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Volumn 7, Issue 1, 2013, Pages 91-101

Clinical use of crizotinib for the treatment of non-small cell lung cancer

Author keywords

ALK; EML4 ALK; HSP90 inhibitors; MET; Non small cell lung cancer; ROS1; Xalkori

Indexed keywords

ANAPLASTIC LYMPHOMA KINASE; CRIZOTINIB; DACOMITINIB; DOCETAXEL; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; GANETESPIB; K RAS PROTEIN; PEMETREXED;

EID: 84876985187     PISSN: 11775475     EISSN: 11775491     Source Type: Journal    
DOI: 10.2147/BTT.S29026     Document Type: Article
Times cited : (36)

References (74)
  • 3
    • 56249109644 scopus 로고    scopus 로고
    • Gefitinib versus docetaxel in previously treated non-small-cell lung cancer (INTEREST): A randomised phase III trial
    • al
    • Kim ES, Hirsh V, Mok T, al. Gefitinib versus docetaxel in previously treated non-small-cell lung cancer (INTEREST): a randomised phase III trial. Lancet. 2008;372(9652):1809-1818.
    • (2008) Lancet , vol.372 , Issue.9652 , pp. 1809-1818
    • Kim, E.S.1    Hirsh, V.2    Mok, T.3
  • 4
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    • Lynch TJ, Bell DW, Sordella R, et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med. 2004;350(21):2129-2139.
    • (2004) N Engl J Med , vol.350 , Issue.21 , pp. 2129-2139
    • Lynch, T.J.1    Bell, D.W.2    Sordella, R.3
  • 5
    • 2342624080 scopus 로고    scopus 로고
    • EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
    • Paez JG, Jänne PA, Lee JC, et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science. 2004;304(5676):1497-1500.
    • (2004) Science , vol.304 , Issue.5676 , pp. 1497-1500
    • Paez, J.G.1    Jänne, P.A.2    Lee, J.C.3
  • 6
    • 22044445517 scopus 로고    scopus 로고
    • Erlotinib in previously treated non-small-cell lung cancer
    • Shepherd FA, Rodrigues Pereira J, Ciuleanu T, et al. Erlotinib in previously treated non-small-cell lung cancer. N Engl J Med. 2005;353(2):123-132.
    • (2005) N Engl J Med , vol.353 , Issue.2 , pp. 123-132
    • Shepherd, F.A.1    Rodrigues Pereira, J.2    Ciuleanu, T.3
  • 7
    • 34547638047 scopus 로고    scopus 로고
    • Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer
    • Soda M, Choi YL, Enomoto M, et al. Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature. 2007;448(7153):561-566.
    • (2007) Nature , vol.448 , Issue.7153 , pp. 561-566
    • Soda, M.1    Choi, Y.L.2    Enomoto, M.3
  • 8
    • 78049425319 scopus 로고    scopus 로고
    • Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer
    • Kwak EL, Bang YJ, Camidge DR, et al. Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer. N Engl J Med. 2010;363(18):1693-1703.
    • (2010) N Engl J Med , vol.363 , Issue.18 , pp. 1693-1703
    • Kwak, E.L.1    Bang, Y.J.2    Camidge, D.R.3
  • 9
    • 58149382583 scopus 로고    scopus 로고
    • A mouse model for EML4-ALK-positive lung cancer
    • Soda M, Takada S, Takeuchi K, et al. A mouse model for EML4-ALK-positive lung cancer. Proc Natl Acad Sci U S A. 2008;105(50):19893-19897.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , Issue.50 , pp. 19893-19897
    • Soda, M.1    Takada, S.2    Takeuchi, K.3
  • 10
    • 0028198206 scopus 로고
    • Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma
    • Morris SW, Kirstein MN, Valentine MB, et al. Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma. Science. 1994;263(5151):1281-1284.
    • (1994) Science , vol.263 , Issue.5151 , pp. 1281-1284
    • Morris, S.W.1    Kirstein, M.N.2    Valentine, M.B.3
  • 11
    • 80555139776 scopus 로고    scopus 로고
    • Identification of driver mutations in tumor specimens from 1,000 patients with lung adenocarcinoma: The NCI's Lung Cancer Mutation Consortium (LCMC)
    • Abstr
    • Kris MG, Johnson BE, Kwiatkowski DJ, et al. Identification of driver mutations in tumor specimens from 1,000 patients with lung adenocarcinoma: the NCI's Lung Cancer Mutation Consortium (LCMC). J Clin Oncol. 2011;29 Suppl:Abstr CRA7506.
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • Kris, M.G.1    Johnson, B.E.2    Kwiatkowski, D.J.3
  • 12
    • 70350140489 scopus 로고    scopus 로고
    • Clinical activity observed in a phase I dose escalation trial of an oral c-met and ALK inhibitor, PF-02341066
    • Kwak EL, Camidge DR, Clark J, et al. Clinical activity observed in a phase I dose escalation trial of an oral c-met and ALK inhibitor, PF-02341066. J Clin Oncol. 2009;27 Suppl:148s.
