, ALK, MET, KRAS. Curr Oncol. 2012;19(Suppl 1):p. S33-S44.
-
(2012)
Curr Oncol
, vol.19
, Issue.SUPPL. 1
-
-
Vincent, M.D.1
-
72
-
-
79955458487
-
Activity of crizotinib (PF02341066), a dual mesenchymal-epithelial transition (MET) and anaplastic lymphoma kinase (ALK) inhibitor, in a non-small cell lung cancer patient with de novo MET amplification
-
Ou SH, et al. Activity of crizotinib (PF02341066), a dual mesenchymal-epithelial transition (MET) and anaplastic lymphoma kinase (ALK) inhibitor, in a non-small cell lung cancer patient with de novo MET amplification. J Thorac Oncol. 2011;6(5):p. 942-946.
-
(2011)
J Thorac Oncol
, vol.6
, Issue.5
, pp. 942-946
-
-
Ou, S.H.1
-
73
-
-
84856816903
-
Clinical improvement and rapid radiographic regression induced by a MET inhibitor in a patient with MET-amplified glioblastoma
-
Chi AS, et al. Clinical improvement and rapid radiographic regression induced by a MET inhibitor in a patient with MET-amplified glioblastoma. ASCO Meeting Abstracts. 2012;29(15_suppl):p. 2072.
-
(2012)
ASCO Meeting Abstracts
, vol.29
, Issue.15 SUPPL
, pp. 2072
-
-
Chi, A.S.1
-
74
-
-
84555190809
-
MET amplification identifies a small and aggressive subgroup of esophagogastric adenocarcinoma with evidence of responsiveness to crizotinib
-
Lennerz JK, et al. MET amplification identifies a small and aggressive subgroup of esophagogastric adenocarcinoma with evidence of responsiveness to crizotinib. J Clin Oncol. 2011;29(36):p. 4803-4810.
-
(2011)
J Clin Oncol
, vol.29
, Issue.36
, pp. 4803-4810
-
-
Lennerz, J.K.1
|