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Volumn 55, Issue 5, 2014, Pages 701-704

Imaging the folate receptor on cancer cells with 99mTc- etarfolatide: Properties, clinical use, and future potential of folate receptor imaging

Author keywords

Folate receptor; Imaging; SPECT; SPECT CT

Indexed keywords

CARBOPLATIN; DOCETAXEL; DOXORUBICIN; ETARFOLATIDE TC 99M; FARLETUZUMAB; FOLATE RECEPTOR; FOLATE RECEPTOR 1; FOLATE RECEPTOR 2; PACLITAXEL; VINTAFOLIDE;

EID: 84901327650     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.113.133074     Document Type: Review
Times cited : (54)

References (35)
  • 1
    • 84864274164 scopus 로고    scopus 로고
    • Clinical translation of folate receptor-targeted therapeutics
    • Teng L, Xie J, Teng L, Lee RJ. Clinical translation of folate receptor-targeted therapeutics. Expert Opin Drug Deliv. 2012;9:901-908.
    • (2012) Expert Opin Drug Deliv. , vol.9 , pp. 901-908
    • Teng, L.1    Xie, J.2    Teng, L.3    Lee, R.J.4
  • 2
    • 1942503303 scopus 로고    scopus 로고
    • Distribution, functionality and gene regulation of folate receptor isoforms: Implications in targeted therapy
    • Elnakat H, Ratnam M. Distribution, functionality and gene regulation of folate receptor isoforms: implications in targeted therapy. Adv Drug Deliv Rev. 2004;56:1067-1084.
    • (2004) Adv Drug Deliv Rev. , vol.56 , pp. 1067-1084
    • Elnakat, H.1    Ratnam, M.2
  • 3
    • 84891854386 scopus 로고    scopus 로고
    • Precedent: A randomized phase ii trial comparing vintafolide (ec145) and pegylated liposomal doxorubicin (pld) in combination versus pld alone in patients with platinum-resistant ovarian cancer
    • Naumann RW, Coleman RL, Burger RA, et al. PRECEDENT: a randomized phase II trial comparing vintafolide (EC145) and pegylated liposomal doxorubicin (PLD) in combination versus PLD alone in patients with platinum-resistant ovarian cancer. J Clin Oncol. 2013;31:4400-4406.
    • (2013) J Clin Oncol. , vol.31 , pp. 4400-4406
    • Naumann, R.W.1    Coleman, R.L.2    Burger, R.A.3
  • 4
    • 84901293905 scopus 로고    scopus 로고
    • Folate-receptor targeted radionuclide imaging agents
    • Jackman AL, Leamon CP, eds. New York, NY: Springer
    • Muller C, Schibli R. Folate-receptor targeted radionuclide imaging agents. In: Jackman AL, Leamon CP, eds. Targeted Drug Strategies for Cancer and Inflammation. New York, NY: Springer; 2011:65-92.
    • (2011) Targeted Drug Strategies for Cancer and Inflammation. , pp. 65-92
    • Muller, C.1    Schibli, R.2
  • 5
    • 39249085399 scopus 로고    scopus 로고
    • Folate receptor alpha as a tumor target in epithelial ovarian cancer
    • Kalli KR, Oberg AL, Keeney GL, et al. Folate receptor alpha as a tumor target in epithelial ovarian cancer. Gynecol Oncol. 2008;108:619-626.
    • (2008) Gynecol Oncol. , vol.108 , pp. 619-626
    • Kalli, K.R.1    Oberg, A.L.2    Keeney, G.L.3
  • 6
    • 84862808121 scopus 로고    scopus 로고
    • Serous ovarian carcinoma patients with high alpha-folate receptor had reducing survival and cytotoxic chemo-response
    • Chen YL, Chang MC, Huang CY, et al. Serous ovarian carcinoma patients with high alpha-folate receptor had reducing survival and cytotoxic chemo-response. Mol Oncol. 2012;6:360-369.