    • (2009) J Clin Oncol , vol.27 , Issue.SUPPL.
    • Kwak, E.L.1    Camidge, D.R.2    Clark, J.3
  • 13
    • 69349083935 scopus 로고    scopus 로고
    • Unique clinicopathologic features characterize ALK rearranged lung adenocarcinoma in the western population
    • Rodig SJ, Mino-Kenudson M, Dacic S, et al. Unique clinicopathologic features characterize ALK rearranged lung adenocarcinoma in the western population. Clin Cancer Res. 2009;15(16):5216-5223.
    • (2009) Clin Cancer Res , vol.15 , Issue.16 , pp. 5216-5223
    • Rodig, S.J.1    Mino-Kenudson, M.2    Dacic, S.3
  • 14
    • 70349336416 scopus 로고    scopus 로고
    • Clinical features and outcome of patients with non small-cell lung cancer who harbor EML4-ALK
    • Shaw AT, Yeap BY, Mino-Kenudson M, et al. Clinical features and outcome of patients with non small-cell lung cancer who harbor EML4-ALK. J Clin Oncol. 2009;27(26):4247-4253.
    • (2009) J Clin Oncol , vol.27 , Issue.26 , pp. 4247-4253
    • Shaw, A.T.1    Yeap, B.Y.2    Mino-Kenudson, M.3
  • 16
    • 37549059613 scopus 로고    scopus 로고
    • Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma
    • Christensen JG, Zou HY, Arango ME, et al. Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma. Mol Cancer Ther. 2007;6(12 Pt 1):3314-3322.
    • (2007) Mol Cancer Ther , vol.6 , Issue.12 Part 1 , pp. 3314-3322
    • Christensen, J.G.1    Zou, H.Y.2    Arango, M.E.3
  • 17
    • 34249324494 scopus 로고    scopus 로고
    • An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms
    • Zou HY, Li Q, Lee JH, et al. An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms. Cancer Res. 2007;67(9):4408-4417.
    • (2007) Cancer Res , vol.67 , Issue.9 , pp. 4408-4417
    • Zou, H.Y.1    Li, Q.2    Lee, J.H.3
  • 18
    • 80052793410 scopus 로고    scopus 로고
    • A novel ALK secondary mutation and EGFR signaling cause resistance to ALK kinase inhibitors
    • Sasaki T, Koivunen J, Ogino A, et al. A novel ALK secondary mutation and EGFR signaling cause resistance to ALK kinase inhibitors. Cancer Res. 2011;71(18):6051-6060.
    • (2011) Cancer Res , vol.71 , Issue.18 , pp. 6051-6060
    • Sasaki, T.1    Koivunen, J.2    Ogino, A.3
  • 19
    • 78650950138 scopus 로고    scopus 로고
    • EGFR and EML4-ALK gene mutations in NSCLC: A case report of erlotinib-resistant patient with both concomitant mutations
    • Tiseo M, Gelsomino F, Boggiani D, et al. EGFR and EML4-ALK gene mutations in NSCLC: A case report of erlotinib-resistant patient with both concomitant mutations. Lung Cancer. 2011;71(2):241-243.
    • (2011) Lung Cancer , vol.71 , Issue.2 , pp. 241-243
    • Tiseo, M.1    Gelsomino, F.2    Boggiani, D.3
  • 20
    • 84864231379 scopus 로고    scopus 로고
    • Comparison of reverse transcription-polymerase chain reaction, immunohistochemistry, and fluorescence in situ hybridization methodologies for detection of echinoderm microtubule-associated proteinlike 4-anaplastic lymphoma kinase fusion-positive non-small cell lung carcinoma: Implications for optimal clinical testing
    • Wallander ML, Geiersbach KB, Tripp SR, Layfield LJ. Comparison of reverse transcription-polymerase chain reaction, immunohistochemistry, and fluorescence in situ hybridization methodologies for detection of echinoderm microtubule-associated proteinlike 4-anaplastic lymphoma kinase fusion-positive non-small cell lung carcinoma: Implications for optimal clinical testing. Arch Pathol Lab Med. 2012;136(7):796-803.
    • (2012) Arch Pathol Lab Med , vol.136 , Issue.7 , pp. 796-803
    • Wallander, M.L.1    Geiersbach, K.B.2    Tripp, S.R.3    Layfield, L.J.4
  • 21
    • 81755161162 scopus 로고    scopus 로고
    • Concomitant EGFR mutation and EML4-ALK gene fusion in non-small cell lung cancer
    • Yang J, Zhang X, Su J, et al. Concomitant EGFR mutation and EML4-ALK gene fusion in non-small cell lung cancer. J Clin Oncol. 2011;29(Suppl 15):10517.
