Functional folate receptor alpha is elevated in the blood of ovarian cancer patients

PLoS ONE

Volumn 4, Issue 7, 2009, Pages

  Basal, Eati ^a   Eghbali Fatourechi, Guiti Z ^a   Kalli, Kimberly R ^b   Hartmann, Lynn C ^b   Goodman, Karin M ^b   Goode, Ellen L ^b   Kamen, Barton A ^c   Low, Philip S ^d   Knutson, Keith L ^a  

^a MAYO GRADUATE SCHOOL   (United States)

^b MAYO CLINIC   (United States)

^c The Leukemia & Lymphoma Society   (United States)

^d PURDUE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; FLUORINATED HYDROCARBON; FOLATE RECEPTOR; FOLATE RECEPTOR ALPHA; UNCLASSIFIED DRUG; CARRIER PROTEIN; CELL SURFACE RECEPTOR; TUMOR MARKER;

ADULT; ADVANCED CANCER; ARTICLE; BINDING ASSAY; CANCER PATIENT; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE MARKER; EARLY CANCER; FEMALE; HUMAN; IMMUNOASSAY; IMMUNOBLOTTING; ISOTOPE LABELING; MICROFILTRATION; OVARY CANCER; PROTEIN BLOOD LEVEL; PROTEIN FUNCTION; BLOOD; CASE CONTROL STUDY; IMMUNOPRECIPITATION; OVARY TUMOR; WESTERN BLOTTING;

BLOTTING, WESTERN; CARRIER PROTEINS; CASE-CONTROL STUDIES; FEMALE; FOLATE RECEPTORS, GPI-ANCHORED; HUMANS; IMMUNOASSAY; IMMUNOPRECIPITATION; OVARIAN NEOPLASMS; RECEPTORS, CELL SURFACE; TUMOR MARKERS, BIOLOGICAL;

EID: 67651108570     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0006292     Document Type: Article

References (21)

1. Jemal A, Siegel R, Ward E, Hao Y, Xu J, et al. (2008) Cancer statistics, 2008. CA Cancer J Clin 58: 71-96.
2. Trimbos JB, Parmar M, Vergote I, Guthrie D, Bolis G, et al. (2003) International Collaborative Ovarian Neoplasm trial 1 and Adjuvant Chemo-Therapy In Ovarian Neoplasm trial: two parallel randomized phase III trials of adjuvant chemotherapy in patients with early-stage ovarian carcinoma. J Natl Cancer Inst 95: 105-112.
3. Mor G, Visintin I, Lai Y, Zhao H, Schwartz P, et al. (2005) Serum protein markers for early detection of ovarian cancer. Proc Natl Acad Sci U S A 102: 7677-7682.
4. Cannistra SA (2004) Cancer of the ovary. N Engl J Med 351: 2519-2529.
5. Fields MM, Chevlen E (2006) Ovarian cancer screening: a look at the evidence. Clin J Oncol Nurs 10: 77-81.
6. Kamen BA, Wang MT, Streckfuss AJ, Peryea X, Anderson RG (1988) Delivery of folates to the cytoplasm of MA104 cells is mediated by a surface membrane receptor that recycles. J Biol Chem 263: 13602-13609.
7. Bueno R, Appasani K, Mercer H, Lester S, Sugarbaker D (2001) The alpha folate receptor is highly activated in malignant pleural mesothelioma. J Thorac Cardiovasc Surg 121: 225-233.
8. Hartmann LC, Keeney GL, Lingle WL, Christianson TJ, Varghese B, et al. (2007) Folate receptor overexpression is associated with poor outcome in breast cancer. Int J Cancer 121: 938-942.
9. Toffoli G, Russo A, Gallo A, Cernigoi C, Miotti S, et al. (1998) Expression of folate binding protein as a prognostic factor for response to platinum-containing chemotherapy and survival in human ovarian cancer. Int J Cancer 79: 121-126.
10. Yang R, Kolb EA, Qin J, Chou A, Sowers R, et al. (2007) The folate receptor alpha is frequently overexpressed in osteosarcoma samples and plays a role in the uptake of the physiologic substrate 5-methyltetrahydrofolate. Clin Cancer Res 13: 2557-2567.
11. Kelemen LE, Sellers TA, Keeney GL, Lingle WL (2005) Multivitamin and alcohol intake and folate receptor alpha expression in ovarian cancer. Cancer Epidemiol Biomarkers Prev 14: 2168-2172.
12. Kamen BA, Caston JD (1974) Direct radiochemical assay for serum folate: competition between 3H-folic acid and 5-methyltetrahydrofolic acid for a folate binder. J Lab Clin Med 83: 164-174.
13. Kamen BA, Caston JD (1975) Purification of folate binding factor in normal umbilical cord serum. Proc Natl Acad Sci U S A 72: 4261-4264.
14. Kalli KR, Oberg AL, Keeney GL, Christianson TJ, Low PS, et al. (2008) Folate receptor alpha as a tumor target in epithelial ovarian cancer. Gynecol Oncol 108: 619-626.
15. Mantovani LT, Miotti S, Menard S, Canevari S, Raspagliesi F, et al. (1994) Folate binding protein distribution in normal tissues and biological fluids from ovarian carcinoma patients as detected by the monoclonal antibodies MOv18 and MOv19. Eur J Cancer 30A: 363-369.
16. Elwood PC, Kane MA, Portillo RM, Kolhouse JF (1986) The isolation, characterization, and comparison of the membrane-associated and soluble folate-binding proteins from human KB cells. J Biol Chem 261: 15416-15423.
17. Kane MA, Elwood PC, Portillo RM, Antony AC, Najfeld V, et al. (1988) Influence on immunoreactive folate-binding proteins of extracellular folate concentration in cultured human cells. J Clin Invest 81: 1398-1406.
18. Luhrs CA, Raskin CA, Durbin R, Wu B, Sadasivan E, et al. (1992) Transfection of a glycosylated phosphatidylinositol-anchored folate-binding protein complementary DNA provides cells with the ability to survive in low folate medium. J Clin Invest 90: 840-847.
19. Parker N, Turk MJ, Westrick E, Lewis JD, Low PS, et al. (2005) Folate receptor expression in carcinomas and normal tissues determined by a quantitative radioligand binding assay. Anal Biochem 338: 284-293.
20. Low PS, Henne WA, Doorneweerd DD (2008) Discovery and development of folic-acid-based receptor targeting for imaging and therapy of cancer and inflammatory diseases. Acc Chem Res 41: 120-129.
21. Kershaw MH, Westwood JA, Parker LL, Wang G, Eshhar Z, et al. (2006) A phase I study on adoptive immunotherapy using gene-modified T cells for ovarian cancer. Clin Cancer Res 12: 6106-6115.