    • (2012) Mol Oncol. , vol.6 , pp. 360-369
    • Chen, Y.L.1    Chang, M.C.2    Huang, C.Y.3
  • 7
    • 84868697449 scopus 로고    scopus 로고
    • Paradoxical impact of two folate receptors, fra and rfc, in ovarian cancer: Effect on cell proliferation, invasion and clinical outcome
    • Siu MK, Kong DS, Chan HY, et al. Paradoxical impact of two folate receptors, FRa and RFC, in ovarian cancer: effect on cell proliferation, invasion and clinical outcome. PLoS ONE. 2012;7:e47201.
    • (2012) PLoS ONE. , vol.7
    • Siu, M.K.1    Kong, D.S.2    Chan, H.Y.3
  • 8
    • 38949215454 scopus 로고    scopus 로고
    • Discovery and development of folic-acidbased receptor targeting for imaging and therapy of cancer and inflammatory diseases
    • Low PS, Henne WA, Doorneweerd DD. Discovery and development of folic-acidbased receptor targeting for imaging and therapy of cancer and inflammatory diseases. Acc Chem Res. 2008;41:120-129.
    • (2008) Acc Chem Res. , vol.41 , pp. 120-129
    • Low, P.S.1    Henne, W.A.2    Doorneweerd, D.D.3
  • 9
    • 84877579319 scopus 로고    scopus 로고
    • Farletuzumab (a monoclonal antibody against folate receptor alpha) in relapsed platinum-sensitive ovarian cancer
    • Armstrong DK, White AJ, Weil SC, Phillips M, Coleman RL. Farletuzumab (a monoclonal antibody against folate receptor alpha) in relapsed platinum-sensitive ovarian cancer. Gynecol Oncol. 2013;129:452-458.
    • (2013) Gynecol Oncol. , vol.129 , pp. 452-458
    • Armstrong, D.K.1    White, A.J.2    Weil, S.C.3    Phillips, M.4    Coleman, R.L.5
  • 10
    • 58849142161 scopus 로고    scopus 로고
    • A functional folate receptor is induced during macrophage activation and can be used to target drugs to activated macrophages
    • Xia W, Hilgenbrink AR, Matteson EL, Lockwood MB, Cheng JX, Low PS. A functional folate receptor is induced during macrophage activation and can be used to target drugs to activated macrophages. Blood. 2009;113:438-446.
    • (2009) Blood. , vol.113 , pp. 438-446
    • Xia, W.1    Hilgenbrink, A.R.2    Matteson, E.L.3    Lockwood, M.B.4    Cheng, J.X.5    Low, P.S.6
  • 11
    • 44849127008 scopus 로고    scopus 로고
    • Exploratory study of 99mtc-ec20 imaging for identifying patients with folate receptor-positive solid tumors
    • Fisher RE, Siegel BA, Edell SL, et al. Exploratory study of 99mTc-EC20 imaging for identifying patients with folate receptor-positive solid tumors. J Nucl Med. 2008;49:899-906.
    • (2008) J Nucl Med. , vol.49 , pp. 899-906
    • Fisher, R.E.1    Siegel, B.A.2    Edell, S.L.3
  • 12
    • 84875884456 scopus 로고    scopus 로고
    • Cellular heterogeneity and molecular evolution in cancer
    • Almendro V, Marusyk A, Polyak K. Cellular heterogeneity and molecular evolution in cancer. Annu Rev Pathol. 2013;8:277-302.
    • (2013) Annu Rev Pathol. , vol.8 , pp. 277-302
    • Almendro, V.1    Marusyk, A.2    Polyak, K.3
  • 13
    • 84901377262 scopus 로고    scopus 로고
    • Phase 2 study of treatment of advanced ovarian cancer with folate-receptor-targeted therapeutic (vintafolide) and companion spect-based imaging agent (99mtc-etarfolatide)
    • In press
    • Morris RT, Joyrich RN, Naumann RW, et al. Phase 2 study of treatment of advanced ovarian cancer with folate-receptor-targeted therapeutic (vintafolide) and companion SPECT-based imaging agent (99mTc-etarfolatide). Ann Oncol. In press.
    • Ann Oncol.
    • Morris, R.T.1    Joyrich, R.N.2    Naumann, R.W.3
  • 14
    • 0027439199 scopus 로고
    • Kinetics and tissue distribution of the radiolabeled chimeric monoclonal antibody mov18 igg and f(ab9)2 fragments in ovarian carcinoma patients
    • Buist MR, Kenemans P, den Hollander W, et al. Kinetics and tissue distribution of the radiolabeled chimeric monoclonal antibody MOv18 IgG and F(ab9)2 fragments in ovarian carcinoma patients. Cancer Res. 1993;53:5413-5418.