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL. 15 , pp. 10517
    • Yang, J.1    Zhang, X.2    Su, J.3
  • 22
    • 78349237453 scopus 로고    scopus 로고
    • Optimizing the detection of lung cancer patients harboring anaplastic lymphoma kinase (ALK) gene rearrangements potentially suitable for ALK inhibitor treatment
    • Camidge DR, Kono SA, Flacco A, et al. Optimizing the detection of lung cancer patients harboring anaplastic lymphoma kinase (ALK) gene rearrangements potentially suitable for ALK inhibitor treatment. Clin Cancer Res. 2010;16(22):5581-5590.
    • (2010) Clin Cancer Res , vol.16 , Issue.22 , pp. 5581-5590
    • Camidge, D.R.1    Kono, S.A.2    Flacco, A.3
  • 23
    • 77954399760 scopus 로고    scopus 로고
    • Fusion of EML4 and ALK is associated with development of lung adenocarcinomas lacking EGFR and KRAS mutations and is correlated with ALK expression
    • Zhang X, Zhang S, Yang X, et al. Fusion of EML4 and ALK is associated with development of lung adenocarcinomas lacking EGFR and KRAS mutations and is correlated with ALK expression. Mol Cancer. 2010;9:188.
    • (2010) Mol Cancer , vol.9 , pp. 188
    • Zhang, X.1    Zhang, S.2    Yang, X.3
  • 24
    • 80052492099 scopus 로고    scopus 로고
    • Progression-free survival (PFS) from a Phase I study of crizotinib (PF-02341066) in patients with ALK-positive non-small cell lung cancer (NSCLC)
    • Camidge DR, Bang Y, Kwak EL, et al. Progression-free survival (PFS) from a Phase I study of crizotinib (PF-02341066) in patients with ALK-positive non-small cell lung cancer (NSCLC). J Clin Oncol. 2011;29(Suppl 15):2501.
    • (2501) J Clin Oncol , vol.29 , Issue.SUPPL. 15 , pp. 2011
    • Camidge, D.R.1    Bang, Y.2    Kwak, E.L.3
  • 25
    • 80051780280 scopus 로고    scopus 로고
    • Initial phase II results with crizotinib in advanced ALK-positive non-small cell lung cancer (NSCLC): Profile 1005
    • Abstr 7514
    • Crino L, Crinò L, Kim D, et al. Initial phase II results with crizotinib in advanced ALK-positive non-small cell lung cancer (NSCLC): Profile 1005. J Clin Oncol. 2011;29 Suppl:Abstr 7514.
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • Crino, L.1    Crinò, L.2    Kim, D.3
  • 26
    • 84876975376 scopus 로고    scopus 로고
    • Xalkori [crizotinib, package insert]. New York, NY: Pfizer Inc
    • Xalkori [crizotinib, package insert]. New York, NY: Pfizer Inc; 2011.
    • (2011)
  • 27
    • 84865431278 scopus 로고    scopus 로고
    • Results of a global phase II study with crizotinib in advanced ALK-positive non-small cell lung cancer (NSCLC)
    • Abstr 7533
    • Kim DW, Ahn MJ, Shi Y, et al. Results of a global phase II study with crizotinib in advanced ALK-positive non-small cell lung cancer (NSCLC). J Clin Oncol. 2012;30 Suppl:Abstr 7533.
    • (2012) J Clin Oncol , vol.30 , Issue.SUPPL.
    • Kim, D.W.1    Ahn, M.J.2    Shi, Y.3
  • 28
    • 84866934606 scopus 로고    scopus 로고
    • Activity and safety of crizotinib in patients with ALK-positive non-small-cell lung cancer: Updated results from a Phase 1study
    • Camidge DR, Bang YJ, Kwak EL, et al. Activity and safety of crizotinib in patients with ALK-positive non-small-cell lung cancer: updated results from a Phase 1study. Lancet Oncol. 2012;13(10):1011-1019.
    • (2012) Lancet Oncol , vol.13 , Issue.10 , pp. 1011-1019
    • Camidge, D.R.1    Bang, Y.J.2    Kwak, E.L.3
  • 29
    • 84877000526 scopus 로고    scopus 로고
    • Phase III study of crizotinib versus pemetrexed or docetaxel chemotherapy in patients with advanced ALK-positive non-small cell lung cancer (NSCLC) (PROFILE 1007). Abstract LBA1 presented at the Annual Congress of the European Society for Medical Oncology, Vienna, Austria
    • Shaw AT, Kim DW, Nakagawa K, et al. Phase III study of crizotinib versus pemetrexed or docetaxel chemotherapy in patients with advanced ALK-positive non-small cell lung cancer (NSCLC) (PROFILE 1007). Abstract LBA1 presented at the Annual Congress of the European Society for Medical Oncology, Vienna, Austria, September 28-October 2, 2012.