    • (1993) Cancer Res. , vol.53 , pp. 5413-5418
    • Buist, M.R.1    Kenemans, P.2    Den Hollander, W.3
  • 15
    • 0038621645 scopus 로고    scopus 로고
    • Evaluation of 111in-dtpa-folate as a receptor-targeted diagnostic agent for ovarian cancer: Initial clinical results
    • Siegel BA, Dehdashti F, Mutch DG, et al. Evaluation of 111In-DTPA-folate as a receptor-targeted diagnostic agent for ovarian cancer: initial clinical results. J Nucl Med. 2003;44:700-707.
    • (2003) J Nucl Med. , vol.44 , pp. 700-707
    • Siegel, B.A.1    Dehdashti, F.2    Mutch, D.G.3
  • 16
    • 0034753128 scopus 로고    scopus 로고
    • Evolution of tc-99m in diagnostic radiopharmaceuticals
    • Banerjee S, Pillai MR, Ramamoorthy N. Evolution of Tc-99m in diagnostic radiopharmaceuticals. Semin Nucl Med. 2001;31:260-277.
    • (2001) Semin Nucl Med. , vol.31 , pp. 260-277
    • Banerjee, S.1    Pillai, M.R.2    Ramamoorthy, N.3
  • 17
    • 0036862058 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of ec20: A new folate-derived, 99mtc-based radiopharmaceutical
    • Leamon CP, Parker MA, Vlahov IR, et al. Synthesis and biological evaluation of EC20: a new folate-derived, 99mTc-based radiopharmaceutical. Bioconjug Chem. 2002;13:1200-1210.
    • (2002) Bioconjug Chem. , vol.13 , pp. 1200-1210
    • Leamon, C.P.1    Parker, M.A.2    Vlahov, I.R.3
  • 18
    • 2642514921 scopus 로고    scopus 로고
    • Preclinical evaluation of 99mtc-ec20 for imaging folate receptor-positive tumors
    • Reddy JA, Xu LC, Parker N, Vetzel M, Leamon CP. Preclinical evaluation of 99mTc-EC20 for imaging folate receptor-positive tumors. J Nucl Med. 2004;45:857-866.
    • (2004) J Nucl Med. , vol.45 , pp. 857-866
    • Reddy, J.A.1    Xu, L.C.2    Parker, N.3    Vetzel, M.4    Leamon, C.P.5
  • 19
    • 84860726550 scopus 로고    scopus 로고
    • Imaging sites of infection using a 99mtc-labeled folate conjugate targeted to folate receptor positive macrophages
    • HenneWA, Rothenbuhler R, Ayala-Lopez W, XiaW, Varghese B, Low PS. Imaging sites of infection using a 99mTc-labeled folate conjugate targeted to folate receptor positive macrophages. Mol Pharm. 2012;9:1435-1440.
    • (2012) Mol Pharm. , vol.9 , pp. 1435-1440
    • Henne, W.A.1    Rothenbuhler, R.2    Ayala-Lopez, W.3    Xia, W.4    Varghese, B.5    Low, P.S.6
  • 20
    • 84863451148 scopus 로고    scopus 로고
    • A folate receptor-A-specific ligand that targets cancer tissue and not sites of inflammation
    • Vaitilingam B, Chelvam V, Kularatne SA, Poh S, Ayala-Lopez W, Low PS. A folate receptor-a-specific ligand that targets cancer tissue and not sites of inflammation. J Nucl Med. 2012;53:1127-1134.
    • (2012) J Nucl Med. , vol.53 , pp. 1127-1134
    • Vaitilingam, B.1    Chelvam, V.2    Kularatne, S.A.3    Poh, S.4    Ayala-Lopez, W.5    Low, P.S.6
  • 21
    • 84878269164 scopus 로고    scopus 로고
    • Folate-based radiotracers for pet imaging: Update and perspectives
    • Müller C. Folate-based radiotracers for PET imaging: update and perspectives. Molecules. 2013;18:5005-5031.