    • (2012) September 28-October , pp. 2
    • Shaw, A.T.1    Kim, D.W.2    Nakagawa, K.3
  • 31
    • 57349113565 scopus 로고    scopus 로고
    • Multiplex reverse transcription-PCR screening for EML4-ALK fusion transcripts
    • Takeuchi K, Choi YL, Soda M, et al. Multiplex reverse transcription-PCR screening for EML4-ALK fusion transcripts. Clin Cancer Res. 2008;14(20):6618-6624.
    • (2008) Clin Cancer Res , vol.14 , Issue.20 , pp. 6618-6624
    • Takeuchi, K.1    Choi, Y.L.2    Soda, M.3
  • 32
    • 78650472876 scopus 로고    scopus 로고
    • Treatment of lung cancer with an ALK inhibitor after EML4-ALK fusion gene detection using endobronchial ultrasound-guided transbronchial needle aspiration
    • Nakajima T, Kimura H, Takeuchi K, et al. Treatment of lung cancer with an ALK inhibitor after EML4-ALK fusion gene detection using endobronchial ultrasound-guided transbronchial needle aspiration. J Thorac Oncol. 2010;5(12):2041-2043.
    • (2010) J Thorac Oncol , vol.5 , Issue.12 , pp. 2041-2043
    • Nakajima, T.1    Kimura, H.2    Takeuchi, K.3
  • 33
    • 48549098388 scopus 로고    scopus 로고
    • Identification of novel isoforms of the EML4-ALK transforming gene in non-small cell lung cancer
    • Choi YL, Takeuchi K, Soda M, et al. Identification of novel isoforms of the EML4-ALK transforming gene in non-small cell lung cancer. Cancer Res. 2008;68(13):4971-4976.
    • (2008) Cancer Res , vol.68 , Issue.13 , pp. 4971-4976
    • Choi, Y.L.1    Takeuchi, K.2    Soda, M.3
  • 34
    • 77649091118 scopus 로고    scopus 로고
    • A novel, highly sensitive antibody allows for the routine detection of ALK-rearranged lung adenocarcinomas by standard immunohistochemistry
    • Mino-Kenudson M, Chirieac LR, Law K, et al. A novel, highly sensitive antibody allows for the routine detection of ALK-rearranged lung adenocarcinomas by standard immunohistochemistry. Clin Cancer Res. 2010;16(5):1561-1571.
    • (2010) Clin Cancer Res , vol.16 , Issue.5 , pp. 1561-1571
    • Mino-Kenudson, M.1    Chirieac, L.R.2    Law, K.3
  • 35
    • 59649127007 scopus 로고    scopus 로고
    • EML4-ALK rearrangement in non-small cell lung cancer and non-tumor lung tissues
    • Martelli MP, Sozzi G, Hernandez L, et al. EML4-ALK rearrangement in non-small cell lung cancer and non-tumor lung tissues. Am J Pathol. 2009;174(2):661-670.
    • (2009) Am J Pathol , vol.174 , Issue.2 , pp. 661-670
    • Martelli, M.P.1    Sozzi, G.2    Hernandez, L.3
  • 36
    • 63949086127 scopus 로고    scopus 로고
    • KIF5B-ALK, a novel fusion oncokinase identified by an immunohistochemistry-based diagnostic system for ALK-positive lung cancer
    • Takeuchi K, Choi YL, Togashi Y, et al. KIF5B-ALK, a novel fusion oncokinase identified by an immunohistochemistry-based diagnostic system for ALK-positive lung cancer. Clin Cancer Res. 2009;15(9):3143-3149.
    • (2009) Clin Cancer Res , vol.15 , Issue.9 , pp. 3143-3149
    • Takeuchi, K.1    Choi, Y.L.2    Togashi, Y.3
  • 37
    • 81755188353 scopus 로고    scopus 로고
    • Asymptomatic profound sinus bradycardia (heart rate # 45) in non-small cell lung cancer patients treated with crizotinib
    • Ou SH, Azada M, Dy J, Stiber JA. Asymptomatic profound sinus bradycardia (heart rate # 45) in non-small cell lung cancer patients treated with crizotinib. J Thorac Oncol. 2011;6(12):2135-2137.
    • (2011) J Thorac Oncol , vol.6 , Issue.12 , pp. 2135-2137
    • Ou, S.H.1    Azada, M.2    Dy, J.3    Stiber, J.A.4
  • 38
    • 78049426513 scopus 로고    scopus 로고
    • ALK Lung Cancer Study Group. EML4-ALK mutations in lung cancer that confer resistance to ALK inhibitors
    • Choi YL, Soda M, Yamashita Y, et al; ALK Lung Cancer Study Group. EML4-ALK mutations in lung cancer that confer resistance to ALK inhibitors. N Engl J Med. 2010;363(18):1734-1739.
    • (2010) N Engl J Med , vol.363 , Issue.18 , pp. 1734-1739
    • Choi, Y.L.1    Soda, M.2    Yamashita, Y.3
  • 39
    • 84856990335 scopus 로고    scopus 로고
    • Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non-small cell lung cancer
    • Doebele RC, Pilling AB, Aisner DL, et al. Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non-small cell lung cancer. Clin Cancer Res. 2012;18(5):1472-1482.
    • (2012) Clin Cancer Res , vol.18 , Issue.5 , pp. 1472-1482
    • Doebele, R.C.1    Pilling, A.B.2    Aisner, D.L.3
  • 40
    • 79956318797 scopus 로고    scopus 로고
    • Therapeutic strategies to overcome crizotinib resistance in non-small cell lung cancers harboring the fusion oncogene EML4-ALK
    • Katayama R, Khan TM, Benes C, et al. Therapeutic strategies to overcome crizotinib resistance in non-small cell lung cancers harboring the fusion oncogene EML4-ALK. Proc Natl Acad Sci U S A. 2011;108(18):7535-7540.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , Issue.18 , pp. 7535-7540
    • Katayama, R.1    Khan, T.M.2    Benes, C.3
  • 41
    • 84856999699 scopus 로고    scopus 로고
    • Mechanisms of acquired crizotinib resistance in ALK-rearranged lung cancers
    • Katayama R, Shaw AT, Khan TM, et al. Mechanisms of acquired crizotinib resistance in ALK-rearranged lung cancers. Sci Transl Med. 2012;4(120):120ra17.
    • (2012) Sci Transl Med , vol.4 , Issue.120
    • Katayama, R.1    Shaw, A.T.2    Khan, T.M.3
  • 42
    • 78649475696 scopus 로고    scopus 로고
    • The neuroblastoma-associated F1174L ALK mutation causes resistance to an ALK kinase inhibitor in ALK-translocated cancers
    • Sasaki T, Okuda K, Zheng W, et al. The neuroblastoma-associated F1174L ALK mutation causes resistance to an ALK kinase inhibitor in ALK-translocated cancers. Cancer Res. 2010;70(24):10038-10043.
    • (2010) Cancer Res , vol.70 , Issue.24 , pp. 10038-10043
    • Sasaki, T.1    Okuda, K.2    Zheng, W.3
  • 43
    • 84869211206 scopus 로고    scopus 로고
    • Activation of HER family signaling as a mechanism of acquired resistance to ALK inhibitors in EML4-ALK-positive non-small cell lung cancer
    • Tanizaki J, Okamoto I, Okabe T, et al. Activation of HER family signaling as a mechanism of acquired resistance to ALK inhibitors in EML4-ALK-positive non-small cell lung cancer. Clin Cancer Res. 2012;18(22):6219-6226.
    • (2012) Clin Cancer Res , vol.18 , Issue.22 , pp. 6219-6226
    • Tanizaki, J.1    Okamoto, I.2    Okabe, T.3
  • 44
    • 0035800507 scopus 로고    scopus 로고
    • Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification
    • Gorre ME, Mohammed M, Ellwood K, et al. Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification. Science. 2001;293(5531):876-880.
    • (2001) Science , vol.293 , Issue.5531 , pp. 876-880
    • Gorre, M.E.1    Mohammed, M.2    Ellwood, K.3
  • 45
    • 18244371651 scopus 로고    scopus 로고
    • Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain
    • Pao W, Miller VA, Politi KA, et al. Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PLoS Med. 2005;2(3):e73.
    • (2005) PLoS Med , vol.2 , Issue.3
    • Pao, W.1    Miller, V.A.2    Politi, K.A.3
  • 46
    • 21144439000 scopus 로고    scopus 로고
    • Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib
    • Kwak EL, Sordella R, Bell DW, et al. Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib. Proc Natl Acad Sci U S A. 2005;102(21):7665-7670.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , Issue.21 , pp. 7665-7670
    • Kwak, E.L.1    Sordella, R.2    Bell, D.W.3
  • 47
    • 57749188299 scopus 로고    scopus 로고
    • Targeting cancer with small molecule kinase inhibitors
    • Zhang J, Yang PL, Gray NS. Targeting cancer with small molecule kinase inhibitors. Nat Rev Cancer. 2009;9(1):28-39.
    • (2009) Nat Rev Cancer , vol.9 , Issue.1 , pp. 28-39
    • Zhang, J.1    Yang, P.L.2    Gray, N.S.3
  • 48
    • 79960250811 scopus 로고    scopus 로고
    • Insights into ALK-driven cancers revealed through development of novel ALK tyrosine kinase inhibitors
    • Lovly CM, Heuckmann JM, de Stanchina E, et al. Insights into ALK-driven cancers revealed through development of novel ALK tyrosine kinase inhibitors. Cancer Res. 2011;71(14):4920-4931.