    • (2013) Molecules. , vol.18 , pp. 5005-5031
    • Müller, C.1
  • 22
    • 33747135111 scopus 로고    scopus 로고
    • Synthesis and preclinical evaluation of a folic acid derivative labeled with 18f for pet imaging of folate receptor-positive tumors
    • Bettio A, Honer M, Müller C, et al. Synthesis and preclinical evaluation of a folic acid derivative labeled with 18F for PET imaging of folate receptor-positive tumors. J Nucl Med. 2006;47:1153-1160.
    • (2006) J Nucl Med. , vol.47 , pp. 1153-1160
    • Bettio, A.1    Honer, M.2    Müller, C.3
  • 23
    • 79851482576 scopus 로고    scopus 로고
    • A new 18flabeled folic acid derivative with improved properties for the pet imaging of folate receptor-positive tumors
    • Ross TL, Honer M, Müller C, Groehn V, Schibli R, Ametamey SM. A new 18Flabeled folic acid derivative with improved properties for the PET imaging of folate receptor-positive tumors. J Nucl Med. 2010;51:1756-1762.
    • (2010) J Nucl Med. , vol.51 , pp. 1756-1762
    • Ross, T.L.1    Honer, M.2    Müller, C.3    Groehn, V.4    Schibli, R.5    Ametamey, S.M.6
  • 24
    • 84874067227 scopus 로고    scopus 로고
    • Radiosynthesis and preclinical evaluation of 39-aza-29-[18f]fluorofolic acid: A novel pet radiotracer for folate receptor targeting
    • Betzel T, Müller C, Groehn V, et al. Radiosynthesis and preclinical evaluation of 39-Aza-29-[18F]fluorofolic acid: a novel PET radiotracer for folate receptor targeting. Bioconjug Chem. 2013;24:205-214.
    • (2013) Bioconjug Chem. , vol.24 , pp. 205-214
    • Betzel, T.1    Müller, C.2    Groehn, V.3
  • 25
    • 84859990896 scopus 로고    scopus 로고
    • Fluoro-deoxy-glucose folate: A novel PET radiotracer with improved in vivo properties for folate receptor targeting
    • Fischer CR, Müller C, Reber J, et al. [18F]fluoro-deoxy-glucose folate: a novel PET radiotracer with improved in vivo properties for folate receptor targeting. Bioconjug Chem. 2012;23:805-813.
    • (2012) Bioconjug Chem. , vol.23 , pp. 805-813
    • Fischer, C.R.1    Müller, C.2    Reber, J.3
  • 26
    • 84860705395 scopus 로고    scopus 로고
    • In vivo imaging of folate receptor positive tumor xenografts using novel 68ga-nodaga-folate conjugates
    • Fani M, Tamma ML, Nicolas GP, et al. In vivo imaging of folate receptor positive tumor xenografts using novel 68Ga-NODAGA-folate conjugates. Mol Pharm. 2012;9: 1136-1145.
    • (2012) Mol Pharm. , vol.9 , pp. 1136-1145
    • Fani, M.1    Tamma, M.L.2    Nicolas, G.P.3
  • 27
    • 79551517797 scopus 로고    scopus 로고
    • Development of new folate-based pet radiotracers: Preclinical evaluation of 68ga-dota-folate conjugates
    • Fani M, Wang X, Nicolas G, et al. Development of new folate-based PET radiotracers: preclinical evaluation of 68Ga-DOTA-folate conjugates. Eur J Nucl Med Mol Imaging. 2011;38:108-119.
    • (2011) Eur J Nucl Med Mol Imaging. , vol.38 , pp. 108-119
    • Fani, M.1    Wang, X.2    Nicolas, G.3
  • 28
    • 84864259555 scopus 로고    scopus 로고
    • Folate receptor alpha expression in lung cancer: Diagnostic and prognostic significance
    • O'Shannessy DJ, Yu G, Smale R, et al. Folate receptor alpha expression in lung cancer: diagnostic and prognostic significance. Oncotarget. 2012;3:414-425.