    • (2011) Cancer Res , vol.71 , Issue.14 , pp. 4920-4931
    • Lovly, C.M.1    Heuckmann, J.M.2    de Stanchina, E.3
  • 49
    • 79955964568 scopus 로고    scopus 로고
    • CH5424802, a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant
    • Sakamoto H, Tsukaguchi T, Hiroshima S, et al. CH5424802, a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant. Cancer Cell. 2011;19(5):679-690.
    • (2011) Cancer Cell , vol.19 , Issue.5 , pp. 679-690
    • Sakamoto, H.1    Tsukaguchi, T.2    Hiroshima, S.3
  • 50
    • 78649973178 scopus 로고    scopus 로고
    • Inhibition of ALK, PI3K/MEK, and HSP90 in murine lung adenocarcinoma induced by EML4-ALK fusion oncogene
    • Chen Z, Sasaki T, Tan X, et al. Inhibition of ALK, PI3K/MEK, and HSP90 in murine lung adenocarcinoma induced by EML4-ALK fusion oncogene. Cancer Res. 2010;70(23):9827-9836.
    • (2010) Cancer Res , vol.70 , Issue.23 , pp. 9827-9836
    • Chen, Z.1    Sasaki, T.2    Tan, X.3
  • 51
    • 84855457952 scopus 로고    scopus 로고
    • Hsp90 molecular chaperone inhibitors: Are we there yet?
    • Neckers L, Workman P. Hsp90 molecular chaperone inhibitors: are we there yet? Clin Cancer Res. 2012;18(1):64-76.
    • (2012) Clin Cancer Res , vol.18 , Issue.1 , pp. 64-76
    • Neckers, L.1    Workman, P.2
  • 52
    • 84876977183 scopus 로고    scopus 로고
    • The GALAXY trial (NCT01348126): A randomized IIB/III study of ganetespib (STA-9090) in combination with docetaxel versus docetaxel alone in subjects with stage IIIB or IV NSCLC
    • Goss GD, et al. The GALAXY trial (NCT01348126): a randomized IIB/III study of ganetespib (STA-9090) in combination with docetaxel versus docetaxel alone in subjects with stage IIIB or IV NSCLC. J Clin Oncol. 2012;30(Suppl 15):TPS7613.
    • (2012) J Clin Oncol , vol.30 , Issue.SUPPL. 15
    • Goss, G.D.1
  • 53
    • 79951885125 scopus 로고    scopus 로고
    • Activity of IPI-504, a novel heat-shock protein 90 inhibitor, in patients with molecularly defined non-small-cell lung cancer
    • Sequist LV, Gettinger S, Senzer NN, et al. Activity of IPI-504, a novel heat-shock protein 90 inhibitor, in patients with molecularly defined non-small-cell lung cancer. J Clin Oncol. 2010;28(33):4953-4960.
    • (2010) J Clin Oncol , vol.28 , Issue.33 , pp. 4953-4960
    • Sequist, L.V.1    Gettinger, S.2    Senzer, N.N.3
  • 54
    • 82555180241 scopus 로고    scopus 로고
    • An open-label Phase II study of the Hsp90 inhibitor ganetespib (STA-9090) as monotherapy in patients with advanced non-small cell lung cancer (NSCLC)
    • Abstr 7500
    • Wong K, Koczywas M, Goldman JW, et al. An open-label Phase II study of the Hsp90 inhibitor ganetespib (STA-9090) as monotherapy in patients with advanced non-small cell lung cancer (NSCLC). J Clin Oncol. 2011;29 Suppl:Abstr 7500.
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • Wong, K.1    Koczywas, M.2    Goldman, J.W.3
  • 55
    • 84866930352 scopus 로고    scopus 로고
    • Combined PI3K/mTOR and MEK inhibition provides broad antitumor activity in faithful murine cancer models
    • Roberts PJ, Usary JE, Darr DB, et al. Combined PI3K/mTOR and MEK inhibition provides broad antitumor activity in faithful murine cancer models. Clin Cancer Res. 2012;18(19):5290-5303.
    • (2012) Clin Cancer Res , vol.18 , Issue.19 , pp. 5290-5303
    • Roberts, P.J.1    Usary, J.E.2    Darr, D.B.3
  • 56
    • 0037402509 scopus 로고    scopus 로고
    • Fusion of FIG to the receptor tyrosine kinase ROS in a glioblastoma with an interstitial del(6)(q21q21)
    • Charest A, Lane K, McMahon K, et al. Fusion of FIG to the receptor tyrosine kinase ROS in a glioblastoma with an interstitial del(6)(q21q21). Genes Chromosomes Cancer. 2003;37(1):58-71.
    • (2003) Genes Chromosomes Cancer , vol.37 , Issue.1 , pp. 58-71
    • Charest, A.1    Lane, K.2    McMahon, K.3
  • 57
    • 79251579592 scopus 로고    scopus 로고
    • Survey of tyrosine kinase signaling reveals ROS kinase fusions in human cholangiocarcinoma
    • Gu TL, Deng X, Huang F, et al. Survey of tyrosine kinase signaling reveals ROS kinase fusions in human cholangiocarcinoma. PLoS One. 2011;6(1):e15640.
    • (2011) PLoS One , vol.6 , Issue.1
    • Gu, T.L.1    Deng, X.2    Huang, F.3
  • 58
    • 0024852378 scopus 로고
    • Characterization of the ros1-gene products expressed in human glioblastoma cell lines
    • Sharma S, Birchmeier C, Nikawa J, O'Neill K, Rodgers L, Wigler M. Characterization of the ros1-gene products expressed in human glioblastoma cell lines. Oncogene Res. 1989;5(2):91-100.
    • (1989) Oncogene Res , vol.5 , Issue.2 , pp. 91-100
    • Sharma, S.1    Birchmeier, C.2    Nikawa, J.3    O'Neill, K.4    Rodgers, L.5    Wigler, M.6
  • 59
    • 36849065315 scopus 로고    scopus 로고
    • Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer
    • Rikova K, Guo A, Zeng Q, et al. Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell. 2007;131(6):1190-1203.
    • (2007) Cell , vol.131 , Issue.6 , pp. 1190-1203
    • Rikova, K.1    Guo, A.2    Zeng, Q.3
  • 60
    • 84865089246 scopus 로고    scopus 로고
    • Analysis of receptor tyrosine kinase ROS1-positive tumors in non-small cell lung cancer: Identification of a FIG-ROS1 fusion
    • Rimkunas VM, Crosby KE, Li D, et al. Analysis of receptor tyrosine kinase ROS1-positive tumors in non-small cell lung cancer: identification of a FIG-ROS1 fusion. Clin Cancer Res. 2012;18(16):4449-4457.
    • (2012) Clin Cancer Res , vol.18 , Issue.16 , pp. 4449-4457
    • Rimkunas, V.M.1    Crosby, K.E.2    Li, D.3
  • 61
    • 84857985225 scopus 로고    scopus 로고
    • RET, ROS1 and ALK fusions in lung cancer
    • Takeuchi K, Soda M, Togashi Y, et al. RET, ROS1 and ALK fusions in lung cancer. Nat Med. 2012;18(3):378-381.
    • (2012) Nat Med , vol.18 , Issue.3 , pp. 378-381
    • Takeuchi, K.1    Soda, M.2    Togashi, Y.3
  • 62
    • 84863338079 scopus 로고    scopus 로고
    • ROS1 rearrangements define a unique molecular class of lung cancers
    • Bergethon K, Shaw AT, Ou SH, et al. ROS1 rearrangements define a unique molecular class of lung cancers. J Clin Oncol. 2012;30(8):863-870.
    • (2012) J Clin Oncol , vol.30 , Issue.8 , pp. 863-870
    • Bergethon, K.1    Shaw, A.T.2    Ou, S.H.3
  • 63
    • 84862846839 scopus 로고    scopus 로고
    • Preclinical rationale for use of the clinically available multitargeted tyrosine kinase inhibitor crizotinib in ROS1-translocated lung cancer
    • Yasuda H, et al. Preclinical rationale for use of the clinically available multitargeted tyrosine kinase inhibitor crizotinib in ROS1-translocated lung cancer. J Thorac Oncol. 2012;7(7):p. 1086-1090.
    • (2012) J Thorac Oncol , vol.7 , Issue.7 , pp. 1086-1090
    • Yasuda, H.1
  • 64
    • 44849126091 scopus 로고    scopus 로고
    • Genomic alterations of anaplastic lymphoma kinase may sensitize tumors to anaplastic lymphoma kinase inhibitors
    • McDermott U, et al. Genomic alterations of anaplastic lymphoma kinase may sensitize tumors to anaplastic lymphoma kinase inhibitors. Cancer Res. 2008;68(9):p. 3389-3395.
    • (2008) Cancer Res , vol.68 , Issue.9 , pp. 3389-3395
    • McDermott, U.1
  • 65
    • 84865092224 scopus 로고    scopus 로고
    • Clinical activity of crizotinib in advanced non-small cell lung cancer (NSCLC) harboring ROS1 gene rearrangement
    • Shaw AT, et al., Clinical activity of crizotinib in advanced non-small cell lung cancer (NSCLC) harboring ROS1 gene rearrangement. ASCO Meeting Abstracts. 2012;30(15_suppl):p. 7508.