    • (2012) Oncotarget. , vol.3 , pp. 414-425
    • O'Shannessy, D.J.1    Yu, G.2    Smale, R.3
  • 29
    • 80053989452 scopus 로고    scopus 로고
    • Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-A targeting: First in-human results
    • van Dam GM, Themelis G, Crane LM, et al. Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-a targeting: first in-human results. Nat Med. 2011;17:1315-1319.
    • (2011) Nat Med. , vol.17 , pp. 1315-1319
    • Van Dam, G.M.1    Themelis, G.2    Crane, L.M.3
  • 30
    • 77952295715 scopus 로고    scopus 로고
    • Imaging of atherosclerosis in apoliprotein e knockout mice: Targeting of a folate-conjugated radiopharmaceutical to activated macrophages
    • Ayala-Ĺopez W, Xia W, Varghese B, Low PS. Imaging of atherosclerosis in apoliprotein e knockout mice: targeting of a folate-conjugated radiopharmaceutical to activated macrophages. J Nucl Med. 2010;51:768-774.
    • (2010) J Nucl Med. , vol.51 , pp. 768-774
    • Ayala-Ĺopez, W.1    Xia, W.2    Varghese, B.3    Low, P.S.4
  • 31
    • 0036068396 scopus 로고    scopus 로고
    • Folate-targeted imaging of activated macrophages in rats with adjuvant-induced arthritis
    • Turk MJ, Breur GJ, Widmer WR, et al. Folate-targeted imaging of activated macrophages in rats with adjuvant-induced arthritis. Arthritis Rheum. 2002;46: 1947-1955.
    • (2002) Arthritis Rheum. , vol.46 , pp. 1947-1955
    • Turk, M.J.1    Breur, G.J.2    Widmer, W.R.3
  • 32
    • 1942503257 scopus 로고    scopus 로고
    • Folate receptor-mediated targeting of therapeutic and imaging agents to activated macrophages in rheumatoid arthritis
    • Paulos CM, Turk MJ, Breur GJ, Low PS. Folate receptor-mediated targeting of therapeutic and imaging agents to activated macrophages in rheumatoid arthritis. Adv Drug Deliv Rev. 2004;56:1205-1217.
    • (2004) Adv Drug Deliv Rev. , vol.56 , pp. 1205-1217
    • Paulos, C.M.1    Turk, M.J.2    Breur, G.J.3    Low, P.S.4
  • 33
    • 67249164181 scopus 로고    scopus 로고
    • Assessment of disease activity in rheumatoid arthritis using a novel folate targeted radiopharmaceutical folatescan
    • Matteson EL, Lowe VJ, Prendergast FG, et al. Assessment of disease activity in rheumatoid arthritis using a novel folate targeted radiopharmaceutical Folatescan. Clin Exp Rheumatol. 2009;27:253-259.
    • (2009) Clin Exp Rheumatol. , vol.27 , pp. 253-259
    • Matteson, E.L.1    Lowe, V.J.2    Prendergast, F.G.3
  • 34
    • 79959858929 scopus 로고    scopus 로고
    • Imaging of activated macrophages in experimental osteoarthritis using folate-targeted animal single-photon-emission computed tomographycomputed tomography
    • Piscaer TM, Müller C, Mindt TL, et al. Imaging of activated macrophages in experimental osteoarthritis using folate-targeted animal single-photon-emission computed tomography/computed tomography. Arthritis Rheum. 2011;63:1898-1907.
    • (2011) Arthritis Rheum. , vol.63 , pp. 1898-1907
    • Piscaer, T.M.1    Müller, C.2    Mindt, T.L.3
  • 35
    • 84898020055 scopus 로고    scopus 로고
    • Folate receptor-targeted single-photon emission computed tomography/computed tomography to detect activated macrophages in atherosclerosis: Can it distinguish vulnerable from stable atherosclerotic plaques?
    • Winkel LC, Groen HC, van Thiel BS, et al. Folate receptor-targeted single-photon emission computed tomography/computed tomography to detect activated macrophages in atherosclerosis: can it distinguish vulnerable from stable atherosclerotic plaques? Mol Imaging. 2013;12:1-5.
    • (2013) Mol Imaging. , vol.12 , pp. 1-5
    • Winkel, L.C.1    Groen, H.C.2    Van Thiel, B.S.3


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