    • (2012) ASCO Meeting Abstracts , vol.30 , Issue.15 SUPPL , pp. 7508
    • Shaw, A.T.1
  • 66
    • 84858341589 scopus 로고    scopus 로고
    • MET signaling: Novel targeted inhibition and its clinical development in lung cancer
    • Feng Y, Thiagarajan PS, Ma PC. MET signaling: novel targeted inhibition and its clinical development in lung cancer. J Thorac Oncol. 2012;7(2):p. 459-467.
    • (2012) J Thorac Oncol , vol.7 , Issue.2 , pp. 459-467
    • Feng, Y.1    Thiagarajan, P.S.2    Ma, P.C.3
  • 67
    • 0038724909 scopus 로고    scopus 로고
    • c-Met: Structure, functions and potential for therapeutic inhibition
    • Ma PC, et al. c-Met: structure, functions and potential for therapeutic inhibition. Cancer Metastasis Rev. 2003;22(4):p. 309-325.
    • (2003) Cancer Metastasis Rev , vol.22 , Issue.4 , pp. 309-325
    • Ma, P.C.1
  • 68
    • 81755165799 scopus 로고    scopus 로고
    • Clinical implications of high MET gene dosage in non-small cell lung cancer patients without previous tyrosine kinase inhibitor treatment
    • Chen YT, et al. Clinical implications of high MET gene dosage in non-small cell lung cancer patients without previous tyrosine kinase inhibitor treatment. J Thorac Oncol. 2011;6(12):p. 2027-2035.
    • (2011) J Thorac Oncol , vol.6 , Issue.12 , pp. 2027-2035
    • Chen, Y.T.1
  • 69
    • 84862777005 scopus 로고    scopus 로고
    • Correlation between MET gene copy number by silver in situ hybridization and protein expression by immunohistochemistry in non-small cell lung cancer
    • Dziadziuszko R, et al. Correlation between MET gene copy number by silver in situ hybridization and protein expression by immunohistochemistry in non-small cell lung cancer. J Thorac Oncol. 2012;7(2):p. 340-347.
    • (2012) J Thorac Oncol , vol.7 , Issue.2 , pp. 340-347
    • Dziadziuszko, R.1
  • 70
    • 84863229341 scopus 로고    scopus 로고
    • High MET copy number and MET overexpression: Poor outcome in non-small cell lung cancer patients
    • Park, S., et al., High MET copy number and MET overexpression: poor outcome in non-small cell lung cancer patients. Histol Histopathol, 2012. 27(2): p. 197-207.
    • (2012) Histol Histopathol , vol.27 , Issue.2 , pp. 197-207
    • Park, S.1
  • 71
    • 84907047245 scopus 로고    scopus 로고
    • Biomarkers that currently affect clinical practice: EGFR, ALK, MET, KRAS
    • Vincent MD, et al., Biomarkers that currently affect clinical practice: EGFR, ALK, MET, KRAS. Curr Oncol. 2012;19(Suppl 1):p. S33-S44.
    • (2012) Curr Oncol , vol.19 , Issue.SUPPL. 1
    • Vincent, M.D.1
  • 72
    • 79955458487 scopus 로고    scopus 로고
    • Activity of crizotinib (PF02341066), a dual mesenchymal-epithelial transition (MET) and anaplastic lymphoma kinase (ALK) inhibitor, in a non-small cell lung cancer patient with de novo MET amplification
    • Ou SH, et al. Activity of crizotinib (PF02341066), a dual mesenchymal-epithelial transition (MET) and anaplastic lymphoma kinase (ALK) inhibitor, in a non-small cell lung cancer patient with de novo MET amplification. J Thorac Oncol. 2011;6(5):p. 942-946.
    • (2011) J Thorac Oncol , vol.6 , Issue.5 , pp. 942-946
    • Ou, S.H.1
  • 73
    • 84856816903 scopus 로고    scopus 로고
    • Clinical improvement and rapid radiographic regression induced by a MET inhibitor in a patient with MET-amplified glioblastoma
    • Chi AS, et al. Clinical improvement and rapid radiographic regression induced by a MET inhibitor in a patient with MET-amplified glioblastoma. ASCO Meeting Abstracts. 2012;29(15_suppl):p. 2072.
    • (2012) ASCO Meeting Abstracts , vol.29 , Issue.15 SUPPL , pp. 2072
    • Chi, A.S.1
  • 74
    • 84555190809 scopus 로고    scopus 로고
    • MET amplification identifies a small and aggressive subgroup of esophagogastric adenocarcinoma with evidence of responsiveness to crizotinib
    • Lennerz JK, et al. MET amplification identifies a small and aggressive subgroup of esophagogastric adenocarcinoma with evidence of responsiveness to crizotinib. J Clin Oncol. 2011;29(36):p. 4803-4810.
    • (2011) J Clin Oncol , vol.29 , Issue.36 , pp. 4803-4810
    • Lennerz, J.K.1


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